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The map label for this gene is pyrF

Identifier: 118580098

GI number: 118580098

Start: 1795164

End: 1795886

Strand: Direct

Name: pyrF

Synonym: Ppro_1676

Alternate gene names: 118580098

Gene position: 1795164-1795886 (Clockwise)

Preceding gene: 118580097

Following gene: 118580099

Centisome position: 44.79

GC content: 63.35

Gene sequence:

>723_bases
ATGAATCGCGATGAAGCGCGGAAAAAAATAATCTTTGCCCTGGATGTGAACGGCATAGCTGAGATCGACCGCTATGCCGG
GCTGCTTTCGGACAGGGTGGGGATGTTCAAGATCGGCAAGGAACTGTTCACCGCCTGCGGACCGGAGGCGGTCGCCACCG
TGCGGCGCCATGGCGGCCAGGTGTTTCTGGACCTGAAGTACCACGACATTCCCAACACGGTGGCCAAGGCAATGTTGGAG
GCAGCCCGCCTGGGTGTCCAGTTGGCCAACCTGCATGCTTTGGGCGGTCTGGAGATGATGGAGACCGCTGCCAGCGCGGT
GCGTCGCGAGTTCGGCGATGACCGTCCCCGACTGCTGGCGGTGACCATCCTGACCTCTTCAACTGCCGAGACCCTGCGAC
GGGTGGGGATCGATCACCCCGTGGAAGAGATGGTGGTCCGGCTGGCTTGTCTGGCCCGGGAGGCGGGCATGGACGGCGTG
GTCGCCTCGCCGCGGGAGATCGGTCTGATCCGCCAGGCCTGTGGCCCCGACTTCCTGATCGTCACCCCCGGCGTTCGCCC
CTCCTTTGCCTCCCAGGATGACCAGAAACGGATCATGAGTCCGGACGATGCCGTCAGAGAGGGGGCCGATTATCTGGTAA
TCGGGCGCCCCATCGCAAAGGCGGACGATCCGGTCCGTGCCGTTGATATGATCGTGGACGAGATCGTTGCGGGGTGCCCA
TGA

Upstream 100 bases:

>100_bases
GGGCCCGGCTTTAGGCACGGAATGAATGAGTAGTATCCAACATGCCGTATAAACAGAGTTTGTTTGAATCAATCGGGCCT
ACGGGGCTCATGGGGCGTGT

Downstream 100 bases:

>100_bases
GAGAGGAACTGGTATTTGGCGTCAATCCGGTTCGGGAGGCGCTGCGCGGCAAACGTGAAATCTTCGGGTTGTACGTTCAG
TCAACGGCCACGGACCACCG

Product: orotidine 5'-phosphate decarboxylase

Products: NA

Alternate protein names: OMP decarboxylase; OMPDCase; OMPdecase

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MNRDEARKKIIFALDVNGIAEIDRYAGLLSDRVGMFKIGKELFTACGPEAVATVRRHGGQVFLDLKYHDIPNTVAKAMLE
AARLGVQLANLHALGGLEMMETAASAVRREFGDDRPRLLAVTILTSSTAETLRRVGIDHPVEEMVVRLACLAREAGMDGV
VASPREIGLIRQACGPDFLIVTPGVRPSFASQDDQKRIMSPDDAVREGADYLVIGRPIAKADDPVRAVDMIVDEIVAGCP

Sequences:

>Translated_240_residues
MNRDEARKKIIFALDVNGIAEIDRYAGLLSDRVGMFKIGKELFTACGPEAVATVRRHGGQVFLDLKYHDIPNTVAKAMLE
AARLGVQLANLHALGGLEMMETAASAVRREFGDDRPRLLAVTILTSSTAETLRRVGIDHPVEEMVVRLACLAREAGMDGV
VASPREIGLIRQACGPDFLIVTPGVRPSFASQDDQKRIMSPDDAVREGADYLVIGRPIAKADDPVRAVDMIVDEIVAGCP
>Mature_240_residues
MNRDEARKKIIFALDVNGIAEIDRYAGLLSDRVGMFKIGKELFTACGPEAVATVRRHGGQVFLDLKYHDIPNTVAKAMLE
AARLGVQLANLHALGGLEMMETAASAVRREFGDDRPRLLAVTILTSSTAETLRRVGIDHPVEEMVVRLACLAREAGMDGV
VASPREIGLIRQACGPDFLIVTPGVRPSFASQDDQKRIMSPDDAVREGADYLVIGRPIAKADDPVRAVDMIVDEIVAGCP

Specific function: Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)

COG id: COG0284

COG function: function code F; Orotidine-5'-phosphate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the OMP decarboxylase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1787537, Length=230, Percent_Identity=41.304347826087, Blast_Score=167, Evalue=4e-43,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PYRF_PELPD (A1APM0)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_901348.1
- ProteinModelPortal:   A1APM0
- STRING:   A1APM0
- GeneID:   4572627
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_1676
- eggNOG:   COG0284
- HOGENOM:   HBG625253
- OMA:   TVHAYPQ
- PhylomeDB:   A1APM0
- ProtClustDB:   CLSK828364
- HAMAP:   MF_01200_B
- InterPro:   IPR013785
- InterPro:   IPR014732
- InterPro:   IPR018089
- InterPro:   IPR001754
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00934
- TIGRFAMs:   TIGR01740

Pfam domain/function: PF00215 OMPdecase; SSF51366 RibP_bind_barrel

EC number: =4.1.1.23

Molecular weight: Translated: 25989; Mature: 25989

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00156 OMPDECASE

Important sites: ACT_SITE 66-66 BINDING 15-15 BINDING 37-37 BINDING 125-125 BINDING 186-186 BINDING 195-195 BINDING 215-215 BINDING 216-216

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRDEARKKIIFALDVNGIAEIDRYAGLLSDRVGMFKIGKELFTACGPEAVATVRRHGGQ
CCHHHHHHEEEEEECCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHCCCE
VFLDLKYHDIPNTVAKAMLEAARLGVQLANLHALGGLEMMETAASAVRREFGDDRPRLLA
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEE
VTILTSSTAETLRRVGIDHPVEEMVVRLACLAREAGMDGVVASPREIGLIRQACGPDFLI
EEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEE
VTPGVRPSFASQDDQKRIMSPDDAVREGADYLVIGRPIAKADDPVRAVDMIVDEIVAGCP
ECCCCCCCCCCCCCHHHCCCCCHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNRDEARKKIIFALDVNGIAEIDRYAGLLSDRVGMFKIGKELFTACGPEAVATVRRHGGQ
CCHHHHHHEEEEEECCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHCCCE
VFLDLKYHDIPNTVAKAMLEAARLGVQLANLHALGGLEMMETAASAVRREFGDDRPRLLA
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEE
VTILTSSTAETLRRVGIDHPVEEMVVRLACLAREAGMDGVVASPREIGLIRQACGPDFLI
EEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEE
VTPGVRPSFASQDDQKRIMSPDDAVREGADYLVIGRPIAKADDPVRAVDMIVDEIVAGCP
ECCCCCCCCCCCCCHHHCCCCCHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA