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The map label for this gene is ispA [C]

Identifier: 118580818

GI number: 118580818

Start: 2602633

End: 2603526

Strand: Reverse

Name: ispA [C]

Synonym: Ppro_2404

Alternate gene names: 118580818

Gene position: 2603526-2602633 (Counterclockwise)

Preceding gene: 118580819

Following gene: 118580817

Centisome position: 64.96

GC content: 65.66

Gene sequence:

>894_bases
ATGGACCTGAAAGCATACCTGAAAGAGCAGTGCGCCCGCGTAGATGCGGCGCTGGACAGCTACCTCCCCCGGGAGACGGA
ACTCCCCCACAGCCTGCACAAGGCCATGCGCTACTCGGTCTTCGCCGGCGGCAAGCGGGTGCGCCCGATTCTGATGCTGG
CCGCCTGCCAGGCCGTGGGAGGTGATACGGAGGTGGCCATCCCGGCTGCCTGCGCCATGGAGATGATCCACACCTACTCC
CTGATCCATGACGACCTGCCTGCCATGGACGACGACGATTTCCGGCGCGGCAACCCCACCAATCACAAGGTGTTCGGTGA
GGCCGTGGCCATTCTGGCCGGCGACGCGCTCCTGACCGAGGCGTTCAAGTTGCTCTCCAATCCGGCCTGCGCGGCCGGCG
TGCCGTCCGAGGCTCGTCTGGCGGTGATCCACCAGATCGCCTCCTGCGCCGGTTCCCACGGCATGGTGGGGGGGCAGGTG
GTTGACATGGAGAGCGAGGGGAAGAGCGACATCGACCTCCCCACGGTGCAGTACATCCACACCCACAAGACCGGCGCCCT
GATCAAGGCGGCCGTGGTGGCTGGCGCCCTTTTGGGCGGCGCGGACCGGGAGAAACTGGCCGCCATAACCCGTTACGGCT
CGGCAGCAGGTCTGGCCTTCCAGATCGCCGACGATATCCTGGACATCGAGGGGACCACCGAAGAGATCGGCAAGGACGCG
GGAAGCGACCAGGCCCGCGGCAAGGCCACCTATCCGGCGGTGATGGGGCTTGCGGCAGCCAAGCAGGAAGCCACAACCAT
GATGGACGAAGCCTTCAAGGCGCTGGAGATCTTCGGCAGCGAGGCCGATCCCCTGCGGGAAATCGCACGCTATATCGTCA
CGCGCAAGAAGTAG

Upstream 100 bases:

>100_bases
GCGCCGCGTGGAGGTGCTGCTGAAGCGCAAGGACGGCAGCTTCAGCCGCGAGCCGTTTCAGCCGGATGAGTAACAACATG
AACCTGATAAAGGAAACGAC

Downstream 100 bases:

>100_bases
TCTTCCGCGAGAGCCTTTTTCTAACGCATGCAAAGCTATACGGCAGGCGGAGAAAGCCTTTGGAAAAACTCCGGATCTTG
CCTGAAGGGCGCGGTTCTCA

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MDLKAYLKEQCARVDAALDSYLPRETELPHSLHKAMRYSVFAGGKRVRPILMLAACQAVGGDTEVAIPAACAMEMIHTYS
LIHDDLPAMDDDDFRRGNPTNHKVFGEAVAILAGDALLTEAFKLLSNPACAAGVPSEARLAVIHQIASCAGSHGMVGGQV
VDMESEGKSDIDLPTVQYIHTHKTGALIKAAVVAGALLGGADREKLAAITRYGSAAGLAFQIADDILDIEGTTEEIGKDA
GSDQARGKATYPAVMGLAAAKQEATTMMDEAFKALEIFGSEADPLREIARYIVTRKK

Sequences:

>Translated_297_residues
MDLKAYLKEQCARVDAALDSYLPRETELPHSLHKAMRYSVFAGGKRVRPILMLAACQAVGGDTEVAIPAACAMEMIHTYS
LIHDDLPAMDDDDFRRGNPTNHKVFGEAVAILAGDALLTEAFKLLSNPACAAGVPSEARLAVIHQIASCAGSHGMVGGQV
VDMESEGKSDIDLPTVQYIHTHKTGALIKAAVVAGALLGGADREKLAAITRYGSAAGLAFQIADDILDIEGTTEEIGKDA
GSDQARGKATYPAVMGLAAAKQEATTMMDEAFKALEIFGSEADPLREIARYIVTRKK
>Mature_297_residues
MDLKAYLKEQCARVDAALDSYLPRETELPHSLHKAMRYSVFAGGKRVRPILMLAACQAVGGDTEVAIPAACAMEMIHTYS
LIHDDLPAMDDDDFRRGNPTNHKVFGEAVAILAGDALLTEAFKLLSNPACAAGVPSEARLAVIHQIASCAGSHGMVGGQV
VDMESEGKSDIDLPTVQYIHTHKTGALIKAAVVAGALLGGADREKLAAITRYGSAAGLAFQIADDILDIEGTTEEIGKDA
GSDQARGKATYPAVMGLAAAKQEATTMMDEAFKALEIFGSEADPLREIARYIVTRKK

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=230, Percent_Identity=30.8695652173913, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1786623, Length=301, Percent_Identity=43.8538205980066, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1789578, Length=265, Percent_Identity=30.188679245283, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17505681, Length=290, Percent_Identity=31.3793103448276, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24651612, Length=224, Percent_Identity=29.4642857142857, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31498; Mature: 31498

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKAYLKEQCARVDAALDSYLPRETELPHSLHKAMRYSVFAGGKRVRPILMLAACQAVG
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
GDTEVAIPAACAMEMIHTYSLIHDDLPAMDDDDFRRGNPTNHKVFGEAVAILAGDALLTE
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AFKLLSNPACAAGVPSEARLAVIHQIASCAGSHGMVGGQVVDMESEGKSDIDLPTVQYIH
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCHHHHHH
THKTGALIKAAVVAGALLGGADREKLAAITRYGSAAGLAFQIADDILDIEGTTEEIGKDA
HCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHCCCC
GSDQARGKATYPAVMGLAAAKQEATTMMDEAFKALEIFGSEADPLREIARYIVTRKK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDLKAYLKEQCARVDAALDSYLPRETELPHSLHKAMRYSVFAGGKRVRPILMLAACQAVG
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
GDTEVAIPAACAMEMIHTYSLIHDDLPAMDDDDFRRGNPTNHKVFGEAVAILAGDALLTE
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AFKLLSNPACAAGVPSEARLAVIHQIASCAGSHGMVGGQVVDMESEGKSDIDLPTVQYIH
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCHHHHHH
THKTGALIKAAVVAGALLGGADREKLAAITRYGSAAGLAFQIADDILDIEGTTEEIGKDA
HCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHCCCC
GSDQARGKATYPAVMGLAAAKQEATTMMDEAFKALEIFGSEADPLREIARYIVTRKK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]