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The map label for this gene is panC

Identifier: 118581935

GI number: 118581935

Start: 3906814

End: 3907668

Strand: Reverse

Name: panC

Synonym: Ppro_3535

Alternate gene names: 118581935

Gene position: 3907668-3906814 (Counterclockwise)

Preceding gene: 118581936

Following gene: 118581933

Centisome position: 97.5

GC content: 63.39

Gene sequence:

>855_bases
ATGAACATCATCGCCGGCATCAACGAAATGCAGACAACCGCCCGCTCTCTGAAACAGCAGGGCAAGAGCATCGCCTTTGT
CCCCACCATGGGGTTCCTGCACGAGGGGCATGCCTCGCTGCTGCGGGAGGGACGCGCACGGGGCGATATCCTGGTGCTCT
CCCTGTTCGTCAATCCGATCCAGTTCGGCCGGAACGAAGACCTGGACCGCTACCCGCGGGACCTGGAGCGGGACCTGGGC
GTTGCTGCCGACTGCGGGGTGGACATCGTCTTCACCCCTTCCGCCACGGAGATGTATCCCGAGGAATTCCAGACCTCCAT
CAGCGTGTCCAGGGTATCGCAGCCGCTGTGCGGAGCCAGCCGGCCCGGGCATTTCGACGGCGTGGCAACGGTGGTGACCA
AGCTGTTCAACATCGTCATGCCCGACATTGCGCTGTTTGGGCGCAAGGATTACCAGCAGCTGGCCGTGATCAGGCGCATG
GTCGCCGACCTGAGCCAGGGGGTGACTATCGTCGGCATGCCCATCGTCCGGGAAAGCGACGGCCTGGCCATGAGTTCGCG
CAACGCTTACCTCGCTCCTCCGGAGCGTCAGAGTGCCCTGGCCCTCTCCCGCTCCATAGCCGCCGTGCGCAACGCGTATG
CCGCCGGAGAGCGCTCCGTCGAGGCGCTCTCGCGCATGGCCCGGGACATCATCAGCCAGGAGGCGCTGCTCAAGATCGAC
TACCTGGAGTTCCGCAACGAGGCAACACTGCAACCCATATCCGAGGCAGCCGGTGACACGCTGTTCGCCCTGGCTGTTAA
CGTTGGAACAACGCGTCTTATCGATAACACCGTACTAGGAGTCTGTCGGGCTTGA

Upstream 100 bases:

>100_bases
CGCTCAGGCGCCTTCCCCACCGAGGAACACTCCTTCAATTGATGCAACGACTCCGCCCAGGGCATGACCCGGGCGGAGTT
TTTAGTATTCGGGGAAAACC

Downstream 100 bases:

>100_bases
CCTCAGGGGCGCCCTCTTTTGTGGCCAAGCCGATTAAAAAAGTTCCGTATGTGTTCGTCTTCCCACCGGCAACCTGGTTA
ATTCAGCCCTTTCAGCGATG

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MNIIAGINEMQTTARSLKQQGKSIAFVPTMGFLHEGHASLLREGRARGDILVLSLFVNPIQFGRNEDLDRYPRDLERDLG
VAADCGVDIVFTPSATEMYPEEFQTSISVSRVSQPLCGASRPGHFDGVATVVTKLFNIVMPDIALFGRKDYQQLAVIRRM
VADLSQGVTIVGMPIVRESDGLAMSSRNAYLAPPERQSALALSRSIAAVRNAYAAGERSVEALSRMARDIISQEALLKID
YLEFRNEATLQPISEAAGDTLFALAVNVGTTRLIDNTVLGVCRA

Sequences:

>Translated_284_residues
MNIIAGINEMQTTARSLKQQGKSIAFVPTMGFLHEGHASLLREGRARGDILVLSLFVNPIQFGRNEDLDRYPRDLERDLG
VAADCGVDIVFTPSATEMYPEEFQTSISVSRVSQPLCGASRPGHFDGVATVVTKLFNIVMPDIALFGRKDYQQLAVIRRM
VADLSQGVTIVGMPIVRESDGLAMSSRNAYLAPPERQSALALSRSIAAVRNAYAAGERSVEALSRMARDIISQEALLKID
YLEFRNEATLQPISEAAGDTLFALAVNVGTTRLIDNTVLGVCRA
>Mature_284_residues
MNIIAGINEMQTTARSLKQQGKSIAFVPTMGFLHEGHASLLREGRARGDILVLSLFVNPIQFGRNEDLDRYPRDLERDLG
VAADCGVDIVFTPSATEMYPEEFQTSISVSRVSQPLCGASRPGHFDGVATVVTKLFNIVMPDIALFGRKDYQQLAVIRRM
VADLSQGVTIVGMPIVRESDGLAMSSRNAYLAPPERQSALALSRSIAAVRNAYAAGERSVEALSRMARDIISQEALLKID
YLEFRNEATLQPISEAAGDTLFALAVNVGTTRLIDNTVLGVCRA

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=281, Percent_Identity=44.8398576512456, Blast_Score=246, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6322046, Length=313, Percent_Identity=38.3386581469649, Blast_Score=182, Evalue=7e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_PELPD (A1AUV7)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_903185.1
- ProteinModelPortal:   A1AUV7
- SMR:   A1AUV7
- STRING:   A1AUV7
- GeneID:   4574617
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_3535
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   DEAHDAK
- PhylomeDB:   A1AUV7
- ProtClustDB:   PRK00380
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 30917; Mature: 30917

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIAGINEMQTTARSLKQQGKSIAFVPTMGFLHEGHASLLREGRARGDILVLSLFVNPI
CCCCCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHH
QFGRNEDLDRYPRDLERDLGVAADCGVDIVFTPSATEMYPEEFQTSISVSRVSQPLCGAS
HCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHCHHHHHHHHHHHHHCCCCCCCC
RPGHFDGVATVVTKLFNIVMPDIALFGRKDYQQLAVIRRMVADLSQGVTIVGMPIVRESD
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECEEECCC
GLAMSSRNAYLAPPERQSALALSRSIAAVRNAYAAGERSVEALSRMARDIISQEALLKID
CCEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
YLEFRNEATLQPISEAAGDTLFALAVNVGTTRLIDNTVLGVCRA
HHHHCCCCCCCHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNIIAGINEMQTTARSLKQQGKSIAFVPTMGFLHEGHASLLREGRARGDILVLSLFVNPI
CCCCCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHH
QFGRNEDLDRYPRDLERDLGVAADCGVDIVFTPSATEMYPEEFQTSISVSRVSQPLCGAS
HCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHCHHHHHHHHHHHHHCCCCCCCC
RPGHFDGVATVVTKLFNIVMPDIALFGRKDYQQLAVIRRMVADLSQGVTIVGMPIVRESD
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECEEECCC
GLAMSSRNAYLAPPERQSALALSRSIAAVRNAYAAGERSVEALSRMARDIISQEALLKID
CCEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
YLEFRNEATLQPISEAAGDTLFALAVNVGTTRLIDNTVLGVCRA
HHHHCCCCCCCHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA