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The map label for this gene is hycD [H]

Identifier: 118581192

GI number: 118581192

Start: 3045816

End: 3046727

Strand: Reverse

Name: hycD [H]

Synonym: Ppro_2785

Alternate gene names: 118581192

Gene position: 3046727-3045816 (Counterclockwise)

Preceding gene: 118581193

Following gene: 118581191

Centisome position: 76.02

GC content: 61.4

Gene sequence:

>912_bases
ATGAACATGATAGTGGGCGTCCTGGTAAACGTCATCCTGGTGTTAGCGCTCGCTCCGCTCTTTCAGGGCGTACTTCGAAA
GGTAACGGCCCGTATCCAGTCGCGTCAGGGACCTCCGATCAACCAGCCCTACCTGGATATCCTGAAACTGTTGGGCAAGG
ACGACATCGAATCCGGTGAAGCCCCCGTGCTGCAGCGTTTCGCCGCCTATCTTCCCCTGGCGGTCATGCTGACCATCGCC
TGCCTGGTGCCCATGGGCTTCAAGGCCCCGCTGTCCGGCTCCGGCGACGTTCTGCTTTTGATCCTGCTGATGACCCTTGC
CGGCATCTGCACCCTGCTGGCCGGCCTGGCCTCCGGCTCCACCTACTCTCTGATCGGCATCAACCGCGAGATGATGTGCA
TGATCACCCTTGAGCCGCTGTTCGCCGTCGCCATCGTCATGGGCGCTCTGGCCAAGGGGAGTTTCAACCTGGACGAAGTG
CTCTCCGGCTCGGTCTACGGCGCAAACGGCATGGCGCTGTCCGGCTTCGCCATGCTGGTGATCATGCTGCTGGCCTTCCA
GGCCTTCGTGGGTCGTGCGCCCTTCGACATCTCCGAAGCTGAAACAGAGATCATGGAAGGGGCCATGGTGGAATACTCCG
GTCCCAAACTGGCCCTGTTCCAGTACGCCAACATGGCCAAACTGGTGGTGTACAGCGCCCTGTTTGTCTCCCTGTTCGTC
CCCTGGGGTTCCGGTCTGGCCGCTCCGATCAGCTTCATCCTGTTCTGGGTCAAGGTCTTCGCCATGGTGCTTCTGGTAAC
CACCATCGCCGCCACCCACGCCCGCTACCGCATCGACCAGGCCATCCGGTACTTCGCGATCATGCTGGCCGTATCCCTGG
TAACCCTGGCCGCCGCCAGCTACGGCTTCTGA

Upstream 100 bases:

>100_bases
CGACATCAGGACCGGCGCACGCAAGAGCTGGACAAAAGCCGAACTTCTCTCGTTGTCCAGATCACGGAAAGGCTAGGAGG
TAGTTGTGGAGAGTAACGTC

Downstream 100 bases:

>100_bases
TAGAGGTGAATGTATGTCCATACTGAGCAAACTGAAAGAGACCGCGATCTGCCTGAACGCCGGCCGGGTAACCATGCCGT
ACCCCTTTGAGTCCAAGCCC

Product: respiratory-chain NADH dehydrogenase, subunit 1

Products: NA

Alternate protein names: FHL subunit 4; Hydrogenase 3 component D [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MNMIVGVLVNVILVLALAPLFQGVLRKVTARIQSRQGPPINQPYLDILKLLGKDDIESGEAPVLQRFAAYLPLAVMLTIA
CLVPMGFKAPLSGSGDVLLLILLMTLAGICTLLAGLASGSTYSLIGINREMMCMITLEPLFAVAIVMGALAKGSFNLDEV
LSGSVYGANGMALSGFAMLVIMLLAFQAFVGRAPFDISEAETEIMEGAMVEYSGPKLALFQYANMAKLVVYSALFVSLFV
PWGSGLAAPISFILFWVKVFAMVLLVTTIAATHARYRIDQAIRYFAIMLAVSLVTLAAASYGF

Sequences:

>Translated_303_residues
MNMIVGVLVNVILVLALAPLFQGVLRKVTARIQSRQGPPINQPYLDILKLLGKDDIESGEAPVLQRFAAYLPLAVMLTIA
CLVPMGFKAPLSGSGDVLLLILLMTLAGICTLLAGLASGSTYSLIGINREMMCMITLEPLFAVAIVMGALAKGSFNLDEV
LSGSVYGANGMALSGFAMLVIMLLAFQAFVGRAPFDISEAETEIMEGAMVEYSGPKLALFQYANMAKLVVYSALFVSLFV
PWGSGLAAPISFILFWVKVFAMVLLVTTIAATHARYRIDQAIRYFAIMLAVSLVTLAAASYGF
>Mature_303_residues
MNMIVGVLVNVILVLALAPLFQGVLRKVTARIQSRQGPPINQPYLDILKLLGKDDIESGEAPVLQRFAAYLPLAVMLTIA
CLVPMGFKAPLSGSGDVLLLILLMTLAGICTLLAGLASGSTYSLIGINREMMCMITLEPLFAVAIVMGALAKGSFNLDEV
LSGSVYGANGMALSGFAMLVIMLLAFQAFVGRAPFDISEAETEIMEGAMVEYSGPKLALFQYANMAKLVVYSALFVSLFV
PWGSGLAAPISFILFWVKVFAMVLLVTTIAATHARYRIDQAIRYFAIMLAVSLVTLAAASYGF

Specific function: Hydrogen metabolism; FHL pathway. [C]

COG id: COG0650

COG function: function code C; Formate hydrogenlyase subunit 4

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=263, Percent_Identity=26.9961977186312, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1789077, Length=288, Percent_Identity=32.6388888888889, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI87082115, Length=244, Percent_Identity=33.6065573770492, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1788618, Length=287, Percent_Identity=28.9198606271777, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: NA

Molecular weight: Translated: 32378; Mature: 32378

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMIVGVLVNVILVLALAPLFQGVLRKVTARIQSRQGPPINQPYLDILKLLGKDDIESGE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCC
APVLQRFAAYLPLAVMLTIACLVPMGFKAPLSGSGDVLLLILLMTLAGICTLLAGLASGS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
TYSLIGINREMMCMITLEPLFAVAIVMGALAKGSFNLDEVLSGSVYGANGMALSGFAMLV
EEEEEECCCCEEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHHHHHHH
IMLLAFQAFVGRAPFDISEAETEIMEGAMVEYSGPKLALFQYANMAKLVVYSALFVSLFV
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
PWGSGLAAPISFILFWVKVFAMVLLVTTIAATHARYRIDQAIRYFAIMLAVSLVTLAAAS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGF
CCC
>Mature Secondary Structure
MNMIVGVLVNVILVLALAPLFQGVLRKVTARIQSRQGPPINQPYLDILKLLGKDDIESGE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCC
APVLQRFAAYLPLAVMLTIACLVPMGFKAPLSGSGDVLLLILLMTLAGICTLLAGLASGS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
TYSLIGINREMMCMITLEPLFAVAIVMGALAKGSFNLDEVLSGSVYGANGMALSGFAMLV
EEEEEECCCCEEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHHHHHHH
IMLLAFQAFVGRAPFDISEAETEIMEGAMVEYSGPKLALFQYANMAKLVVYSALFVSLFV
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
PWGSGLAAPISFILFWVKVFAMVLLVTTIAATHARYRIDQAIRYFAIMLAVSLVTLAAAS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGF
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2187144; 9278503 [H]