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The map label for this gene is mazG [H]

Identifier: 119356001

GI number: 119356001

Start: 171220

End: 172038

Strand: Reverse

Name: mazG [H]

Synonym: Cpha266_0151

Alternate gene names: 119356001

Gene position: 172038-171220 (Counterclockwise)

Preceding gene: 119356005

Following gene: 119355968

Centisome position: 5.49

GC content: 54.46

Gene sequence:

>819_bases
ATGCCGATACCCCGGAACACTACTACAGAAGAACGGAAAGCCGCCATTCTCGCAAAAAGGGAACGCTCGCTCAGCGAACA
TTTCGAACGGGTGGTAAGCCTTGTTGATGTCCTGCGCAACGAATGCCCGTGGGATCGGAAGCAGACGCCCGCTTCGCTTG
CCCATCTCCTGCTTGAGGAGAGCTATGAGCTGGTTCACGCCATTGACGAAAACGACGATATCGAGCTGAAAAAGGAGCTT
GGCGACCTCTTTCTCCACCTCTGCTTTCAGGTTATCCTTGCCGAAGAAACGCAAAAATTCACCTTTTCAGACGTTTTCGA
AGCCTTGTCGGCAAAACTGATCGGCCGTCACCCGCATGTCTTCGGCGATACCGTTGCCGACACCGAACAGGAGGTGCTGA
AAAACTGGGAAACGCTGAAACTTCAGGAGGGACGAAAAAAGCTGCTTGACGGGGTGCCGAAAGCCATGTCGGAGCTCCTT
CGCGCATACCGGGTGCAGAAAAAGGTGTCGGGTGTCGGGTTCGACTGGCAGAACGACGAGGGCGTGCTCGATAAACTCGT
CGAAGAGATTGCCGAGCTGAAAAACGCAGCGACAAAGGAGGAACAGGAGGAGGAGTTCGGCGACCTGCTCTTTACCGTCG
TGAACTACAGCCGGTTTATTGGTGCAAACCCTGAAGACGCCCTGCGAAAGGCAACCAACAAGTTCATGAAACGGTTTGAG
GCCGTCGAAGCAACGGTACAGCAATCAGGCCGGAACTGGCAGGCGTTCTCCGCTGAAGAACTCGACCTGCTCTGGCAGAA
AGCCAAGAATGAGCTGTAG

Upstream 100 bases:

>100_bases
ACAGGTAACGGAGGTGAAGAAAAAACCTTTTCGGTGAAAGGTAAGGAATATTGCAGAGAACTGTTAACTTTGAGAGCACT
GAAACCACCCGACTCTCACT

Downstream 100 bases:

>100_bases
CCGACGACCGGACGGAATCGACGTTTCATCTGTTCCTGCGCTTCAGGCTCTTCTCTGAACGGTTATACGCGCAGCGGCGC
CAGTCAGGTCATGCGCCGGA

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MPIPRNTTTEERKAAILAKRERSLSEHFERVVSLVDVLRNECPWDRKQTPASLAHLLLEESYELVHAIDENDDIELKKEL
GDLFLHLCFQVILAEETQKFTFSDVFEALSAKLIGRHPHVFGDTVADTEQEVLKNWETLKLQEGRKKLLDGVPKAMSELL
RAYRVQKKVSGVGFDWQNDEGVLDKLVEEIAELKNAATKEEQEEEFGDLLFTVVNYSRFIGANPEDALRKATNKFMKRFE
AVEATVQQSGRNWQAFSAEELDLLWQKAKNEL

Sequences:

>Translated_272_residues
MPIPRNTTTEERKAAILAKRERSLSEHFERVVSLVDVLRNECPWDRKQTPASLAHLLLEESYELVHAIDENDDIELKKEL
GDLFLHLCFQVILAEETQKFTFSDVFEALSAKLIGRHPHVFGDTVADTEQEVLKNWETLKLQEGRKKLLDGVPKAMSELL
RAYRVQKKVSGVGFDWQNDEGVLDKLVEEIAELKNAATKEEQEEEFGDLLFTVVNYSRFIGANPEDALRKATNKFMKRFE
AVEATVQQSGRNWQAFSAEELDLLWQKAKNEL
>Mature_271_residues
PIPRNTTTEERKAAILAKRERSLSEHFERVVSLVDVLRNECPWDRKQTPASLAHLLLEESYELVHAIDENDDIELKKELG
DLFLHLCFQVILAEETQKFTFSDVFEALSAKLIGRHPHVFGDTVADTEQEVLKNWETLKLQEGRKKLLDGVPKAMSELLR
AYRVQKKVSGVGFDWQNDEGVLDKLVEEIAELKNAATKEEQEEEFGDLLFTVVNYSRFIGANPEDALRKATNKFMKRFEA
VEATVQQSGRNWQAFSAEELDLLWQKAKNEL

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=257, Percent_Identity=39.6887159533074, Blast_Score=186, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 31275; Mature: 31144

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00014 ER_TARGET

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIPRNTTTEERKAAILAKRERSLSEHFERVVSLVDVLRNECPWDRKQTPASLAHLLLEE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
SYELVHAIDENDDIELKKELGDLFLHLCFQVILAEETQKFTFSDVFEALSAKLIGRHPHV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
FGDTVADTEQEVLKNWETLKLQEGRKKLLDGVPKAMSELLRAYRVQKKVSGVGFDWQNDE
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GVLDKLVEEIAELKNAATKEEQEEEFGDLLFTVVNYSRFIGANPEDALRKATNKFMKRFE
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AVEATVQQSGRNWQAFSAEELDLLWQKAKNEL
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PIPRNTTTEERKAAILAKRERSLSEHFERVVSLVDVLRNECPWDRKQTPASLAHLLLEE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
SYELVHAIDENDDIELKKELGDLFLHLCFQVILAEETQKFTFSDVFEALSAKLIGRHPHV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
FGDTVADTEQEVLKNWETLKLQEGRKKLLDGVPKAMSELLRAYRVQKKVSGVGFDWQNDE
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GVLDKLVEEIAELKNAATKEEQEEEFGDLLFTVVNYSRFIGANPEDALRKATNKFMKRFE
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AVEATVQQSGRNWQAFSAEELDLLWQKAKNEL
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]