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The map label for this gene is dapL

Identifier: 118581464

GI number: 118581464

Start: 3349868

End: 3351100

Strand: Reverse

Name: dapL

Synonym: Ppro_3061

Alternate gene names: 118581464

Gene position: 3351100-3349868 (Counterclockwise)

Preceding gene: 118581465

Following gene: 118581463

Centisome position: 83.61

GC content: 60.67

Gene sequence:

>1233_bases
ATGGCAAAGATAAATGACAACTACCTGAAGCTGAAAGCCGGGTACCTCTTCCCCGAAATCGGCCGCCGCGTGCGTGCCTT
TGCGGAAGCCAATCCCCAGGCCAACGTGATCCGCCTCGGCATTGGCGATGTGACCAGGCCGCTCCCCCCGGCAATCCTCA
AGGCATTCCACGACGCGGTCGACGACCTGGCCAAGGTCGAGACCTTTGCCGGCTACGGCCCGGAGCAGGGGTACGACTGG
CTGATCAACTCGGTCATCGAGAAGTCCTACAACAAGCTGGGGGTAGAACTCAAGACCAGCGAGATTTTTGTCTCCGACGG
TTCCAAGTGCGACTGTGCCAATATCCTGGACATCTTCGCCATGGACAACGTGGTGGCCATCGGCGATCCGGTCTACCCGG
TGTACAACGACACCAACGTCATGATCGGCCGCACCGGCGAGGCTGACGACAGGGGCTACTACAAGGGGATCGTCTACATG
CCCTGTACCGAGGCCAACGGCTTCATTCCGACGCTGCCCACGGAGAAGGTGGACATCATCTACCTCTGCTTCCCCAACAA
CCCCACCGGCACCGTGGCCAGCCGGGAGGAACTGAAGAAGTGGGTCGATTACGCCATTGCCAATAACGCCGTGATCTTCT
TCGATGCCGCCTACGAGGCCTTTATCACTGATCCGGCCATCCCCCATTCCATCTACGAGATCGAGGGGGCAAAGAAGTGT
GCCATCGAGTTCCGCTCCTTCTCCAAGACCGCCGGATTCACCGGTGTGCGCTGCGGCCTGGTTGTGGTTCCGGAGGAGGT
CATGGGCAGCACGGCCACGGGTGAAGCCTACAGCTTCAACAAACTCTGGCTGCGCCGCACCACCACCAAGTTCAACGGCG
CCTCCTATCCGGTACAGAGGGCCGCCGCCGCGGTCTATACCGACGAGGGCTGGGCCCAGACCAAGGAAATCATCGATTAC
TACATGGAGAACGCCCGCATCATTCGCGAAGGGCTTGCCGAGGCCGGTTGCACGGTCTACGGCGGGGTTAACGCCCCCTA
TATCTGGCTCAAGACCCCCGGCGGCATGAGCAGCTGGGAATTCTTCGACAAACTCCTGACCGAGTGTAACGTGGTCGGGA
CCCCCGGCAGCGGCTTCGGGCCCAGCGGGGAGGGGTTCTTCCGGCTGTCCGCCTTCGGCAACCGGGAGAACGTGATCGAA
GCGGTGGAGAGAATCAAGAAGAACCTGAAGTAG

Upstream 100 bases:

>100_bases
GGCGCCCGGTCTCTACGACATGCAGGATGTGCTTGGTTTGAAATAGCTTTTCCGTTTGCAGGCGCTGTGCAATTTCATAT
CGAACAAAGGATATTCGCGT

Downstream 100 bases:

>100_bases
CACAAAGGGCGCCCATGAGGCGCCCTTTGTGCTTTACGGTATACTATCTCGTGGCCAATGGTTTCACAGGGAATACGAAG
AACGCGTTGTTGCCGTTCTT

Product: L,L-diaminopimelate aminotransferase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MAKINDNYLKLKAGYLFPEIGRRVRAFAEANPQANVIRLGIGDVTRPLPPAILKAFHDAVDDLAKVETFAGYGPEQGYDW
LINSVIEKSYNKLGVELKTSEIFVSDGSKCDCANILDIFAMDNVVAIGDPVYPVYNDTNVMIGRTGEADDRGYYKGIVYM
PCTEANGFIPTLPTEKVDIIYLCFPNNPTGTVASREELKKWVDYAIANNAVIFFDAAYEAFITDPAIPHSIYEIEGAKKC
AIEFRSFSKTAGFTGVRCGLVVVPEEVMGSTATGEAYSFNKLWLRRTTTKFNGASYPVQRAAAAVYTDEGWAQTKEIIDY
YMENARIIREGLAEAGCTVYGGVNAPYIWLKTPGGMSSWEFFDKLLTECNVVGTPGSGFGPSGEGFFRLSAFGNRENVIE
AVERIKKNLK

Sequences:

>Translated_410_residues
MAKINDNYLKLKAGYLFPEIGRRVRAFAEANPQANVIRLGIGDVTRPLPPAILKAFHDAVDDLAKVETFAGYGPEQGYDW
LINSVIEKSYNKLGVELKTSEIFVSDGSKCDCANILDIFAMDNVVAIGDPVYPVYNDTNVMIGRTGEADDRGYYKGIVYM
PCTEANGFIPTLPTEKVDIIYLCFPNNPTGTVASREELKKWVDYAIANNAVIFFDAAYEAFITDPAIPHSIYEIEGAKKC
AIEFRSFSKTAGFTGVRCGLVVVPEEVMGSTATGEAYSFNKLWLRRTTTKFNGASYPVQRAAAAVYTDEGWAQTKEIIDY
YMENARIIREGLAEAGCTVYGGVNAPYIWLKTPGGMSSWEFFDKLLTECNVVGTPGSGFGPSGEGFFRLSAFGNRENVIE
AVERIKKNLK
>Mature_409_residues
AKINDNYLKLKAGYLFPEIGRRVRAFAEANPQANVIRLGIGDVTRPLPPAILKAFHDAVDDLAKVETFAGYGPEQGYDWL
INSVIEKSYNKLGVELKTSEIFVSDGSKCDCANILDIFAMDNVVAIGDPVYPVYNDTNVMIGRTGEADDRGYYKGIVYMP
CTEANGFIPTLPTEKVDIIYLCFPNNPTGTVASREELKKWVDYAIANNAVIFFDAAYEAFITDPAIPHSIYEIEGAKKCA
IEFRSFSKTAGFTGVRCGLVVVPEEVMGSTATGEAYSFNKLWLRRTTTKFNGASYPVQRAAAAVYTDEGWAQTKEIIDYY
MENARIIREGLAEAGCTVYGGVNAPYIWLKTPGGMSSWEFFDKLLTECNVVGTPGSGFGPSGEGFFRLSAFGNRENVIEA
VERIKKNLK

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788722, Length=388, Percent_Identity=26.2886597938144, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788627, Length=241, Percent_Identity=27.3858921161826, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DAPAT_PELPD (A1ATI6)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902714.1
- ProteinModelPortal:   A1ATI6
- SMR:   A1ATI6
- STRING:   A1ATI6
- GeneID:   4574106
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_3061
- eggNOG:   COG0436
- HOGENOM:   HBG645860
- OMA:   VDLIYLC
- ProtClustDB:   PRK07590
- HAMAP:   MF_01642
- InterPro:   IPR004839
- InterPro:   IPR019942
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR03542

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.83

Molecular weight: Translated: 45175; Mature: 45044

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: BINDING 42-42 BINDING 72-72 BINDING 75-75 BINDING 109-109 BINDING 132-132 BINDING 187-187 BINDING 187-187 BINDING 215-215 BINDING 218-218 BINDING 246-246 BINDING 248-248 BINDING 257-257 BINDING 292-292 BINDING 388-388

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKINDNYLKLKAGYLFPEIGRRVRAFAEANPQANVIRLGIGDVTRPLPPAILKAFHDAV
CCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHH
DDLAKVETFAGYGPEQGYDWLINSVIEKSYNKLGVELKTSEIFVSDGSKCDCANILDIFA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCHHHHHHHHH
MDNVVAIGDPVYPVYNDTNVMIGRTGEADDRGYYKGIVYMPCTEANGFIPTLPTEKVDII
CCCEEEECCCCCEEECCCEEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEE
YLCFPNNPTGTVASREELKKWVDYAIANNAVIFFDAAYEAFITDPAIPHSIYEIEGAKKC
EEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHCCCCCCCCCEEEECCCHHH
AIEFRSFSKTAGFTGVRCGLVVVPEEVMGSTATGEAYSFNKLWLRRTTTKFNGASYPVQR
HHHHHHHHCCCCCCCEEEEEEEECHHHHCCCCCCCCEECCEEEEEEECCCCCCCCCCHHH
AAAAVYTDEGWAQTKEIIDYYMENARIIREGLAEAGCTVYGGVNAPYIWLKTPGGMSSWE
HHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEECCCCCCHHH
FFDKLLTECNVVGTPGSGFGPSGEGFFRLSAFGNRENVIEAVERIKKNLK
HHHHHHHHCEEEECCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKINDNYLKLKAGYLFPEIGRRVRAFAEANPQANVIRLGIGDVTRPLPPAILKAFHDAV
CCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHH
DDLAKVETFAGYGPEQGYDWLINSVIEKSYNKLGVELKTSEIFVSDGSKCDCANILDIFA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCHHHHHHHHH
MDNVVAIGDPVYPVYNDTNVMIGRTGEADDRGYYKGIVYMPCTEANGFIPTLPTEKVDII
CCCEEEECCCCCEEECCCEEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEE
YLCFPNNPTGTVASREELKKWVDYAIANNAVIFFDAAYEAFITDPAIPHSIYEIEGAKKC
EEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHCCCCCCCCCEEEECCCHHH
AIEFRSFSKTAGFTGVRCGLVVVPEEVMGSTATGEAYSFNKLWLRRTTTKFNGASYPVQR
HHHHHHHHCCCCCCCEEEEEEEECHHHHCCCCCCCCEECCEEEEEEECCCCCCCCCCHHH
AAAAVYTDEGWAQTKEIIDYYMENARIIREGLAEAGCTVYGGVNAPYIWLKTPGGMSSWE
HHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEECCCCCCHHH
FFDKLLTECNVVGTPGSGFGPSGEGFFRLSAFGNRENVIEAVERIKKNLK
HHHHHHHHCEEEECCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA