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The map label for this gene is 119355906

Identifier: 119355906

GI number: 119355906

Start: 60768

End: 62186

Strand: Reverse

Name: 119355906

Synonym: Cpha266_0056

Alternate gene names: NA

Gene position: 62186-60768 (Counterclockwise)

Preceding gene: 119355909

Following gene: 119355905

Centisome position: 1.98

GC content: 51.73

Gene sequence:

>1419_bases
ATGGCGCGTAAAAAAAACGGAAACACTCCACAGGAGTATGGCGAATTCTCTCCATCAGGTAAGCTGCGTACCGCTATTAT
CGAGGGGAATACGTTTGGGTACAAGTCGGTTCAGTATACTGACGTTGATGGAATGGCCATGTTTGAAGGGGACATCATTC
TCGGCAAGGTTGCCGATGTCGACAGCAAAACCGAGCAGCGCAAACGGGAGATACAGCAGGGGGTTACGCTGCGGGGCATT
ACCATTACAGGAGCCAAGTACCGATGGCCGAACTGTAAAGTCCCCTACACCATCGATACGGCTCTGCCTAATCAGAGCAG
AGTAACCGATGCCATAGCCCACTGGGAGGCAAAAACAAAGTTCCGGTTTATTCTTCGAACAAATGCCAATGCGTCAAGTT
ATCCTGACTGGGTAACATTCAGATCGGGTTCCGGCTGCAGCTCCTATGTCGGGAAACAGGGCGGCCAGCAATACATTAAT
CTTGCCTCGGGATGCTCGAAAGGCAATACCATTCATGAAATCGGCCATACCATAGGGCTTTGGCACGAACACAGCCGTGA
AGACCGGAACGCATTTGTCACCATTCACTGGGATAAAATCATCGCAGGGTATGAACACAATTTCAATCAGCAGATAAGCG
ATGGTGATGATGTCGGCGCTTATGACTACGGATCCATTATGCACTATCCGAGAACCGCCTTTTCAACTGACGGCTCGGAA
ACCATCACCCCGACCGATCCGTCCGCATCGATAGGCCAGAGAACTGCTCTCAGCGCCGGTGACATTGCGGCAGCAAACTC
TCTCTGCCCGACCGTTTCGCTCTGTCCCGCAGCGCCGAAAACCTGTCCCGGTGCACCGATACAGGTTTGCCCTGTTTCAC
CGAAACTCGTATGTCCTCCGGGAATAAAGCTCGCCTGTCCTCCGGGAATAAAACAACTTTGTCCTCCGGGAATAAAACAA
AGTTGTCCCTCAGCACCAATTCAGGTTATCTGTCCGCCAGGGATAAAACTCGCTTGTCCTCCGGGAATAAAAGTCACTTG
TCCTCCTGTGCCGAAAATACCGATCTGCCCACCGTCACCGGTTCCGGGATGTGCTGCCGGCCCGACAAACAAACCGTGGG
TCGGACCGGAGGGGTACACAACAACCTATCGGCTTGATCCTGCGTCCGGAGCTTACTACAGCGATGAGGCCCCTCCTCCA
GGCATGAATCAGATGCCTCCGGTTGTCATCAACATTAATTTTCACGGTTATCAACCTCCTTCCATTCAATCGGATTATGC
ACAATACGACCCCTCCGCCTATGAAAATCAGGACTGGACAGCAACGGAGTATCCTGATCCCGGAGAGGAAGCTGATGATT
CGATAACAAACGAAGAGAGCGAAGCACCGGAAGATTTCAATCCTGAATGTTCGGAGTAA

Upstream 100 bases:

>100_bases
CTCAAGAATTTTTTCGTTGTTCTAAAAAACCTGATACAGATTTTTTCTGCAGTATAGTTCTGAAGGCATCCTCTTTTACA
ACCACAAAAAGGAGAAAACT

Downstream 100 bases:

>100_bases
ACCGCTCAAGTATTAATCATCAACCATGGCAGTATCGCGCAACAAGCCGATACTGCCGTGATCTACCATACATCCATGCA
TTATCCCTATTTCCCGTTTT

Product: peptidase M12A, astacin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MARKKNGNTPQEYGEFSPSGKLRTAIIEGNTFGYKSVQYTDVDGMAMFEGDIILGKVADVDSKTEQRKREIQQGVTLRGI
TITGAKYRWPNCKVPYTIDTALPNQSRVTDAIAHWEAKTKFRFILRTNANASSYPDWVTFRSGSGCSSYVGKQGGQQYIN
LASGCSKGNTIHEIGHTIGLWHEHSREDRNAFVTIHWDKIIAGYEHNFNQQISDGDDVGAYDYGSIMHYPRTAFSTDGSE
TITPTDPSASIGQRTALSAGDIAAANSLCPTVSLCPAAPKTCPGAPIQVCPVSPKLVCPPGIKLACPPGIKQLCPPGIKQ
SCPSAPIQVICPPGIKLACPPGIKVTCPPVPKIPICPPSPVPGCAAGPTNKPWVGPEGYTTTYRLDPASGAYYSDEAPPP
GMNQMPPVVININFHGYQPPSIQSDYAQYDPSAYENQDWTATEYPDPGEEADDSITNEESEAPEDFNPECSE

Sequences:

>Translated_472_residues
MARKKNGNTPQEYGEFSPSGKLRTAIIEGNTFGYKSVQYTDVDGMAMFEGDIILGKVADVDSKTEQRKREIQQGVTLRGI
TITGAKYRWPNCKVPYTIDTALPNQSRVTDAIAHWEAKTKFRFILRTNANASSYPDWVTFRSGSGCSSYVGKQGGQQYIN
LASGCSKGNTIHEIGHTIGLWHEHSREDRNAFVTIHWDKIIAGYEHNFNQQISDGDDVGAYDYGSIMHYPRTAFSTDGSE
TITPTDPSASIGQRTALSAGDIAAANSLCPTVSLCPAAPKTCPGAPIQVCPVSPKLVCPPGIKLACPPGIKQLCPPGIKQ
SCPSAPIQVICPPGIKLACPPGIKVTCPPVPKIPICPPSPVPGCAAGPTNKPWVGPEGYTTTYRLDPASGAYYSDEAPPP
GMNQMPPVVININFHGYQPPSIQSDYAQYDPSAYENQDWTATEYPDPGEEADDSITNEESEAPEDFNPECSE
>Mature_471_residues
ARKKNGNTPQEYGEFSPSGKLRTAIIEGNTFGYKSVQYTDVDGMAMFEGDIILGKVADVDSKTEQRKREIQQGVTLRGIT
ITGAKYRWPNCKVPYTIDTALPNQSRVTDAIAHWEAKTKFRFILRTNANASSYPDWVTFRSGSGCSSYVGKQGGQQYINL
ASGCSKGNTIHEIGHTIGLWHEHSREDRNAFVTIHWDKIIAGYEHNFNQQISDGDDVGAYDYGSIMHYPRTAFSTDGSET
ITPTDPSASIGQRTALSAGDIAAANSLCPTVSLCPAAPKTCPGAPIQVCPVSPKLVCPPGIKLACPPGIKQLCPPGIKQS
CPSAPIQVICPPGIKLACPPGIKVTCPPVPKIPICPPSPVPGCAAGPTNKPWVGPEGYTTTYRLDPASGAYYSDEAPPPG
MNQMPPVVININFHGYQPPSIQSDYAQYDPSAYENQDWTATEYPDPGEEADDSITNEESEAPEDFNPECSE

Specific function: Zinc metallendopeptidase that cleaves preferentially on amino-terminal side of aspartate-containing substrates [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ricin B-type lectin domain [H]

Homologues:

Organism=Homo sapiens, GI157502169, Length=198, Percent_Identity=35.3535353535354, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI153070264, Length=234, Percent_Identity=35.042735042735, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI22547221, Length=259, Percent_Identity=34.7490347490347, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI6912724, Length=216, Percent_Identity=37.5, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI4502421, Length=204, Percent_Identity=38.2352941176471, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI5453579, Length=204, Percent_Identity=38.2352941176471, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI153070262, Length=235, Percent_Identity=31.4893617021277, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71980967, Length=269, Percent_Identity=35.6877323420074, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI71986189, Length=242, Percent_Identity=36.7768595041322, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71989620, Length=200, Percent_Identity=37, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI71981168, Length=235, Percent_Identity=34.0425531914894, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71996833, Length=242, Percent_Identity=35.1239669421488, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71995692, Length=284, Percent_Identity=33.8028169014084, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17568533, Length=280, Percent_Identity=34.2857142857143, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI115532764, Length=194, Percent_Identity=36.0824742268041, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71981193, Length=232, Percent_Identity=33.1896551724138, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI193210526, Length=235, Percent_Identity=34.0425531914894, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI25152806, Length=198, Percent_Identity=37.3737373737374, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI25149641, Length=213, Percent_Identity=34.2723004694836, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71989942, Length=249, Percent_Identity=34.5381526104418, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71989946, Length=249, Percent_Identity=34.5381526104418, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71983097, Length=205, Percent_Identity=34.1463414634146, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71983649, Length=186, Percent_Identity=37.0967741935484, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71983640, Length=186, Percent_Identity=37.0967741935484, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI72000269, Length=273, Percent_Identity=31.8681318681319, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71986142, Length=195, Percent_Identity=31.2820512820513, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71996019, Length=270, Percent_Identity=27.7777777777778, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI86562912, Length=245, Percent_Identity=30.2040816326531, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71993705, Length=339, Percent_Identity=29.2035398230088, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71996558, Length=196, Percent_Identity=30.6122448979592, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71996566, Length=196, Percent_Identity=30.6122448979592, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71991562, Length=197, Percent_Identity=29.4416243654822, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI25150905, Length=232, Percent_Identity=31.0344827586207, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562122, Length=264, Percent_Identity=26.5151515151515, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17509235, Length=189, Percent_Identity=30.1587301587302, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17534131, Length=198, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115532766, Length=97, Percent_Identity=41.2371134020619, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562124, Length=168, Percent_Identity=31.547619047619, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI86564100, Length=175, Percent_Identity=30.8571428571429, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115534560, Length=175, Percent_Identity=30.8571428571429, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17568805, Length=222, Percent_Identity=27.4774774774775, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI72000541, Length=147, Percent_Identity=30.6122448979592, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32566667, Length=190, Percent_Identity=27.8947368421053, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25149215, Length=190, Percent_Identity=27.8947368421053, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71993835, Length=195, Percent_Identity=30.2564102564103, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI17136740, Length=204, Percent_Identity=40.6862745098039, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24649765, Length=204, Percent_Identity=40.6862745098039, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI21355491, Length=201, Percent_Identity=35.3233830845771, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24643089, Length=230, Percent_Identity=32.6086956521739, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI19921382, Length=237, Percent_Identity=34.1772151898734, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24644493, Length=213, Percent_Identity=34.2723004694836, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI45549230, Length=215, Percent_Identity=35.3488372093023, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24649626, Length=199, Percent_Identity=35.1758793969849, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI19921388, Length=192, Percent_Identity=37.5, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19921390, Length=197, Percent_Identity=35.5329949238579, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI20129545, Length=200, Percent_Identity=36, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19921386, Length=203, Percent_Identity=32.512315270936, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI19921384, Length=203, Percent_Identity=31.0344827586207, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001506
- InterPro:   IPR006026
- InterPro:   IPR008997
- InterPro:   IPR000772 [H]

Pfam domain/function: PF01400 Astacin; PF00652 Ricin_B_lectin [H]

EC number: =3.4.24.76 [H]

Molecular weight: Translated: 50923; Mature: 50792

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKKNGNTPQEYGEFSPSGKLRTAIIEGNTFGYKSVQYTDVDGMAMFEGDIILGKVADV
CCCCCCCCCHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCCCEEEEECCEEEEEECCC
DSKTEQRKREIQQGVTLRGITITGAKYRWPNCKVPYTIDTALPNQSRVTDAIAHWEAKTK
CCHHHHHHHHHHCCCEEEEEEEECCEEECCCCCCCEEEECCCCCHHHHHHHHHHHCCCCE
FRFILRTNANASSYPDWVTFRSGSGCSSYVGKQGGQQYINLASGCSKGNTIHEIGHTIGL
EEEEEEECCCCCCCCCEEEEECCCCHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
WHEHSREDRNAFVTIHWDKIIAGYEHNFNQQISDGDDVGAYDYGSIMHYPRTAFSTDGSE
HHHCCCCCCCEEEEEEHHHEEECCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHCCCCCCC
TITPTDPSASIGQRTALSAGDIAAANSLCPTVSLCPAAPKTCPGAPIQVCPVSPKLVCPP
EECCCCCCCCCCCHHCCCCCCHHHHCCCCCCCEECCCCCCCCCCCCEEEECCCCCEECCC
GIKLACPPGIKQLCPPGIKQSCPSAPIQVICPPGIKLACPPGIKVTCPPVPKIPICPPSP
CCEEECCCCHHHHCCCCHHHHCCCCCEEEECCCCCEEECCCCCEEECCCCCCCCCCCCCC
VPGCAAGPTNKPWVGPEGYTTTYRLDPASGAYYSDEAPPPGMNQMPPVVININFHGYQPP
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
SIQSDYAQYDPSAYENQDWTATEYPDPGEEADDSITNEESEAPEDFNPECSE
CCCCHHHHCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ARKKNGNTPQEYGEFSPSGKLRTAIIEGNTFGYKSVQYTDVDGMAMFEGDIILGKVADV
CCCCCCCCHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCCCEEEEECCEEEEEECCC
DSKTEQRKREIQQGVTLRGITITGAKYRWPNCKVPYTIDTALPNQSRVTDAIAHWEAKTK
CCHHHHHHHHHHCCCEEEEEEEECCEEECCCCCCCEEEECCCCCHHHHHHHHHHHCCCCE
FRFILRTNANASSYPDWVTFRSGSGCSSYVGKQGGQQYINLASGCSKGNTIHEIGHTIGL
EEEEEEECCCCCCCCCEEEEECCCCHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
WHEHSREDRNAFVTIHWDKIIAGYEHNFNQQISDGDDVGAYDYGSIMHYPRTAFSTDGSE
HHHCCCCCCCEEEEEEHHHEEECCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHCCCCCCC
TITPTDPSASIGQRTALSAGDIAAANSLCPTVSLCPAAPKTCPGAPIQVCPVSPKLVCPP
EECCCCCCCCCCCHHCCCCCCHHHHCCCCCCCEECCCCCCCCCCCCEEEECCCCCEECCC
GIKLACPPGIKQLCPPGIKQSCPSAPIQVICPPGIKLACPPGIKVTCPPVPKIPICPPSP
CCEEECCCCHHHHCCCCHHHHCCCCCEEEECCCCCEEECCCCCEEECCCCCCCCCCCCCC
VPGCAAGPTNKPWVGPEGYTTTYRLDPASGAYYSDEAPPPGMNQMPPVVININFHGYQPP
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
SIQSDYAQYDPSAYENQDWTATEYPDPGEEADDSITNEESEAPEDFNPECSE
CCCCHHHHCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7771796; 7768917 [H]