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The map label for this gene is lon [H]

Identifier: 118581016

GI number: 118581016

Start: 2828012

End: 2830483

Strand: Reverse

Name: lon [H]

Synonym: Ppro_2604

Alternate gene names: 118581016

Gene position: 2830483-2828012 (Counterclockwise)

Preceding gene: 118581017

Following gene: 118581015

Centisome position: 70.62

GC content: 61.89

Gene sequence:

>2472_bases
TTGAGTGAAACCGAAAAAGACATTGAAAAGCAGGATGCGGAAGAGCTGAAAATACCCGATGAATTACCGCTCTTGCCGGT
ACGGGACGTGGTGGTCTACCCGTTCATGATCATTCCGCTTTTCGTTGGGCGCGAGATGTCGGTCAAAGCCGTGGACAGCG
CCCTGGCGGGAGACCGCATGATCCTTTTGGCCACCCAGTACGAGATCAGCGAGGAAGATCCACCGCCGGACAAGATTTAC
GGCGTCGGCACGGTGGCCATGATCATGCGCATGCTCAAACTGCCCGACGGCAGGATCAAGATCCTGGTCCAGGGGTTGGC
CAAGGCCCGCATCACCGAATTTACCTCGGAGAAGCCGTTCTATACGGTACGTGTCGAACGCTTGAACGATATGCCGCTGC
TTGATGCGACCCTGGAGACAGAGGCCCTGGTGCGCACCGTGCGGGAGCAGTTGGCCAAGGTTGTGGAACTGGGCAAGCAG
GTCTCCCCCGAGGTGATAGTCATACTGGAGAATATCCAGGATCCGGGGAGCATGGCCGACCTGATCGCCAGCAACATGGG
GCTCAAGGTTGCCGACGCCCAGCAGCTCCTGGAAACGGTGGATCCCATAACCCGCCTGACCAAGATCAACGAACTGCTCA
ATCGTGAGGTGGAACTCTTAAGCGTGCAGGCCAAGATCCAGAGCGCGGCCCGCGAGGAGATGGGCAAGAACCAGCGGGAG
TACTACCTGCGGGAGCAGATGCGGGCCATCCAGCAGGAGCTGGGGGACGGCGAGGGGAAGGAGGATCTGATCGAGATCCG
CAAGGCCATCGAGTCCGCCAGAATGCCGGAGAGCGTGCAGAAGGAGGCGCTGAAACAGCTGGGCCGCCTGGAGAACATGC
ACCCCGATGCCGGCGAGGCCGGCATCATCCGCACCTACCTGGACTGGCTGGTGGAGATCCCCTGGAGCAAGTCCAGCCGC
GACAGCCTGGACATCGGTCGTGCCGAGAAGATCCTGAATGAGGACCACTTCTATCTGGACAAGATCAAGGAGCGCATCCT
GGAGTTCCTCTCCGTGCGCAAGCTGAAGAAGAAGATGAAAGGGCCGATCCTCTGCTTCGTCGGCCCTCCCGGCGTGGGCA
AGACCTCCCTGGGCAAGTCCATCGCCCGGGCCATGAACCGCAAGTTCGTGCGCATCTCCCTGGGGGGGGTGCGTGACGAG
GCCGAGATTCGCGGTCATCGCCGCACCTACATCGGCGCGCTTCCCGGGCGTATCATCCAGGGGATGAAGCAGGCCGGCAC
CAACAATCCGGTCTTCATGCTGGACGAGCTGGACAAGCTGGGCTACGACTACAAGGGGGATCCCTCATCGGCGCTCCTGG
AGGTGCTGGACCCGGAGCAGAACCACTCCTTCTCCGACCACTACATCAACCAGCCCTACAACCTGTCCAACGTGATGTTC
ATCGCCACCGCCAACCAGATCGACCCGGTGCCGTCGGCCCTGCGCGACCGCATGGAGGTGATCACCCTCTCGGGCTACAC
CGAGGAGGAGAAGCTGGAGATCTCCCGGCGTTTCCTGGTGCCGCGCCAGATGAAGGAGAATGGCCTGAAGGAGAAGAACA
TCGCCTTTGACGACGAGGCCATTGCCGAGATCATCGCCAAATATACCCGCGAGGCCGGGCTGCGCAACCTGGAGCGGGAG
ATCGGCACGGTCTGCCGCAAGGTGGCCCGCAAGGTGGCCGAGGGGCAGAAACGCATCACCCGGGTGACTGCCAAGAACCT
GCATACCTTCCTGGGCGCGCCCAAGTTCATGCGGGAAGAGGACCTGGACAGAAACGAAATCGGCGTGGTCAACGGCCTGG
CCTGGACCCCGGTGGGGGGTGAAATCCTGCACATCGAAGCGTCACAGATGCAGGGCAAGGCCGGCCTGACCCTCACCGGT
CAGCTGGGGGACGTGATGAAGGAGTCGGCCCAGGCCGCCCATTCCTACATCCGCGCCCATGCCGAGGAACTGAGCATCAA
GCCGGAGTTCTTTCAGCAACATGAGATCCACGTGCATGTTCCGGCCGGCGCTATCCCCAAGGACGGCCCTTCCGCCGGGG
TCGCCATGACAACGGCCCTGGTCTCGGTCATAACCCGCATTCCGGTCAGGAAAGACGTGGCCATGACCGGCGAGATCACC
CTGCGGGGCAAGGTTCTGCCCATCGGCGGGTTGAAGGAGAAGATCCTGGCCGCCGTACGCTCGGAGATGAAAACGGTGAT
CATACCGGCCCAGAACAAGAAGGATTTGGAGGACGTCCCGGCCGAGATCCTCAAGAGGGTAAAGATCGTGCCGGTGACCA
AGATCGACGAGGTGCTCAAGCTGGCACTGGAGAAGTATCCGCCCCCCCTGGCGGCCACTCCGGCGGGGAGTGTCCCCAAA
AAGCGGACAACCAGAGGCGCCGCGGCGCCGAATTCGCCCGATCAGGGACTCCCGGCCAGCGCCAAGGGATAG

Upstream 100 bases:

>100_bases
GCAATCCCTGCTCCATTACCGCCGAATACCGCTTGGGCGTGCTGCGGGTGACGTGCCCAAAGAGTGATGGCCTGCAGGTA
CCCATAAAGGAGATTACACC

Downstream 100 bases:

>100_bases
CCGTTACTGAGACGCTAACCGGAGAGGGGGATACGATGCCGTCCATGGCATCCTATCCCCCTCCTTTTTGGAGGGAAGGT
CAATGGATCTGCGCGATAGC

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 823; Mature: 822

Protein sequence:

>823_residues
MSETEKDIEKQDAEELKIPDELPLLPVRDVVVYPFMIIPLFVGREMSVKAVDSALAGDRMILLATQYEISEEDPPPDKIY
GVGTVAMIMRMLKLPDGRIKILVQGLAKARITEFTSEKPFYTVRVERLNDMPLLDATLETEALVRTVREQLAKVVELGKQ
VSPEVIVILENIQDPGSMADLIASNMGLKVADAQQLLETVDPITRLTKINELLNREVELLSVQAKIQSAAREEMGKNQRE
YYLREQMRAIQQELGDGEGKEDLIEIRKAIESARMPESVQKEALKQLGRLENMHPDAGEAGIIRTYLDWLVEIPWSKSSR
DSLDIGRAEKILNEDHFYLDKIKERILEFLSVRKLKKKMKGPILCFVGPPGVGKTSLGKSIARAMNRKFVRISLGGVRDE
AEIRGHRRTYIGALPGRIIQGMKQAGTNNPVFMLDELDKLGYDYKGDPSSALLEVLDPEQNHSFSDHYINQPYNLSNVMF
IATANQIDPVPSALRDRMEVITLSGYTEEEKLEISRRFLVPRQMKENGLKEKNIAFDDEAIAEIIAKYTREAGLRNLERE
IGTVCRKVARKVAEGQKRITRVTAKNLHTFLGAPKFMREEDLDRNEIGVVNGLAWTPVGGEILHIEASQMQGKAGLTLTG
QLGDVMKESAQAAHSYIRAHAEELSIKPEFFQQHEIHVHVPAGAIPKDGPSAGVAMTTALVSVITRIPVRKDVAMTGEIT
LRGKVLPIGGLKEKILAAVRSEMKTVIIPAQNKKDLEDVPAEILKRVKIVPVTKIDEVLKLALEKYPPPLAATPAGSVPK
KRTTRGAAAPNSPDQGLPASAKG

Sequences:

>Translated_823_residues
MSETEKDIEKQDAEELKIPDELPLLPVRDVVVYPFMIIPLFVGREMSVKAVDSALAGDRMILLATQYEISEEDPPPDKIY
GVGTVAMIMRMLKLPDGRIKILVQGLAKARITEFTSEKPFYTVRVERLNDMPLLDATLETEALVRTVREQLAKVVELGKQ
VSPEVIVILENIQDPGSMADLIASNMGLKVADAQQLLETVDPITRLTKINELLNREVELLSVQAKIQSAAREEMGKNQRE
YYLREQMRAIQQELGDGEGKEDLIEIRKAIESARMPESVQKEALKQLGRLENMHPDAGEAGIIRTYLDWLVEIPWSKSSR
DSLDIGRAEKILNEDHFYLDKIKERILEFLSVRKLKKKMKGPILCFVGPPGVGKTSLGKSIARAMNRKFVRISLGGVRDE
AEIRGHRRTYIGALPGRIIQGMKQAGTNNPVFMLDELDKLGYDYKGDPSSALLEVLDPEQNHSFSDHYINQPYNLSNVMF
IATANQIDPVPSALRDRMEVITLSGYTEEEKLEISRRFLVPRQMKENGLKEKNIAFDDEAIAEIIAKYTREAGLRNLERE
IGTVCRKVARKVAEGQKRITRVTAKNLHTFLGAPKFMREEDLDRNEIGVVNGLAWTPVGGEILHIEASQMQGKAGLTLTG
QLGDVMKESAQAAHSYIRAHAEELSIKPEFFQQHEIHVHVPAGAIPKDGPSAGVAMTTALVSVITRIPVRKDVAMTGEIT
LRGKVLPIGGLKEKILAAVRSEMKTVIIPAQNKKDLEDVPAEILKRVKIVPVTKIDEVLKLALEKYPPPLAATPAGSVPK
KRTTRGAAAPNSPDQGLPASAKG
>Mature_822_residues
SETEKDIEKQDAEELKIPDELPLLPVRDVVVYPFMIIPLFVGREMSVKAVDSALAGDRMILLATQYEISEEDPPPDKIYG
VGTVAMIMRMLKLPDGRIKILVQGLAKARITEFTSEKPFYTVRVERLNDMPLLDATLETEALVRTVREQLAKVVELGKQV
SPEVIVILENIQDPGSMADLIASNMGLKVADAQQLLETVDPITRLTKINELLNREVELLSVQAKIQSAAREEMGKNQREY
YLREQMRAIQQELGDGEGKEDLIEIRKAIESARMPESVQKEALKQLGRLENMHPDAGEAGIIRTYLDWLVEIPWSKSSRD
SLDIGRAEKILNEDHFYLDKIKERILEFLSVRKLKKKMKGPILCFVGPPGVGKTSLGKSIARAMNRKFVRISLGGVRDEA
EIRGHRRTYIGALPGRIIQGMKQAGTNNPVFMLDELDKLGYDYKGDPSSALLEVLDPEQNHSFSDHYINQPYNLSNVMFI
ATANQIDPVPSALRDRMEVITLSGYTEEEKLEISRRFLVPRQMKENGLKEKNIAFDDEAIAEIIAKYTREAGLRNLEREI
GTVCRKVARKVAEGQKRITRVTAKNLHTFLGAPKFMREEDLDRNEIGVVNGLAWTPVGGEILHIEASQMQGKAGLTLTGQ
LGDVMKESAQAAHSYIRAHAEELSIKPEFFQQHEIHVHVPAGAIPKDGPSAGVAMTTALVSVITRIPVRKDVAMTGEITL
RGKVLPIGGLKEKILAAVRSEMKTVIIPAQNKKDLEDVPAEILKRVKIVPVTKIDEVLKLALEKYPPPLAATPAGSVPKK
RTTRGAAAPNSPDQGLPASAKG

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=837, Percent_Identity=39.7849462365591, Blast_Score=578, Evalue=1e-165,
Organism=Homo sapiens, GI21396489, Length=840, Percent_Identity=37.8571428571429, Blast_Score=544, Evalue=1e-154,
Organism=Escherichia coli, GI1786643, Length=777, Percent_Identity=51.0939510939511, Blast_Score=807, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17556486, Length=797, Percent_Identity=35.3826850690088, Blast_Score=480, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17505831, Length=690, Percent_Identity=38.4057971014493, Blast_Score=479, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6319449, Length=721, Percent_Identity=38.6962552011096, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24666867, Length=685, Percent_Identity=43.3576642335766, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI221513036, Length=685, Percent_Identity=43.3576642335766, Blast_Score=549, Evalue=1e-156,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 91483; Mature: 91352

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETEKDIEKQDAEELKIPDELPLLPVRDVVVYPFMIIPLFVGREMSVKAVDSALAGDRM
CCCCHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCE
ILLATQYEISEEDPPPDKIYGVGTVAMIMRMLKLPDGRIKILVQGLAKARITEFTSEKPF
EEEEEEEECCCCCCCCHHEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCE
YTVRVERLNDMPLLDATLETEALVRTVREQLAKVVELGKQVSPEVIVILENIQDPGSMAD
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHH
LIASNMGLKVADAQQLLETVDPITRLTKINELLNREVELLSVQAKIQSAAREEMGKNQRE
HHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHH
YYLREQMRAIQQELGDGEGKEDLIEIRKAIESARMPESVQKEALKQLGRLENMHPDAGEA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCC
GIIRTYLDWLVEIPWSKSSRDSLDIGRAEKILNEDHFYLDKIKERILEFLSVRKLKKKMK
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GPILCFVGPPGVGKTSLGKSIARAMNRKFVRISLGGVRDEAEIRGHRRTYIGALPGRIIQ
CCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCHHHHHHCCHHHHHH
GMKQAGTNNPVFMLDELDKLGYDYKGDPSSALLEVLDPEQNHSFSDHYINQPYNLSNVMF
HHHHCCCCCCEEEEECHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHCCCCCCCCCEEE
IATANQIDPVPSALRDRMEVITLSGYTEEEKLEISRRFLVPRQMKENGLKEKNIAFDDEA
EEECCCCCCCHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCHHH
IAEIIAKYTREAGLRNLEREIGTVCRKVARKVAEGQKRITRVTAKNLHTFLGAPKFMREE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHC
DLDRNEIGVVNGLAWTPVGGEILHIEASQMQGKAGLTLTGQLGDVMKESAQAAHSYIRAH
CCCCCCCCEECCCEECCCCCEEEEEEHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHHH
AEELSIKPEFFQQHEIHVHVPAGAIPKDGPSAGVAMTTALVSVITRIPVRKDVAMTGEIT
HHHCCCCHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECEEE
LRGKVLPIGGLKEKILAAVRSEMKTVIIPAQNKKDLEDVPAEILKRVKIVPVTKIDEVLK
EEEEEEECCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHH
LALEKYPPPLAATPAGSVPKKRTTRGAAAPNSPDQGLPASAKG
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SETEKDIEKQDAEELKIPDELPLLPVRDVVVYPFMIIPLFVGREMSVKAVDSALAGDRM
CCCHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCE
ILLATQYEISEEDPPPDKIYGVGTVAMIMRMLKLPDGRIKILVQGLAKARITEFTSEKPF
EEEEEEEECCCCCCCCHHEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCE
YTVRVERLNDMPLLDATLETEALVRTVREQLAKVVELGKQVSPEVIVILENIQDPGSMAD
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHH
LIASNMGLKVADAQQLLETVDPITRLTKINELLNREVELLSVQAKIQSAAREEMGKNQRE
HHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHH
YYLREQMRAIQQELGDGEGKEDLIEIRKAIESARMPESVQKEALKQLGRLENMHPDAGEA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCC
GIIRTYLDWLVEIPWSKSSRDSLDIGRAEKILNEDHFYLDKIKERILEFLSVRKLKKKMK
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GPILCFVGPPGVGKTSLGKSIARAMNRKFVRISLGGVRDEAEIRGHRRTYIGALPGRIIQ
CCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCHHHHHHCCHHHHHH
GMKQAGTNNPVFMLDELDKLGYDYKGDPSSALLEVLDPEQNHSFSDHYINQPYNLSNVMF
HHHHCCCCCCEEEEECHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHCCCCCCCCCEEE
IATANQIDPVPSALRDRMEVITLSGYTEEEKLEISRRFLVPRQMKENGLKEKNIAFDDEA
EEECCCCCCCHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCHHH
IAEIIAKYTREAGLRNLEREIGTVCRKVARKVAEGQKRITRVTAKNLHTFLGAPKFMREE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHC
DLDRNEIGVVNGLAWTPVGGEILHIEASQMQGKAGLTLTGQLGDVMKESAQAAHSYIRAH
CCCCCCCCEECCCEECCCCCEEEEEEHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHHH
AEELSIKPEFFQQHEIHVHVPAGAIPKDGPSAGVAMTTALVSVITRIPVRKDVAMTGEIT
HHHCCCCHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECEEE
LRGKVLPIGGLKEKILAAVRSEMKTVIIPAQNKKDLEDVPAEILKRVKIVPVTKIDEVLK
EEEEEEECCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHH
LALEKYPPPLAATPAGSVPKKRTTRGAAAPNSPDQGLPASAKG
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA