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The map label for this gene is lexA1 [H]

Identifier: 118580319

GI number: 118580319

Start: 2049771

End: 2050373

Strand: Direct

Name: lexA1 [H]

Synonym: Ppro_1901

Alternate gene names: 118580319

Gene position: 2049771-2050373 (Clockwise)

Preceding gene: 118580311

Following gene: 118580320

Centisome position: 51.14

GC content: 49.09

Gene sequence:

>603_bases
ATGGAAGCCCTATCTCCGCGACAAAAGCAGGTTCTTGAATTCATCAGGGGATATGTTGCCCAGAACGAGTATCCCCCATC
ATTGCGCGATATTGGCAATTACATTGGGGTATCCGGCAATACGGCTGTCCTTAGTCACTTGGAAGCTTTGGAACGTAAAG
GACACATCCGCCGCGATACAGGCAGCTCACGGAGGATTGTGTTAATTCGTGATAAACAGCATGAGGTCTTACAGATACCG
ATTGTCGGAACGGTTCAGGCCGGAATACCGACTCTTGCTGTCGAGAGCATCGAAGGGTATTACCCGATGGAAAAGATGCA
ACTCAGAGGCGGCACCTTCTTCCTCCGGGTCAAGGGTGATTCCATGATTAACGATGCCATCATGGACGGCGACCTTGCCT
TGATTCGACCACAGGAAACAGCGGAAAACGGTGATATAGTCGTTGCCTTAATTGAAGACGAGGCAACCCTGAAGAGGTTT
TATCGCGAGGGGGACTTTATTCGGTTAGAGCCAAGCAATACCAACTTTGCAGTAATCGTCATTTCTGCCAAAGATGTTAC
CATTATCGGCAAGGCCATCAAGATTGTCCGCGACATCGACTAA

Upstream 100 bases:

>100_bases
CAATCGCCCCGAGTGTACCATTTAGTACATGTCCTAAACGGTAGTCAAATGAGCAGTTGTACCGTTTGGTAAGTATCCTA
AAAAGTACATCGAGGAACAC

Downstream 100 bases:

>100_bases
TGCAAGCCGGACTCCCTATCCGCATAGCCGTTGTTTATCAAGCAGGAGTCAAACCAAAGCCAGTCTGGTTTGAGCTGAAC
CGTAAACAGCACCGGATCGC

Product: SOS-response transcriptional repressor LexA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MEALSPRQKQVLEFIRGYVAQNEYPPSLRDIGNYIGVSGNTAVLSHLEALERKGHIRRDTGSSRRIVLIRDKQHEVLQIP
IVGTVQAGIPTLAVESIEGYYPMEKMQLRGGTFFLRVKGDSMINDAIMDGDLALIRPQETAENGDIVVALIEDEATLKRF
YREGDFIRLEPSNTNFAVIVISAKDVTIIGKAIKIVRDID

Sequences:

>Translated_200_residues
MEALSPRQKQVLEFIRGYVAQNEYPPSLRDIGNYIGVSGNTAVLSHLEALERKGHIRRDTGSSRRIVLIRDKQHEVLQIP
IVGTVQAGIPTLAVESIEGYYPMEKMQLRGGTFFLRVKGDSMINDAIMDGDLALIRPQETAENGDIVVALIEDEATLKRF
YREGDFIRLEPSNTNFAVIVISAKDVTIIGKAIKIVRDID
>Mature_200_residues
MEALSPRQKQVLEFIRGYVAQNEYPPSLRDIGNYIGVSGNTAVLSHLEALERKGHIRRDTGSSRRIVLIRDKQHEVLQIP
IVGTVQAGIPTLAVESIEGYYPMEKMQLRGGTFFLRVKGDSMINDAIMDGDLALIRPQETAENGDIVVALIEDEATLKRF
YREGDFIRLEPSNTNFAVIVISAKDVTIIGKAIKIVRDID

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=203, Percent_Identity=37.9310344827586, Blast_Score=133, Evalue=7e-33,
Organism=Escherichia coli, GI1787431, Length=127, Percent_Identity=32.2834645669291, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 22322; Mature: 22322

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEALSPRQKQVLEFIRGYVAQNEYPPSLRDIGNYIGVSGNTAVLSHLEALERKGHIRRDT
CCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCEECCC
GSSRRIVLIRDKQHEVLQIPIVGTVQAGIPTLAVESIEGYYPMEKMQLRGGTFFLRVKGD
CCCCEEEEEECCCCCEEEEEEEEEECCCCCEEEEECCCCCCCHHHEEECCCEEEEEECCC
SMINDAIMDGDLALIRPQETAENGDIVVALIEDEATLKRFYREGDFIRLEPSNTNFAVIV
CHHHHHHCCCCEEEECCCCCCCCCCEEEEEECCCHHHHHHHHCCCEEEECCCCCCEEEEE
ISAKDVTIIGKAIKIVRDID
EECCCEEEEHHHHHHHHCCC
>Mature Secondary Structure
MEALSPRQKQVLEFIRGYVAQNEYPPSLRDIGNYIGVSGNTAVLSHLEALERKGHIRRDT
CCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCEECCC
GSSRRIVLIRDKQHEVLQIPIVGTVQAGIPTLAVESIEGYYPMEKMQLRGGTFFLRVKGD
CCCCEEEEEECCCCCEEEEEEEEEECCCCCEEEEECCCCCCCHHHEEECCCEEEEEECCC
SMINDAIMDGDLALIRPQETAENGDIVVALIEDEATLKRFYREGDFIRLEPSNTNFAVIV
CHHHHHHCCCCEEEECCCCCCCCCCEEEEEECCCHHHHHHHHCCCEEEECCCCCCEEEEE
ISAKDVTIIGKAIKIVRDID
EECCCEEEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA