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The map label for this gene is purE [H]

Identifier: 118581001

GI number: 118581001

Start: 2807856

End: 2808377

Strand: Reverse

Name: purE [H]

Synonym: Ppro_2589

Alternate gene names: 118581001

Gene position: 2808377-2807856 (Counterclockwise)

Preceding gene: 118581002

Following gene: 118581000

Centisome position: 70.07

GC content: 63.6

Gene sequence:

>522_bases
ATGCATGTCAATCCACAGGTTCTGATTATCATGGGGAGTAATTCGGATCTGCCGGTAATGCAGGAGGCGGCGGACCTTTT
GGGGCAGTTCGATGTTCCCTGCGAGATGAGGGTCTCGTCGGCTCACCGTTCTCCCGTCAAGACGGCAAAGCTGGCCGCTG
AGGCCGGCGAACGGGGAGTCAAGGTTATCATCGCCGGGGCCGGCATGGCCGCCCATCTGGCCGGTGTGATCGCGTCCGAG
ACGATCCTGCCGGTGATCGGGGTTCCGGTGGGGGGAGGCGCCCTGAGCGGCGTCGATGCATTGTACTCCACGGTACAGAT
GCCGGGTGGCATTCCGGTGGCAACCATGGCCATCGGCAAGGCCGGGGCGAAGAACGCCGGTGTCCTGGCCGTACAGATAC
TGGCCCTCTCTGACGAGCGTCTGGCTCAGGCTCTGCGGGATTACCGCCGGGAGATGGCCCTGGACGTTGAACGACGTGAC
GCCGATCTGCAGGCTCTCAGGGCGGTTGACGAAGCGCACTGA

Upstream 100 bases:

>100_bases
CGAGAGACGGTGTCCGGCGGTCGGGGCTGACCATGGTTTTGATTGCCGAATCCTGAGAGAACGTTTTTCTATGCCGCATG
GAAAGAGGGGAGGAGAGAGT

Downstream 100 bases:

>100_bases
GAAGGGGCCGACCAGCTGCACTGCATATGACAAGCAGTGACCCCTACCGGGAACGGGCGATACAGCGAAAGGGATAACAA
TTCAGCTTGTTATCCCTTTT

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MHVNPQVLIIMGSNSDLPVMQEAADLLGQFDVPCEMRVSSAHRSPVKTAKLAAEAGERGVKVIIAGAGMAAHLAGVIASE
TILPVIGVPVGGGALSGVDALYSTVQMPGGIPVATMAIGKAGAKNAGVLAVQILALSDERLAQALRDYRREMALDVERRD
ADLQALRAVDEAH

Sequences:

>Translated_173_residues
MHVNPQVLIIMGSNSDLPVMQEAADLLGQFDVPCEMRVSSAHRSPVKTAKLAAEAGERGVKVIIAGAGMAAHLAGVIASE
TILPVIGVPVGGGALSGVDALYSTVQMPGGIPVATMAIGKAGAKNAGVLAVQILALSDERLAQALRDYRREMALDVERRD
ADLQALRAVDEAH
>Mature_173_residues
MHVNPQVLIIMGSNSDLPVMQEAADLLGQFDVPCEMRVSSAHRSPVKTAKLAAEAGERGVKVIIAGAGMAAHLAGVIASE
TILPVIGVPVGGGALSGVDALYSTVQMPGGIPVATMAIGKAGAKNAGVLAVQILALSDERLAQALRDYRREMALDVERRD
ADLQALRAVDEAH

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Homo sapiens, GI119220559, Length=142, Percent_Identity=33.0985915492958, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI119220557, Length=142, Percent_Identity=33.0985915492958, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI5453539, Length=142, Percent_Identity=33.0985915492958, Blast_Score=77, Evalue=9e-15,
Organism=Escherichia coli, GI1786734, Length=148, Percent_Identity=58.1081081081081, Blast_Score=130, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6324702, Length=146, Percent_Identity=52.0547945205479, Blast_Score=141, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17883; Mature: 17883

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVNPQVLIIMGSNSDLPVMQEAADLLGQFDVPCEMRVSSAHRSPVKTAKLAAEAGERGV
CCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCHHEEHHCCCCCCHHHHHHHHHCCCCCE
KVIIAGAGMAAHLAGVIASETILPVIGVPVGGGALSGVDALYSTVQMPGGIPVATMAIGK
EEEEECCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCC
AGAKNAGVLAVQILALSDERLAQALRDYRREMALDVERRDADLQALRAVDEAH
CCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHCCC
>Mature Secondary Structure
MHVNPQVLIIMGSNSDLPVMQEAADLLGQFDVPCEMRVSSAHRSPVKTAKLAAEAGERGV
CCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCHHEEHHCCCCCCHHHHHHHHHCCCCCE
KVIIAGAGMAAHLAGVIASETILPVIGVPVGGGALSGVDALYSTVQMPGGIPVATMAIGK
EEEEECCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCC
AGAKNAGVLAVQILALSDERLAQALRDYRREMALDVERRDADLQALRAVDEAH
CCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]