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The map label for this gene is ppiA [H]

Identifier: 118581412

GI number: 118581412

Start: 3280315

End: 3280833

Strand: Direct

Name: ppiA [H]

Synonym: Ppro_3007

Alternate gene names: 118581412

Gene position: 3280315-3280833 (Clockwise)

Preceding gene: 118581411

Following gene: 118581418

Centisome position: 81.84

GC content: 56.84

Gene sequence:

>519_bases
ATGTCAGAACAAAATCCGCGGGTCCTGCTGGAAACATCCATGGGGTCCATTACCGTCGAACTGTTCAAGGAAAAAGCGCC
CATCACCGTCAAGAACTTCCTCGGCTACGTCAAGGACGGCTTCTACGACGGACTGATCTTTCACCGGGTGATCAAGGATT
TCATGATTCAGGGGGGTGGCCTGAACGAGGCCATGGAACAGAAGAAGCCCAAGTTCGCCATCAAGAACGAGGCAACCAAC
AAGCTCTCCAACAAACGGGGCACCCTGGCCATGGCCCGCACCGCCATCGTGGATTCCGCCACCTCGCAGTTCTTCATCAA
CACCGTTGACAACGCCTTCCTGGACCACCAGGGCAAGCAGCCCGACCGCTTTGGCTACTGCGTCTTCGGCCAGGTTCTGG
AGGGGATGGATGTGGTTGACCAGATCCGCGCCGTCAAGACCGGCAATAAAAACGGCCACGGCGATGTTCCGCTGGAGCCG
GTTTACATCACCAGCGCCACGTTGATCGAAGCGGAATAA

Upstream 100 bases:

>100_bases
GCGCTGAAAAGGGTTCCGGTTTGGCCAGCTCTGTGCTACATAACGGATTCGCGCAATCGAGCGACAGCACCAGAGCACCA
CAACGCACCGGAGGTTTCAT

Downstream 100 bases:

>100_bases
GCGCGCTACCCCCCAGCTTCAACGCCCCGCTTCCGCCACGGAAACGGGGCGTTTTTTCATGCCGCGTCCCCCGTATTTTC
CTGCCGGGCGATGACCCCAT

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MSEQNPRVLLETSMGSITVELFKEKAPITVKNFLGYVKDGFYDGLIFHRVIKDFMIQGGGLNEAMEQKKPKFAIKNEATN
KLSNKRGTLAMARTAIVDSATSQFFINTVDNAFLDHQGKQPDRFGYCVFGQVLEGMDVVDQIRAVKTGNKNGHGDVPLEP
VYITSATLIEAE

Sequences:

>Translated_172_residues
MSEQNPRVLLETSMGSITVELFKEKAPITVKNFLGYVKDGFYDGLIFHRVIKDFMIQGGGLNEAMEQKKPKFAIKNEATN
KLSNKRGTLAMARTAIVDSATSQFFINTVDNAFLDHQGKQPDRFGYCVFGQVLEGMDVVDQIRAVKTGNKNGHGDVPLEP
VYITSATLIEAE
>Mature_171_residues
SEQNPRVLLETSMGSITVELFKEKAPITVKNFLGYVKDGFYDGLIFHRVIKDFMIQGGGLNEAMEQKKPKFAIKNEATNK
LSNKRGTLAMARTAIVDSATSQFFINTVDNAFLDHQGKQPDRFGYCVFGQVLEGMDVVDQIRAVKTGNKNGHGDVPLEPV
YITSATLIEAE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=170, Percent_Identity=37.6470588235294, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI24308049, Length=163, Percent_Identity=36.1963190184049, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI19557636, Length=170, Percent_Identity=33.5294117647059, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI4758950, Length=175, Percent_Identity=36, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI22547215, Length=165, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI22547212, Length=165, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI7657473, Length=165, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI64276486, Length=104, Percent_Identity=36.5384615384615, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1789763, Length=165, Percent_Identity=58.1818181818182, Blast_Score=190, Evalue=5e-50,
Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=56.441717791411, Blast_Score=182, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=34.9315068493151, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=34.9315068493151, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17539496, Length=154, Percent_Identity=36.3636363636364, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17506311, Length=167, Percent_Identity=34.7305389221557, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17552780, Length=165, Percent_Identity=38.1818181818182, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17532643, Length=165, Percent_Identity=37.5757575757576, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17565860, Length=194, Percent_Identity=32.4742268041237, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532641, Length=168, Percent_Identity=31.547619047619, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17506307, Length=168, Percent_Identity=35.7142857142857, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17551282, Length=195, Percent_Identity=31.7948717948718, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551284, Length=180, Percent_Identity=32.7777777777778, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71997782, Length=132, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=156, Percent_Identity=35.8974358974359, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320510, Length=169, Percent_Identity=36.094674556213, Blast_Score=69, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321848, Length=165, Percent_Identity=33.9393939393939, Blast_Score=66, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17986117, Length=162, Percent_Identity=38.8888888888889, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI19922912, Length=164, Percent_Identity=35.9756097560976, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19922376, Length=168, Percent_Identity=29.7619047619048, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136360, Length=168, Percent_Identity=35.1190476190476, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45549139, Length=157, Percent_Identity=36.3057324840764, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 19064; Mature: 18933

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQNPRVLLETSMGSITVELFKEKAPITVKNFLGYVKDGFYDGLIFHRVIKDFMIQGGG
CCCCCCCEEEEECCCCEEEEEHHCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
LNEAMEQKKPKFAIKNEATNKLSNKRGTLAMARTAIVDSATSQFFINTVDNAFLDHQGKQ
CCHHHHHCCCCEEECCHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
PDRFGYCVFGQVLEGMDVVDQIRAVKTGNKNGHGDVPLEPVYITSATLIEAE
CCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEECC
>Mature Secondary Structure 
SEQNPRVLLETSMGSITVELFKEKAPITVKNFLGYVKDGFYDGLIFHRVIKDFMIQGGG
CCCCCCEEEEECCCCEEEEEHHCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
LNEAMEQKKPKFAIKNEATNKLSNKRGTLAMARTAIVDSATSQFFINTVDNAFLDHQGKQ
CCHHHHHCCCCEEECCHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
PDRFGYCVFGQVLEGMDVVDQIRAVKTGNKNGHGDVPLEPVYITSATLIEAE
CCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]