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The map label for this gene is garR [H]

Identifier: 118580612

GI number: 118580612

Start: 2367892

End: 2368764

Strand: Reverse

Name: garR [H]

Synonym: Ppro_2197

Alternate gene names: 118580612

Gene position: 2368764-2367892 (Counterclockwise)

Preceding gene: 118580615

Following gene: 118580607

Centisome position: 59.1

GC content: 65.06

Gene sequence:

>873_bases
ATGGGTACCATTGGATTCATTGGACTTGGCATCATGGGAACCCCCATGGCGGCGAACCTGATCAAGGCGGGGTTCAGGCT
GACGGTCTGGAACCGCACCCCGGAAAAATGCGTTCCGCTGACCGAACTGGGGGCGGTGCAGGCCGCTTCTCCCCGTCAGG
TGGTGGAGGCGTCGGATGTCACCATCGCCATGCTTGCCGACCCTGCCGCGGCCGAGGCGGTCTGTCGGGGAGATGAGGGC
GTGGTTGCCGGCATCAAGCCGGGCAAGGGATACGTGGATATGTCGACGGTGGCCCCTGAAACCGCCCAATCGGTTGCCAA
GGCGGTGCGGGAAGCGGGGGGGCTGTTCCTGGAGGCGCCGGTTTTGGGGAGCAAGAAGCCGGCCGAGGACGGCACCCTGG
TCATCCTGGCTGCCGGGGATCGCCCCCTGTTCGATCAGGCGCAACCGGCACTAGCGGCGATGGGAAAGAAGATTCTGTTC
CTGGGAGAGGTGGGGCAGGGGGCGCGCATGAAGCTCGTGGCCAACATGGTCATGGGCGGCATGATGACCATGCTCTGCGA
GGGATTGACACTGGGCGCCAGGGCTGGACTGGAGTCGGCCGACATCCTGGACGTGCTGGATGCCGGGGCGATGTCGAACC
CCATGTTCCGGTTGAAGGGGCCGCAGATCGTCCAGGACAGGTTCCCGCCGGCCTTTCCCCTCAAGCATATGCAGAAGGAC
CTGCGCCTGGCGCTGAACCTGGGCAACCAGTTGGGGCAGGCGCTGCACACCACCGCTTCGGCCAACGAACTCTTCAAGAC
GGCGCTGGGAATGGGGCTGGGAGACAGCGATTTCGCGGCGGTCAGCCGGGTTGTCGGCCCCGTGAAACAGTAG

Upstream 100 bases:

>100_bases
TCCTCCTGAGCCCGTTTTTCGGGGAGAGCCATTTTGCTTTATCCTGTTTGTGTGCTAGTCTGGTGCCGCTTCATGGAGTT
TACAGAAGGAGGAAATCAGT

Downstream 100 bases:

>100_bases
CCGCGGAGAGGTTGGCGCTCCGTCAGGCTGGCATCATGAACAGCCCGTAAAAAAAGCCTCCCCCCGTCCTTCCCGTCTGG
GAACGGAACAGGGGGAGGCT

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MGTIGFIGLGIMGTPMAANLIKAGFRLTVWNRTPEKCVPLTELGAVQAASPRQVVEASDVTIAMLADPAAAEAVCRGDEG
VVAGIKPGKGYVDMSTVAPETAQSVAKAVREAGGLFLEAPVLGSKKPAEDGTLVILAAGDRPLFDQAQPALAAMGKKILF
LGEVGQGARMKLVANMVMGGMMTMLCEGLTLGARAGLESADILDVLDAGAMSNPMFRLKGPQIVQDRFPPAFPLKHMQKD
LRLALNLGNQLGQALHTTASANELFKTALGMGLGDSDFAAVSRVVGPVKQ

Sequences:

>Translated_290_residues
MGTIGFIGLGIMGTPMAANLIKAGFRLTVWNRTPEKCVPLTELGAVQAASPRQVVEASDVTIAMLADPAAAEAVCRGDEG
VVAGIKPGKGYVDMSTVAPETAQSVAKAVREAGGLFLEAPVLGSKKPAEDGTLVILAAGDRPLFDQAQPALAAMGKKILF
LGEVGQGARMKLVANMVMGGMMTMLCEGLTLGARAGLESADILDVLDAGAMSNPMFRLKGPQIVQDRFPPAFPLKHMQKD
LRLALNLGNQLGQALHTTASANELFKTALGMGLGDSDFAAVSRVVGPVKQ
>Mature_289_residues
GTIGFIGLGIMGTPMAANLIKAGFRLTVWNRTPEKCVPLTELGAVQAASPRQVVEASDVTIAMLADPAAAEAVCRGDEGV
VAGIKPGKGYVDMSTVAPETAQSVAKAVREAGGLFLEAPVLGSKKPAEDGTLVILAAGDRPLFDQAQPALAAMGKKILFL
GEVGQGARMKLVANMVMGGMMTMLCEGLTLGARAGLESADILDVLDAGAMSNPMFRLKGPQIVQDRFPPAFPLKHMQKDL
RLALNLGNQLGQALHTTASANELFKTALGMGLGDSDFAAVSRVVGPVKQ

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=280, Percent_Identity=45.3571428571429, Blast_Score=246, Evalue=1e-65,
Organism=Homo sapiens, GI23308751, Length=288, Percent_Identity=31.25, Blast_Score=132, Evalue=5e-31,
Organism=Escherichia coli, GI145693186, Length=279, Percent_Identity=33.3333333333333, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI1786719, Length=278, Percent_Identity=35.9712230215827, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI1790315, Length=288, Percent_Identity=30.5555555555556, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1789092, Length=285, Percent_Identity=28.0701754385965, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17557316, Length=259, Percent_Identity=30.8880308880309, Blast_Score=97, Evalue=8e-21,
Organism=Drosophila melanogaster, GI28574115, Length=281, Percent_Identity=37.3665480427046, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24655230, Length=286, Percent_Identity=30.0699300699301, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI19922568, Length=286, Percent_Identity=30.0699300699301, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30053; Mature: 29921

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTIGFIGLGIMGTPMAANLIKAGFRLTVWNRTPEKCVPLTELGAVQAASPRQVVEASDV
CCCCEEEECCCCCCHHHHHHHHCCCEEEEECCCHHHCCCHHHHCCCCCCCCHHHHCCCCE
TIAMLADPAAAEAVCRGDEGVVAGIKPGKGYVDMSTVAPETAQSVAKAVREAGGLFLEAP
EEEEECCCHHHHHHHCCCCCEEEECCCCCCEEEHHHCCCHHHHHHHHHHHHHCCEEEECC
VLGSKKPAEDGTLVILAAGDRPLFDQAQPALAAMGKKILFLGEVGQGARMKLVANMVMGG
CCCCCCCCCCCCEEEEECCCCCCHHHCCHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHH
MMTMLCEGLTLGARAGLESADILDVLDAGAMSNPMFRLKGPQIVQDRFPPAFPLKHMQKD
HHHHHHCCCCHHHHCCCCCHHHHHHHHCCCCCCCEEEECCCHHHHHCCCCCCCHHHHHHH
LRLALNLGNQLGQALHTTASANELFKTALGMGLGDSDFAAVSRVVGPVKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GTIGFIGLGIMGTPMAANLIKAGFRLTVWNRTPEKCVPLTELGAVQAASPRQVVEASDV
CCCEEEECCCCCCHHHHHHHHCCCEEEEECCCHHHCCCHHHHCCCCCCCCHHHHCCCCE
TIAMLADPAAAEAVCRGDEGVVAGIKPGKGYVDMSTVAPETAQSVAKAVREAGGLFLEAP
EEEEECCCHHHHHHHCCCCCEEEECCCCCCEEEHHHCCCHHHHHHHHHHHHHCCEEEECC
VLGSKKPAEDGTLVILAAGDRPLFDQAQPALAAMGKKILFLGEVGQGARMKLVANMVMGG
CCCCCCCCCCCCEEEEECCCCCCHHHCCHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHH
MMTMLCEGLTLGARAGLESADILDVLDAGAMSNPMFRLKGPQIVQDRFPPAFPLKHMQKD
HHHHHHCCCCHHHHCCCCCHHHHHHHHCCCCCCCEEEECCCHHHHHCCCCCCCHHHHHHH
LRLALNLGNQLGQALHTTASANELFKTALGMGLGDSDFAAVSRVVGPVKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]