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The map label for this gene is uppS [H]

Identifier: 118580464

GI number: 118580464

Start: 2197192

End: 2197947

Strand: Direct

Name: uppS [H]

Synonym: Ppro_2048

Alternate gene names: 118580464

Gene position: 2197192-2197947 (Clockwise)

Preceding gene: 118580463

Following gene: 118580465

Centisome position: 54.82

GC content: 60.32

Gene sequence:

>756_bases
ATGCGCGAGCTCGACCCTGAACGGCTCCCCGTCCATCTGGCAATCATCATGGATGGCAACGGACGCTGGGCCCAGCAGCG
CATGCTCAAACGCATCGTCGGCCACCAGCGGGGCGCCGAGACGGTCAACATGGTTGTGGAACATGCCTGGCGCCTGGGCA
TACAATACCTGACCCTGTTCGCCTTCTCCTCCGAGAACTGGTCCCGGCCGGCAATCGAGGTGCGCGCCCTCATGTCCCTG
CTGAAGAAGTACATCCGCAAGGAGACGGCGCGCATGATGCGCAAGAACATCCGCTACAATGTCATCGGCAACCGCAGCGA
CCTTCCCGTCGATGTCAACGAGACACTGGATGAGGCCATCAAGCAGACCTCGGTCAATACCGGCATGACGCTCACCCTGG
CGCTCTCCTACGGCGGGCGCCAGGAACTGAGCATGGCTGCCCGCCGCCTCGCATGCGACGTCCGTGACGGGAAAATAACC
CCCGATGACATTTCGGTGGAAAACTTCGGCACCTATCTGGATACGGGCGGCCTGCCGGACCCGGATTTTCTGATCCGCAC
CAGCGGCGAGATGCGCATCAGCAATTTCCTGCTCTGGCAACTGGCCTATACCGAGCTCTACTTTACCGAAACGAACTGGC
CCGACTTCACCATCAACGAGTTCAACAAGGCCCTGATCGATTTTCAGTCCCGTGAACGCCGCTTCGGCAAGACCAGCGAC
CAGATCTCCCCGAGGAACAAGCCATCAAACGCCTGA

Upstream 100 bases:

>100_bases
TGAAGAAGTATGAAAAAGAGGTTCAGGACAACACCAAGAGCTTCGAGATCAAAATCGACGAGGCAATGACCAACAAGGAA
AAAGAGGTCATGGAGGTTTG

Downstream 100 bases:

>100_bases
TTACCGCCTTCATTCTCCTGCCGGTGGTCATCCTGACCATTACCCACGGAGGGCCGCTGCTCTTTACCGGACTGATCGGC
ATCGTAGCCGCCATCGCCAT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MRELDPERLPVHLAIIMDGNGRWAQQRMLKRIVGHQRGAETVNMVVEHAWRLGIQYLTLFAFSSENWSRPAIEVRALMSL
LKKYIRKETARMMRKNIRYNVIGNRSDLPVDVNETLDEAIKQTSVNTGMTLTLALSYGGRQELSMAARRLACDVRDGKIT
PDDISVENFGTYLDTGGLPDPDFLIRTSGEMRISNFLLWQLAYTELYFTETNWPDFTINEFNKALIDFQSRERRFGKTSD
QISPRNKPSNA

Sequences:

>Translated_251_residues
MRELDPERLPVHLAIIMDGNGRWAQQRMLKRIVGHQRGAETVNMVVEHAWRLGIQYLTLFAFSSENWSRPAIEVRALMSL
LKKYIRKETARMMRKNIRYNVIGNRSDLPVDVNETLDEAIKQTSVNTGMTLTLALSYGGRQELSMAARRLACDVRDGKIT
PDDISVENFGTYLDTGGLPDPDFLIRTSGEMRISNFLLWQLAYTELYFTETNWPDFTINEFNKALIDFQSRERRFGKTSD
QISPRNKPSNA
>Mature_251_residues
MRELDPERLPVHLAIIMDGNGRWAQQRMLKRIVGHQRGAETVNMVVEHAWRLGIQYLTLFAFSSENWSRPAIEVRALMSL
LKKYIRKETARMMRKNIRYNVIGNRSDLPVDVNETLDEAIKQTSVNTGMTLTLALSYGGRQELSMAARRLACDVRDGKIT
PDDISVENFGTYLDTGGLPDPDFLIRTSGEMRISNFLLWQLAYTELYFTETNWPDFTINEFNKALIDFQSRERRFGKTSD
QISPRNKPSNA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=242, Percent_Identity=34.7107438016529, Blast_Score=150, Evalue=9e-37,
Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=36.1607142857143, Blast_Score=149, Evalue=2e-36,
Organism=Escherichia coli, GI1786371, Length=236, Percent_Identity=46.6101694915254, Blast_Score=209, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71993029, Length=247, Percent_Identity=32.7935222672065, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=32.8638497652582, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6323748, Length=219, Percent_Identity=29.2237442922374, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI18857969, Length=226, Percent_Identity=35.8407079646018, Blast_Score=138, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28895; Mature: 28895

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS01066 UPP_SYNTHETASE ; PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRELDPERLPVHLAIIMDGNGRWAQQRMLKRIVGHQRGAETVNMVVEHAWRLGIQYLTLF
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHE
AFSSENWSRPAIEVRALMSLLKKYIRKETARMMRKNIRYNVIGNRSDLPVDVNETLDEAI
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHH
KQTSVNTGMTLTLALSYGGRQELSMAARRLACDVRDGKITPDDISVENFGTYLDTGGLPD
HHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCC
PDFLIRTSGEMRISNFLLWQLAYTELYFTETNWPDFTINEFNKALIDFQSRERRFGKTSD
CCEEEECCCCEEHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
QISPRNKPSNA
CCCCCCCCCCC
>Mature Secondary Structure
MRELDPERLPVHLAIIMDGNGRWAQQRMLKRIVGHQRGAETVNMVVEHAWRLGIQYLTLF
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHE
AFSSENWSRPAIEVRALMSLLKKYIRKETARMMRKNIRYNVIGNRSDLPVDVNETLDEAI
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHH
KQTSVNTGMTLTLALSYGGRQELSMAARRLACDVRDGKITPDDISVENFGTYLDTGGLPD
HHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCC
PDFLIRTSGEMRISNFLLWQLAYTELYFTETNWPDFTINEFNKALIDFQSRERRFGKTSD
CCEEEECCCCEEHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
QISPRNKPSNA
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA