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The map label for this gene is gmhA

Identifier: 118581991

GI number: 118581991

Start: 3972367

End: 3972936

Strand: Reverse

Name: gmhA

Synonym: Ppro_3592

Alternate gene names: 118581991

Gene position: 3972936-3972367 (Counterclockwise)

Preceding gene: 118581992

Following gene: 118581990

Centisome position: 99.13

GC content: 63.51

Gene sequence:

>570_bases
ATGCTTGATGACATAACGACCCAGCTCAAGTCCCGCCGGGCGCTCTTTGAACTGATCGCGCGGGACATGCCGCCGCTGAT
GGCCGACATGGCGGCACAGCTGGTAGAGGCGTTCAGAAAGGGCAACAAGCTTTTGGTGATGGGTAACGGCGGTTCGGCTG
CCGATGCCCAGCACCTGGCGGCGGAGATCGTGGGGCGCTTCAAGATGGAGCGCAGGGCCCTGCCGGCCATCTCACTCTCC
ACCGACAGCTCCATCCTCACCGCCCTTGGCAACGACTACGGCTTCGACGCCGTGTTCCGCCGCCAGGTTGAAGCGCTGGC
CCAGGCAGGCGATGTGGTGCTGGGCATCTCCACCAGTGGTAACTCCCCCAACGTGCGCAGCGCCTTACAGCTGGCCAGGG
AGCGGGGGTGCCGAACCATGGGGCTTTTGGGGCGGGATGGCGGCAGTATCAGGTCGTTGTGTGACCTGGCCCTGGTGGTC
CCTTCGTTGGACACCCCTACCATCCAGGAGGGGCACATCACCATCATCCATATCGTCTGCGACCTGGTGGAGAAGGCGTT
GTTTGCCTGA

Upstream 100 bases:

>100_bases
GCCGGATCCGGTTTTGGCGAGGGTGCAGCGCTGCTCCCCTTCGGCGACATGGCCCGCGATCTGGATTTCCCCGACAACGC
CCACTACGGGAGGAGTGCCC

Downstream 100 bases:

>100_bases
GGCGGTACAGGGTTCAGGGCCAAGAGGTTTTCGGCTGAAGAGCCCGAAGCCGGAACGGAGTGAGTATGGATCGCAAATCG
ATTGAATCGATCTTCAACAG

Product: phosphoheptose isomerase

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MLDDITTQLKSRRALFELIARDMPPLMADMAAQLVEAFRKGNKLLVMGNGGSAADAQHLAAEIVGRFKMERRALPAISLS
TDSSILTALGNDYGFDAVFRRQVEALAQAGDVVLGISTSGNSPNVRSALQLARERGCRTMGLLGRDGGSIRSLCDLALVV
PSLDTPTIQEGHITIIHIVCDLVEKALFA

Sequences:

>Translated_189_residues
MLDDITTQLKSRRALFELIARDMPPLMADMAAQLVEAFRKGNKLLVMGNGGSAADAQHLAAEIVGRFKMERRALPAISLS
TDSSILTALGNDYGFDAVFRRQVEALAQAGDVVLGISTSGNSPNVRSALQLARERGCRTMGLLGRDGGSIRSLCDLALVV
PSLDTPTIQEGHITIIHIVCDLVEKALFA
>Mature_189_residues
MLDDITTQLKSRRALFELIARDMPPLMADMAAQLVEAFRKGNKLLVMGNGGSAADAQHLAAEIVGRFKMERRALPAISLS
TDSSILTALGNDYGFDAVFRRQVEALAQAGDVVLGISTSGNSPNVRSALQLARERGCRTMGLLGRDGGSIRSLCDLALVV
PSLDTPTIQEGHITIIHIVCDLVEKALFA

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1786416, Length=158, Percent_Identity=46.2025316455696, Blast_Score=144, Evalue=3e-36,
Organism=Escherichia coli, GI1789539, Length=189, Percent_Identity=41.7989417989418, Blast_Score=142, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHA_PELPD (A1AV13)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_903241.1
- ProteinModelPortal:   A1AV13
- SMR:   A1AV13
- STRING:   A1AV13
- GeneID:   4574672
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_3592
- eggNOG:   COG0279
- HOGENOM:   HBG671955
- OMA:   QEMHILI
- PhylomeDB:   A1AV13
- ProtClustDB:   PRK13937
- GO:   GO:0005737
- HAMAP:   MF_00067
- InterPro:   IPR004515
- InterPro:   IPR020620
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00441

Pfam domain/function: PF01380 SIS

EC number: =5.3.1.28

Molecular weight: Translated: 20233; Mature: 20233

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS51464 SIS

Important sites: BINDING 62-62 BINDING 122-122 BINDING 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDDITTQLKSRRALFELIARDMPPLMADMAAQLVEAFRKGNKLLVMGNGGSAADAQHLA
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
AEIVGRFKMERRALPAISLSTDSSILTALGNDYGFDAVFRRQVEALAQAGDVVLGISTSG
HHHHHHHHHHHHCCCEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEECCC
NSPNVRSALQLARERGCRTMGLLGRDGGSIRSLCDLALVVPSLDTPTIQEGHITIIHIVC
CCCCHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
DLVEKALFA
HHHHHHHCC
>Mature Secondary Structure
MLDDITTQLKSRRALFELIARDMPPLMADMAAQLVEAFRKGNKLLVMGNGGSAADAQHLA
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
AEIVGRFKMERRALPAISLSTDSSILTALGNDYGFDAVFRRQVEALAQAGDVVLGISTSG
HHHHHHHHHHHHCCCEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEECCC
NSPNVRSALQLARERGCRTMGLLGRDGGSIRSLCDLALVVPSLDTPTIQEGHITIIHIVC
CCCCHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
DLVEKALFA
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA