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The map label for this gene is lolC [H]

Identifier: 118581420

GI number: 118581420

Start: 3294513

End: 3295775

Strand: Direct

Name: lolC [H]

Synonym: Ppro_3015

Alternate gene names: 118581420

Gene position: 3294513-3295775 (Clockwise)

Preceding gene: 118581419

Following gene: 118581421

Centisome position: 82.2

GC content: 59.62

Gene sequence:

>1263_bases
ATGCCTTTCGAACTTCTCATCTGCCTGCGCTATCTCAAGGCAAAACGTAAATCGACCTTTATCTCCATCATCAGCCTGAT
CTCCACAGCCGGGGTCAGCCTGGGAGTCATGGCGCTGATCGTGGTTCTGGCGGTCATGACCGGCTTCGAGGAAGACCTGA
AGGAAAAAATCCTGGGAACCAATGCCCATGTGGTGGTCATCCGCAACGGGCTCCCCATGGATGAGTACCGCCAGGTCATG
GAGAAGCTGACCGCCATGCCGGGGATCACCGCCGCCACCCCCTTCATCTACAATCAGGTCATGCTCTCCTCGGGCAGGAA
CGTTTCCGGCGTCGTCCTGCGGGGCATCGACGTACCTTCGGACCGCCTGGTAACGCGACTGAACGCGTCGTTGGTGGAGG
GGAACACCGATAACCTGGACCCGAAGATGGGCGACGGCGCCGTTGCCCTGCCGGGGCTGCTGATCGGCAAGGAGCTGGCC
AGAAATCTCAACCTGCGGCTGGGGGACCGGATCAACGTCGTCTCGCCCATGGGGAACATAACCCCCCTGGGAATGATTCC
CCGCATGAAGCCGTTCAGAGTGGTCGGCATCTTCAACACCGGCATGTTCGAGTACGACTCGACCCTGGCCTACGTCAGCC
TGACCCAGGCACAGACGTTCTTCGACCTGGGAGACACCGTAACCGGCATCCAGCTCAAGGTGAAGGATGTCTACCACACC
GGCGAACTGGCCCGCGAGATCAACCGCGTTCTGGGCAGCGACTACTTCGCCCGCGACTGGATGCAGATGAACCGCAACAT
CCTCTTCGCCCTCAAGACGGAGAAGGTGGTCATGTTCGTGATCCTGACCCTGATCGTGCTGGTTGCCGCTTTTGGTATTG
CCTCAACCCTGTTTATGGTGGTAATGGAAAAAACCAGGGACATCGCCATCCTCAAATCCATGGGCGCCACCGGAAGCAGC
ATCATGAAGATATTCGTCATGGAGGGGCTGATCATCGGCGTTATCGGCACGCTGCTGGGGGTCGCCTCGGGGCTTCTGAT
CGCCCTCAACCTGGAGCCGATCATCGACACGATCCAGAAGGTCACCGGCCAGAACTTCTTCAGCAAGGACATCTACTACC
TAGACCATTTCCCCTCCCAGGTGGTGCCCGCCGACGTGGCGCTGATCTCGGTCACGGCGGTGCTGATCTCCTTCATCGCC
ACGCTCTACCCCGCCTGGCAGGCGTCGCGCATGCTTCCGGCAGAGGCGCTGCGCTATGAGTAA

Upstream 100 bases:

>100_bases
GGAAACGGATAACGGAAACCAGGGACCGGGGACGGGTAAAAGTTTTTACCGTTCTCCGGTCCCCGGTCCCCGGCTCCCGG
TTCCCGGTCCCCGCTTTACC

Downstream 100 bases:

>100_bases
GCTGCTGGAGGCGCGCGACCTGCGCAAGAGCTACGGCAACGGGGAGAGCCGGGTAAATGTGCTGAACGGCATCGACCTGG
ACCTGGAGCAGGGCACCACA

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MPFELLICLRYLKAKRKSTFISIISLISTAGVSLGVMALIVVLAVMTGFEEDLKEKILGTNAHVVVIRNGLPMDEYRQVM
EKLTAMPGITAATPFIYNQVMLSSGRNVSGVVLRGIDVPSDRLVTRLNASLVEGNTDNLDPKMGDGAVALPGLLIGKELA
RNLNLRLGDRINVVSPMGNITPLGMIPRMKPFRVVGIFNTGMFEYDSTLAYVSLTQAQTFFDLGDTVTGIQLKVKDVYHT
GELAREINRVLGSDYFARDWMQMNRNILFALKTEKVVMFVILTLIVLVAAFGIASTLFMVVMEKTRDIAILKSMGATGSS
IMKIFVMEGLIIGVIGTLLGVASGLLIALNLEPIIDTIQKVTGQNFFSKDIYYLDHFPSQVVPADVALISVTAVLISFIA
TLYPAWQASRMLPAEALRYE

Sequences:

>Translated_420_residues
MPFELLICLRYLKAKRKSTFISIISLISTAGVSLGVMALIVVLAVMTGFEEDLKEKILGTNAHVVVIRNGLPMDEYRQVM
EKLTAMPGITAATPFIYNQVMLSSGRNVSGVVLRGIDVPSDRLVTRLNASLVEGNTDNLDPKMGDGAVALPGLLIGKELA
RNLNLRLGDRINVVSPMGNITPLGMIPRMKPFRVVGIFNTGMFEYDSTLAYVSLTQAQTFFDLGDTVTGIQLKVKDVYHT
GELAREINRVLGSDYFARDWMQMNRNILFALKTEKVVMFVILTLIVLVAAFGIASTLFMVVMEKTRDIAILKSMGATGSS
IMKIFVMEGLIIGVIGTLLGVASGLLIALNLEPIIDTIQKVTGQNFFSKDIYYLDHFPSQVVPADVALISVTAVLISFIA
TLYPAWQASRMLPAEALRYE
>Mature_419_residues
PFELLICLRYLKAKRKSTFISIISLISTAGVSLGVMALIVVLAVMTGFEEDLKEKILGTNAHVVVIRNGLPMDEYRQVME
KLTAMPGITAATPFIYNQVMLSSGRNVSGVVLRGIDVPSDRLVTRLNASLVEGNTDNLDPKMGDGAVALPGLLIGKELAR
NLNLRLGDRINVVSPMGNITPLGMIPRMKPFRVVGIFNTGMFEYDSTLAYVSLTQAQTFFDLGDTVTGIQLKVKDVYHTG
ELAREINRVLGSDYFARDWMQMNRNILFALKTEKVVMFVILTLIVLVAAFGIASTLFMVVMEKTRDIAILKSMGATGSSI
MKIFVMEGLIIGVIGTLLGVASGLLIALNLEPIIDTIQKVTGQNFFSKDIYYLDHFPSQVVPADVALISVTAVLISFIAT
LYPAWQASRMLPAEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=417, Percent_Identity=34.2925659472422, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1787360, Length=426, Percent_Identity=32.8638497652582, Blast_Score=170, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45994; Mature: 45863

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFELLICLRYLKAKRKSTFISIISLISTAGVSLGVMALIVVLAVMTGFEEDLKEKILGT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
NAHVVVIRNGLPMDEYRQVMEKLTAMPGITAATPFIYNQVMLSSGRNVSGVVLRGIDVPS
CCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCH
DRLVTRLNASLVEGNTDNLDPKMGDGAVALPGLLIGKELARNLNLRLGDRINVVSPMGNI
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCEEEECCCCCC
TPLGMIPRMKPFRVVGIFNTGMFEYDSTLAYVSLTQAQTFFDLGDTVTGIQLKVKDVYHT
CCCCCCCCCCCEEEEEEEECCCEEECCCEEEEEHHHHHHHHHCCCCEECEEEEEEHHHHH
GELAREINRVLGSDYFARDWMQMNRNILFALKTEKVVMFVILTLIVLVAAFGIASTLFMV
HHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMEKTRDIAILKSMGATGSSIMKIFVMEGLIIGVIGTLLGVASGLLIALNLEPIIDTIQK
HHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHH
VTGQNFFSKDIYYLDHFPSQVVPADVALISVTAVLISFIATLYPAWQASRMLPAEALRYE
HHCCCCHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC
>Mature Secondary Structure 
PFELLICLRYLKAKRKSTFISIISLISTAGVSLGVMALIVVLAVMTGFEEDLKEKILGT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
NAHVVVIRNGLPMDEYRQVMEKLTAMPGITAATPFIYNQVMLSSGRNVSGVVLRGIDVPS
CCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCH
DRLVTRLNASLVEGNTDNLDPKMGDGAVALPGLLIGKELARNLNLRLGDRINVVSPMGNI
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCEEEECCCCCC
TPLGMIPRMKPFRVVGIFNTGMFEYDSTLAYVSLTQAQTFFDLGDTVTGIQLKVKDVYHT
CCCCCCCCCCCEEEEEEEECCCEEECCCEEEEEHHHHHHHHHCCCCEECEEEEEEHHHHH
GELAREINRVLGSDYFARDWMQMNRNILFALKTEKVVMFVILTLIVLVAAFGIASTLFMV
HHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMEKTRDIAILKSMGATGSSIMKIFVMEGLIIGVIGTLLGVASGLLIALNLEPIIDTIQK
HHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHH
VTGQNFFSKDIYYLDHFPSQVVPADVALISVTAVLISFIATLYPAWQASRMLPAEALRYE
HHCCCCHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]