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The map label for this gene is sdhA [H]

Identifier: 119356024

GI number: 119356024

Start: 202132

End: 203835

Strand: Reverse

Name: sdhA [H]

Synonym: Cpha266_0177

Alternate gene names: 119356024

Gene position: 203835-202132 (Counterclockwise)

Preceding gene: 119356025

Following gene: 119356023

Centisome position: 6.5

GC content: 50.35

Gene sequence:

>1704_bases
ATGAAACCATTTGATATCGTTATTGTCGGAGGAGGCGGTGCAGGATTATATGCTGCTATGGAGGCCATGAAAACCAATCC
CTCCCTGAATATCGCCGTTTTATCGAAAGTCTATCCAAACCGCTCACATACCTCGGCAGCCCAGGGAGGAGCCAATGCGG
CCCTTGCCAACAAGGCAAAGGATGACACCGTCGAAATGCATATTTTCGACACCATCAAAGGCAGTGATTACCTTGCCGAT
CAGGATGCAGTCGATATCCTCTGTTCCGAAGCGCCAAAAATCATCCGTGAGCTCGACAACATAGGCACTCCATGGTCGCG
CCTTGACGATAATACTATTGCCCAGAGGCCTTTCGGTGGAGCCGGACGACCGCGATGCTGCTACTGCGCAGACAAAACCG
GCCATACCATTCTGCAGACGCTTTATGAACAGTGTCTGAAAAAAGGGGTCTTTTTCTTCAATGAATATTTTTCCCTGAGC
CTTTCAGTCAATAACAGCCGTATGAGAGGCCTGCTTGCCATCAACATGAAAACAGGCAAGATCGAAGCTTTTCCTGCCAA
AACGGTTATTTTCGCAACCGGCGGCTATGCGAAAATGTACTGGAACCGCTCCAGCAATGCCGCAGGCAATACCGGTGATG
GACAGGCCATAGCCTACCGTGCAGGAATTCCTCTCAAAGATATGGAGTTTGTCCAGTTTCACCCGACCGGCCTGAGAAAA
AGCGGCCTCCTCGTAACTGAAGGAGCCAGAGGCGAAGGCGGCTATCTTGTCAATAAAGACGGCGAACGGTTCATGTCGAG
ATATGCTCCCGAAAAAATGGAGCTGGGCCCAAGAGACCTTGTTTCTCGTTCCATCGAAACGGAAATCCTGCAGGGAAGAG
GCTTTGACAGCCCGGCAGGTAAATATATCCACCTTGATCTGACCCATCTTGGGGCAGAGCTGATCAAATCAAGGCTACCC
CAGATCCGGGAAATGTCGATGAATTTCGAAGGCGTCGACCCTATAGAAGAACCGATTCCCGTCAGGCCAACCGCGCATTA
TTCCATGGGCGGCATTGATACCGACAACTATGGCAGAACGGTAATGGACGGCGTCTATGCCGCAGGGGAGTGTGCCTGCG
TATCGGTACACGGAGCAAACCGGCTTGGCGGCAACTCGCTTCTCGACATCCTCGTATTCGGACGAATTGCCGGACACACA
GCCGCAGAAGAGGCAGGAAAATTCGAACCGGGAAACATTTCCCCTGAAGAGATCAAAGCCAAAGACGAAGAACTCAGAAG
CTTCATGCAATCTTCGGGACATTACGAACGCTATGGCGCACTGAGGGAAGAGCTTGGCCAAACCCTTGCGCTTAATGTCG
GCATATACAGAGAGGCATCTAAAATCAGTCGAGGGATGGAGGACCTGTCACTATTGAAAGATCGCTTCAAGAAAATACGT
GTTTTCGACTCCAGCGACATCTTCAATACCAATCTTATTCAGGTTCTTGAACTGCAGAACATGCTGGATCTGGCCGAAAC
CGTCGCAACGGGAGCTCTTGCAAGAGAGGAAAGCCGTGGCTCACATACAAGAAATGACTTCCCGACAAGGAACGATGAAA
AATGGCACAAACACACATTGGCAACCCTTGAAAACGGGACGGTAAAACTCGGTCAAAAACCTGTAACGATGGGCAGGTAT
GAACTCCAGGAAAGAACCTATTAA

Upstream 100 bases:

>100_bases
CGGTCAGAGATACATAGTTTAATCTTCAGGGTACAATCGTTGCGACCCTTCTTACCATCAGTGATGCTGTTTTTCCAGCC
TCATAAAGCTATTTGAGCGT

Downstream 100 bases:

>100_bases
CTCAATGCACATGACGGGAGCAGCAGAACAGCATAAAGAAGAAAAAAGGGATATAACCTTTCGGGTATTCCGATTTAACC
CGCAGGTAGACATCAAACCC

Product: succinate dehydrogenase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MKPFDIVIVGGGGAGLYAAMEAMKTNPSLNIAVLSKVYPNRSHTSAAQGGANAALANKAKDDTVEMHIFDTIKGSDYLAD
QDAVDILCSEAPKIIRELDNIGTPWSRLDDNTIAQRPFGGAGRPRCCYCADKTGHTILQTLYEQCLKKGVFFFNEYFSLS
LSVNNSRMRGLLAINMKTGKIEAFPAKTVIFATGGYAKMYWNRSSNAAGNTGDGQAIAYRAGIPLKDMEFVQFHPTGLRK
SGLLVTEGARGEGGYLVNKDGERFMSRYAPEKMELGPRDLVSRSIETEILQGRGFDSPAGKYIHLDLTHLGAELIKSRLP
QIREMSMNFEGVDPIEEPIPVRPTAHYSMGGIDTDNYGRTVMDGVYAAGECACVSVHGANRLGGNSLLDILVFGRIAGHT
AAEEAGKFEPGNISPEEIKAKDEELRSFMQSSGHYERYGALREELGQTLALNVGIYREASKISRGMEDLSLLKDRFKKIR
VFDSSDIFNTNLIQVLELQNMLDLAETVATGALAREESRGSHTRNDFPTRNDEKWHKHTLATLENGTVKLGQKPVTMGRY
ELQERTY

Sequences:

>Translated_567_residues
MKPFDIVIVGGGGAGLYAAMEAMKTNPSLNIAVLSKVYPNRSHTSAAQGGANAALANKAKDDTVEMHIFDTIKGSDYLAD
QDAVDILCSEAPKIIRELDNIGTPWSRLDDNTIAQRPFGGAGRPRCCYCADKTGHTILQTLYEQCLKKGVFFFNEYFSLS
LSVNNSRMRGLLAINMKTGKIEAFPAKTVIFATGGYAKMYWNRSSNAAGNTGDGQAIAYRAGIPLKDMEFVQFHPTGLRK
SGLLVTEGARGEGGYLVNKDGERFMSRYAPEKMELGPRDLVSRSIETEILQGRGFDSPAGKYIHLDLTHLGAELIKSRLP
QIREMSMNFEGVDPIEEPIPVRPTAHYSMGGIDTDNYGRTVMDGVYAAGECACVSVHGANRLGGNSLLDILVFGRIAGHT
AAEEAGKFEPGNISPEEIKAKDEELRSFMQSSGHYERYGALREELGQTLALNVGIYREASKISRGMEDLSLLKDRFKKIR
VFDSSDIFNTNLIQVLELQNMLDLAETVATGALAREESRGSHTRNDFPTRNDEKWHKHTLATLENGTVKLGQKPVTMGRY
ELQERTY
>Mature_567_residues
MKPFDIVIVGGGGAGLYAAMEAMKTNPSLNIAVLSKVYPNRSHTSAAQGGANAALANKAKDDTVEMHIFDTIKGSDYLAD
QDAVDILCSEAPKIIRELDNIGTPWSRLDDNTIAQRPFGGAGRPRCCYCADKTGHTILQTLYEQCLKKGVFFFNEYFSLS
LSVNNSRMRGLLAINMKTGKIEAFPAKTVIFATGGYAKMYWNRSSNAAGNTGDGQAIAYRAGIPLKDMEFVQFHPTGLRK
SGLLVTEGARGEGGYLVNKDGERFMSRYAPEKMELGPRDLVSRSIETEILQGRGFDSPAGKYIHLDLTHLGAELIKSRLP
QIREMSMNFEGVDPIEEPIPVRPTAHYSMGGIDTDNYGRTVMDGVYAAGECACVSVHGANRLGGNSLLDILVFGRIAGHT
AAEEAGKFEPGNISPEEIKAKDEELRSFMQSSGHYERYGALREELGQTLALNVGIYREASKISRGMEDLSLLKDRFKKIR
VFDSSDIFNTNLIQVLELQNMLDLAETVATGALAREESRGSHTRNDFPTRNDEKWHKHTLATLENGTVKLGQKPVTMGRY
ELQERTY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=566, Percent_Identity=42.5795053003534, Blast_Score=442, Evalue=1e-124,
Organism=Escherichia coli, GI1786942, Length=560, Percent_Identity=46.0714285714286, Blast_Score=460, Evalue=1e-130,
Organism=Escherichia coli, GI1790597, Length=554, Percent_Identity=42.4187725631769, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI1788928, Length=545, Percent_Identity=31.743119266055, Blast_Score=238, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI17505833, Length=570, Percent_Identity=42.9824561403509, Blast_Score=427, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17550100, Length=569, Percent_Identity=43.585237258348, Blast_Score=426, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI71986328, Length=433, Percent_Identity=26.3279445727483, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322701, Length=534, Percent_Identity=46.0674157303371, Blast_Score=463, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6322416, Length=539, Percent_Identity=45.2690166975881, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI17137288, Length=562, Percent_Identity=43.4163701067616, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24655642, Length=562, Percent_Identity=43.4163701067616, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24655647, Length=562, Percent_Identity=43.4163701067616, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24663005, Length=572, Percent_Identity=42.3076923076923, Blast_Score=433, Evalue=1e-121,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 62367; Mature: 62367

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPFDIVIVGGGGAGLYAAMEAMKTNPSLNIAVLSKVYPNRSHTSAAQGGANAALANKAK
CCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEEEHHCCCCCCCCHHCCCCCHHHHCCCC
DDTVEMHIFDTIKGSDYLADQDAVDILCSEAPKIIRELDNIGTPWSRLDDNTIAQRPFGG
CCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCC
AGRPRCCYCADKTGHTILQTLYEQCLKKGVFFFNEYFSLSLSVNNSRMRGLLAINMKTGK
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCEEEEEEEEECCE
IEAFPAKTVIFATGGYAKMYWNRSSNAAGNTGDGQAIAYRAGIPLKDMEFVQFHPTGLRK
EEECCCCEEEEECCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCC
SGLLVTEGARGEGGYLVNKDGERFMSRYAPEKMELGPRDLVSRSIETEILQGRGFDSPAG
CCEEEECCCCCCCCEEECCCHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
KYIHLDLTHLGAELIKSRLPQIREMSMNFEGVDPIEEPIPVRPTAHYSMGGIDTDNYGRT
CEEEEEHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
VMDGVYAAGECACVSVHGANRLGGNSLLDILVFGRIAGHTAAEEAGKFEPGNISPEEIKA
HHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHC
KDEELRSFMQSSGHYERYGALREELGQTLALNVGIYREASKISRGMEDLSLLKDRFKKIR
CHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECHHHHHHHHHCCHHHHHHHHHHHHHEE
VFDSSDIFNTNLIQVLELQNMLDLAETVATGALAREESRGSHTRNDFPTRNDEKWHKHTL
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
ATLENGTVKLGQKPVTMGRYELQERTY
HHCCCCEEEECCCCCCCCHHHHHHCCC
>Mature Secondary Structure
MKPFDIVIVGGGGAGLYAAMEAMKTNPSLNIAVLSKVYPNRSHTSAAQGGANAALANKAK
CCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEEEHHCCCCCCCCHHCCCCCHHHHCCCC
DDTVEMHIFDTIKGSDYLADQDAVDILCSEAPKIIRELDNIGTPWSRLDDNTIAQRPFGG
CCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCC
AGRPRCCYCADKTGHTILQTLYEQCLKKGVFFFNEYFSLSLSVNNSRMRGLLAINMKTGK
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCEEEEEEEEECCE
IEAFPAKTVIFATGGYAKMYWNRSSNAAGNTGDGQAIAYRAGIPLKDMEFVQFHPTGLRK
EEECCCCEEEEECCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCC
SGLLVTEGARGEGGYLVNKDGERFMSRYAPEKMELGPRDLVSRSIETEILQGRGFDSPAG
CCEEEECCCCCCCCEEECCCHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
KYIHLDLTHLGAELIKSRLPQIREMSMNFEGVDPIEEPIPVRPTAHYSMGGIDTDNYGRT
CEEEEEHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
VMDGVYAAGECACVSVHGANRLGGNSLLDILVFGRIAGHTAAEEAGKFEPGNISPEEIKA
HHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHC
KDEELRSFMQSSGHYERYGALREELGQTLALNVGIYREASKISRGMEDLSLLKDRFKKIR
CHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECHHHHHHHHHCCHHHHHHHHHHHHHEE
VFDSSDIFNTNLIQVLELQNMLDLAETVATGALAREESRGSHTRNDFPTRNDEKWHKHTL
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
ATLENGTVKLGQKPVTMGRYELQERTY
HHCCCCEEEECCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA