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The map label for this gene is truD [H]

Identifier: 118580122

GI number: 118580122

Start: 1827501

End: 1828703

Strand: Direct

Name: truD [H]

Synonym: Ppro_1701

Alternate gene names: 118580122

Gene position: 1827501-1828703 (Clockwise)

Preceding gene: 118580121

Following gene: 118580123

Centisome position: 45.6

GC content: 63.76

Gene sequence:

>1203_bases
ATGTCCGAGCAGCGCTATCTGACCGCCCATCTGCCGGGGTGCGGCGGGGTCATCAAACAGTCTCCCGACGATTTCATTGT
CACGGAGATCCCGGCCTATGAGCCGTGCGGTTCCGGCGAGCACCTCTACCTGACCATCGAGAAGCGCGGCCTGACCACGC
TGGAGGCCATACGCCTGATCGCCCGCAGCTTAAGCCTGCCGGAGCGGGAGATCGGCTACGCCGGCATGAAGGACAGCGTC
GGCGTCACCCGCCAGACCATCTCCGTGCCCCGCATCCGGCCGGAGGAGGTTGCCGGACTCAGTCTGAAGGGGGTGCAACT
GATCTCGGCACTGCGTCATACCAACAAGCTTAAGCTGGGGCACCTGAAGGGCAACCGCTTCAACCTGGTCGTGCGCTCCG
TTAACGAAGGGGCTCTTGCGGCGGCATCGGCCATACTCAAGGTTCTCGTGGAGCGGGGAGTGCCCAACCGCTTCGGCTAC
CAGCGTTACGGTGTTCAGGGTAATTCCCATCTTATCGGCGCTGCCATGCTGCGGGGCGACTGGAAGGGGGCCGTGGATCT
GCTCATGGGGGATCCCCAGTTGCTGCGTGACGACCAGTGGCGATCCGCCATCCAGGCTTACCAGCGGGGAGACGTGGCTG
AGGCGCTGCGCCTGCTGCCCCGCCACTGCGACTGTGAACGGAGCGTGCTACAGCGTCTGGTTTCCCGGCCAGGCGCCTGG
GAAAAGGCTTTTGGCGCCGTCCACCCCCGCCTGAGGAAACTGTACCTCTCCGCCTATCAGTCCAGCCTCTTCGACCGGGT
CGTGGAAGAGCGACTCGACCGCATCGACCGGGTCATGGAGGGGGATCTGGCCTGGAAGCATGTCAACGGAGCCTGTTTCC
TGGTGGAGGATCAGGAACAGGAGCAGCCGCGGGCCGAGCGCTTCGAGATCTCCCCGAGCGGGCCGATGTTCGGCACGAAA
ATGATGCAGCCCCAAGGAGAGCCGCGTAACATGGAAGAGCGTATCCTGGCGGAGGAAGGGCTCACCCTCGATTCCTTCGG
GGCACAGAGCGGAGTCGCCATGGAGGGGCAGCGCAGGGCGTTGCGGGTGCCGCTGGGCAATCCTTCCTGCAGCCAGGAGG
GGAGTAGCCTGTGTCTGGAATTTTTCCTACCCAAGGGGAGTTACGCCACCTCGGTTCTGCGGGAGATAACCAAGAACTTC
TGA

Upstream 100 bases:

>100_bases
CGCAGCCTGAATCTCTCCACCTCGGCCGGCATCGTGCTCTACGAGGCGCTGCGCCAAGCCGGGCAGATCGTCTGACGAAA
CCATCTCCCTGGGGGTAACC

Downstream 100 bases:

>100_bases
AGCGATACGGATACCTGCCGGAACAGGAGTCTGGCATGAAGCCGGAACCGTGACACCTTACGGACTCATCTCGCTTTACA
TGCCTCAGTCCGGGCGCCCC

Product: pseudouridylate synthase

Products: NA

Alternate protein names: tRNA pseudouridylate synthase D; tRNA-uridine isomerase D [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MSEQRYLTAHLPGCGGVIKQSPDDFIVTEIPAYEPCGSGEHLYLTIEKRGLTTLEAIRLIARSLSLPEREIGYAGMKDSV
GVTRQTISVPRIRPEEVAGLSLKGVQLISALRHTNKLKLGHLKGNRFNLVVRSVNEGALAAASAILKVLVERGVPNRFGY
QRYGVQGNSHLIGAAMLRGDWKGAVDLLMGDPQLLRDDQWRSAIQAYQRGDVAEALRLLPRHCDCERSVLQRLVSRPGAW
EKAFGAVHPRLRKLYLSAYQSSLFDRVVEERLDRIDRVMEGDLAWKHVNGACFLVEDQEQEQPRAERFEISPSGPMFGTK
MMQPQGEPRNMEERILAEEGLTLDSFGAQSGVAMEGQRRALRVPLGNPSCSQEGSSLCLEFFLPKGSYATSVLREITKNF

Sequences:

>Translated_400_residues
MSEQRYLTAHLPGCGGVIKQSPDDFIVTEIPAYEPCGSGEHLYLTIEKRGLTTLEAIRLIARSLSLPEREIGYAGMKDSV
GVTRQTISVPRIRPEEVAGLSLKGVQLISALRHTNKLKLGHLKGNRFNLVVRSVNEGALAAASAILKVLVERGVPNRFGY
QRYGVQGNSHLIGAAMLRGDWKGAVDLLMGDPQLLRDDQWRSAIQAYQRGDVAEALRLLPRHCDCERSVLQRLVSRPGAW
EKAFGAVHPRLRKLYLSAYQSSLFDRVVEERLDRIDRVMEGDLAWKHVNGACFLVEDQEQEQPRAERFEISPSGPMFGTK
MMQPQGEPRNMEERILAEEGLTLDSFGAQSGVAMEGQRRALRVPLGNPSCSQEGSSLCLEFFLPKGSYATSVLREITKNF
>Mature_399_residues
SEQRYLTAHLPGCGGVIKQSPDDFIVTEIPAYEPCGSGEHLYLTIEKRGLTTLEAIRLIARSLSLPEREIGYAGMKDSVG
VTRQTISVPRIRPEEVAGLSLKGVQLISALRHTNKLKLGHLKGNRFNLVVRSVNEGALAAASAILKVLVERGVPNRFGYQ
RYGVQGNSHLIGAAMLRGDWKGAVDLLMGDPQLLRDDQWRSAIQAYQRGDVAEALRLLPRHCDCERSVLQRLVSRPGAWE
KAFGAVHPRLRKLYLSAYQSSLFDRVVEERLDRIDRVMEGDLAWKHVNGACFLVEDQEQEQPRAERFEISPSGPMFGTKM
MQPQGEPRNMEERILAEEGLTLDSFGAQSGVAMEGQRRALRVPLGNPSCSQEGSSLCLEFFLPKGSYATSVLREITKNF

Specific function: Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs [H]

COG id: COG0585

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRUD domain [H]

Homologues:

Organism=Homo sapiens, GI148762985, Length=410, Percent_Identity=25.8536585365854, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI148762961, Length=410, Percent_Identity=25.8536585365854, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI148762948, Length=410, Percent_Identity=25.8536585365854, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI50727002, Length=404, Percent_Identity=25, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1789102, Length=165, Percent_Identity=38.7878787878788, Blast_Score=109, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17557232, Length=393, Percent_Identity=26.972010178117, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324817, Length=254, Percent_Identity=31.496062992126, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21355799, Length=449, Percent_Identity=24.7216035634744, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR001656
- InterPro:   IPR020119
- InterPro:   IPR011760 [H]

Pfam domain/function: PF01142 TruD [H]

EC number: NA

Molecular weight: Translated: 44498; Mature: 44366

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS50984 TRUD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQRYLTAHLPGCGGVIKQSPDDFIVTEIPAYEPCGSGEHLYLTIEKRGLTTLEAIRLI
CCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCHHHHHHHHH
ARSLSLPEREIGYAGMKDSVGVTRQTISVPRIRPEEVAGLSLKGVQLISALRHTNKLKLG
HHHHCCCHHHCCCCCCCCCCCCCHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCEEEE
HLKGNRFNLVVRSVNEGALAAASAILKVLVERGVPNRFGYQRYGVQGNSHLIGAAMLRGD
EECCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCEEEHHHHHCC
WKGAVDLLMGDPQLLRDDQWRSAIQAYQRGDVAEALRLLPRHCDCERSVLQRLVSRPGAW
CCCHHHHHCCCHHHHCCHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCH
EKAFGAVHPRLRKLYLSAYQSSLFDRVVEERLDRIDRVMEGDLAWKHVNGACFLVEDQEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCHH
EQPRAERFEISPSGPMFGTKMMQPQGEPRNMEERILAEEGLTLDSFGAQSGVAMEGQRRA
CCCHHHCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCCCCEECCCCCE
LRVPLGNPSCSQEGSSLCLEFFLPKGSYATSVLREITKNF
EEECCCCCCCCCCHHHEEEEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEQRYLTAHLPGCGGVIKQSPDDFIVTEIPAYEPCGSGEHLYLTIEKRGLTTLEAIRLI
CCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCHHHHHHHHH
ARSLSLPEREIGYAGMKDSVGVTRQTISVPRIRPEEVAGLSLKGVQLISALRHTNKLKLG
HHHHCCCHHHCCCCCCCCCCCCCHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCEEEE
HLKGNRFNLVVRSVNEGALAAASAILKVLVERGVPNRFGYQRYGVQGNSHLIGAAMLRGD
EECCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCEEEHHHHHCC
WKGAVDLLMGDPQLLRDDQWRSAIQAYQRGDVAEALRLLPRHCDCERSVLQRLVSRPGAW
CCCHHHHHCCCHHHHCCHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCH
EKAFGAVHPRLRKLYLSAYQSSLFDRVVEERLDRIDRVMEGDLAWKHVNGACFLVEDQEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCHH
EQPRAERFEISPSGPMFGTKMMQPQGEPRNMEERILAEEGLTLDSFGAQSGVAMEGQRRA
CCCHHHCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCCCCEECCCCCE
LRVPLGNPSCSQEGSSLCLEFFLPKGSYATSVLREITKNF
EEECCCCCCCCCCHHHEEEEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA