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The map label for this gene is pdhR [H]

Identifier: 118581081

GI number: 118581081

Start: 2904186

End: 2904917

Strand: Reverse

Name: pdhR [H]

Synonym: Ppro_2670

Alternate gene names: 118581081

Gene position: 2904917-2904186 (Counterclockwise)

Preceding gene: 118581082

Following gene: 118581067

Centisome position: 72.48

GC content: 58.88

Gene sequence:

>732_bases
ATGAAATTCAAGCCCATAAAGCCAAAGAAGGTATCTCTTCAGATTGCCGAGCAGATACGGAATTCCATTCTGGCCGGTGA
TTTCGTTCCCGGCGACAAGCTTCCCCCTGAACGAGAACTTGCCGAGATGTTCGGTGTTTCCCGCCCCTCGGTGCGTGAGG
CGCTCAATATCCTCTCAGCCGCCGGAATGGTCATGTCCTACCACGGTGGCGGGACGGTGGTGCTGTCGCTGGTGGATACG
GCGGTCGGCAACTTCCTCTCCGAACTGATCCGGGTCCAGCAGGAGCGGGCGCTGGATGTTATCGAGGTGCGCAAAGGGAT
GGAGTCGTGGACCGTGTACTATGCGGCCCTGCGTGCCCTCCCCGAGGATATCCAGCGCCTGGAGGAGATTGTCATGGGAA
TGGAGCGCAATTTGGATACGGGGAAGCCGTCCGAGGATCTCGATGCCAACTTCCACGTGGTCATTGCCCGCGCCACCCAC
AACATCGTCTGGCTGCACCTGATGCAGAGCCTTTTCGATGCCATGAAGGAATTTCAGCAGAGCGTCTGGCGCGCCGTCTA
CCTCACGCGTGAAGACCACCACCTGCTTTACACCCATCACAGCCGAATCTTCGAGGCGATTCGCCACAGGGATGCGGAGG
CTGCCCGTGATGCGATGATTGAGCACCTTACCTTTGCCGAACAGCGCAGCACAGCCTATGTGGCCCGTGCGGCGGCGGAG
ACTGAGAAATAG

Upstream 100 bases:

>100_bases
ACCGGCTGTTTTGTCCCCAAGCGCTGTTAATAGCATTTTCTTAAAGAATAAACGCCATTGAAAGGTCTGGAGTAGCAATA
CCCCACATGCATCGAATCCT

Downstream 100 bases:

>100_bases
GTGTGAGTGACGATCTGTGATTGCCTTGAATGCAAAAAACGCTGAGGCCGGCTCCCCTGGGGAGCCGGCCTCAGCGTTTT
TTTGGGGGTGAGGAACACAG

Product: GntR domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MKFKPIKPKKVSLQIAEQIRNSILAGDFVPGDKLPPERELAEMFGVSRPSVREALNILSAAGMVMSYHGGGTVVLSLVDT
AVGNFLSELIRVQQERALDVIEVRKGMESWTVYYAALRALPEDIQRLEEIVMGMERNLDTGKPSEDLDANFHVVIARATH
NIVWLHLMQSLFDAMKEFQQSVWRAVYLTREDHHLLYTHHSRIFEAIRHRDAEAARDAMIEHLTFAEQRSTAYVARAAAE
TEK

Sequences:

>Translated_243_residues
MKFKPIKPKKVSLQIAEQIRNSILAGDFVPGDKLPPERELAEMFGVSRPSVREALNILSAAGMVMSYHGGGTVVLSLVDT
AVGNFLSELIRVQQERALDVIEVRKGMESWTVYYAALRALPEDIQRLEEIVMGMERNLDTGKPSEDLDANFHVVIARATH
NIVWLHLMQSLFDAMKEFQQSVWRAVYLTREDHHLLYTHHSRIFEAIRHRDAEAARDAMIEHLTFAEQRSTAYVARAAAE
TEK
>Mature_243_residues
MKFKPIKPKKVSLQIAEQIRNSILAGDFVPGDKLPPERELAEMFGVSRPSVREALNILSAAGMVMSYHGGGTVVLSLVDT
AVGNFLSELIRVQQERALDVIEVRKGMESWTVYYAALRALPEDIQRLEEIVMGMERNLDTGKPSEDLDANFHVVIARATH
NIVWLHLMQSLFDAMKEFQQSVWRAVYLTREDHHLLYTHHSRIFEAIRHRDAEAARDAMIEHLTFAEQRSTAYVARAAAE
TEK

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=234, Percent_Identity=37.6068376068376, Blast_Score=147, Evalue=6e-37,
Organism=Escherichia coli, GI1790032, Length=225, Percent_Identity=34.2222222222222, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1790780, Length=224, Percent_Identity=33.0357142857143, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1789621, Length=232, Percent_Identity=29.7413793103448, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1789353, Length=214, Percent_Identity=28.5046728971963, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI48994955, Length=214, Percent_Identity=28.0373831775701, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI87082208, Length=222, Percent_Identity=26.5765765765766, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 27596; Mature: 27596

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFKPIKPKKVSLQIAEQIRNSILAGDFVPGDKLPPERELAEMFGVSRPSVREALNILSA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHH
AGMVMSYHGGGTVVLSLVDTAVGNFLSELIRVQQERALDVIEVRKGMESWTVYYAALRAL
HHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
PEDIQRLEEIVMGMERNLDTGKPSEDLDANFHVVIARATHNIVWLHLMQSLFDAMKEFQQ
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHH
SVWRAVYLTREDHHLLYTHHSRIFEAIRHRDAEAARDAMIEHLTFAEQRSTAYVARAAAE
HHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEK
CCC
>Mature Secondary Structure
MKFKPIKPKKVSLQIAEQIRNSILAGDFVPGDKLPPERELAEMFGVSRPSVREALNILSA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHH
AGMVMSYHGGGTVVLSLVDTAVGNFLSELIRVQQERALDVIEVRKGMESWTVYYAALRAL
HHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
PEDIQRLEEIVMGMERNLDTGKPSEDLDANFHVVIARATHNIVWLHLMQSLFDAMKEFQQ
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHH
SVWRAVYLTREDHHLLYTHHSRIFEAIRHRDAEAARDAMIEHLTFAEQRSTAYVARAAAE
HHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]