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The map label for this gene is bioF [C]

Identifier: 119355963

GI number: 119355963

Start: 133086

End: 134270

Strand: Direct

Name: bioF [C]

Synonym: Cpha266_0113

Alternate gene names: 119355963

Gene position: 133086-134270 (Clockwise)

Preceding gene: 119355962

Following gene: 119355964

Centisome position: 4.25

GC content: 54.26

Gene sequence:

>1185_bases
ATGGTTCAACTGAGCGGAAGCATGATGCCGATCCGTGAATCAATAGAGCGGGAGCTGCTGGCGCTTCGCCAGAAGGGCCG
CTACCGGGAACTTCCTTCCGTAACGCAGCGGAGCGGGAACCGTATCCGTATTGGCGGCAAGCTGCTGCTGAACCTCTCTT
CCAATGATTATCTGGGCCTTGGCGACCGACGGGAGATGCTCGATCGCTATCTCGTAACGCTTCGGGAGGCAGGATATGCC
ATGACCAGTTCCTCATCGAGATTGCTTACCGGCAATCATCCTCTTTATGGCGAGCTCGAGCAAACTCTTGCCGATCTGTA
CGGGCGTGAAGCCGCACTGGTTTTCAACAGTGGTTATCATGCCAATACCGGAATTCTTCCCGCACTCAGTACTCGGCATG
ACCTTATTCTCTGCGACAGACTTAATCATGCGAGTATTATTGACGGCCTCATGATTGCCGCTGCGCCCTACATCCGATAT
CGGCACGGTGATTATCAACATCTGGAGGAGCTGCTTTCTGACGCTGCCGGACGGTATCGTCAGCTTTTTATTATCAGCGA
ATCGGTGTTCAGCATGGATGGTGATCTTGCTGACCTTGAACGACTTGTGGCCTTGAAAAAACGGTACGGTGCATTTCTGA
TTATCGATGAAGCGCATGGGGTCGGCGTGTTCGGTCAAAAAGGACTTGGTCTCTGTGAGGTCGCGGGCATGGTGGAGGGG
ATCGATATGATTGTAGGAACATTCGGCAAAGCATTTGCTTCTGTCGGAGCCTACGCGGTGATGGATACGTTGTTCAGAGA
GTATCTGATCAATACCATGCGCCCGCTGATTTTTACGACTGCCCTTCCTCCGGCGATTCTCGGCTGGAGCCTTGCCGTCG
TGCGGCAGCAGGCGGTAATGAGTGATGAGCGAAACCGTCTTCAGGCGCTTGCTGCAAGGCTTCGCAACGCACTGCGGGAG
CGGGGGCTGGCTGTTGCGGGTGAAAGTCAGATTGTTCCCGTTGTCGCAGGCGGCGACAGGCAGGCTGTTCTGCTTGCTGA
AAAACTTGCCGCAGCGGGAATTCTTGCCCTTCCGGTACGTCCCCCGACCGTTCCTGAAAACAGCGCACGTCTTCGGCTTT
CACTAAGGGCGGATTTGCAGTGGGAAGATATCGAGTCTGTTCCTGAACTTCTTCAAGGTTTATGA

Upstream 100 bases:

>100_bases
TTTTGATGCTTTCGGGTGCGGACGGGCTGCTTACCGGCGGCTATCTTACCACAAGGGGGCGAGCGACAGCGGATGACCGC
ATGTTCATGCGGCAACTCCA

Downstream 100 bases:

>100_bases
GATCATGAAAACAGCGTGGATTTCAAGGACGGGAGAATTGGAACTGCTCCTGTTTTTTGCCGGGTGGGGCATGGACAGCG
CTCTTGCCGAGCATCTTTGG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MVQLSGSMMPIRESIERELLALRQKGRYRELPSVTQRSGNRIRIGGKLLLNLSSNDYLGLGDRREMLDRYLVTLREAGYA
MTSSSSRLLTGNHPLYGELEQTLADLYGREAALVFNSGYHANTGILPALSTRHDLILCDRLNHASIIDGLMIAAAPYIRY
RHGDYQHLEELLSDAAGRYRQLFIISESVFSMDGDLADLERLVALKKRYGAFLIIDEAHGVGVFGQKGLGLCEVAGMVEG
IDMIVGTFGKAFASVGAYAVMDTLFREYLINTMRPLIFTTALPPAILGWSLAVVRQQAVMSDERNRLQALAARLRNALRE
RGLAVAGESQIVPVVAGGDRQAVLLAEKLAAAGILALPVRPPTVPENSARLRLSLRADLQWEDIESVPELLQGL

Sequences:

>Translated_394_residues
MVQLSGSMMPIRESIERELLALRQKGRYRELPSVTQRSGNRIRIGGKLLLNLSSNDYLGLGDRREMLDRYLVTLREAGYA
MTSSSSRLLTGNHPLYGELEQTLADLYGREAALVFNSGYHANTGILPALSTRHDLILCDRLNHASIIDGLMIAAAPYIRY
RHGDYQHLEELLSDAAGRYRQLFIISESVFSMDGDLADLERLVALKKRYGAFLIIDEAHGVGVFGQKGLGLCEVAGMVEG
IDMIVGTFGKAFASVGAYAVMDTLFREYLINTMRPLIFTTALPPAILGWSLAVVRQQAVMSDERNRLQALAARLRNALRE
RGLAVAGESQIVPVVAGGDRQAVLLAEKLAAAGILALPVRPPTVPENSARLRLSLRADLQWEDIESVPELLQGL
>Mature_394_residues
MVQLSGSMMPIRESIERELLALRQKGRYRELPSVTQRSGNRIRIGGKLLLNLSSNDYLGLGDRREMLDRYLVTLREAGYA
MTSSSSRLLTGNHPLYGELEQTLADLYGREAALVFNSGYHANTGILPALSTRHDLILCDRLNHASIIDGLMIAAAPYIRY
RHGDYQHLEELLSDAAGRYRQLFIISESVFSMDGDLADLERLVALKKRYGAFLIIDEAHGVGVFGQKGLGLCEVAGMVEG
IDMIVGTFGKAFASVGAYAVMDTLFREYLINTMRPLIFTTALPPAILGWSLAVVRQQAVMSDERNRLQALAARLRNALRE
RGLAVAGESQIVPVVAGGDRQAVLLAEKLAAAGILALPVRPPTVPENSARLRLSLRADLQWEDIESVPELLQGL

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=386, Percent_Identity=33.9378238341969, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI284448556, Length=412, Percent_Identity=31.7961165048544, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI83977442, Length=338, Percent_Identity=33.4319526627219, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI83977440, Length=338, Percent_Identity=33.4319526627219, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI83977444, Length=338, Percent_Identity=33.4319526627219, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4502025, Length=341, Percent_Identity=33.4310850439883, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI40316939, Length=341, Percent_Identity=33.4310850439883, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI4758668, Length=370, Percent_Identity=29.7297297297297, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI119220554, Length=362, Percent_Identity=29.8342541436464, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI5454084, Length=265, Percent_Identity=26.7924528301887, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1786993, Length=368, Percent_Identity=34.7826086956522, Blast_Score=197, Evalue=7e-52,
Organism=Escherichia coli, GI1790046, Length=382, Percent_Identity=32.7225130890052, Blast_Score=190, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71994529, Length=384, Percent_Identity=32.03125, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI32566772, Length=399, Percent_Identity=30.5764411027569, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17560914, Length=312, Percent_Identity=28.2051282051282, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17560912, Length=312, Percent_Identity=28.2051282051282, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI71982625, Length=300, Percent_Identity=25.3333333333333, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71982617, Length=300, Percent_Identity=25.3333333333333, Blast_Score=105, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6320438, Length=391, Percent_Identity=31.7135549872123, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320267, Length=355, Percent_Identity=29.8591549295775, Blast_Score=159, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6323954, Length=280, Percent_Identity=25.3571428571429, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24662918, Length=371, Percent_Identity=33.4231805929919, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI17137420, Length=386, Percent_Identity=29.2746113989637, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI17136286, Length=358, Percent_Identity=28.2122905027933, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24653280, Length=387, Percent_Identity=27.6485788113695, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24653276, Length=387, Percent_Identity=27.6485788113695, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24653278, Length=387, Percent_Identity=27.6485788113695, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43329; Mature: 43329

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQLSGSMMPIRESIERELLALRQKGRYRELPSVTQRSGNRIRIGGKLLLNLSSNDYLGL
CEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEECCEEEEEECCCCCCCC
GDRREMLDRYLVTLREAGYAMTSSSSRLLTGNHPLYGELEQTLADLYGREAALVFNSGYH
CCHHHHHHHHHHHHHHCCCEEECCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCC
ANTGILPALSTRHDLILCDRLNHASIIDGLMIAAAPYIRYRHGDYQHLEELLSDAAGRYR
CCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHCCHHE
QLFIISESVFSMDGDLADLERLVALKKRYGAFLIIDEAHGVGVFGQKGLGLCEVAGMVEG
EEEEEEHHHHHCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
IDMIVGTFGKAFASVGAYAVMDTLFREYLINTMRPLIFTTALPPAILGWSLAVVRQQAVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SDERNRLQALAARLRNALRERGLAVAGESQIVPVVAGGDRQAVLLAEKLAAAGILALPVR
HHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEEECCCCCCHHHHHHHHHCCEEEECCC
PPTVPENSARLRLSLRADLQWEDIESVPELLQGL
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MVQLSGSMMPIRESIERELLALRQKGRYRELPSVTQRSGNRIRIGGKLLLNLSSNDYLGL
CEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEECCEEEEEECCCCCCCC
GDRREMLDRYLVTLREAGYAMTSSSSRLLTGNHPLYGELEQTLADLYGREAALVFNSGYH
CCHHHHHHHHHHHHHHCCCEEECCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCC
ANTGILPALSTRHDLILCDRLNHASIIDGLMIAAAPYIRYRHGDYQHLEELLSDAAGRYR
CCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHCCHHE
QLFIISESVFSMDGDLADLERLVALKKRYGAFLIIDEAHGVGVFGQKGLGLCEVAGMVEG
EEEEEEHHHHHCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
IDMIVGTFGKAFASVGAYAVMDTLFREYLINTMRPLIFTTALPPAILGWSLAVVRQQAVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SDERNRLQALAARLRNALRERGLAVAGESQIVPVVAGGDRQAVLLAEKLAAAGILALPVR
HHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEEECCCCCCHHHHHHHHHCCEEEECCC
PPTVPENSARLRLSLRADLQWEDIESVPELLQGL
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA