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The map label for this gene is lpxK

Identifier: 118581433

GI number: 118581433

Start: 3309380

End: 3310465

Strand: Direct

Name: lpxK

Synonym: Ppro_3028

Alternate gene names: 118581433

Gene position: 3309380-3310465 (Clockwise)

Preceding gene: 118581432

Following gene: 118581434

Centisome position: 82.57

GC content: 66.39

Gene sequence:

>1086_bases
ATGAACTCCTCCCTTGCCACATACTGGCGCGCCCTGGCCAGCGGCACGCGCCGTTCCCTCCCCGACCGGTCGCTGCTGTC
ACTGCTTGTCCCGTTCTCCCTGCTCTACGCCCTGATCCAGCGCCTGCGTGCGGTGCTCTATCGCGTGAGACTCCTGAAGA
GCAGGCGCCTCCCCCGACCGGTGATCTCCGTCGGCAACCTGACTGTGGGAGGCACCGGCAAGACGCCGGTCACGGCACAC
ATCGCCCGCTGGCTTCTGGCGGAGGGATACCGGGTGGCGGTCCTCTCCCGCGGCTACGGCGGCTCCCTGGAGGGGCACAC
GGCGGTCGTCAGCGACGGCCGCACCGTCATGATGGAGGCGGAACAGTGCGGCGACGAACCCTTTCTATTGTCCTCCACCA
TCCCCGGCCTGATGGTAGTCATGGGGAGCGACCGCTTCAGCGCGGGAATGCTGGCCATGGAACAGCTGGCGCCCGACGTC
TTCCTGCTGGACGACGGCTACCAGCACCTGCGCCTTACGCGCGACCTGAACATCCTGCTTTTGGACCACGCCCTTCCCTT
CGGCAACGGTTGGACCCTGCCGGCCGGAGTGCTGCGGGAACCGACATCGGCTGCCGGCCGCGCCGACCTGGTCATCCGCA
CCAGATGCCCCCGCATCGCCCCCTGCCCCTCTCCCCTTCCCGGCATCCCCTCCTGCACGGCACGCCATAGCCTGGGAAAC
GTCATTCCCCTGGGCAACGGAGCGGCGTTCCCCATGGAATCGCTGCGCGGCCGGAGGGTGCTGGCCTTCGCCGGCATCGC
CGACCCGTACGGCTTTTTCGAGGAACTGCGCGAACAAGGATTGAATCTGGTGGCCGAATTGGCCATGCCCGACCATGTGG
CCTACGATGACAACCGCATCGCCGAAATCGGCCGTCGCCTGCACGGCTCCGGGGCTGAGTTCGCCGTCACCACCGAGAAG
GACGGAGTCAAGCTGCTGGGCCTGCAACGGGAGTGTGCTGAGAAAATCCTGTTGGCGCGACTGGAGCTGATCATCGCCGA
TCCGGCCCCGCTGACTGACGCGCTGCGCAATTTGCTTCAAAAATGA

Upstream 100 bases:

>100_bases
TGGGAGCAAACGGCCTGGCCATGATGGAGGAAAACGGCGGCGCCACTGAGCGCCACATGGGGATGATCGGCGAACAGTTC
GTCGAACCGGTGGCGAAGGG

Downstream 100 bases:

>100_bases
CCGCGGCTGTGGCACTATGACGCGCCACACCATTTCACGTTCATCGGTTACCCATGCTCACGAATGATCTGTGTACAACC
CTGGCCTGCCCCGTCTGCAA

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MNSSLATYWRALASGTRRSLPDRSLLSLLVPFSLLYALIQRLRAVLYRVRLLKSRRLPRPVISVGNLTVGGTGKTPVTAH
IARWLLAEGYRVAVLSRGYGGSLEGHTAVVSDGRTVMMEAEQCGDEPFLLSSTIPGLMVVMGSDRFSAGMLAMEQLAPDV
FLLDDGYQHLRLTRDLNILLLDHALPFGNGWTLPAGVLREPTSAAGRADLVIRTRCPRIAPCPSPLPGIPSCTARHSLGN
VIPLGNGAAFPMESLRGRRVLAFAGIADPYGFFEELREQGLNLVAELAMPDHVAYDDNRIAEIGRRLHGSGAEFAVTTEK
DGVKLLGLQRECAEKILLARLELIIADPAPLTDALRNLLQK

Sequences:

>Translated_361_residues
MNSSLATYWRALASGTRRSLPDRSLLSLLVPFSLLYALIQRLRAVLYRVRLLKSRRLPRPVISVGNLTVGGTGKTPVTAH
IARWLLAEGYRVAVLSRGYGGSLEGHTAVVSDGRTVMMEAEQCGDEPFLLSSTIPGLMVVMGSDRFSAGMLAMEQLAPDV
FLLDDGYQHLRLTRDLNILLLDHALPFGNGWTLPAGVLREPTSAAGRADLVIRTRCPRIAPCPSPLPGIPSCTARHSLGN
VIPLGNGAAFPMESLRGRRVLAFAGIADPYGFFEELREQGLNLVAELAMPDHVAYDDNRIAEIGRRLHGSGAEFAVTTEK
DGVKLLGLQRECAEKILLARLELIIADPAPLTDALRNLLQK
>Mature_361_residues
MNSSLATYWRALASGTRRSLPDRSLLSLLVPFSLLYALIQRLRAVLYRVRLLKSRRLPRPVISVGNLTVGGTGKTPVTAH
IARWLLAEGYRVAVLSRGYGGSLEGHTAVVSDGRTVMMEAEQCGDEPFLLSSTIPGLMVVMGSDRFSAGMLAMEQLAPDV
FLLDDGYQHLRLTRDLNILLLDHALPFGNGWTLPAGVLREPTSAAGRADLVIRTRCPRIAPCPSPLPGIPSCTARHSLGN
VIPLGNGAAFPMESLRGRRVLAFAGIADPYGFFEELREQGLNLVAELAMPDHVAYDDNRIAEIGRRLHGSGAEFAVTTEK
DGVKLLGLQRECAEKILLARLELIIADPAPLTDALRNLLQK

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=310, Percent_Identity=34.8387096774194, Blast_Score=142, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_PELPD (A1ATF5)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902683.1
- STRING:   A1ATF5
- GeneID:   4574283
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_3028
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   DEPVLIH
- PhylomeDB:   A1ATF5
- ProtClustDB:   CLSK828780
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 39216; Mature: 39216

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSSLATYWRALASGTRRSLPDRSLLSLLVPFSLLYALIQRLRAVLYRVRLLKSRRLPRP
CCCHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VISVGNLTVGGTGKTPVTAHIARWLLAEGYRVAVLSRGYGGSLEGHTAVVSDGRTVMMEA
CEEECCEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCEEEEEH
EQCGDEPFLLSSTIPGLMVVMGSDRFSAGMLAMEQLAPDVFLLDDGYQHLRLTRDLNILL
HHCCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEECCCHHHEEEECCCEEEE
LDHALPFGNGWTLPAGVLREPTSAAGRADLVIRTRCPRIAPCPSPLPGIPSCTARHSLGN
EECCCCCCCCCCCCHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHCCCC
VIPLGNGAAFPMESLRGRRVLAFAGIADPYGFFEELREQGLNLVAELAMPDHVAYDDNRI
EEECCCCCCCCHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
AEIGRRLHGSGAEFAVTTEKDGVKLLGLQRECAEKILLARLELIIADPAPLTDALRNLLQ
HHHHHHHCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHC
K
C
>Mature Secondary Structure
MNSSLATYWRALASGTRRSLPDRSLLSLLVPFSLLYALIQRLRAVLYRVRLLKSRRLPRP
CCCHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VISVGNLTVGGTGKTPVTAHIARWLLAEGYRVAVLSRGYGGSLEGHTAVVSDGRTVMMEA
CEEECCEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCEEEEEH
EQCGDEPFLLSSTIPGLMVVMGSDRFSAGMLAMEQLAPDVFLLDDGYQHLRLTRDLNILL
HHCCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEECCCHHHEEEECCCEEEE
LDHALPFGNGWTLPAGVLREPTSAAGRADLVIRTRCPRIAPCPSPLPGIPSCTARHSLGN
EECCCCCCCCCCCCHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHCCCC
VIPLGNGAAFPMESLRGRRVLAFAGIADPYGFFEELREQGLNLVAELAMPDHVAYDDNRI
EEECCCCCCCCHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
AEIGRRLHGSGAEFAVTTEKDGVKLLGLQRECAEKILLARLELIIADPAPLTDALRNLLQ
HHHHHHHCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA