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The map label for this gene is atoC [H]

Identifier: 118581751

GI number: 118581751

Start: 3699111

End: 3700508

Strand: Reverse

Name: atoC [H]

Synonym: Ppro_3351

Alternate gene names: 118581751

Gene position: 3700508-3699111 (Counterclockwise)

Preceding gene: 118581752

Following gene: 118581750

Centisome position: 92.33

GC content: 60.01

Gene sequence:

>1398_bases
ATGAACAACCAGCGGAAATCGGGAAGCATACTGATCGTTGACGACGAACGGGGGCAGCGGGATATCCTCAAGCTGATCCT
CAGGAAAGAGGGTTACGACATCGTGGATGTTCCCGGAGTAGGCGAGGCGCTGGAGCAGCTGGACAGGCGCGAGTTCGACC
TGATCCTGACCGACCTGAAGATGCAGGGTCAGAGCGGCCTGGACCTGCTGGAAAGGGTGCTCTCCGACGACCCGCAGCAG
TGCGTGATCCTGATGACCGCCCACGGTTCGGTGGACTCGGCGGTGGAGGCCATGCGCATGGGGGCCTTCGACTACCTGGA
AAAACCGCTGGAGCGTGATAATCTGGTACTTACCTTGCAGCGTGCATTCGAACGTATCGGTCTGGTGCGCGAAAACCGGG
TGCTACAGAAGCGGGTCGCCTCGACCACGCCCATACCCAGCATGCTGGGCGACCACCCTAGGATGGCGGAAGTTTTCCGG
GTTGTCGCCAAGATTGCTGCCACCACATCCACGGTGCTGATCGTGGGGGAATCGGGTACCGGCAAGGAACTGGTTGCCCG
GGCGATTCACGAGGGAAGCCAGCGCCGGGACAATCCGTTCATGGCCATTAACTGTGCCGCCATACCGGAAACCCTGATCG
AAAGCGAACTGTTCGGTCACGAAAAAGGGAGCTTCACCGGAGCACATGCCCGGGAACTGGGCGTATTCGAGGCGGCCAAC
GGCGGCACGGTCTTTCTGGACGAGATCGGCGAGATGAATGTCTCCATGCAGGCCAAGTTGCTGCGGGCCATCCAGGAGAA
GGAGGTCCGCCGGGTGGGGGGCAGGGTCAACATCCCGCTGGACGTGCGCATCATCTCGGCAACCAACAAGGAACTGGAAC
AGGAAATCAGGCGGGGCAGTTTTCGCGAGGATCTCTACTACCGCCTCAACGTCATCCGCATCAACCTGCCTCCCCTGCGG
GAGCGGGGAAGCGATGTCAAAACATTGGCAGAATTCTTTGTCAAAAAATACAGCCTTGCCACCGGCATTGACGTGGAAGG
CATCTCCCGGCCGGCTCTCAAGCTGCTGATGAACTATTCCTGGCCCGGAAACGTGCGCCAGCTGGAATCGGTCATCGAGC
GTGCGGTGCTGATGGCCGAGAGCAGTGTCATCGAGCCGGGAGATTTGCCGGCAGAGATCACCTCGACGTCGCTTCTGGCC
GGCGTCGTCCCCTTCGACCTGCCGCCAGAGGGGATCGACATGGAAACCCTGGAGAAGAATCTGATCATCAAAGCCATGGA
GCGTGCCGACTGGGTCATCGGCAAGGCAGCTCCGCTCCTGGGCATGAGCTACAAGACCCTGCAGTACCGGTTGGAGAAAT
TTGCCATCGAACGGCCGGACAGGAGGCAGAGGAATTAG

Upstream 100 bases:

>100_bases
GGAACGACCTTTACGCTCCTGCTGCCGCTGGAACGGGGGCCACATGAGGGAAACCTTGAAACGCACGAACCATGAGACAA
TACGATACGGGGCTTGAAGT

Downstream 100 bases:

>100_bases
TCAGTCATGGCGTGTTTTCTTGCCCTTGGGCTCTGTCGGCCAAAAAGAAAGTACAGCGCTTCTACCCAGGTGTAGATACT
TTTCGGCTGCTAACAGGTCT

Product: two component sigma54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MNNQRKSGSILIVDDERGQRDILKLILRKEGYDIVDVPGVGEALEQLDRREFDLILTDLKMQGQSGLDLLERVLSDDPQQ
CVILMTAHGSVDSAVEAMRMGAFDYLEKPLERDNLVLTLQRAFERIGLVRENRVLQKRVASTTPIPSMLGDHPRMAEVFR
VVAKIAATTSTVLIVGESGTGKELVARAIHEGSQRRDNPFMAINCAAIPETLIESELFGHEKGSFTGAHARELGVFEAAN
GGTVFLDEIGEMNVSMQAKLLRAIQEKEVRRVGGRVNIPLDVRIISATNKELEQEIRRGSFREDLYYRLNVIRINLPPLR
ERGSDVKTLAEFFVKKYSLATGIDVEGISRPALKLLMNYSWPGNVRQLESVIERAVLMAESSVIEPGDLPAEITSTSLLA
GVVPFDLPPEGIDMETLEKNLIIKAMERADWVIGKAAPLLGMSYKTLQYRLEKFAIERPDRRQRN

Sequences:

>Translated_465_residues
MNNQRKSGSILIVDDERGQRDILKLILRKEGYDIVDVPGVGEALEQLDRREFDLILTDLKMQGQSGLDLLERVLSDDPQQ
CVILMTAHGSVDSAVEAMRMGAFDYLEKPLERDNLVLTLQRAFERIGLVRENRVLQKRVASTTPIPSMLGDHPRMAEVFR
VVAKIAATTSTVLIVGESGTGKELVARAIHEGSQRRDNPFMAINCAAIPETLIESELFGHEKGSFTGAHARELGVFEAAN
GGTVFLDEIGEMNVSMQAKLLRAIQEKEVRRVGGRVNIPLDVRIISATNKELEQEIRRGSFREDLYYRLNVIRINLPPLR
ERGSDVKTLAEFFVKKYSLATGIDVEGISRPALKLLMNYSWPGNVRQLESVIERAVLMAESSVIEPGDLPAEITSTSLLA
GVVPFDLPPEGIDMETLEKNLIIKAMERADWVIGKAAPLLGMSYKTLQYRLEKFAIERPDRRQRN
>Mature_465_residues
MNNQRKSGSILIVDDERGQRDILKLILRKEGYDIVDVPGVGEALEQLDRREFDLILTDLKMQGQSGLDLLERVLSDDPQQ
CVILMTAHGSVDSAVEAMRMGAFDYLEKPLERDNLVLTLQRAFERIGLVRENRVLQKRVASTTPIPSMLGDHPRMAEVFR
VVAKIAATTSTVLIVGESGTGKELVARAIHEGSQRRDNPFMAINCAAIPETLIESELFGHEKGSFTGAHARELGVFEAAN
GGTVFLDEIGEMNVSMQAKLLRAIQEKEVRRVGGRVNIPLDVRIISATNKELEQEIRRGSFREDLYYRLNVIRINLPPLR
ERGSDVKTLAEFFVKKYSLATGIDVEGISRPALKLLMNYSWPGNVRQLESVIERAVLMAESSVIEPGDLPAEITSTSLLA
GVVPFDLPPEGIDMETLEKNLIIKAMERADWVIGKAAPLLGMSYKTLQYRLEKFAIERPDRRQRN

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=456, Percent_Identity=43.2017543859649, Blast_Score=367, Evalue=1e-102,
Organism=Escherichia coli, GI1790437, Length=444, Percent_Identity=43.4684684684685, Blast_Score=352, Evalue=4e-98,
Organism=Escherichia coli, GI1790299, Length=472, Percent_Identity=39.1949152542373, Blast_Score=321, Evalue=7e-89,
Organism=Escherichia coli, GI1788905, Length=380, Percent_Identity=44.4736842105263, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI87082117, Length=339, Percent_Identity=41.8879056047198, Blast_Score=263, Evalue=3e-71,
Organism=Escherichia coli, GI1789233, Length=322, Percent_Identity=43.7888198757764, Blast_Score=252, Evalue=3e-68,
Organism=Escherichia coli, GI1789087, Length=337, Percent_Identity=42.1364985163205, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI87082152, Length=235, Percent_Identity=49.7872340425532, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1786524, Length=244, Percent_Identity=47.9508196721311, Blast_Score=229, Evalue=4e-61,
Organism=Escherichia coli, GI1787583, Length=285, Percent_Identity=42.8070175438597, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI87081872, Length=324, Percent_Identity=39.5061728395062, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI87081858, Length=321, Percent_Identity=29.595015576324, Blast_Score=141, Evalue=8e-35,
Organism=Escherichia coli, GI1789828, Length=243, Percent_Identity=34.5679012345679, Blast_Score=140, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51988; Mature: 51988

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNQRKSGSILIVDDERGQRDILKLILRKEGYDIVDVPGVGEALEQLDRREFDLILTDLK
CCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHEEHHH
MQGQSGLDLLERVLSDDPQQCVILMTAHGSVDSAVEAMRMGAFDYLEKPLERDNLVLTLQ
HCCCCCHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCHHHHHHCCCCCCCEEEEHH
RAFERIGLVRENRVLQKRVASTTPIPSMLGDHPRMAEVFRVVAKIAATTSTVLIVGESGT
HHHHHHCCHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHCCEEEEEEECCCC
GKELVARAIHEGSQRRDNPFMAINCAAIPETLIESELFGHEKGSFTGAHARELGVFEAAN
CHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEECC
GGTVFLDEIGEMNVSMQAKLLRAIQEKEVRRVGGRVNIPLDVRIISATNKELEQEIRRGS
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCEEEEEEECCCHHHHHHHHCCC
FREDLYYRLNVIRINLPPLRERGSDVKTLAEFFVKKYSLATGIDVEGISRPALKLLMNYS
CHHHHEEEEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
WPGNVRQLESVIERAVLMAESSVIEPGDLPAEITSTSLLAGVVPFDLPPEGIDMETLEKN
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
LIIKAMERADWVIGKAAPLLGMSYKTLQYRLEKFAIERPDRRQRN
HHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNNQRKSGSILIVDDERGQRDILKLILRKEGYDIVDVPGVGEALEQLDRREFDLILTDLK
CCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHEEHHH
MQGQSGLDLLERVLSDDPQQCVILMTAHGSVDSAVEAMRMGAFDYLEKPLERDNLVLTLQ
HCCCCCHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCHHHHHHCCCCCCCEEEEHH
RAFERIGLVRENRVLQKRVASTTPIPSMLGDHPRMAEVFRVVAKIAATTSTVLIVGESGT
HHHHHHCCHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHCCEEEEEEECCCC
GKELVARAIHEGSQRRDNPFMAINCAAIPETLIESELFGHEKGSFTGAHARELGVFEAAN
CHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEECC
GGTVFLDEIGEMNVSMQAKLLRAIQEKEVRRVGGRVNIPLDVRIISATNKELEQEIRRGS
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCEEEEEEECCCHHHHHHHHCCC
FREDLYYRLNVIRINLPPLRERGSDVKTLAEFFVKKYSLATGIDVEGISRPALKLLMNYS
CHHHHEEEEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
WPGNVRQLESVIERAVLMAESSVIEPGDLPAEITSTSLLAGVVPFDLPPEGIDMETLEKN
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
LIIKAMERADWVIGKAAPLLGMSYKTLQYRLEKFAIERPDRRQRN
HHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]