Click here to switch to the map view.

The map label for this gene is mutS2 [H]

Identifier: 118581340

GI number: 118581340

Start: 3208202

End: 3210568

Strand: Reverse

Name: mutS2 [H]

Synonym: Ppro_2935

Alternate gene names: 118581340

Gene position: 3210568-3208202 (Counterclockwise)

Preceding gene: 118581341

Following gene: 118581339

Centisome position: 80.1

GC content: 66.03

Gene sequence:

>2367_bases
ATGATCAGTCACCAAACCCTGAAGCGCCTGGAATTCGACAAGATTCTGGCTGAAATCTCCGGCCATGTTCACAGCGAGGT
TACGGCCGCCCGGCTTATGGATACCGTGCCGTTGAGCGACGGGGGGGCTATTGCCTCCATCTCCGGACGCATCGAGGAGA
TTCGCTCCCTTGCCAGCCAGGGCATTGCCCTGCGTCTGCAGCCCTTCCAGGATATCCGGCCGCTCATGGAGCTGCTCCGG
CCGGTTGGCGCCTTTCTGGGGCCGCGGGAGCTTTTGATCTTCATCCCGGTGCTGGAGATCTTCGGCGACATCGCCCGTCA
GTTCGCGCCCCGCAACGACATCCCGCTGCTCAAGGGACTCGATCCCCCCCTGAAGGGCTTCGCCGATATCCTGGAGCCGC
TGGCCGCCTCCATCGATCAGGACGGCGGCATCATGGACAGCGCCTCCACGGCATTACGGGAGATCCGCCGCGCAAAGCGT
TCGCTGGCATCCCGCATCCGCAAGAAGATCGAGGAGATCGTCCGCGACAACAATATCGAGATCTTTCTGCAGGACGATTT
CATAACCCAGCGTTCGGGGCGCTGGGTTATCCCGGTGCGCATGGATTCCAAGGGGATGGTCAAGGGGGTGGTGCACGACG
TCTCCTCGTCGGGGGAGACCGCCTTCATGGAACCGCTGGAGATCATCCCCTTCGTCAACGAGCTGGAAAACCTGAGCGCC
GAGGAAAAGGCCGAGGAGATCCGCATCCTCCGCCAGCTTTCGTCCTGGATCCGCCAGGATGCGGCCGAGATCAGCGCCTG
TTTCGAAACCCTGCTGACCCTGGATGAGCTTGCCAGTATCGCCCGCTTCGCCGACACCCATGCCCTGGAACCCCCCAGCC
TGAACGGCGAAGGGGTGCTGCGCCTGGCCGGGGCGCGCCACCCGTTGCTGCTGATGCTCCAGGCCCAGGGGGCGCTTTCC
CGGGTGGAGCCGCTGGACCTGCAGTTGGGGGGCGAGGGGACGGTCATGGTGATCACCGGGCCCAATGCCGGCGGCAAGAC
CATCGCCCTGAAAACTGCCGGGGTGCTGGTGCTCATGGCGCTGTGCGGCATGCCGGTGCCGGCCGATGGCGCCAGCTCCA
CCTTTCCCCTGCTGGACGACCTGCTGGTGGATATGGGGGACGAACAGTCCATCGAACAGAGCCTCTCCACCTTCTCCGCC
CATGTGTCCCGCGTCGCCGCCATACTGGAGCAGGCGGGGCCGCGCTCCCTGGTGCTGCTGGACGAACTGGGCGCGGGAAC
GGAGCCGCAGCAGGGGGCGGCCATCGCCTGCGGCGTGCTGCGGGAATTGCGGGAGCGGGGCGCCATGGTCATCGCCACCA
CTCACCTGTCGGAGATCATCGGTTATGTCCATGCCACGGAGGGGATGGTCAACGCCGGCATGGAGTACGACGCCGAGACC
TACACGCCGCTCTACCGCCTGATCAGCGGACAGCCGGGACATTCCCATGCCATCGAGATCGCCCGGCGCTACGGCATGCC
CGACCGGGTGATCAGCTTTGCCCGGGAGATGCTGGGAACGGCCAGCGAAGAGTTCACCAGTCTCTTGGCCGAGTTGCACC
GCAAGCGGGGGGAGCTGGAGCATGGCGCTGCCCAACTTGAGCGGGAACGGGAGCAGGTCAGGGCCATCCGTAGGGAGCTG
GAAGCCCGCAGCGCTACTATCGAACAGGCCAGGCAGGAGACGCGGGAAAAAGCCTGGGCCGATGCGCGGGAGGTGATCTC
CACGGCCCGGCGCCGCATGAACGAGCTTTTGGACGAGTATCGGCGCGAACGCCGCAGCGAGAGCATCGAGAAGCTGCGCC
GCGTGGAGGCCGAGGTCACCGAACAGCTCAGCCCCCGGGATCTGGCCGGTGACGATCAGCCCCTGGGCGAGGTGGCCGAG
GGTGACAGCGTGCGCATCCGCTCCCTGGGGCACGACGGTCGCGTGCTCCAGCTGCTCCCCAAACAGGGCAGGGCGCGGGT
CAGGGCCGGCAGCATGGAGCTGGAGGTGCCGCTCAGCGATCTGGTGGCACCGTTGAAACAAACAGGCGGCACGGCGACTC
GGCCATCGGGAGGTGACTGGAGGGTGCAGGCGGTCGAGGAGGGGGAGCGGGAGCTGAAGCTGATCGGCCTGCGGGTGGAG
GAAGCGCTGGCGCTCCTGGACCCCTTTCTCAGCCAGGCCTCCCTGGGCTCCTTTTCCGAGGTGCGCATCATCCATGGCCT
TGGTTCGGGACGACTGCGTCAGGCGGTGCGGGAGCATCTGGCACATCACCAGCTGGTGGAGGAGTTCCGTCCCGGAAACG
CCCATGAGGGGCGGGATGGCGCCACGGTGGTCACCTTGCGCAGGTAA

Upstream 100 bases:

>100_bases
TCGAGGCCCAGACTGGAGCAGAGACCGGAGAAATGCGGCGCATCGCGCGCCTGCGCAAACAGAAGAACCGTCGCAGAAGG
CGGGCAGAGAAGAAGGACGC

Downstream 100 bases:

>100_bases
TACGGAAATCAATGAAGAGGATGAGTGATGGATTTTTTTGTCAGCGAGGTCAGTGAGCAGGAGATCAGGCGTGAGCGGGA
GAAGTCCCGGGAACTGCGGC

Product: MutS2 family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 788; Mature: 788

Protein sequence:

>788_residues
MISHQTLKRLEFDKILAEISGHVHSEVTAARLMDTVPLSDGGAIASISGRIEEIRSLASQGIALRLQPFQDIRPLMELLR
PVGAFLGPRELLIFIPVLEIFGDIARQFAPRNDIPLLKGLDPPLKGFADILEPLAASIDQDGGIMDSASTALREIRRAKR
SLASRIRKKIEEIVRDNNIEIFLQDDFITQRSGRWVIPVRMDSKGMVKGVVHDVSSSGETAFMEPLEIIPFVNELENLSA
EEKAEEIRILRQLSSWIRQDAAEISACFETLLTLDELASIARFADTHALEPPSLNGEGVLRLAGARHPLLLMLQAQGALS
RVEPLDLQLGGEGTVMVITGPNAGGKTIALKTAGVLVLMALCGMPVPADGASSTFPLLDDLLVDMGDEQSIEQSLSTFSA
HVSRVAAILEQAGPRSLVLLDELGAGTEPQQGAAIACGVLRELRERGAMVIATTHLSEIIGYVHATEGMVNAGMEYDAET
YTPLYRLISGQPGHSHAIEIARRYGMPDRVISFAREMLGTASEEFTSLLAELHRKRGELEHGAAQLEREREQVRAIRREL
EARSATIEQARQETREKAWADAREVISTARRRMNELLDEYRRERRSESIEKLRRVEAEVTEQLSPRDLAGDDQPLGEVAE
GDSVRIRSLGHDGRVLQLLPKQGRARVRAGSMELEVPLSDLVAPLKQTGGTATRPSGGDWRVQAVEEGERELKLIGLRVE
EALALLDPFLSQASLGSFSEVRIIHGLGSGRLRQAVREHLAHHQLVEEFRPGNAHEGRDGATVVTLRR

Sequences:

>Translated_788_residues
MISHQTLKRLEFDKILAEISGHVHSEVTAARLMDTVPLSDGGAIASISGRIEEIRSLASQGIALRLQPFQDIRPLMELLR
PVGAFLGPRELLIFIPVLEIFGDIARQFAPRNDIPLLKGLDPPLKGFADILEPLAASIDQDGGIMDSASTALREIRRAKR
SLASRIRKKIEEIVRDNNIEIFLQDDFITQRSGRWVIPVRMDSKGMVKGVVHDVSSSGETAFMEPLEIIPFVNELENLSA
EEKAEEIRILRQLSSWIRQDAAEISACFETLLTLDELASIARFADTHALEPPSLNGEGVLRLAGARHPLLLMLQAQGALS
RVEPLDLQLGGEGTVMVITGPNAGGKTIALKTAGVLVLMALCGMPVPADGASSTFPLLDDLLVDMGDEQSIEQSLSTFSA
HVSRVAAILEQAGPRSLVLLDELGAGTEPQQGAAIACGVLRELRERGAMVIATTHLSEIIGYVHATEGMVNAGMEYDAET
YTPLYRLISGQPGHSHAIEIARRYGMPDRVISFAREMLGTASEEFTSLLAELHRKRGELEHGAAQLEREREQVRAIRREL
EARSATIEQARQETREKAWADAREVISTARRRMNELLDEYRRERRSESIEKLRRVEAEVTEQLSPRDLAGDDQPLGEVAE
GDSVRIRSLGHDGRVLQLLPKQGRARVRAGSMELEVPLSDLVAPLKQTGGTATRPSGGDWRVQAVEEGERELKLIGLRVE
EALALLDPFLSQASLGSFSEVRIIHGLGSGRLRQAVREHLAHHQLVEEFRPGNAHEGRDGATVVTLRR
>Mature_788_residues
MISHQTLKRLEFDKILAEISGHVHSEVTAARLMDTVPLSDGGAIASISGRIEEIRSLASQGIALRLQPFQDIRPLMELLR
PVGAFLGPRELLIFIPVLEIFGDIARQFAPRNDIPLLKGLDPPLKGFADILEPLAASIDQDGGIMDSASTALREIRRAKR
SLASRIRKKIEEIVRDNNIEIFLQDDFITQRSGRWVIPVRMDSKGMVKGVVHDVSSSGETAFMEPLEIIPFVNELENLSA
EEKAEEIRILRQLSSWIRQDAAEISACFETLLTLDELASIARFADTHALEPPSLNGEGVLRLAGARHPLLLMLQAQGALS
RVEPLDLQLGGEGTVMVITGPNAGGKTIALKTAGVLVLMALCGMPVPADGASSTFPLLDDLLVDMGDEQSIEQSLSTFSA
HVSRVAAILEQAGPRSLVLLDELGAGTEPQQGAAIACGVLRELRERGAMVIATTHLSEIIGYVHATEGMVNAGMEYDAET
YTPLYRLISGQPGHSHAIEIARRYGMPDRVISFAREMLGTASEEFTSLLAELHRKRGELEHGAAQLEREREQVRAIRREL
EARSATIEQARQETREKAWADAREVISTARRRMNELLDEYRRERRSESIEKLRRVEAEVTEQLSPRDLAGDDQPLGEVAE
GDSVRIRSLGHDGRVLQLLPKQGRARVRAGSMELEVPLSDLVAPLKQTGGTATRPSGGDWRVQAVEEGERELKLIGLRVE
EALALLDPFLSQASLGSFSEVRIIHGLGSGRLRQAVREHLAHHQLVEEFRPGNAHEGRDGATVVTLRR

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI26638666, Length=292, Percent_Identity=30.1369863013699, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI4505253, Length=292, Percent_Identity=30.1369863013699, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI26638664, Length=293, Percent_Identity=30.0341296928328, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI4504191, Length=282, Percent_Identity=31.2056737588652, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI284813531, Length=490, Percent_Identity=25.5102040816327, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI262231786, Length=232, Percent_Identity=31.8965517241379, Blast_Score=91, Evalue=5e-18,
Organism=Homo sapiens, GI4557761, Length=346, Percent_Identity=27.1676300578035, Blast_Score=91, Evalue=6e-18,
Organism=Homo sapiens, GI36949366, Length=374, Percent_Identity=25.4010695187166, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI1789089, Length=300, Percent_Identity=26.6666666666667, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17534743, Length=333, Percent_Identity=25.2252252252252, Blast_Score=100, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17508445, Length=263, Percent_Identity=29.277566539924, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17539736, Length=254, Percent_Identity=26.7716535433071, Blast_Score=87, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17508447, Length=266, Percent_Identity=28.1954887218045, Blast_Score=76, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324482, Length=409, Percent_Identity=26.161369193154, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6321912, Length=322, Percent_Identity=26.0869565217391, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319935, Length=266, Percent_Identity=26.6917293233083, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320302, Length=235, Percent_Identity=28.936170212766, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320047, Length=269, Percent_Identity=23.4200743494424, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321109, Length=230, Percent_Identity=26.5217391304348, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24584320, Length=271, Percent_Identity=31.7343173431734, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24664545, Length=284, Percent_Identity=29.5774647887324, Blast_Score=107, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 86566; Mature: 86566

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISHQTLKRLEFDKILAEISGHVHSEVTAARLMDTVPLSDGGAIASISGRIEEIRSLASQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHC
GIALRLQPFQDIRPLMELLRPVGAFLGPRELLIFIPVLEIFGDIARQFAPRNDIPLLKGL
CCEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCC
DPPLKGFADILEPLAASIDQDGGIMDSASTALREIRRAKRSLASRIRKKIEEIVRDNNIE
CCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
IFLQDDFITQRSGRWVIPVRMDSKGMVKGVVHDVSSSGETAFMEPLEIIPFVNELENLSA
EEEECCCEECCCCCEEEEEEECCCCHHHHHHHHHCCCCCCHHHCHHHHHHHHHHHHCCCH
EEKAEEIRILRQLSSWIRQDAAEISACFETLLTLDELASIARFADTHALEPPSLNGEGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
RLAGARHPLLLMLQAQGALSRVEPLDLQLGGEGTVMVITGPNAGGKTIALKTAGVLVLMA
EECCCCCCEEEEEECCCCHHHCCCCCEEECCCCEEEEEECCCCCCCEEEEHHHHHHHHHH
LCGMPVPADGASSTFPLLDDLLVDMGDEQSIEQSLSTFSAHVSRVAAILEQAGPRSLVLL
HHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
DELGAGTEPQQGAAIACGVLRELRERGAMVIATTHLSEIIGYVHATEGMVNAGMEYDAET
ECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCHHHHCCCCCCCHH
YTPLYRLISGQPGHSHAIEIARRYGMPDRVISFAREMLGTASEEFTSLLAELHRKRGELE
HHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHH
HGAAQLEREREQVRAIRRELEARSATIEQARQETREKAWADAREVISTARRRMNELLDEY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRERRSESIEKLRRVEAEVTEQLSPRDLAGDDQPLGEVAEGDSVRIRSLGHDGRVLQLLP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCEEEEECCCCCCEEEECC
KQGRARVRAGSMELEVPLSDLVAPLKQTGGTATRPSGGDWRVQAVEEGERELKLIGLRVE
CCCCCEEECCCEEEECCHHHHHHHHHHCCCCCCCCCCCCEEEEEHHCCCCCHHHHHHHHH
EALALLDPFLSQASLGSFSEVRIIHGLGSGRLRQAVREHLAHHQLVEEFRPGNAHEGRDG
HHHHHHHHHHHHHCCCCCHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ATVVTLRR
CEEEEEEC
>Mature Secondary Structure
MISHQTLKRLEFDKILAEISGHVHSEVTAARLMDTVPLSDGGAIASISGRIEEIRSLASQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHC
GIALRLQPFQDIRPLMELLRPVGAFLGPRELLIFIPVLEIFGDIARQFAPRNDIPLLKGL
CCEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCC
DPPLKGFADILEPLAASIDQDGGIMDSASTALREIRRAKRSLASRIRKKIEEIVRDNNIE
CCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
IFLQDDFITQRSGRWVIPVRMDSKGMVKGVVHDVSSSGETAFMEPLEIIPFVNELENLSA
EEEECCCEECCCCCEEEEEEECCCCHHHHHHHHHCCCCCCHHHCHHHHHHHHHHHHCCCH
EEKAEEIRILRQLSSWIRQDAAEISACFETLLTLDELASIARFADTHALEPPSLNGEGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
RLAGARHPLLLMLQAQGALSRVEPLDLQLGGEGTVMVITGPNAGGKTIALKTAGVLVLMA
EECCCCCCEEEEEECCCCHHHCCCCCEEECCCCEEEEEECCCCCCCEEEEHHHHHHHHHH
LCGMPVPADGASSTFPLLDDLLVDMGDEQSIEQSLSTFSAHVSRVAAILEQAGPRSLVLL
HHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
DELGAGTEPQQGAAIACGVLRELRERGAMVIATTHLSEIIGYVHATEGMVNAGMEYDAET
ECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCHHHHCCCCCCCHH
YTPLYRLISGQPGHSHAIEIARRYGMPDRVISFAREMLGTASEEFTSLLAELHRKRGELE
HHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHH
HGAAQLEREREQVRAIRRELEARSATIEQARQETREKAWADAREVISTARRRMNELLDEY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRERRSESIEKLRRVEAEVTEQLSPRDLAGDDQPLGEVAEGDSVRIRSLGHDGRVLQLLP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCEEEEECCCCCCEEEECC
KQGRARVRAGSMELEVPLSDLVAPLKQTGGTATRPSGGDWRVQAVEEGERELKLIGLRVE
CCCCCEEECCCEEEECCHHHHHHHHHHCCCCCCCCCCCCEEEEEHHCCCCCHHHHHHHHH
EALALLDPFLSQASLGSFSEVRIIHGLGSGRLRQAVREHLAHHQLVEEFRPGNAHEGRDG
HHHHHHHHHHHHHCCCCCHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ATVVTLRR
CEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA