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The map label for this gene is bioF

Identifier: 118580509

GI number: 118580509

Start: 2251939

End: 2253114

Strand: Reverse

Name: bioF

Synonym: Ppro_2093

Alternate gene names: 118580509

Gene position: 2253114-2251939 (Counterclockwise)

Preceding gene: 118580510

Following gene: 118580508

Centisome position: 56.22

GC content: 66.84

Gene sequence:

>1176_bases
ATGGGTCGTACAGTACAGGATGAGTTGGAGCAGATCCGCGCTAAGGGGCTGTTCCGCTCCACGCGCCTGATCCAGGGACG
GCAGTCTGCGCGGGTGACCATGGAGGGGCGCCAGCTGCTCTTGCTCTGCTCCAACAACTATCTGGGATTGGCCGAGCACC
CGGCCCTCATCGCGGCCTCCATGGCAGCCGCCGAACAGTTCGGCAGTTCCAGCGGCGCCTCGCGCCTGGTTTCCGGCAGC
ATGGAGCCGCACGAGGCCCTGGAAACGGCGGTGGCGGCATTCAAGCGCACCGAGAGCGCCCTGGCCTTCAACAGCGGCTA
TGCCGCCAACACCGGTATCATCCAGGCCCTGGTGGGCAGGGGGGACGTGATCTTCTGCGACCGCCTCAACCATGCCAGCA
TCATCGACGGCGCCCTGCTCTCCGGCGCCCGGTTGGTGCGCTATCCCCACAACGATGCCGTTGCCCTGGCCGGGCTGATG
GAAAAGCAGCGCGGCACGGGGCGCTGCCTGATCGTCAGCGACGGCGTCTTCAGCATGGACGGCGACCTGGCGCCGCTGGC
GGAGCTTGCGGAACTCCGTCGGCGCCACGATGCCTTGCTGATGGTGGACGATGCCCACGGCTGCGGCGTGCTGGGCGAAC
AGGGGAGGGGAAGCGCTGAACTGCTGGGGGTTCTCTCCCATATCGATATCCACGTGGGGACCTTCGGCAAGGCGTTGGGG
AGCTTTGGCGCCTATGCCGCCCTCTCCCGGGAACTGCGCGATCTCCTTGTCAACCGCGCCCGCAGCTTCATCTTCTCCAC
CTCCCTGCCGCCGGCGGTGCTGGCGGTTTCCACGGCAGCCCTGGAACTGGTTCAGGCGGCCGAGGGGGACGAACTGAGGA
AGCGGCTCCGCGACAACACATCCCTGTTCCGGGGGCTGCTGCGGGATGCCGGTTTTTTCCTGGGGGAGGGAAACACCCAG
ATCGTGCCGATCCTCACCGGCGGCGCCGAAGAGACCATGGACTTCTCCCGGCAACTGCTGGAGGAGGGAATGTTCGTCCA
GGGGATACGCCCCCCCACCGTGCCTGCCGGCGCCTGCCGGTTGCGCTGCACGGTCATGGCAACCCATTCGCCCCAGGACC
TGACCTGGGCCGCGGAACGGATCACCCATATCGGCAGGCGTCTGGGAGTGGTTTGA

Upstream 100 bases:

>100_bases
CCGCCTGATTGCGGCCAGCGCTGTCGGATTTTGTTGACGGCGTTTTTATTTGCCGCTATTGTCAACTTTCTTTTTAGTGA
TGGTTGACCAGGGAGGGGGC

Downstream 100 bases:

>100_bases
TGCCTTGGCTCAGGCTCGGGAGCGGACGGCGCCTCTGGTACGAGGATCAGGGGGAGGGGATTCCGCTGGTGCTGCTGCAC
GGCTGGTGCATGTCGTCGCA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MGRTVQDELEQIRAKGLFRSTRLIQGRQSARVTMEGRQLLLLCSNNYLGLAEHPALIAASMAAAEQFGSSSGASRLVSGS
MEPHEALETAVAAFKRTESALAFNSGYAANTGIIQALVGRGDVIFCDRLNHASIIDGALLSGARLVRYPHNDAVALAGLM
EKQRGTGRCLIVSDGVFSMDGDLAPLAELAELRRRHDALLMVDDAHGCGVLGEQGRGSAELLGVLSHIDIHVGTFGKALG
SFGAYAALSRELRDLLVNRARSFIFSTSLPPAVLAVSTAALELVQAAEGDELRKRLRDNTSLFRGLLRDAGFFLGEGNTQ
IVPILTGGAEETMDFSRQLLEEGMFVQGIRPPTVPAGACRLRCTVMATHSPQDLTWAAERITHIGRRLGVV

Sequences:

>Translated_391_residues
MGRTVQDELEQIRAKGLFRSTRLIQGRQSARVTMEGRQLLLLCSNNYLGLAEHPALIAASMAAAEQFGSSSGASRLVSGS
MEPHEALETAVAAFKRTESALAFNSGYAANTGIIQALVGRGDVIFCDRLNHASIIDGALLSGARLVRYPHNDAVALAGLM
EKQRGTGRCLIVSDGVFSMDGDLAPLAELAELRRRHDALLMVDDAHGCGVLGEQGRGSAELLGVLSHIDIHVGTFGKALG
SFGAYAALSRELRDLLVNRARSFIFSTSLPPAVLAVSTAALELVQAAEGDELRKRLRDNTSLFRGLLRDAGFFLGEGNTQ
IVPILTGGAEETMDFSRQLLEEGMFVQGIRPPTVPAGACRLRCTVMATHSPQDLTWAAERITHIGRRLGVV
>Mature_390_residues
GRTVQDELEQIRAKGLFRSTRLIQGRQSARVTMEGRQLLLLCSNNYLGLAEHPALIAASMAAAEQFGSSSGASRLVSGSM
EPHEALETAVAAFKRTESALAFNSGYAANTGIIQALVGRGDVIFCDRLNHASIIDGALLSGARLVRYPHNDAVALAGLME
KQRGTGRCLIVSDGVFSMDGDLAPLAELAELRRRHDALLMVDDAHGCGVLGEQGRGSAELLGVLSHIDIHVGTFGKALGS
FGAYAALSRELRDLLVNRARSFIFSTSLPPAVLAVSTAALELVQAAEGDELRKRLRDNTSLFRGLLRDAGFFLGEGNTQI
VPILTGGAEETMDFSRQLLEEGMFVQGIRPPTVPAGACRLRCTVMATHSPQDLTWAAERITHIGRRLGVV

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily

Homologues:

Organism=Homo sapiens, GI7657118, Length=391, Percent_Identity=38.8746803069054, Blast_Score=265, Evalue=7e-71,
Organism=Homo sapiens, GI284448556, Length=417, Percent_Identity=36.4508393285372, Blast_Score=254, Evalue=8e-68,
Organism=Homo sapiens, GI83977442, Length=355, Percent_Identity=35.2112676056338, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI83977444, Length=355, Percent_Identity=35.2112676056338, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI83977440, Length=355, Percent_Identity=35.2112676056338, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI4502025, Length=359, Percent_Identity=32.8690807799443, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI40316939, Length=359, Percent_Identity=32.8690807799443, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI4758668, Length=358, Percent_Identity=32.4022346368715, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI119220554, Length=365, Percent_Identity=30.958904109589, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI5454084, Length=268, Percent_Identity=29.4776119402985, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1790046, Length=393, Percent_Identity=42.2391857506361, Blast_Score=308, Evalue=4e-85,
Organism=Escherichia coli, GI1786993, Length=340, Percent_Identity=43.5294117647059, Blast_Score=253, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71994529, Length=392, Percent_Identity=37.7551020408163, Blast_Score=259, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI32566772, Length=368, Percent_Identity=29.6195652173913, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17560914, Length=358, Percent_Identity=27.3743016759777, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17560912, Length=358, Percent_Identity=27.3743016759777, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI71982625, Length=298, Percent_Identity=25.8389261744966, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71982617, Length=298, Percent_Identity=25.503355704698, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320438, Length=401, Percent_Identity=31.4214463840399, Blast_Score=179, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6320267, Length=365, Percent_Identity=30.1369863013699, Blast_Score=173, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6323954, Length=276, Percent_Identity=28.2608695652174, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24662918, Length=389, Percent_Identity=37.0179948586118, Blast_Score=268, Evalue=4e-72,
Organism=Drosophila melanogaster, GI17137420, Length=337, Percent_Identity=35.3115727002967, Blast_Score=197, Evalue=9e-51,
Organism=Drosophila melanogaster, GI17136286, Length=382, Percent_Identity=29.3193717277487, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24653280, Length=273, Percent_Identity=27.4725274725275, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24653276, Length=273, Percent_Identity=27.4725274725275, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24653278, Length=273, Percent_Identity=27.4725274725275, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOF_PELPD (A1AQT1)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_901759.1
- ProteinModelPortal:   A1AQT1
- SMR:   A1AQT1
- STRING:   A1AQT1
- GeneID:   4573334
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2093
- eggNOG:   COG0156
- HOGENOM:   HBG649839
- OMA:   QGIRPPT
- PhylomeDB:   A1AQT1
- ProtClustDB:   CLSK828920
- HAMAP:   MF_01693
- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.47

Molecular weight: Translated: 41816; Mature: 41684

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 19-19 BINDING 131-131 BINDING 178-178 BINDING 353-353

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRTVQDELEQIRAKGLFRSTRLIQGRQSARVTMEGRQLLLLCSNNYLGLAEHPALIAAS
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEEECCCCCCCCCCCHHHHHH
MAAAEQFGSSSGASRLVSGSMEPHEALETAVAAFKRTESALAFNSGYAANTGIIQALVGR
HHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHCC
GDVIFCDRLNHASIIDGALLSGARLVRYPHNDAVALAGLMEKQRGTGRCLIVSDGVFSMD
CCEEEEECCCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCEEECC
GDLAPLAELAELRRRHDALLMVDDAHGCGVLGEQGRGSAELLGVLSHIDIHVGTFGKALG
CCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHEEECHHHHHHH
SFGAYAALSRELRDLLVNRARSFIFSTSLPPAVLAVSTAALELVQAAEGDELRKRLRDNT
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCH
SLFRGLLRDAGFFLGEGNTQIVPILTGGAEETMDFSRQLLEEGMFVQGIRPPTVPAGACR
HHHHHHHHHCCEEEECCCCEEEEEEECCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCEE
LRCTVMATHSPQDLTWAAERITHIGRRLGVV
EEEEEEEECCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GRTVQDELEQIRAKGLFRSTRLIQGRQSARVTMEGRQLLLLCSNNYLGLAEHPALIAAS
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEEECCCCCCCCCCCHHHHHH
MAAAEQFGSSSGASRLVSGSMEPHEALETAVAAFKRTESALAFNSGYAANTGIIQALVGR
HHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHCC
GDVIFCDRLNHASIIDGALLSGARLVRYPHNDAVALAGLMEKQRGTGRCLIVSDGVFSMD
CCEEEEECCCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCEEECC
GDLAPLAELAELRRRHDALLMVDDAHGCGVLGEQGRGSAELLGVLSHIDIHVGTFGKALG
CCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHEEECHHHHHHH
SFGAYAALSRELRDLLVNRARSFIFSTSLPPAVLAVSTAALELVQAAEGDELRKRLRDNT
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCH
SLFRGLLRDAGFFLGEGNTQIVPILTGGAEETMDFSRQLLEEGMFVQGIRPPTVPAGACR
HHHHHHHHHCCEEEECCCCEEEEEEECCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCEE
LRCTVMATHSPQDLTWAAERITHIGRRLGVV
EEEEEEEECCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA