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The map label for this gene is mutL

Identifier: 118581367

GI number: 118581367

Start: 3232682

End: 3234508

Strand: Direct

Name: mutL

Synonym: Ppro_2962

Alternate gene names: 118581367

Gene position: 3232682-3234508 (Clockwise)

Preceding gene: 118581366

Following gene: 118581368

Centisome position: 80.66

GC content: 66.39

Gene sequence:

>1827_bases
GTGTCCCAGCGCATCGCAATCCTGCCCGAAATCATCACCAACAAAATCGCCGCCGGCGAGGTTGTGGAACGACCTGCATC
GGTCATCAAGGAGCTGATTGAAAACTCCCTGGATGCCGGCGCAACGGATATCTCCGTGGAGATCGCTGCAGGGGGCAGGC
GCCTGATCAGGATCACGGACAACGGACACGGCATGTCCCGCGAGGACGCCCTCCTGTCCCTGGAGCGCCACGCCACCAGC
AAAATCAGGAGCGACAATGATCTGGACGGCATCCACACCCTCGGTTTCCGCGGCGAGGCGCTCCCCTCCGTCGCGTCGGT
CTCCCGCCTGCGCCTGAGCAGCCGAGAAACGGACAGCCCGGAGGGGACCGAGATCATCGTGGAGGGGGGAAAGGTGCGGG
ATGTGAGGGCCTGCGGCATGGCCCCCGGCACGGTGATCAGCGTCGAACAGATCTTCTTCAACACCCCGGCACGGCTCAAG
TTTCTGCGCAGCGCCGAAACCGAGGCCGGCCATGTGGGGGACTGCCTGACCCGCATGGCCATCTCCCGACCCGATGTGGC
CTTCAGCTGCAGCAGCGACGGCCGCGACCTGCTGCGGGTGCAGCGGGGAGACCTGCTGCGGCGCCTTTCCCAGGCCCTGG
GGAAGGGTACCGCCGCCAGCCTGCACGAGCTGCATCTCTCCCGCGACGGAATCGACATCAGCGGCTACATCTCCTCCCCC
GCCGCCTGCCGCTCCACCACCAGCGCCATGTTCACCTACATAAACGGCCGTTTCATCCGGGACAAGGTGATCCAGCACGC
CATCATGCAGGCCTACCGGGGAGTCATGGACCGGGGCCGCTACCCGGTGGTGGCCCTGTTTATCCAACTCCCCCCCGCCG
AGGTGGATGTGAATGTGCATCCCACCAAGCACGAGGTGCGCTTCCGCCGCCAGTCGCTGGTGCATGATACGCTGCAATCG
GCCCTGGAAGAGCTGCTCAAGCGCTCCCCCTGGCTGCCCCGCCCCCAGACTCCGGTTCAACCGGCCGCCGTCGGCGCCCC
ATCCATAAGCCAGGCCTACCGGGAGCGGGTCGCCGCCGCGGCCCAGGCATCCCTGGCCATGGCCCGCAAACCGGATCCCC
CCCGCTTCCATGAGACGGCGAGGCCACAACCGGACCCGCGGCATACCCCCGGGACGGAAAGCGTATCGGTCAGGGAGGCG
CCCACCCCCTTCCTACCCCGGGAGCCTGCCGCCGACCCCCAGGGATATTTCTCGGCACTGAGGATCATCGGACAGTTCCA
CGACGAGTACATCCTCTGCCAGTCCGGGGATCAGCTGGTGATCATCGACCAGCACGCGGCCAGCGAACGGGTTGCCTTCC
AGAAGCTGCGCCACCAGTTCGACACCGACGGAGTGGAGTCCCAACGCCTGCTCTTCCCCGAGACACTGGAACTCTCCTTC
AGCGAAGCGGACACGGCCAGGCGCTTCGGTAACGAACTGGCCCGCATCGGCTTCGAGCTGGAGCCCTTCGGCGGCAACAC
GGTCATCGTCAGCGCCATCCCCCGCCTGGCAATCGCCCGTGACGCCAGCGGACTGATCAGGGATCTGCTGGCCGAGCTGA
CCCAGCTGGGCGCCAGCTCGGCCTTCCTGGATAGCCGCGACGCCCTGCTCTCGCGTATCGCCTGCCACAGCGTCGTACGC
GGCGTCCATCGCCTGGAAGAGCGCCAGATCAGGGAACTGCTGCACGGCATGGACGGCACCGACTTCGCCGCCAGCTGCCC
CCATGGCCGCCCGGTTTCCCATGTCATCACCCTGGGAGAACTGGAGAGGATCTTCAAACGCACATGA

Upstream 100 bases:

>100_bases
GACGCAGCCATAAAGAAATAGTCCGTTTCCACGACGCCTTATCAACCAGAGCGGGGCAGCCCGCTCTTTTTTGTTCCCCT
GCACTCCCTGGAGTTTTTCC

Downstream 100 bases:

>100_bases
CAGGGCCGGCACTCCCCCGCATACTGATCATCTGCGGACCCACCGCCTCGGGCAAGAGCGAACTGGCGGTACGACTGGCG
CGGGAACTGGACGGAGAGAT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MSQRIAILPEIITNKIAAGEVVERPASVIKELIENSLDAGATDISVEIAAGGRRLIRITDNGHGMSREDALLSLERHATS
KIRSDNDLDGIHTLGFRGEALPSVASVSRLRLSSRETDSPEGTEIIVEGGKVRDVRACGMAPGTVISVEQIFFNTPARLK
FLRSAETEAGHVGDCLTRMAISRPDVAFSCSSDGRDLLRVQRGDLLRRLSQALGKGTAASLHELHLSRDGIDISGYISSP
AACRSTTSAMFTYINGRFIRDKVIQHAIMQAYRGVMDRGRYPVVALFIQLPPAEVDVNVHPTKHEVRFRRQSLVHDTLQS
ALEELLKRSPWLPRPQTPVQPAAVGAPSISQAYRERVAAAAQASLAMARKPDPPRFHETARPQPDPRHTPGTESVSVREA
PTPFLPREPAADPQGYFSALRIIGQFHDEYILCQSGDQLVIIDQHAASERVAFQKLRHQFDTDGVESQRLLFPETLELSF
SEADTARRFGNELARIGFELEPFGGNTVIVSAIPRLAIARDASGLIRDLLAELTQLGASSAFLDSRDALLSRIACHSVVR
GVHRLEERQIRELLHGMDGTDFAASCPHGRPVSHVITLGELERIFKRT

Sequences:

>Translated_608_residues
MSQRIAILPEIITNKIAAGEVVERPASVIKELIENSLDAGATDISVEIAAGGRRLIRITDNGHGMSREDALLSLERHATS
KIRSDNDLDGIHTLGFRGEALPSVASVSRLRLSSRETDSPEGTEIIVEGGKVRDVRACGMAPGTVISVEQIFFNTPARLK
FLRSAETEAGHVGDCLTRMAISRPDVAFSCSSDGRDLLRVQRGDLLRRLSQALGKGTAASLHELHLSRDGIDISGYISSP
AACRSTTSAMFTYINGRFIRDKVIQHAIMQAYRGVMDRGRYPVVALFIQLPPAEVDVNVHPTKHEVRFRRQSLVHDTLQS
ALEELLKRSPWLPRPQTPVQPAAVGAPSISQAYRERVAAAAQASLAMARKPDPPRFHETARPQPDPRHTPGTESVSVREA
PTPFLPREPAADPQGYFSALRIIGQFHDEYILCQSGDQLVIIDQHAASERVAFQKLRHQFDTDGVESQRLLFPETLELSF
SEADTARRFGNELARIGFELEPFGGNTVIVSAIPRLAIARDASGLIRDLLAELTQLGASSAFLDSRDALLSRIACHSVVR
GVHRLEERQIRELLHGMDGTDFAASCPHGRPVSHVITLGELERIFKRT
>Mature_607_residues
SQRIAILPEIITNKIAAGEVVERPASVIKELIENSLDAGATDISVEIAAGGRRLIRITDNGHGMSREDALLSLERHATSK
IRSDNDLDGIHTLGFRGEALPSVASVSRLRLSSRETDSPEGTEIIVEGGKVRDVRACGMAPGTVISVEQIFFNTPARLKF
LRSAETEAGHVGDCLTRMAISRPDVAFSCSSDGRDLLRVQRGDLLRRLSQALGKGTAASLHELHLSRDGIDISGYISSPA
ACRSTTSAMFTYINGRFIRDKVIQHAIMQAYRGVMDRGRYPVVALFIQLPPAEVDVNVHPTKHEVRFRRQSLVHDTLQSA
LEELLKRSPWLPRPQTPVQPAAVGAPSISQAYRERVAAAAQASLAMARKPDPPRFHETARPQPDPRHTPGTESVSVREAP
TPFLPREPAADPQGYFSALRIIGQFHDEYILCQSGDQLVIIDQHAASERVAFQKLRHQFDTDGVESQRLLFPETLELSFS
EADTARRFGNELARIGFELEPFGGNTVIVSAIPRLAIARDASGLIRDLLAELTQLGASSAFLDSRDALLSRIACHSVVRG
VHRLEERQIRELLHGMDGTDFAASCPHGRPVSHVITLGELERIFKRT

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=326, Percent_Identity=33.7423312883436, Blast_Score=190, Evalue=4e-48,
Organism=Homo sapiens, GI4505911, Length=345, Percent_Identity=29.8550724637681, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI189458898, Length=345, Percent_Identity=29.8550724637681, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI189458896, Length=342, Percent_Identity=28.9473684210526, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI4505913, Length=343, Percent_Identity=28.2798833819242, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI310128478, Length=343, Percent_Identity=28.2798833819242, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI91992162, Length=355, Percent_Identity=24.7887323943662, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI91992160, Length=355, Percent_Identity=24.7887323943662, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI263191589, Length=235, Percent_Identity=25.9574468085106, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI310128480, Length=305, Percent_Identity=26.2295081967213, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1790612, Length=565, Percent_Identity=35.5752212389381, Blast_Score=278, Evalue=9e-76,
Organism=Caenorhabditis elegans, GI71991825, Length=314, Percent_Identity=36.3057324840764, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17562796, Length=349, Percent_Identity=27.7936962750716, Blast_Score=127, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323819, Length=330, Percent_Identity=33.9393939393939, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6324247, Length=420, Percent_Identity=25.7142857142857, Blast_Score=116, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6325093, Length=300, Percent_Identity=27.3333333333333, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136968, Length=334, Percent_Identity=35.3293413173653, Blast_Score=199, Evalue=7e-51,
Organism=Drosophila melanogaster, GI17136970, Length=354, Percent_Identity=25.1412429378531, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_PELPD (A1AT89)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902617.1
- ProteinModelPortal:   A1AT89
- SMR:   A1AT89
- STRING:   A1AT89
- GeneID:   4574468
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2962
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- PhylomeDB:   A1AT89
- ProtClustDB:   PRK00095
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 66741; Mature: 66610

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQRIAILPEIITNKIAAGEVVERPASVIKELIENSLDAGATDISVEIAAGGRRLIRITD
CCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEC
NGHGMSREDALLSLERHATSKIRSDNDLDGIHTLGFRGEALPSVASVSRLRLSSRETDSP
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCC
EGTEIIVEGGKVRDVRACGMAPGTVISVEQIFFNTPARLKFLRSAETEAGHVGDCLTRMA
CCCEEEEECCCEEEHHHCCCCCCCEEEHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHH
ISRPDVAFSCSSDGRDLLRVQRGDLLRRLSQALGKGTAASLHELHLSRDGIDISGYISSP
HCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEECCCCC
AACRSTTSAMFTYINGRFIRDKVIQHAIMQAYRGVMDRGRYPVVALFIQLPPAEVDVNVH
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEECC
PTKHEVRFRRQSLVHDTLQSALEELLKRSPWLPRPQTPVQPAAVGAPSISQAYRERVAAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
AQASLAMARKPDPPRFHETARPQPDPRHTPGTESVSVREAPTPFLPREPAADPQGYFSAL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHH
RIIGQFHDEYILCQSGDQLVIIDQHAASERVAFQKLRHQFDTDGVESQRLLFPETLELSF
HHHHHHCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEECCHHHCCCC
SEADTARRFGNELARIGFELEPFGGNTVIVSAIPRLAIARDASGLIRDLLAELTQLGASS
HHHHHHHHHHHHHHHCCCEEECCCCCEEEEEHHHHHHHHCCHHHHHHHHHHHHHHCCCCH
AFLDSRDALLSRIACHSVVRGVHRLEERQIRELLHGMDGTDFAASCPHGRPVSHVITLGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
LERIFKRT
HHHHHHCC
>Mature Secondary Structure 
SQRIAILPEIITNKIAAGEVVERPASVIKELIENSLDAGATDISVEIAAGGRRLIRITD
CCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEC
NGHGMSREDALLSLERHATSKIRSDNDLDGIHTLGFRGEALPSVASVSRLRLSSRETDSP
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCC
EGTEIIVEGGKVRDVRACGMAPGTVISVEQIFFNTPARLKFLRSAETEAGHVGDCLTRMA
CCCEEEEECCCEEEHHHCCCCCCCEEEHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHH
ISRPDVAFSCSSDGRDLLRVQRGDLLRRLSQALGKGTAASLHELHLSRDGIDISGYISSP
HCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEECCCCC
AACRSTTSAMFTYINGRFIRDKVIQHAIMQAYRGVMDRGRYPVVALFIQLPPAEVDVNVH
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEECC
PTKHEVRFRRQSLVHDTLQSALEELLKRSPWLPRPQTPVQPAAVGAPSISQAYRERVAAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
AQASLAMARKPDPPRFHETARPQPDPRHTPGTESVSVREAPTPFLPREPAADPQGYFSAL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHH
RIIGQFHDEYILCQSGDQLVIIDQHAASERVAFQKLRHQFDTDGVESQRLLFPETLELSF
HHHHHHCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEECCHHHCCCC
SEADTARRFGNELARIGFELEPFGGNTVIVSAIPRLAIARDASGLIRDLLAELTQLGASS
HHHHHHHHHHHHHHHCCCEEECCCCCEEEEEHHHHHHHHCCHHHHHHHHHHHHHHCCCCH
AFLDSRDALLSRIACHSVVRGVHRLEERQIRELLHGMDGTDFAASCPHGRPVSHVITLGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
LERIFKRT
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA