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The map label for this gene is msrAB [H]

Identifier: 118581353

GI number: 118581353

Start: 3219319

End: 3220287

Strand: Direct

Name: msrAB [H]

Synonym: Ppro_2948

Alternate gene names: 118581353

Gene position: 3219319-3220287 (Clockwise)

Preceding gene: 118581352

Following gene: 118581354

Centisome position: 80.32

GC content: 62.44

Gene sequence:

>969_bases
ATGAAAGACAAACCTGCAGCTTACCAGAAAGCGGAACCTGATCAACTGAAGAAACGGCTCACCCCGGAGCAGTACCGGGT
CACCCAGCAGTGCGGCACCGAGCCCCCCTTCCAGAATGCCTACTGGAACAACCACGATCCCGGCATCTACGTGGACGTGG
TTTCCGGCGAGCCGCTGTTCAGCTCCCTGCACAAGTTCGACTCCGGCAGCGGCTGGCCCAGTTTTTCCCAGCCCCTGGAG
AAGGAGCAGATCACCAGCAGGGAAGACACCGGTCAGGGCATGGGGCGCACCGAGGTCCGCTCCCGGGACGGGGACTCCCA
CCTGGGGCATCTCTTCAATGACGGCCCTGCGCCCACCGGCCAGCGCTACTGCATCAACTCCGCCGCGCTGCGCTTCATCC
CGGCCGGCAAACTGTGGAGCGAGGGATACGGCCTCTATGCGCCGCGGTTCGAGGCCGCTGGCGTCAAGACCGATGCGCCG
GAATGCGAGACAACCGTACTGGCCGGAGGCTGTTTCTGGGGCATGCAGGACATCCTGCGCACAATACCGGGAGTGGTTTC
CACACGGGTGGGCTACACTGGCGGGCACCTGAAAAACCCGCGCTACGAGGACACCCACGACTCCAAGAGCGGGCACGCCG
AGAGCGTGGAGATCGTCTTCGACCCGCGCCGACTGAGCTATGAGGAGTTGCTGGCCACCTGGTTCTTCCGCATGCACGAC
CCCACCACCAAAGACCGCCAGGGGAACGACCAGGGAAGCCAGTACCGGTCAGCCATTTTTTACACAAGTGAGCTTCAGCG
AACCATCGCCGAGCGGGTCAAGCGTACGGTGGACAGGTCAGGGAAATGGAAAGCGCCGCTGGTCACCGAAATCGTCCCGG
CCACGACCTTCTACCCGGCCGAGGAGTACCACCAGGATTATCTGCTAAAAAACCCGGGGGGATACAGCTGCCACTATCTG
AGGGATTGA

Upstream 100 bases:

>100_bases
AAAGCAGAACAGATGGCTGTATTCCGTTGTCGCCCTGCTGACATGGATCACTGCATCTCTATGCCTGGCATCCTGCGACA
GCAGCGGAAAGGGGGCTATG

Downstream 100 bases:

>100_bases
GCCGCCGCGACCTGCCCAGGTGCGCTATCGATAGTTTTTGCACCTGGAGGTGAGACCGGAAATGGGATACACTGCGTTGC
CGCAACAGAAAGATCACGGA

Product: bifunctional methionine sulfoxide reductase B/A protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MKDKPAAYQKAEPDQLKKRLTPEQYRVTQQCGTEPPFQNAYWNNHDPGIYVDVVSGEPLFSSLHKFDSGSGWPSFSQPLE
KEQITSREDTGQGMGRTEVRSRDGDSHLGHLFNDGPAPTGQRYCINSAALRFIPAGKLWSEGYGLYAPRFEAAGVKTDAP
ECETTVLAGGCFWGMQDILRTIPGVVSTRVGYTGGHLKNPRYEDTHDSKSGHAESVEIVFDPRRLSYEELLATWFFRMHD
PTTKDRQGNDQGSQYRSAIFYTSELQRTIAERVKRTVDRSGKWKAPLVTEIVPATTFYPAEEYHQDYLLKNPGGYSCHYL
RD

Sequences:

>Translated_322_residues
MKDKPAAYQKAEPDQLKKRLTPEQYRVTQQCGTEPPFQNAYWNNHDPGIYVDVVSGEPLFSSLHKFDSGSGWPSFSQPLE
KEQITSREDTGQGMGRTEVRSRDGDSHLGHLFNDGPAPTGQRYCINSAALRFIPAGKLWSEGYGLYAPRFEAAGVKTDAP
ECETTVLAGGCFWGMQDILRTIPGVVSTRVGYTGGHLKNPRYEDTHDSKSGHAESVEIVFDPRRLSYEELLATWFFRMHD
PTTKDRQGNDQGSQYRSAIFYTSELQRTIAERVKRTVDRSGKWKAPLVTEIVPATTFYPAEEYHQDYLLKNPGGYSCHYL
RD
>Mature_322_residues
MKDKPAAYQKAEPDQLKKRLTPEQYRVTQQCGTEPPFQNAYWNNHDPGIYVDVVSGEPLFSSLHKFDSGSGWPSFSQPLE
KEQITSREDTGQGMGRTEVRSRDGDSHLGHLFNDGPAPTGQRYCINSAALRFIPAGKLWSEGYGLYAPRFEAAGVKTDAP
ECETTVLAGGCFWGMQDILRTIPGVVSTRVGYTGGHLKNPRYEDTHDSKSGHAESVEIVFDPRRLSYEELLATWFFRMHD
PTTKDRQGNDQGSQYRSAIFYTSELQRTIAERVKRTVDRSGKWKAPLVTEIVPATTFYPAEEYHQDYLLKNPGGYSCHYL
RD

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=121, Percent_Identity=57.8512396694215, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI301336162, Length=121, Percent_Identity=57.8512396694215, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI73089054, Length=121, Percent_Identity=57.8512396694215, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI37620216, Length=121, Percent_Identity=57.8512396694215, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI208609995, Length=173, Percent_Identity=44.5086705202312, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI6912516, Length=174, Percent_Identity=44.2528735632184, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI117606353, Length=125, Percent_Identity=50.4, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI208609993, Length=109, Percent_Identity=49.5412844036697, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1788077, Length=132, Percent_Identity=48.4848484848485, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1790665, Length=166, Percent_Identity=43.9759036144578, Blast_Score=129, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17553450, Length=120, Percent_Identity=44.1666666666667, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI115532676, Length=120, Percent_Identity=44.1666666666667, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17533973, Length=141, Percent_Identity=37.5886524822695, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=178, Percent_Identity=37.0786516853933, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6319816, Length=119, Percent_Identity=33.6134453781513, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI221378664, Length=124, Percent_Identity=46.7741935483871, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI45553335, Length=123, Percent_Identity=47.9674796747967, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI21356369, Length=123, Percent_Identity=47.9674796747967, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24645799, Length=123, Percent_Identity=47.9674796747967, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI221378662, Length=131, Percent_Identity=44.2748091603053, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24645804, Length=134, Percent_Identity=44.7761194029851, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24645801, Length=134, Percent_Identity=44.7761194029851, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24664627, Length=150, Percent_Identity=36, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45553131, Length=144, Percent_Identity=36.8055555555556, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664631, Length=150, Percent_Identity=34.6666666666667, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.12; =1.8.4.11 [H]

Molecular weight: Translated: 36375; Mature: 36375

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDKPAAYQKAEPDQLKKRLTPEQYRVTQQCGTEPPFQNAYWNNHDPGIYVDVVSGEPLF
CCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHH
SSLHKFDSGSGWPSFSQPLEKEQITSREDTGQGMGRTEVRSRDGDSHLGHLFNDGPAPTG
HHHHHCCCCCCCCCHHCCHHHHHHCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCCCCCCC
QRYCINSAALRFIPAGKLWSEGYGLYAPRFEAAGVKTDAPECETTVLAGGCFWGMQDILR
CEEEHHHHHHEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHH
TIPGVVSTRVGYTGGHLKNPRYEDTHDSKSGHAESVEIVFDPRRLSYEELLATWFFRMHD
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCC
PTTKDRQGNDQGSQYRSAIFYTSELQRTIAERVKRTVDRSGKWKAPLVTEIVPATTFYPA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCH
EEYHQDYLLKNPGGYSCHYLRD
HHHHCHHEEECCCCCCEEECCC
>Mature Secondary Structure
MKDKPAAYQKAEPDQLKKRLTPEQYRVTQQCGTEPPFQNAYWNNHDPGIYVDVVSGEPLF
CCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHH
SSLHKFDSGSGWPSFSQPLEKEQITSREDTGQGMGRTEVRSRDGDSHLGHLFNDGPAPTG
HHHHHCCCCCCCCCHHCCHHHHHHCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCCCCCCC
QRYCINSAALRFIPAGKLWSEGYGLYAPRFEAAGVKTDAPECETTVLAGGCFWGMQDILR
CEEEHHHHHHEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHH
TIPGVVSTRVGYTGGHLKNPRYEDTHDSKSGHAESVEIVFDPRRLSYEELLATWFFRMHD
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCC
PTTKDRQGNDQGSQYRSAIFYTSELQRTIAERVKRTVDRSGKWKAPLVTEIVPATTFYPA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCH
EEYHQDYLLKNPGGYSCHYLRD
HHHHCHHEEECCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]