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The map label for this gene is ilvC

Identifier: 118580967

GI number: 118580967

Start: 2767717

End: 2768733

Strand: Reverse

Name: ilvC

Synonym: Ppro_2555

Alternate gene names: 118580967

Gene position: 2768733-2767717 (Counterclockwise)

Preceding gene: 118580968

Following gene: 118580966

Centisome position: 69.08

GC content: 59.88

Gene sequence:

>1017_bases
ATGAAAGTCTATTACGACAAGGATTGCAATCTGGCGGTATTGAAAAACAAGACGGTAGCCATCATCGGTTATGGTTCGCA
GGGGCATGCCCATGCCCTGAATCTTAACGATTCCGGCATTGATGTGATCGTAGGTCTCAGAAAGGAATCCCCTTCCGTCA
AGAAGGCTACCGATGCCGGCCTGAAGGTCCTCGGCGTGGCCGAGGCGGCCAAAGCCGCAGATATCGTGATGATTCTGCTG
CCTGACGAGACCCAGGGTGACGTGTATCGCGCCGAGATCGGCCCGAACCTGAAGGAAGGAGCCACCATCGCCTTCGGCCA
TGGCTTCAACATTCACTTCGGCCAGATCGAGCCCCGTGCCGATATCAACGTCTTCATGGTCGCCCCCAAGGGACCGGGCC
ACATGGTACGCCACGAATACACCAGGGGGGGCGGCGTTCCCTGTCTGGTAGCCATCCACCAGGATCCCTCTGGCAAGACC
AAGGAGATCGCCCTGGCCTATGCCTCCGCGGTCGGCGGCGGCCGTTCCGGGATCATCGAAACCAACTTCCGCGAGGAGAC
CGAGACCGACCTGTTCGGCGAGCAGGCCGTGCTCTGCGGCGGCATCTCCGCCCTGATCCAGGCCGGTTTCGAGACACTGG
TGGAAGCCGGCTATGCCCCTGAGATGGCCTATTTCGAGTGTCTGCACGAGACCAAGCTGATCGTCGACCTGATCTACGAG
GGCGGCATCGCCAACATGCGCTACTCTGTCTCCAATACCGCCGAGTACGGCGACCTGACCCGCGGACCGCGCGTGGTCAA
CGAAGAGACCAAGTGGGAGATGAAGAAGATCCTGGACGAGATCCAGACCGGTGAGTTCTGCAAGGAGTGGATGCTGGAGA
ACAAGGCCAACAAGCCGACCTTCAATGCCCTGCGCCGCCGCGGCAGCGAACACCAGATCGAGGAAGTGGGCGCACGTCTG
CGCGCCATGATGCCCTGGATCGGCAAGAACAAGATTGTCGACAAGGCGAAGAACTAG

Upstream 100 bases:

>100_bases
TTTACATTGACAGCTTCCGGTTGATGTAGTACTTTCATTCTTCTTTAAATCAATAGGTTGAACCGGTTTTCCGGATAATC
TGCAGGGAGGATGTGACAGA

Downstream 100 bases:

>100_bases
CTCGCGTTTCCGTTGCTCCAACACCCCTCTTCCCACGGGAGAGGGGTGTTATTCTTTTTTGGCTGAATCAGTGACGCCTG
GATGACGGAAGCGGGCGTAA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKVYYDKDCNLAVLKNKTVAIIGYGSQGHAHALNLNDSGIDVIVGLRKESPSVKKATDAGLKVLGVAEAAKAADIVMILL
PDETQGDVYRAEIGPNLKEGATIAFGHGFNIHFGQIEPRADINVFMVAPKGPGHMVRHEYTRGGGVPCLVAIHQDPSGKT
KEIALAYASAVGGGRSGIIETNFREETETDLFGEQAVLCGGISALIQAGFETLVEAGYAPEMAYFECLHETKLIVDLIYE
GGIANMRYSVSNTAEYGDLTRGPRVVNEETKWEMKKILDEIQTGEFCKEWMLENKANKPTFNALRRRGSEHQIEEVGARL
RAMMPWIGKNKIVDKAKN

Sequences:

>Translated_338_residues
MKVYYDKDCNLAVLKNKTVAIIGYGSQGHAHALNLNDSGIDVIVGLRKESPSVKKATDAGLKVLGVAEAAKAADIVMILL
PDETQGDVYRAEIGPNLKEGATIAFGHGFNIHFGQIEPRADINVFMVAPKGPGHMVRHEYTRGGGVPCLVAIHQDPSGKT
KEIALAYASAVGGGRSGIIETNFREETETDLFGEQAVLCGGISALIQAGFETLVEAGYAPEMAYFECLHETKLIVDLIYE
GGIANMRYSVSNTAEYGDLTRGPRVVNEETKWEMKKILDEIQTGEFCKEWMLENKANKPTFNALRRRGSEHQIEEVGARL
RAMMPWIGKNKIVDKAKN
>Mature_338_residues
MKVYYDKDCNLAVLKNKTVAIIGYGSQGHAHALNLNDSGIDVIVGLRKESPSVKKATDAGLKVLGVAEAAKAADIVMILL
PDETQGDVYRAEIGPNLKEGATIAFGHGFNIHFGQIEPRADINVFMVAPKGPGHMVRHEYTRGGGVPCLVAIHQDPSGKT
KEIALAYASAVGGGRSGIIETNFREETETDLFGEQAVLCGGISALIQAGFETLVEAGYAPEMAYFECLHETKLIVDLIYE
GGIANMRYSVSNTAEYGDLTRGPRVVNEETKWEMKKILDEIQTGEFCKEWMLENKANKPTFNALRRRGSEHQIEEVGARL
RAMMPWIGKNKIVDKAKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=293, Percent_Identity=40.6143344709898, Blast_Score=172, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6323387, Length=261, Percent_Identity=38.6973180076628, Blast_Score=147, Evalue=3e-36,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_PELPD (A1AS39)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902217.1
- ProteinModelPortal:   A1AS39
- SMR:   A1AS39
- STRING:   A1AS39
- GeneID:   4572453
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2555
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   A1AS39
- ProtClustDB:   PRK05479
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36911; Mature: 36911

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVYYDKDCNLAVLKNKTVAIIGYGSQGHAHALNLNDSGIDVIVGLRKESPSVKKATDAG
CCEEECCCCCEEEEECCEEEEEEECCCCCEEEEECCCCCEEEEEEECCCCCCCHHHHHCC
LKVLGVAEAAKAADIVMILLPDETQGDVYRAEIGPNLKEGATIAFGHGFNIHFGQIEPRA
EEEEEHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEEECCCEEEECCCCCCC
DINVFMVAPKGPGHMVRHEYTRGGGVPCLVAIHQDPSGKTKEIALAYASAVGGGRSGIIE
CCEEEEECCCCCCCCHHEECCCCCCCEEEEEEECCCCCCCCEEEEEEEHHCCCCCCCEEE
TNFREETETDLFGEQAVLCGGISALIQAGFETLVEAGYAPEMAYFECLHETKLIVDLIYE
CCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGIANMRYSVSNTAEYGDLTRGPRVVNEETKWEMKKILDEIQTGEFCKEWMLENKANKPT
CCCCEEEEECCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCH
FNALRRRGSEHQIEEVGARLRAMMPWIGKNKIVDKAKN
HHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHCCCC
>Mature Secondary Structure
MKVYYDKDCNLAVLKNKTVAIIGYGSQGHAHALNLNDSGIDVIVGLRKESPSVKKATDAG
CCEEECCCCCEEEEECCEEEEEEECCCCCEEEEECCCCCEEEEEEECCCCCCCHHHHHCC
LKVLGVAEAAKAADIVMILLPDETQGDVYRAEIGPNLKEGATIAFGHGFNIHFGQIEPRA
EEEEEHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEEECCCEEEECCCCCCC
DINVFMVAPKGPGHMVRHEYTRGGGVPCLVAIHQDPSGKTKEIALAYASAVGGGRSGIIE
CCEEEEECCCCCCCCHHEECCCCCCCEEEEEEECCCCCCCCEEEEEEEHHCCCCCCCEEE
TNFREETETDLFGEQAVLCGGISALIQAGFETLVEAGYAPEMAYFECLHETKLIVDLIYE
CCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGIANMRYSVSNTAEYGDLTRGPRVVNEETKWEMKKILDEIQTGEFCKEWMLENKANKPT
CCCCEEEEECCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCH
FNALRRRGSEHQIEEVGARLRAMMPWIGKNKIVDKAKN
HHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA