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The map label for this gene is prsA [H]

Identifier: 118581987

GI number: 118581987

Start: 3967817

End: 3968719

Strand: Direct

Name: prsA [H]

Synonym: Ppro_3588

Alternate gene names: 118581987

Gene position: 3967817-3968719 (Clockwise)

Preceding gene: 118581986

Following gene: 118581988

Centisome position: 99.0

GC content: 58.36

Gene sequence:

>903_bases
GTGAACAGCATCACGAGAACAAAATGTATAGCCGTTGCGCTCTGCTCTGTCGCTCTCTTCGCCTGCCAGGGAACACCCGG
TTCCTCCACGGCGACAAAGCAGGAGGGACAGGTTCTTGCCGAGGTTAACGGCAAGAAGATCACCAGTGGCGATTTCAGCC
GTGAAGTCAAGAATCTCCCGGAGTACCTGCGGGCCATGGCCACGACCCCCCAGGGGCGCAAGGAGATGCTGGACACCATG
GTGATCCGTGAGCTGATCCTGCAGAAAGCCTCCAAGGACGGCCTGGACAAGGGGCCGGAGATCGAGGAGAAGTTGCAGGA
GCTGAAAAAGCGCCTGATCGTGGAAGCTTTTCTGAAGAAAAAGGTAGAGACCGACGCCCAGATCTCCGATGCCGACCTGA
AGAAGTTCTACGACCAGAATATCGACAAATTCAAGGCTGGCGAGCAGATCAGGGCCAGCCACATCCTGGTGAAAACTGAG
AAGGAAGCCAAGGAAATCCTAGCACAGCTCAAGGGGGGCGCTGCGTTCGAGGAACTGGCCAGGAAGCACTCCGTGGATTC
CTCTTCCGCCAAGGGGGGCGATCTGGGATGGTTCGGCAAGGGCGCCATGGTTCCGGCCTTTGAACGTGCCGCCCTGGCCC
TCAAGGAGGGGCAGGTATCGGACGTGGTCAAATCCGACTTCGGCTTCCACATCATCAAGCTGACCGGCAAGCGTCCCGCC
GGCACGCGCCCCTTCGACGAGGTCAAGGACCAGATCAAGGCGGCTCTCATGCCGTCCAAGCAGCAGGAGATCTTCCAGAA
GATCAAGGATGAGCTCAAGAAGAGCGCCAAGATCACGGTCAAGGAAGATGCGCTGAATGCCATGAGCGAACCGGCACAAC
CGGCCGTGCCGGAAAAGAAGTAG

Upstream 100 bases:

>100_bases
AGGTCCGGCCGGCAGGCCAGAAAGCGCTTGAAAAGGCAGGGACGGTATGATAATTTTTGAAAAATTTTCATAAAACAATG
AGCTGCAAAAGGAGTCTGCT

Downstream 100 bases:

>100_bases
TTGATCCTGTCCGGAATCGCCTCTTCACATCACTCTGACTGAGTTCACGGCAAAAGGGTGGGGCTGTACGTGCTCACCCT
TTTGCTGCATGTTACGCACT

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MNSITRTKCIAVALCSVALFACQGTPGSSTATKQEGQVLAEVNGKKITSGDFSREVKNLPEYLRAMATTPQGRKEMLDTM
VIRELILQKASKDGLDKGPEIEEKLQELKKRLIVEAFLKKKVETDAQISDADLKKFYDQNIDKFKAGEQIRASHILVKTE
KEAKEILAQLKGGAAFEELARKHSVDSSSAKGGDLGWFGKGAMVPAFERAALALKEGQVSDVVKSDFGFHIIKLTGKRPA
GTRPFDEVKDQIKAALMPSKQQEIFQKIKDELKKSAKITVKEDALNAMSEPAQPAVPEKK

Sequences:

>Translated_300_residues
MNSITRTKCIAVALCSVALFACQGTPGSSTATKQEGQVLAEVNGKKITSGDFSREVKNLPEYLRAMATTPQGRKEMLDTM
VIRELILQKASKDGLDKGPEIEEKLQELKKRLIVEAFLKKKVETDAQISDADLKKFYDQNIDKFKAGEQIRASHILVKTE
KEAKEILAQLKGGAAFEELARKHSVDSSSAKGGDLGWFGKGAMVPAFERAALALKEGQVSDVVKSDFGFHIIKLTGKRPA
GTRPFDEVKDQIKAALMPSKQQEIFQKIKDELKKSAKITVKEDALNAMSEPAQPAVPEKK
>Mature_300_residues
MNSITRTKCIAVALCSVALFACQGTPGSSTATKQEGQVLAEVNGKKITSGDFSREVKNLPEYLRAMATTPQGRKEMLDTM
VIRELILQKASKDGLDKGPEIEEKLQELKKRLIVEAFLKKKVETDAQISDADLKKFYDQNIDKFKAGEQIRASHILVKTE
KEAKEILAQLKGGAAFEELARKHSVDSSSAKGGDLGWFGKGAMVPAFERAALALKEGQVSDVVKSDFGFHIIKLTGKRPA
GTRPFDEVKDQIKAALMPSKQQEIFQKIKDELKKSAKITVKEDALNAMSEPAQPAVPEKK

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI38679892, Length=99, Percent_Identity=36.3636363636364, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1786645, Length=150, Percent_Identity=37.3333333333333, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1790211, Length=83, Percent_Identity=46.9879518072289, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17537235, Length=99, Percent_Identity=35.3535353535354, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322478, Length=78, Percent_Identity=48.7179487179487, Blast_Score=75, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21356303, Length=100, Percent_Identity=39, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17647355, Length=82, Percent_Identity=45.1219512195122, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 32932; Mature: 32932

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSITRTKCIAVALCSVALFACQGTPGSSTATKQEGQVLAEVNGKKITSGDFSREVKNLP
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCEEEECCCCCCCCCHHHHHHHHHH
EYLRAMATTPQGRKEMLDTMVIRELILQKASKDGLDKGPEIEEKLQELKKRLIVEAFLKK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KVETDAQISDADLKKFYDQNIDKFKAGEQIRASHILVKTEKEAKEILAQLKGGAAFEELA
HHHCCCCCCHHHHHHHHHCCHHHHHCCCHHHHHHHEEECHHHHHHHHHHHCCCHHHHHHH
RKHSVDSSSAKGGDLGWFGKGAMVPAFERAALALKEGQVSDVVKSDFGFHIIKLTGKRPA
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCEEEEEEECCCCC
GTRPFDEVKDQIKAALMPSKQQEIFQKIKDELKKSAKITVKEDALNAMSEPAQPAVPEKK
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCEEEHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNSITRTKCIAVALCSVALFACQGTPGSSTATKQEGQVLAEVNGKKITSGDFSREVKNLP
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCEEEECCCCCCCCCHHHHHHHHHH
EYLRAMATTPQGRKEMLDTMVIRELILQKASKDGLDKGPEIEEKLQELKKRLIVEAFLKK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KVETDAQISDADLKKFYDQNIDKFKAGEQIRASHILVKTEKEAKEILAQLKGGAAFEELA
HHHCCCCCCHHHHHHHHHCCHHHHHCCCHHHHHHHEEECHHHHHHHHHHHCCCHHHHHHH
RKHSVDSSSAKGGDLGWFGKGAMVPAFERAALALKEGQVSDVVKSDFGFHIIKLTGKRPA
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCEEEEEEECCCCC
GTRPFDEVKDQIKAALMPSKQQEIFQKIKDELKKSAKITVKEDALNAMSEPAQPAVPEKK
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCEEEHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]