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The map label for this gene is thrS

Identifier: 118580723

GI number: 118580723

Start: 2489364

End: 2491274

Strand: Reverse

Name: thrS

Synonym: Ppro_2308

Alternate gene names: 118580723

Gene position: 2491274-2489364 (Counterclockwise)

Preceding gene: 118580724

Following gene: 118580722

Centisome position: 62.16

GC content: 59.6

Gene sequence:

>1911_bases
ATGTCATCTATTTCGATTGCACTGCCAGACGGTTCGAAGCGTGAGATTGCATCCGGTTCGACTATTGCTGATTTGGCTGC
TTCCATCGGCGCCGGCCTTGCCAAGGCTGCCATTGCCGGGAAGCTGGACGGAGAACTGGTCGATCTTTCGACGGAGCTGA
AGGACGATTCCCGGGTTGAGATCATCACCGAAAAGAGCCCGGAGGCGCTGACCGTCATCCGCCACTCCGCCGCCCATCTC
ATGGCCCAGGCGGTTAAGGAACTGTTCCCCCAGGCCAAGGTGACCATCGGTCCTGCCATCGAGAGCGGCTTCTACTACGA
TTTTGACATGGACGCCCCCTTCACTCCCGAAGACCTGGAGCGTATCGAAGCCAGGATGGCCGAACTGGCGGCTGCCAACC
AGAAGATCGAGCGCAGAGTGCTCTCCAGCAGCGAGGCGGTCAGCCTGTTTTCGGGTATGGGTGAAAACTACAAGGTTGAG
CTGATCAACGATCTGGCAGCAGAGACGGTTTCGGTTTACAGCCAGGGCGATTTCGCCGACCTCTGCCGCGGCCCCCATCT
TCCCTCCACCTCGCGCATCAAGGCCTTCAAGCTGCTCTCCATCGCCGGCGCCTACTGGCGCGGCGACGAGAAGAACCGCA
TGCTGCAGCGCATCTACGGCACGGCCTTCGCGGACAAGAAGGAGCTGGAGGCGTACCTGCACCGCCTGGAGGAATCCAAA
CGTCGCGACCACCGCAGGCTGGGCAGAGAACTGGACCTGTTCTCCTTCTCCGACGAGGTGGGCGCCGGCCTGGTGATCTG
GCACCCCAAGGGGGCCATGCTGCGCACAATCCTGGAGGATTTCGAGCGCCGCGAGCACCTGAAGCGCGGCTACGACATCG
TCCTCGGCCCGCAGATACTGAAGAAGGAACTCTGGCAGCGTTCCGGCCATTACGAAAACTACCGCGAGAACATGTATTTC
ACCGAGGTTGACGAGCAGAGCTATGGCATCAAGCCGATGAACTGTCTCGCCCACATGATGATCTACAAGTCCCATCTGAG
GAGTTACCGCGACCTGCCGCTGCGCTACTTCGAACTGGGCACGGTGCATCGCCATGAGCGCGCCGGCGTGCTGCACGGCC
TTCTGCGCGTGCGTGGTTTTACCCAGGACGATGCCCATATTCTCTGCGCACCGGAGCAACTGGACGGTGAGATCAAGGGT
GTGCTGAAATTCGTCAGCGACGTCATGGCCATCTTCGGCTTCGAGTACGAAATGGAGCTCTCCACCCGGCCGGAGAAATC
CATCGGCGATGATGCTGCCTGGGAACTGGCCACCGAGGCGCTGCTCTCGGCTCTCAAGGATACGGGGCGCTCCTTTGAGA
TCAACGAGGGAGACGGCGCATTTTACGGCCCCAAGATCGATATCAAGCTGAAAGACGCGCTTGACAGGCGCTGGCAGTGT
GCTACTATCCAGTGCGATTTTACCCTGCCGGAACGCTTTGACCTGCAGTACGTTGCGGCCGATGGCGAAAAAAAGCGCCC
GGTCATGGTGCACAGGGTCGTCCTGGGCGCCATCGAACGCTTCATCGGTGTGCTGATCGAACACTACGCTGGCAACTTCC
CGCTCTGGCTCTCGCCGGTTCAGGCCATGCTGGTCACCGTTACCGACAACCATATCCCCTATGCCCAGGGGGTACTGGAG
CACCTCAGGGAAGCGGGTATCAGGGTCCAGGGTGATTTCCGCAATGAGAAACTGAGCTTCAAGATTCGCGAGGCTCAGCT
CCAGAAGGTCCCCTACATGCTGGTGATCGGCGACAAGGAGATGGAGTCGGCTACGGTGACCCCGCGCTTCCGTGACGGCA
AGAACCTGGTGGCCATGAAGCCCGAGGATTTTGTTGCCTTTGTCGTAGAGGAAACCAAGAACTTCAGATAG

Upstream 100 bases:

>100_bases
CTTTTCAGGCGGGACGCGCTGCTCCCGTGATTGTGTGCTTCGGACGTTAGTTGTGTCGTAACTGCCGGTGACGGCGAAAG
GTTTTAAACTGGGTACTCCA

Downstream 100 bases:

>100_bases
ACGCCCGCGCCCGTTTCGCGGCGTCGGAACTGTTCCACCCAGGAGGTGCAGTCATAGCAAAACCGACCGTAAACATCAAT
AATGCCATCCGAGCAGCGGA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 636; Mature: 635

Protein sequence:

>636_residues
MSSISIALPDGSKREIASGSTIADLAASIGAGLAKAAIAGKLDGELVDLSTELKDDSRVEIITEKSPEALTVIRHSAAHL
MAQAVKELFPQAKVTIGPAIESGFYYDFDMDAPFTPEDLERIEARMAELAAANQKIERRVLSSSEAVSLFSGMGENYKVE
LINDLAAETVSVYSQGDFADLCRGPHLPSTSRIKAFKLLSIAGAYWRGDEKNRMLQRIYGTAFADKKELEAYLHRLEESK
RRDHRRLGRELDLFSFSDEVGAGLVIWHPKGAMLRTILEDFERREHLKRGYDIVLGPQILKKELWQRSGHYENYRENMYF
TEVDEQSYGIKPMNCLAHMMIYKSHLRSYRDLPLRYFELGTVHRHERAGVLHGLLRVRGFTQDDAHILCAPEQLDGEIKG
VLKFVSDVMAIFGFEYEMELSTRPEKSIGDDAAWELATEALLSALKDTGRSFEINEGDGAFYGPKIDIKLKDALDRRWQC
ATIQCDFTLPERFDLQYVAADGEKKRPVMVHRVVLGAIERFIGVLIEHYAGNFPLWLSPVQAMLVTVTDNHIPYAQGVLE
HLREAGIRVQGDFRNEKLSFKIREAQLQKVPYMLVIGDKEMESATVTPRFRDGKNLVAMKPEDFVAFVVEETKNFR

Sequences:

>Translated_636_residues
MSSISIALPDGSKREIASGSTIADLAASIGAGLAKAAIAGKLDGELVDLSTELKDDSRVEIITEKSPEALTVIRHSAAHL
MAQAVKELFPQAKVTIGPAIESGFYYDFDMDAPFTPEDLERIEARMAELAAANQKIERRVLSSSEAVSLFSGMGENYKVE
LINDLAAETVSVYSQGDFADLCRGPHLPSTSRIKAFKLLSIAGAYWRGDEKNRMLQRIYGTAFADKKELEAYLHRLEESK
RRDHRRLGRELDLFSFSDEVGAGLVIWHPKGAMLRTILEDFERREHLKRGYDIVLGPQILKKELWQRSGHYENYRENMYF
TEVDEQSYGIKPMNCLAHMMIYKSHLRSYRDLPLRYFELGTVHRHERAGVLHGLLRVRGFTQDDAHILCAPEQLDGEIKG
VLKFVSDVMAIFGFEYEMELSTRPEKSIGDDAAWELATEALLSALKDTGRSFEINEGDGAFYGPKIDIKLKDALDRRWQC
ATIQCDFTLPERFDLQYVAADGEKKRPVMVHRVVLGAIERFIGVLIEHYAGNFPLWLSPVQAMLVTVTDNHIPYAQGVLE
HLREAGIRVQGDFRNEKLSFKIREAQLQKVPYMLVIGDKEMESATVTPRFRDGKNLVAMKPEDFVAFVVEETKNFR
>Mature_635_residues
SSISIALPDGSKREIASGSTIADLAASIGAGLAKAAIAGKLDGELVDLSTELKDDSRVEIITEKSPEALTVIRHSAAHLM
AQAVKELFPQAKVTIGPAIESGFYYDFDMDAPFTPEDLERIEARMAELAAANQKIERRVLSSSEAVSLFSGMGENYKVEL
INDLAAETVSVYSQGDFADLCRGPHLPSTSRIKAFKLLSIAGAYWRGDEKNRMLQRIYGTAFADKKELEAYLHRLEESKR
RDHRRLGRELDLFSFSDEVGAGLVIWHPKGAMLRTILEDFERREHLKRGYDIVLGPQILKKELWQRSGHYENYRENMYFT
EVDEQSYGIKPMNCLAHMMIYKSHLRSYRDLPLRYFELGTVHRHERAGVLHGLLRVRGFTQDDAHILCAPEQLDGEIKGV
LKFVSDVMAIFGFEYEMELSTRPEKSIGDDAAWELATEALLSALKDTGRSFEINEGDGAFYGPKIDIKLKDALDRRWQCA
TIQCDFTLPERFDLQYVAADGEKKRPVMVHRVVLGAIERFIGVLIEHYAGNFPLWLSPVQAMLVTVTDNHIPYAQGVLEH
LREAGIRVQGDFRNEKLSFKIREAQLQKVPYMLVIGDKEMESATVTPRFRDGKNLVAMKPEDFVAFVVEETKNFR

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=616, Percent_Identity=41.7207792207792, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI38570111, Length=621, Percent_Identity=40.5797101449275, Blast_Score=487, Evalue=1e-137,
Organism=Homo sapiens, GI20070344, Length=636, Percent_Identity=39.4654088050315, Blast_Score=424, Evalue=1e-118,
Organism=Escherichia coli, GI1788013, Length=632, Percent_Identity=48.4177215189873, Blast_Score=643, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984192, Length=619, Percent_Identity=39.7415185783522, Blast_Score=485, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI71984184, Length=619, Percent_Identity=39.7415185783522, Blast_Score=485, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6322112, Length=639, Percent_Identity=40.8450704225352, Blast_Score=496, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6322654, Length=394, Percent_Identity=37.8172588832487, Blast_Score=287, Evalue=4e-78,
Organism=Drosophila melanogaster, GI24583842, Length=615, Percent_Identity=41.4634146341463, Blast_Score=512, Evalue=1e-145,
Organism=Drosophila melanogaster, GI28574141, Length=615, Percent_Identity=41.4634146341463, Blast_Score=512, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24583839, Length=615, Percent_Identity=41.4634146341463, Blast_Score=512, Evalue=1e-145,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_PELPD (A1ARE5)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_901973.1
- ProteinModelPortal:   A1ARE5
- SMR:   A1ARE5
- STRING:   A1ARE5
- GeneID:   4574914
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2308
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   TAKDPEC
- PhylomeDB:   A1ARE5
- ProtClustDB:   PRK00413
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 71879; Mature: 71748

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSISIALPDGSKREIASGSTIADLAASIGAGLAKAAIAGKLDGELVDLSTELKDDSRVE
CCCEEEECCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCEEECCHHCCCCCCEE
IITEKSPEALTVIRHSAAHLMAQAVKELFPQAKVTIGPAIESGFYYDFDMDAPFTPEDLE
EEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCCHHHHH
RIEARMAELAAANQKIERRVLSSSEAVSLFSGMGENYKVELINDLAAETVSVYSQGDFAD
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCCHHH
LCRGPHLPSTSRIKAFKLLSIAGAYWRGDEKNRMLQRIYGTAFADKKELEAYLHRLEESK
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RRDHRRLGRELDLFSFSDEVGAGLVIWHPKGAMLRTILEDFERREHLKRGYDIVLGPQIL
HHHHHHHCCCCCCEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEECHHHH
KKELWQRSGHYENYRENMYFTEVDEQSYGIKPMNCLAHMMIYKSHLRSYRDLPLRYFELG
HHHHHHHCCCCCHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECC
TVHRHERAGVLHGLLRVRGFTQDDAHILCAPEQLDGEIKGVLKFVSDVMAIFGFEYEMEL
CCHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHCHHHHHHHHHHHHHHHHHCCCEEEEE
STRPEKSIGDDAAWELATEALLSALKDTGRSFEINEGDGAFYGPKIDIKLKDALDRRWQC
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECCEEEEEEHHHHCCCEEE
ATIQCDFTLPERFDLQYVAADGEKKRPVMVHRVVLGAIERFIGVLIEHYAGNFPLWLSPV
EEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCC
QAMLVTVTDNHIPYAQGVLEHLREAGIRVQGDFRNEKLSFKIREAQLQKVPYMLVIGDKE
CEEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCEEEEEEHHHHHHHCCEEEEECCCC
MESATVTPRFRDGKNLVAMKPEDFVAFVVEETKNFR
CCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCC
>Mature Secondary Structure 
SSISIALPDGSKREIASGSTIADLAASIGAGLAKAAIAGKLDGELVDLSTELKDDSRVE
CCEEEECCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCEEECCHHCCCCCCEE
IITEKSPEALTVIRHSAAHLMAQAVKELFPQAKVTIGPAIESGFYYDFDMDAPFTPEDLE
EEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCCHHHHH
RIEARMAELAAANQKIERRVLSSSEAVSLFSGMGENYKVELINDLAAETVSVYSQGDFAD
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCCHHH
LCRGPHLPSTSRIKAFKLLSIAGAYWRGDEKNRMLQRIYGTAFADKKELEAYLHRLEESK
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RRDHRRLGRELDLFSFSDEVGAGLVIWHPKGAMLRTILEDFERREHLKRGYDIVLGPQIL
HHHHHHHCCCCCCEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEECHHHH
KKELWQRSGHYENYRENMYFTEVDEQSYGIKPMNCLAHMMIYKSHLRSYRDLPLRYFELG
HHHHHHHCCCCCHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECC
TVHRHERAGVLHGLLRVRGFTQDDAHILCAPEQLDGEIKGVLKFVSDVMAIFGFEYEMEL
CCHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHCHHHHHHHHHHHHHHHHHCCCEEEEE
STRPEKSIGDDAAWELATEALLSALKDTGRSFEINEGDGAFYGPKIDIKLKDALDRRWQC
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECCEEEEEEHHHHCCCEEE
ATIQCDFTLPERFDLQYVAADGEKKRPVMVHRVVLGAIERFIGVLIEHYAGNFPLWLSPV
EEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCC
QAMLVTVTDNHIPYAQGVLEHLREAGIRVQGDFRNEKLSFKIREAQLQKVPYMLVIGDKE
CEEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCEEEEEEHHHHHHHCCEEEEECCCC
MESATVTPRFRDGKNLVAMKPEDFVAFVVEETKNFR
CCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA