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The map label for this gene is hemL

Identifier: 118581077

GI number: 118581077

Start: 2900969

End: 2902255

Strand: Direct

Name: hemL

Synonym: Ppro_2666

Alternate gene names: 118581077

Gene position: 2900969-2902255 (Clockwise)

Preceding gene: 118581076

Following gene: 118581078

Centisome position: 72.38

GC content: 61.31

Gene sequence:

>1287_bases
ATGAAACAGGACCGTTCCAGCGCACTCTTCCAGCAGGCCAGGCAATCCATTCCCGGCGGCGTCAACAGCCCGGTCAGAGC
CTTCAAATCAGTCGGCTCAGACCCGCTCTTCATACAATCTGCATCCGGTTGCACTATCACCGATGTGGACGGCAATACAT
TCATCGACTACGTCGGTTCCTGGGGGCCGATGATAGTTGGACACTGCCATCCGCAGGTCGTCGAGGCCGTCAGGCAGGCA
GCCGGGAGTGGCGCCAGTTTCGGCGCCCCCACGGAGCGCGAGATAACCCTGGCAAACATGGTGATTGACGCCGTTCCCTC
CATCGAAATGGTCCGCATGGTCAGTTCCGGCACGGAAGCCACCATGAGCGCCATCCGCCTGGCCCGCGGATATACCGGTC
GCGACAACATCATCAAATTCTCCGGCTGCTACCACGGCCATGCAGACTCTCTGCTGGTCAGGGCCGGCTCCGGGGCAGCG
ACGTTCGGCATTCCCGACTCTCCCGGTGTTCCGGCCGATTTTGCCAAACACACCCTGACGGCCGAATTCAACTCACTCGA
CTCGGTCAGGCAACTGGTAGCGGACAACCCCGAAAGCATCGCCTGCATCATCGTCGAACCGGTGGCCGGCAACATGGGCA
CCGTCCCTCCCCGGGACGGTTTCCTGGAGGGACTGCGTCAGATCTGCAGCAACGAGGGAATCGTGTTGATCTTCGACGAG
GTCATGACCGGTTTCCGCGTGGCCTATGGCGGGGCACAGGAACGCTACGGCGTCACTCCCGACATGACCACACTGGGCAA
GATCATCGGCGGCGGACTCCCGGTGGGCGCTTTCGGGGGCAGGCGAGAGATCATGGAAATGCTTTCCCCCTCGGGAAGCG
TCTATCAGGCAGGCACCCTGTCAGGCAACCCCCTGGCCATGAGCGCCGGGATCGCCACCCTCTCACTCCTGAAACAGCCC
GGTTTCTACGAGAGCCTGGAAGAGAAGAGCCGCCATCTGGCAGAAGGCATCACCGATGCCGCTCGACTGGCGGGATACCC
CATCCAGACGACCAGAGTGGGAAGCATGTTCTGCGCTTTTTTCTCGGGCCAGGAAGTCTACGACTGGGCCGGAGCCTCAG
GCTGCGACACCGCTGCTTTTGCGGCATATTTCAAGGCCATGCTCAACGAGGGGATCTATCTGGCGCCATCCCAGTTCGAG
ACCGCCTTCGTCTCTGCTGCCCACACTGACGCCGATATCGAGGCAACCATCCGCGCTGCCGCCAGATGCTTCAAACTGAT
TTCGTGA

Upstream 100 bases:

>100_bases
TCAACCTTGACATCATCGCCCCGCATGCTACCATCCTGCGAACAAGTATCAGTAACTATTACTACAACCCACTCCAACTC
CCCCAAGGTACCGAACAGCC

Downstream 100 bases:

>100_bases
TGAACAGCATTACAGGTGCCACACGGTTTTTTTCGGTCATGGATCATGAAACCTGACAGGCAAAACCTCTTTCACAGCCT
AGCCATGATTTCCGGCATGG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MKQDRSSALFQQARQSIPGGVNSPVRAFKSVGSDPLFIQSASGCTITDVDGNTFIDYVGSWGPMIVGHCHPQVVEAVRQA
AGSGASFGAPTEREITLANMVIDAVPSIEMVRMVSSGTEATMSAIRLARGYTGRDNIIKFSGCYHGHADSLLVRAGSGAA
TFGIPDSPGVPADFAKHTLTAEFNSLDSVRQLVADNPESIACIIVEPVAGNMGTVPPRDGFLEGLRQICSNEGIVLIFDE
VMTGFRVAYGGAQERYGVTPDMTTLGKIIGGGLPVGAFGGRREIMEMLSPSGSVYQAGTLSGNPLAMSAGIATLSLLKQP
GFYESLEEKSRHLAEGITDAARLAGYPIQTTRVGSMFCAFFSGQEVYDWAGASGCDTAAFAAYFKAMLNEGIYLAPSQFE
TAFVSAAHTDADIEATIRAAARCFKLIS

Sequences:

>Translated_428_residues
MKQDRSSALFQQARQSIPGGVNSPVRAFKSVGSDPLFIQSASGCTITDVDGNTFIDYVGSWGPMIVGHCHPQVVEAVRQA
AGSGASFGAPTEREITLANMVIDAVPSIEMVRMVSSGTEATMSAIRLARGYTGRDNIIKFSGCYHGHADSLLVRAGSGAA
TFGIPDSPGVPADFAKHTLTAEFNSLDSVRQLVADNPESIACIIVEPVAGNMGTVPPRDGFLEGLRQICSNEGIVLIFDE
VMTGFRVAYGGAQERYGVTPDMTTLGKIIGGGLPVGAFGGRREIMEMLSPSGSVYQAGTLSGNPLAMSAGIATLSLLKQP
GFYESLEEKSRHLAEGITDAARLAGYPIQTTRVGSMFCAFFSGQEVYDWAGASGCDTAAFAAYFKAMLNEGIYLAPSQFE
TAFVSAAHTDADIEATIRAAARCFKLIS
>Mature_428_residues
MKQDRSSALFQQARQSIPGGVNSPVRAFKSVGSDPLFIQSASGCTITDVDGNTFIDYVGSWGPMIVGHCHPQVVEAVRQA
AGSGASFGAPTEREITLANMVIDAVPSIEMVRMVSSGTEATMSAIRLARGYTGRDNIIKFSGCYHGHADSLLVRAGSGAA
TFGIPDSPGVPADFAKHTLTAEFNSLDSVRQLVADNPESIACIIVEPVAGNMGTVPPRDGFLEGLRQICSNEGIVLIFDE
VMTGFRVAYGGAQERYGVTPDMTTLGKIIGGGLPVGAFGGRREIMEMLSPSGSVYQAGTLSGNPLAMSAGIATLSLLKQP
GFYESLEEKSRHLAEGITDAARLAGYPIQTTRVGSMFCAFFSGQEVYDWAGASGCDTAAFAAYFKAMLNEGIYLAPSQFE
TAFVSAAHTDADIEATIRAAARCFKLIS

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=348, Percent_Identity=27.8735632183908, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI37574042, Length=329, Percent_Identity=27.355623100304, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI24119277, Length=306, Percent_Identity=26.1437908496732, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI226442709, Length=296, Percent_Identity=27.3648648648649, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI226442705, Length=328, Percent_Identity=25.609756097561, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI284507298, Length=270, Percent_Identity=30, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1786349, Length=421, Percent_Identity=61.0451306413302, Blast_Score=524, Evalue=1e-150,
Organism=Escherichia coli, GI1789016, Length=351, Percent_Identity=31.6239316239316, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788044, Length=315, Percent_Identity=31.1111111111111, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1787560, Length=341, Percent_Identity=31.3782991202346, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI145693181, Length=344, Percent_Identity=29.9418604651163, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789759, Length=305, Percent_Identity=30.1639344262295, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1786991, Length=326, Percent_Identity=30.3680981595092, Blast_Score=102, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=370, Percent_Identity=29.7297297297297, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25144271, Length=348, Percent_Identity=26.4367816091954, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=210, Percent_Identity=30, Blast_Score=85, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6323470, Length=301, Percent_Identity=27.2425249169435, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324432, Length=336, Percent_Identity=25.297619047619, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21357415, Length=305, Percent_Identity=26.2295081967213, Blast_Score=98, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_PELPD (A1ASE9)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902327.1
- ProteinModelPortal:   A1ASE9
- SMR:   A1ASE9
- STRING:   A1ASE9
- GeneID:   4574012
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2666
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   VGCFGGK
- PhylomeDB:   A1ASE9
- ProtClustDB:   PRK00062
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 45050; Mature: 45050

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQDRSSALFQQARQSIPGGVNSPVRAFKSVGSDPLFIQSASGCTITDVDGNTFIDYVGS
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCCCCEEEECCCCCHHHHHCC
WGPMIVGHCHPQVVEAVRQAAGSGASFGAPTEREITLANMVIDAVPSIEMVRMVSSGTEA
CCCEEEECCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCHHH
TMSAIRLARGYTGRDNIIKFSGCYHGHADSLLVRAGSGAATFGIPDSPGVPADFAKHTLT
HHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEECCCCCEECCCCCCCCCCHHHHHHHHH
AEFNSLDSVRQLVADNPESIACIIVEPVAGNMGTVPPRDGFLEGLRQICSNEGIVLIFDE
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEHHH
VMTGFRVAYGGAQERYGVTPDMTTLGKIIGGGLPVGAFGGRREIMEMLSPSGSVYQAGTL
HHHHHEEHCCCCHHCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEECCC
SGNPLAMSAGIATLSLLKQPGFYESLEEKSRHLAEGITDAARLAGYPIQTTRVGSMFCAF
CCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
FSGQEVYDWAGASGCDTAAFAAYFKAMLNEGIYLAPSQFETAFVSAAHTDADIEATIRAA
HCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCHHHHHHHHH
ARCFKLIS
HHHHHHCC
>Mature Secondary Structure
MKQDRSSALFQQARQSIPGGVNSPVRAFKSVGSDPLFIQSASGCTITDVDGNTFIDYVGS
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCCCCEEEECCCCCHHHHHCC
WGPMIVGHCHPQVVEAVRQAAGSGASFGAPTEREITLANMVIDAVPSIEMVRMVSSGTEA
CCCEEEECCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCHHH
TMSAIRLARGYTGRDNIIKFSGCYHGHADSLLVRAGSGAATFGIPDSPGVPADFAKHTLT
HHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEECCCCCEECCCCCCCCCCHHHHHHHHH
AEFNSLDSVRQLVADNPESIACIIVEPVAGNMGTVPPRDGFLEGLRQICSNEGIVLIFDE
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEHHH
VMTGFRVAYGGAQERYGVTPDMTTLGKIIGGGLPVGAFGGRREIMEMLSPSGSVYQAGTL
HHHHHEEHCCCCHHCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEECCC
SGNPLAMSAGIATLSLLKQPGFYESLEEKSRHLAEGITDAARLAGYPIQTTRVGSMFCAF
CCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
FSGQEVYDWAGASGCDTAAFAAYFKAMLNEGIYLAPSQFETAFVSAAHTDADIEATIRAA
HCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCHHHHHHHHH
ARCFKLIS
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA