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The map label for this gene is pbpA [H]

Identifier: 118581301

GI number: 118581301

Start: 3168383

End: 3169780

Strand: Direct

Name: pbpA [H]

Synonym: Ppro_2896

Alternate gene names: 118581301

Gene position: 3168383-3169780 (Clockwise)

Preceding gene: 118581300

Following gene: 118581303

Centisome position: 79.05

GC content: 62.16

Gene sequence:

>1398_bases
ATGCAGGACCTCAAATATCTGACTGAAAAAAAACGTTTCCCCCTGATCGCCACCTCCAGAGCCAACAAGGGCAACCGAAA
ATTGGCGGCCTCTCGTCATCACCTCTCGCGCCAACTGAGTCTGTCCAGCGAGGAGAAGCGCCGTCGTTTCAAGCAGCTGC
TGCTGGTTCTGGCCGCCCTGGCGGTGATAACACCGCTCTGCCTGTACACCTTGCGCGCGGTACCCGCTGCTGCCAGGGGA
ATGGTAGCATGGCTCCAGAAGCAGCGCAGCCAGACCCCCCGGGAGGCCTTGGCCGCAAAACAGCCCGAGGCCAGCCCCTT
CCAGATGGCCACCTCGCTCTTGGACTCCGCCGTCATGGACGGCGACCGCTTCACGGCCCGAACCGGCAAGGGCGACACGC
TTCACTACACTATCCAGGGTGATCTGCAGAAACGGGTCCATGACTTCATGGCGGACAGGGAGGTCCCCTACGGCGTCTTT
GTGGCCATCGAACCTGCGACCGGCAGGATTCTGGCCATGACCGCCCACTCATCCATCAACCCGGAGTGGGAACGTCACGC
ATTTTTCGACGTCTACCCCATGGCTTCGCTGTTCAAGATCGTCACCGCCTCGGCAGCCCTGGAAAACAGACTCATGACCC
CTGATACCGTTGTGGAATTCCGCGGCGGATTCGTTTCCGAGAGTCCCCGTTATTGGCAGGCCAGCCCGCGCGGCAGGAAC
AACCGCCTGGACGTGAGCTGTGCCATGGGCAAGTCAGTCAACCCGGTCTACGGGAGGGTTGCAGCCGACATCGCCGGTAA
GACCAATGTCATGCAATCGGTAAACAGGTTCGGGTTCAACCAGAAACTGCTGCCGGGCATCCCGGTCAAGGAGAGCCAGG
CAATGGAGCCGCTGGATGACCATGGCCTGATGCTCATGGGGGCGGGCCTGGACCACGAGGTAAAGATCTCGCCGCTACAT
GCCGCCGCCATGATGGCGGCCATTGCCAACAACGGCCGCATGATGTCTCCCGGCCTGACCGAGAGCCTGACCGCCCCGTC
CGGAAAGGCCAGGCTTACCCATACCCCCCGCGAGATCCGCCGCCTCGTTTCTCCCGAAACGGCCCAATCCCTGACCCGCA
TGCTCTCCAGCACCGTGACCAGCGGAACATCCCGCAGGGCGTTCCACGACCGCCAGGGGCGTCCTTTCCTGGATGTTGAC
GTCTGCGCCAAGACCGGCTCCATCGATGGCACCGATCCCCAGGGGCACTATTCCTGGTTCGCTGCCTTCGCGCCGGCCCA
GAATCCGCGTATCGCCCTGGTGGCCCTGGTCATCAACCAGGACCGTTGGAAGATCAAATCCTCCCAGGTGGGGCAACAGG
CCCTGATGGCGTTTTTCGACAGGGAGAGGAATCCCTAG

Upstream 100 bases:

>100_bases
TTGCAACGACGCTTCTGGCCGGACGAGTCGTCCCTGATTGATTGACATAAACCGCGATTTGCCTGTATAGTCTCGCACAT
CTCACAGATCCCGGAATGCC

Downstream 100 bases:

>100_bases
CGCCCACGCTGGGTTTGCCCCTACGGGCGATCAGGCAGGTACTCGCTGAGACGTAGCCTGCCTGCCACCATCTCGCCATA
GGTCAGGCGCTCCATCCACT

Product: penicillin-binding protein, transpeptidase

Products: NA

Alternate protein names: PBPA [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MQDLKYLTEKKRFPLIATSRANKGNRKLAASRHHLSRQLSLSSEEKRRRFKQLLLVLAALAVITPLCLYTLRAVPAAARG
MVAWLQKQRSQTPREALAAKQPEASPFQMATSLLDSAVMDGDRFTARTGKGDTLHYTIQGDLQKRVHDFMADREVPYGVF
VAIEPATGRILAMTAHSSINPEWERHAFFDVYPMASLFKIVTASAALENRLMTPDTVVEFRGGFVSESPRYWQASPRGRN
NRLDVSCAMGKSVNPVYGRVAADIAGKTNVMQSVNRFGFNQKLLPGIPVKESQAMEPLDDHGLMLMGAGLDHEVKISPLH
AAAMMAAIANNGRMMSPGLTESLTAPSGKARLTHTPREIRRLVSPETAQSLTRMLSSTVTSGTSRRAFHDRQGRPFLDVD
VCAKTGSIDGTDPQGHYSWFAAFAPAQNPRIALVALVINQDRWKIKSSQVGQQALMAFFDRERNP

Sequences:

>Translated_465_residues
MQDLKYLTEKKRFPLIATSRANKGNRKLAASRHHLSRQLSLSSEEKRRRFKQLLLVLAALAVITPLCLYTLRAVPAAARG
MVAWLQKQRSQTPREALAAKQPEASPFQMATSLLDSAVMDGDRFTARTGKGDTLHYTIQGDLQKRVHDFMADREVPYGVF
VAIEPATGRILAMTAHSSINPEWERHAFFDVYPMASLFKIVTASAALENRLMTPDTVVEFRGGFVSESPRYWQASPRGRN
NRLDVSCAMGKSVNPVYGRVAADIAGKTNVMQSVNRFGFNQKLLPGIPVKESQAMEPLDDHGLMLMGAGLDHEVKISPLH
AAAMMAAIANNGRMMSPGLTESLTAPSGKARLTHTPREIRRLVSPETAQSLTRMLSSTVTSGTSRRAFHDRQGRPFLDVD
VCAKTGSIDGTDPQGHYSWFAAFAPAQNPRIALVALVINQDRWKIKSSQVGQQALMAFFDRERNP
>Mature_465_residues
MQDLKYLTEKKRFPLIATSRANKGNRKLAASRHHLSRQLSLSSEEKRRRFKQLLLVLAALAVITPLCLYTLRAVPAAARG
MVAWLQKQRSQTPREALAAKQPEASPFQMATSLLDSAVMDGDRFTARTGKGDTLHYTIQGDLQKRVHDFMADREVPYGVF
VAIEPATGRILAMTAHSSINPEWERHAFFDVYPMASLFKIVTASAALENRLMTPDTVVEFRGGFVSESPRYWQASPRGRN
NRLDVSCAMGKSVNPVYGRVAADIAGKTNVMQSVNRFGFNQKLLPGIPVKESQAMEPLDDHGLMLMGAGLDHEVKISPLH
AAAMMAAIANNGRMMSPGLTESLTAPSGKARLTHTPREIRRLVSPETAQSLTRMLSSTVTSGTSRRAFHDRQGRPFLDVD
VCAKTGSIDGTDPQGHYSWFAAFAPAQNPRIALVALVINQDRWKIKSSQVGQQALMAFFDRERNP

Specific function: Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Probable). Note=Localized to the division site (septum) along with newly synthesized peptidoglycan, between segregated nucleoids (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 51412; Mature: 51412

Theoretical pI: Translated: 10.68; Mature: 10.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDLKYLTEKKRFPLIATSRANKGNRKLAASRHHLSRQLSLSSEEKRRRFKQLLLVLAAL
CCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AVITPLCLYTLRAVPAAARGMVAWLQKQRSQTPREALAAKQPEASPFQMATSLLDSAVMD
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCC
GDRFTARTGKGDTLHYTIQGDLQKRVHDFMADREVPYGVFVAIEPATGRILAMTAHSSIN
CCCEEEECCCCCEEEEEEECHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEECCCCC
PEWERHAFFDVYPMASLFKIVTASAALENRLMTPDTVVEFRGGFVSESPRYWQASPRGRN
CCHHHCEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCEECCCCCCC
NRLDVSCAMGKSVNPVYGRVAADIAGKTNVMQSVNRFGFNQKLLPGIPVKESQAMEPLDD
CEEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
HGLMLMGAGLDHEVKISPLHAAAMMAAIANNGRMMSPGLTESLTAPSGKARLTHTPREIR
CCEEEEECCCCCEEEECHHHHHHHHHHHHCCCEEECCCCCHHCCCCCCCCEECCCHHHHH
RLVSPETAQSLTRMLSSTVTSGTSRRAFHDRQGRPFLDVDVCAKTGSIDGTDPQGHYSWF
HHHCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCEEEHHHHHCCCCCCCCCCCCCCEEE
AAFAPAQNPRIALVALVINQDRWKIKSSQVGQQALMAFFDRERNP
EEECCCCCCCEEEEEEEECCCCCEECHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQDLKYLTEKKRFPLIATSRANKGNRKLAASRHHLSRQLSLSSEEKRRRFKQLLLVLAAL
CCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AVITPLCLYTLRAVPAAARGMVAWLQKQRSQTPREALAAKQPEASPFQMATSLLDSAVMD
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCC
GDRFTARTGKGDTLHYTIQGDLQKRVHDFMADREVPYGVFVAIEPATGRILAMTAHSSIN
CCCEEEECCCCCEEEEEEECHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEECCCCC
PEWERHAFFDVYPMASLFKIVTASAALENRLMTPDTVVEFRGGFVSESPRYWQASPRGRN
CCHHHCEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCEECCCCCCC
NRLDVSCAMGKSVNPVYGRVAADIAGKTNVMQSVNRFGFNQKLLPGIPVKESQAMEPLDD
CEEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
HGLMLMGAGLDHEVKISPLHAAAMMAAIANNGRMMSPGLTESLTAPSGKARLTHTPREIR
CCEEEEECCCCCEEEECHHHHHHHHHHHHCCCEEECCCCCHHCCCCCCCCEECCCHHHHH
RLVSPETAQSLTRMLSSTVTSGTSRRAFHDRQGRPFLDVDVCAKTGSIDGTDPQGHYSWF
HHHCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCEEEHHHHHCCCCCCCCCCCCCCEEE
AAFAPAQNPRIALVALVINQDRWKIKSSQVGQQALMAFFDRERNP
EEECCCCCCCEEEEEEEECCCCCEECHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA