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The map label for this gene is frdB [H]

Identifier: 119356023

GI number: 119356023

Start: 201087

End: 202157

Strand: Reverse

Name: frdB [H]

Synonym: Cpha266_0176

Alternate gene names: 119356023

Gene position: 202157-201087 (Counterclockwise)

Preceding gene: 119356024

Following gene: 119356022

Centisome position: 6.45

GC content: 48.55

Gene sequence:

>1071_bases
ATGAACTCCAGGAAAGAACCTATTAACTCAATGCACATGACGGGAGCAGCAGAACAGCATAAAGAAGAAAAAAGGGATAT
AACCTTTCGGGTATTCCGATTTAACCCGCAGGTAGACATCAAACCCTATTTCGATGACTACACCATCCCTGTTGAACGAG
GCATTACCGTTCTCCGAGCACTCAATTATATAAAGGAGCATGTCGATCCAACGGTAAGTTACAGAGCATTCTGCCAGGCA
GGAATCTGTGGATCCTGCGGCATGCGGGTAAACGGCATATCGAAGCTTGCTTGCACCACACAGGTCTGGGACGAGCTTGA
CCGGTGTAAAGAACCCGGAATCCTCAGGGTTGAGCCTCTGCGCAATATGCCCCCCATAAAAGACCTCATCGTTGACATGG
ATCCTCTTGTCGACAAGATGAAACACTATATGAACTGGGTCGACTCATCAATGCCTGAATCCGAAATGGGCAAAAAAGAG
TTTCTTGTATCAGAAGATGAGTTTTTAAAATACGACAAGGCGACAGACTGCATACTCTGCGCATCATGCGTTTCGGAATG
CACCATTCTGAGAGCACACAAAGAGTATGTATCCCCCGCTGTTCTCCTGAAATCCTACAGAATGAACGTTGACAGCCGCG
ACTCAATTCACGACACACGCCTTGCCGAACTGGTAAAGGATCACGGCGTCTGGGATTGTACGCACTGCTATCGCTGTCAG
GAAACCTGCGTCAAAAGCATTCCCATCATGGATGCCATCCACGGCATACGCGAAAACGCTCTGGAGGTCAGAGGAACAAA
AGACACCAGCGGCGCGAAACATGCCGAAGCCTTCATGGATGATATCGCAAAGAAAGGAAAACTCGTTGAAGCCACCCTGC
CGTTCCGGACAAATGGTGTGCTATGGACACTGCAGAATCTGTTGCCCATGGCAGTAAAAATGATCATGAAGCGCCGTACG
CCTCCTCCACCGCCTATGGTAAAACCATCCAAGGGAATCAAGGCGTTCCGGGAAGAGTTCAGAGAGATGACGGAGCACGT
CAAAGATGATCATCAGACACATAACAAATAA

Upstream 100 bases:

>100_bases
TTCCCGACAAGGAACGATGAAAAATGGCACAAACACACATTGGCAACCCTTGAAAACGGGACGGTAAAACTCGGTCAAAA
ACCTGTAACGATGGGCAGGT

Downstream 100 bases:

>100_bases
TCGGGGGAGAATCGCGAGATGAAACGGTATGCATACTACCTGAGCTGTATAAACGAATCCATGACGAAGGAGCTCGACCG
CTCAATCGACCTGTGGCAAA

Product: succinate dehydrogenase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MNSRKEPINSMHMTGAAEQHKEEKRDITFRVFRFNPQVDIKPYFDDYTIPVERGITVLRALNYIKEHVDPTVSYRAFCQA
GICGSCGMRVNGISKLACTTQVWDELDRCKEPGILRVEPLRNMPPIKDLIVDMDPLVDKMKHYMNWVDSSMPESEMGKKE
FLVSEDEFLKYDKATDCILCASCVSECTILRAHKEYVSPAVLLKSYRMNVDSRDSIHDTRLAELVKDHGVWDCTHCYRCQ
ETCVKSIPIMDAIHGIRENALEVRGTKDTSGAKHAEAFMDDIAKKGKLVEATLPFRTNGVLWTLQNLLPMAVKMIMKRRT
PPPPPMVKPSKGIKAFREEFREMTEHVKDDHQTHNK

Sequences:

>Translated_356_residues
MNSRKEPINSMHMTGAAEQHKEEKRDITFRVFRFNPQVDIKPYFDDYTIPVERGITVLRALNYIKEHVDPTVSYRAFCQA
GICGSCGMRVNGISKLACTTQVWDELDRCKEPGILRVEPLRNMPPIKDLIVDMDPLVDKMKHYMNWVDSSMPESEMGKKE
FLVSEDEFLKYDKATDCILCASCVSECTILRAHKEYVSPAVLLKSYRMNVDSRDSIHDTRLAELVKDHGVWDCTHCYRCQ
ETCVKSIPIMDAIHGIRENALEVRGTKDTSGAKHAEAFMDDIAKKGKLVEATLPFRTNGVLWTLQNLLPMAVKMIMKRRT
PPPPPMVKPSKGIKAFREEFREMTEHVKDDHQTHNK
>Mature_356_residues
MNSRKEPINSMHMTGAAEQHKEEKRDITFRVFRFNPQVDIKPYFDDYTIPVERGITVLRALNYIKEHVDPTVSYRAFCQA
GICGSCGMRVNGISKLACTTQVWDELDRCKEPGILRVEPLRNMPPIKDLIVDMDPLVDKMKHYMNWVDSSMPESEMGKKE
FLVSEDEFLKYDKATDCILCASCVSECTILRAHKEYVSPAVLLKSYRMNVDSRDSIHDTRLAELVKDHGVWDCTHCYRCQ
ETCVKSIPIMDAIHGIRENALEVRGTKDTSGAKHAEAFMDDIAKKGKLVEATLPFRTNGVLWTLQNLLPMAVKMIMKRRT
PPPPPMVKPSKGIKAFREEFREMTEHVKDDHQTHNK

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=247, Percent_Identity=33.6032388663968, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1790596, Length=232, Percent_Identity=33.6206896551724, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1786943, Length=243, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17533915, Length=246, Percent_Identity=31.7073170731707, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322987, Length=236, Percent_Identity=33.8983050847458, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI17137106, Length=247, Percent_Identity=33.6032388663968, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24643156, Length=233, Percent_Identity=32.618025751073, Blast_Score=133, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 40852; Mature: 40852

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
8.7 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
8.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSRKEPINSMHMTGAAEQHKEEKRDITFRVFRFNPQVDIKPYFDDYTIPVERGITVLRA
CCCCCCCHHHHHHCCCHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
LNYIKEHVDPTVSYRAFCQAGICGSCGMRVNGISKLACTTQVWDELDRCKEPGILRVEPL
HHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCC
RNMPPIKDLIVDMDPLVDKMKHYMNWVDSSMPESEMGKKEFLVSEDEFLKYDKATDCILC
CCCCCHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHCCCHHHCCCCHHHHHHCCCCHHHHH
ASCVSECTILRAHKEYVSPAVLLKSYRMNVDSRDSIHDTRLAELVKDHGVWDCTHCYRCQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
ETCVKSIPIMDAIHGIRENALEVRGTKDTSGAKHAEAFMDDIAKKGKLVEATLPFRTNGV
HHHHHHCCHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCH
LWTLQNLLPMAVKMIMKRRTPPPPPMVKPSKGIKAFREEFREMTEHVKDDHQTHNK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNSRKEPINSMHMTGAAEQHKEEKRDITFRVFRFNPQVDIKPYFDDYTIPVERGITVLRA
CCCCCCCHHHHHHCCCHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
LNYIKEHVDPTVSYRAFCQAGICGSCGMRVNGISKLACTTQVWDELDRCKEPGILRVEPL
HHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCC
RNMPPIKDLIVDMDPLVDKMKHYMNWVDSSMPESEMGKKEFLVSEDEFLKYDKATDCILC
CCCCCHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHCCCHHHCCCCHHHHHHCCCCHHHHH
ASCVSECTILRAHKEYVSPAVLLKSYRMNVDSRDSIHDTRLAELVKDHGVWDCTHCYRCQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
ETCVKSIPIMDAIHGIRENALEVRGTKDTSGAKHAEAFMDDIAKKGKLVEATLPFRTNGV
HHHHHHCCHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCH
LWTLQNLLPMAVKMIMKRRTPPPPPMVKPSKGIKAFREEFREMTEHVKDDHQTHNK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]