Click here to switch to the map view.

The map label for this gene is dxs1 [H]

Identifier: 118580817

GI number: 118580817

Start: 2600464

End: 2602344

Strand: Reverse

Name: dxs1 [H]

Synonym: Ppro_2403

Alternate gene names: 118580817

Gene position: 2602344-2600464 (Counterclockwise)

Preceding gene: 118580818

Following gene: 118580816

Centisome position: 64.93

GC content: 64.43

Gene sequence:

>1881_bases
ATGGCACTACTGGACACAATCGACTCCCCTGCCGACCTGAAAAGGCTTCCGGTTTCCCGGCTTCCCCAGGTGGCCGAAGA
GCTGCGACGGGTGATCATCCAGACCTGCTCGACCAACGGCGGCCACCTGGCCCCCAGCCTGGGGGTGGTGGAACTGACCA
TCGCCCTGCACCGGGTCTTCTCCACCCCGGAGGACAAGATCGTCTGGGACGTGGGGCACCAGGCATACGCCCACAAGCTG
CTCACCGGCCGTCGCGACCGCTTCTCCACCCTGCGCAAGCTGGACGGCATCAGCGGCTTTCCCAAGCGTGACGAATCGCC
CCACGATGCCTTCGAGGTGGGGCATGCCTCCACCTCCATTTCGGCCGCCACCGGCCTGGCTGCGGCCCGCGACCTGGCCG
GGCGCAGGAACAAGGTGCTGGCGGTGATCGGCGACGGCTCCATGACCGGCGGCATGGCCTACGAGGCAATGAACCATGCC
GGCCACATGAACCGGGACATGATCGTGATCCTGAACGACAACGAGATGTCCATCGCCGAGAACGTGGGCGCGCTCTCCAA
TTTCCTGACCCGCACCGGTTCCAGCGAGTTCGTCTACCGCTTCAAGAAGAACGTGGAGTCCTTCCTGGGCCGCAAGGACA
CCGTGGGCAAGAATCTGCTGCACCTGGCCAAGAAGCTGGAGGACTCCTTCAAGGGATTCTTTACCCCGGGCATGCTCTTC
GAGGCCTTCGGGTTCGAGTACATCGGCCCCATCGACGGCCATGACCTGCCCATGCTGCTGGAGACCCTGGAGAAGGTCAA
GAAGTACCACGATGCCGTGCTGATCCATGTGTTGACCAAGAAGGGCAAGGGGTACAAGCCGGCCGAGGACGATCCGTCAC
TGTTTCACGGGGTCGGCCCCTTTGATCTGGAGAGCGGCAGGGTGCTCAAGGGGAAGGGGGGGGCGGCCTCCTACACCGCC
ATCTTCGGCTCAGCACTCTGCAAGCTGGCTGCCGATGACGAACGGGTGGTGGCCATCACCGCCGCCATGCCCGATGGCAC
CGGTCTGATCCCTTTTTCCCGGCAGTTTCCGAAGCGTTTCTTCGATGTGGGCATCGCCGAACAGCATGCCGTCACCTTCG
CGGCCGGCCTGGCCACCCAGGGGTTTCGACCGGTTTTCACTGTCTACTCGTCGTTCCTGCAGCGGGCCTATGACCTGGTG
TTTCACGATGTCTGCCTGCAGAACCTGCCGGTTATCTTCGCCCTGGATCGAGCCGGCGTGGTGGGCAATGACGGCCCGAC
CCACCACGGCAGCCTGGATATCTCCCTGCTGCGACACCTGCCCAATATGACCGTCATGGCACCCAGGGACGAGAACGAAC
TGCAACACATGCTGGCAACCGCGCTGGGGATGCAGGGACCGGTGGCCCTGCGCTACCCCCGCGGCAACGGCGTGGGAGTG
GCGTTGGACCAGATCATTACGCCATTGCCGGTCGGCCGGGCCGAAGTGCTGCGCGAAGGGAAGGACGGGGCGGTGCTGGC
TCTGGGAAGCATGGTCCATCCGGCTCTGGAGGCTGCTCTGCAGCTGGAGCGCGACGGTGGCCCCAGTCTGGCGGTGGTCA
ACGCCCGCTTCGTCAAGCCGCTGGATGAAGAACTGATCCAGTTTTTGGCCCGCACCTACGGCCGACTGATCACCCTGGAA
GAGAACGCGCTGCAGGGCGGTTTCGGCAGCGCTGTCCTGGAACTTCTGGAGGAAAAGGGGATTCGCGGCACGCGGGTCCT
GCGGCTGGGGTATCCCGACGCCCAGATCCCCCAGGGGGACCAGGGAGTTTTGCGCGCCATGCTGGGCCTGGACCCCGCCG
GACTGGCTTCCTCCATGGAGGCGTTTCTGCGCCGGGATTGA

Upstream 100 bases:

>100_bases
TTCTTTGTGCCTTTGTGTGAGAACCGAGATCGTTTTTTCTCCTGTCGTTTTTGTCCCCATGCAAGAATGAGCCAGGATTA
TTTCTATTCAACGGGTGTTT

Downstream 100 bases:

>100_bases
AAACCGATGTGATTTCTATGTGCCGGAAACGGTAAGCGGAATGTTTGCTCCCTGCGCCCACAACGGAACCATGCCGCATA
GGGGCGCATGCTGGAGCAGG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase 1; DXP synthase 1; DXPS 1 [H]

Number of amino acids: Translated: 626; Mature: 625

Protein sequence:

>626_residues
MALLDTIDSPADLKRLPVSRLPQVAEELRRVIIQTCSTNGGHLAPSLGVVELTIALHRVFSTPEDKIVWDVGHQAYAHKL
LTGRRDRFSTLRKLDGISGFPKRDESPHDAFEVGHASTSISAATGLAAARDLAGRRNKVLAVIGDGSMTGGMAYEAMNHA
GHMNRDMIVILNDNEMSIAENVGALSNFLTRTGSSEFVYRFKKNVESFLGRKDTVGKNLLHLAKKLEDSFKGFFTPGMLF
EAFGFEYIGPIDGHDLPMLLETLEKVKKYHDAVLIHVLTKKGKGYKPAEDDPSLFHGVGPFDLESGRVLKGKGGAASYTA
IFGSALCKLAADDERVVAITAAMPDGTGLIPFSRQFPKRFFDVGIAEQHAVTFAAGLATQGFRPVFTVYSSFLQRAYDLV
FHDVCLQNLPVIFALDRAGVVGNDGPTHHGSLDISLLRHLPNMTVMAPRDENELQHMLATALGMQGPVALRYPRGNGVGV
ALDQIITPLPVGRAEVLREGKDGAVLALGSMVHPALEAALQLERDGGPSLAVVNARFVKPLDEELIQFLARTYGRLITLE
ENALQGGFGSAVLELLEEKGIRGTRVLRLGYPDAQIPQGDQGVLRAMLGLDPAGLASSMEAFLRRD

Sequences:

>Translated_626_residues
MALLDTIDSPADLKRLPVSRLPQVAEELRRVIIQTCSTNGGHLAPSLGVVELTIALHRVFSTPEDKIVWDVGHQAYAHKL
LTGRRDRFSTLRKLDGISGFPKRDESPHDAFEVGHASTSISAATGLAAARDLAGRRNKVLAVIGDGSMTGGMAYEAMNHA
GHMNRDMIVILNDNEMSIAENVGALSNFLTRTGSSEFVYRFKKNVESFLGRKDTVGKNLLHLAKKLEDSFKGFFTPGMLF
EAFGFEYIGPIDGHDLPMLLETLEKVKKYHDAVLIHVLTKKGKGYKPAEDDPSLFHGVGPFDLESGRVLKGKGGAASYTA
IFGSALCKLAADDERVVAITAAMPDGTGLIPFSRQFPKRFFDVGIAEQHAVTFAAGLATQGFRPVFTVYSSFLQRAYDLV
FHDVCLQNLPVIFALDRAGVVGNDGPTHHGSLDISLLRHLPNMTVMAPRDENELQHMLATALGMQGPVALRYPRGNGVGV
ALDQIITPLPVGRAEVLREGKDGAVLALGSMVHPALEAALQLERDGGPSLAVVNARFVKPLDEELIQFLARTYGRLITLE
ENALQGGFGSAVLELLEEKGIRGTRVLRLGYPDAQIPQGDQGVLRAMLGLDPAGLASSMEAFLRRD
>Mature_625_residues
ALLDTIDSPADLKRLPVSRLPQVAEELRRVIIQTCSTNGGHLAPSLGVVELTIALHRVFSTPEDKIVWDVGHQAYAHKLL
TGRRDRFSTLRKLDGISGFPKRDESPHDAFEVGHASTSISAATGLAAARDLAGRRNKVLAVIGDGSMTGGMAYEAMNHAG
HMNRDMIVILNDNEMSIAENVGALSNFLTRTGSSEFVYRFKKNVESFLGRKDTVGKNLLHLAKKLEDSFKGFFTPGMLFE
AFGFEYIGPIDGHDLPMLLETLEKVKKYHDAVLIHVLTKKGKGYKPAEDDPSLFHGVGPFDLESGRVLKGKGGAASYTAI
FGSALCKLAADDERVVAITAAMPDGTGLIPFSRQFPKRFFDVGIAEQHAVTFAAGLATQGFRPVFTVYSSFLQRAYDLVF
HDVCLQNLPVIFALDRAGVVGNDGPTHHGSLDISLLRHLPNMTVMAPRDENELQHMLATALGMQGPVALRYPRGNGVGVA
LDQIITPLPVGRAEVLREGKDGAVLALGSMVHPALEAALQLERDGGPSLAVVNARFVKPLDEELIQFLARTYGRLITLEE
NALQGGFGSAVLELLEEKGIRGTRVLRLGYPDAQIPQGDQGVLRAMLGLDPAGLASSMEAFLRRD

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=564, Percent_Identity=25, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI4507521, Length=564, Percent_Identity=25, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI133778974, Length=604, Percent_Identity=25.8278145695364, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI225637459, Length=456, Percent_Identity=25.8771929824561, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI225637461, Length=456, Percent_Identity=25.8771929824561, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI225637463, Length=456, Percent_Identity=25.8771929824561, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI4557353, Length=232, Percent_Identity=25.4310344827586, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI34101272, Length=232, Percent_Identity=25.4310344827586, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1786622, Length=622, Percent_Identity=49.6784565916399, Blast_Score=603, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI17539652, Length=624, Percent_Identity=25.4807692307692, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17506935, Length=164, Percent_Identity=26.219512195122, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI45551847, Length=681, Percent_Identity=25.1101321585903, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45550715, Length=681, Percent_Identity=25.1101321585903, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24645119, Length=595, Percent_Identity=25.546218487395, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24666278, Length=663, Percent_Identity=26.9984917043741, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21358145, Length=277, Percent_Identity=25.9927797833935, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650940, Length=277, Percent_Identity=25.9927797833935, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67787; Mature: 67656

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLDTIDSPADLKRLPVSRLPQVAEELRRVIIQTCSTNGGHLAPSLGVVELTIALHRVF
CCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
STPEDKIVWDVGHQAYAHKLLTGRRDRFSTLRKLDGISGFPKRDESPHDAFEVGHASTSI
CCCCCCEEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCH
SAATGLAAARDLAGRRNKVLAVIGDGSMTGGMAYEAMNHAGHMNRDMIVILNDNEMSIAE
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCEEEEECCCCHHHHH
NVGALSNFLTRTGSSEFVYRFKKNVESFLGRKDTVGKNLLHLAKKLEDSFKGFFTPGMLF
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
EAFGFEYIGPIDGHDLPMLLETLEKVKKYHDAVLIHVLTKKGKGYKPAEDDPSLFHGVGP
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCHHHCCCCC
FDLESGRVLKGKGGAASYTAIFGSALCKLAADDERVVAITAAMPDGTGLIPFSRQFPKRF
CCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCHHHHHHH
FDVGIAEQHAVTFAAGLATQGFRPVFTVYSSFLQRAYDLVFHDVCLQNLPVIFALDRAGV
HHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
VGNDGPTHHGSLDISLLRHLPNMTVMAPRDENELQHMLATALGMQGPVALRYPRGNGVGV
CCCCCCCCCCCCHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCEE
ALDQIITPLPVGRAEVLREGKDGAVLALGSMVHPALEAALQLERDGGPSLAVVNARFVKP
EHHHHHCCCCCCHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCC
LDEELIQFLARTYGRLITLEENALQGGFGSAVLELLEEKGIRGTRVLRLGYPDAQIPQGD
HHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC
QGVLRAMLGLDPAGLASSMEAFLRRD
HHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALLDTIDSPADLKRLPVSRLPQVAEELRRVIIQTCSTNGGHLAPSLGVVELTIALHRVF
CCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
STPEDKIVWDVGHQAYAHKLLTGRRDRFSTLRKLDGISGFPKRDESPHDAFEVGHASTSI
CCCCCCEEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCH
SAATGLAAARDLAGRRNKVLAVIGDGSMTGGMAYEAMNHAGHMNRDMIVILNDNEMSIAE
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCEEEEECCCCHHHHH
NVGALSNFLTRTGSSEFVYRFKKNVESFLGRKDTVGKNLLHLAKKLEDSFKGFFTPGMLF
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
EAFGFEYIGPIDGHDLPMLLETLEKVKKYHDAVLIHVLTKKGKGYKPAEDDPSLFHGVGP
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCHHHCCCCC
FDLESGRVLKGKGGAASYTAIFGSALCKLAADDERVVAITAAMPDGTGLIPFSRQFPKRF
CCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCHHHHHHH
FDVGIAEQHAVTFAAGLATQGFRPVFTVYSSFLQRAYDLVFHDVCLQNLPVIFALDRAGV
HHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
VGNDGPTHHGSLDISLLRHLPNMTVMAPRDENELQHMLATALGMQGPVALRYPRGNGVGV
CCCCCCCCCCCCHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCEE
ALDQIITPLPVGRAEVLREGKDGAVLALGSMVHPALEAALQLERDGGPSLAVVNARFVKP
EHHHHHCCCCCCHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCC
LDEELIQFLARTYGRLITLEENALQGGFGSAVLELLEEKGIRGTRVLRLGYPDAQIPQGD
HHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC
QGVLRAMLGLDPAGLASSMEAFLRRD
HHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA