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The map label for this gene is trpE [H]

Identifier: 118580005

GI number: 118580005

Start: 1689263

End: 1690738

Strand: Reverse

Name: trpE [H]

Synonym: Ppro_1582

Alternate gene names: 118580005

Gene position: 1690738-1689263 (Counterclockwise)

Preceding gene: 118580017

Following gene: 118580004

Centisome position: 42.18

GC content: 63.28

Gene sequence:

>1476_bases
ATGGCCTGCCCCGATTTTACTACATTCCTGGAATTATCAAGCCGCGGCAACCTGATACCGGTATACCGGGAGATCATGGC
GGATATGGACACCCCCGTCAGCGCCTTCAGAAAGCTGGATGACGGCCGTTTTTCCTTTCTGCTGGAGAGTATCGAGGGTG
GTGAAAAATGGGCGCGCTACAGTTTTCTCGGCTCCACCCCCTCCATGATCGTCCGCTCCAAGGGGAGTTGCGTGGAAATC
ATCGAGGACGGCGTGACCACCACCCTGTCCAGTGACGACCCACTGAGATGCGTCCGTGATGTGATGGCCCGCTTCACCCC
CGTGGAGGTGGAGGGACTGCCGCGCTTCTTCGGCGGCGCGGTCGGCTACCTGGGCTACGACATGGTGCGACACTTCGAGC
ATCTGCCGACCACGAAACCGGCTGTCATCGACGCCTACGACACCTACCTCTTAATAACCGACACCATCGTGATCTTCGAC
ACCATGAGCCAGAAGATAAAGGTGGTCTCCAACGCCCATGTCAGCCAGGGCAAATCCCCCCGCCAGGCCTATGACGAGGC
CATCGCCAACATAGAGTCCATCGTGAAGCGGCTGCGCATGCCCCTACCGGACATGACCGTGCCCCCCAGTGCCCGGCGAA
CGGAACTGCGCTCCAACATCAGCCGGGAGGAGTACGAGGCAGGCGTTGAAAAAGCCAAGGAGTACATCCGGGCCGGCGAC
ATCATCCAGGTCGTCCCCTCCCAGCGCTTCAGCGGAAAACTGGAGGCCGACCCCTTCGACGTCTACCGGGTCATGCGCAC
CCTCAACCCCTCCCCCTACATGTTCTTCCTGCGTCTTGACGGCACCATCATCGCCGGCGCCTCGCCGGAAGTCATGGTGC
GCAAGGAGGGGACCGGCGTGGAACTGCGTCCCATCGCCGGCACCCGCCCGCGGGGCGTCAGCGGCGAGGAGGACATCCGC
CTGGCGGAGGAACTTTTGGCCGACCCCAAGGAGCGGGCCGAACATGTCATGCTGGTTGACCTGGGCAGGAACGACCTGGG
CAGGGTCTGCGAGACCGGCAGCGTGAAGGTGTCCGAGCTGATGGTCATCGAACGCTACTCCCACGTCATGCACATCGTCT
CCAACGTGCAGGGAGAGCTGAAGCCGGAGAGCGACGCCTTCGACCTGGTGCGGGCAACGCTTCCGGCCGGCACCCTCTCG
GGGGCGCCCAAGATCAGGGCCATGCAGATCATCGACGAACTGGAGCCGGTGCGCCGGGAAGTCTACGGCGGCGCGGTGGG
GTACTTCTCCTTCTCCGGCAACATGGACTTGGCCATCACCATCCGCACCCTGGTGATCAAGGACGGCATGGTACACCTGC
AGGCCGGCGGCGGCGTGGTGGCAGACTCGGACCCGGCCGCGGAGTGGCAGGAGACTGTCAACAAGGCCATGGCCGCGCGA
CGGGCCATCGAGATCGCCGAGGGAGGGCTGGAATAA

Upstream 100 bases:

>100_bases
TAAAAAGGACCGTAAACGTGCCGTGGCGGCCATCCTTGACAGGCCATCACGCCTATGCTAGCTTGTAAACCCTTTGCAAT
TTCAAATCTTTGGAGTCAGC

Downstream 100 bases:

>100_bases
AATGCTTTTGATGATCGACAACTACGACTCCTTCACCTTCAACATCGTCCAGTACTTCGGTCAACTGGGTGAAAATGTGC
GGGTGCACCGCAACGACAAA

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MACPDFTTFLELSSRGNLIPVYREIMADMDTPVSAFRKLDDGRFSFLLESIEGGEKWARYSFLGSTPSMIVRSKGSCVEI
IEDGVTTTLSSDDPLRCVRDVMARFTPVEVEGLPRFFGGAVGYLGYDMVRHFEHLPTTKPAVIDAYDTYLLITDTIVIFD
TMSQKIKVVSNAHVSQGKSPRQAYDEAIANIESIVKRLRMPLPDMTVPPSARRTELRSNISREEYEAGVEKAKEYIRAGD
IIQVVPSQRFSGKLEADPFDVYRVMRTLNPSPYMFFLRLDGTIIAGASPEVMVRKEGTGVELRPIAGTRPRGVSGEEDIR
LAEELLADPKERAEHVMLVDLGRNDLGRVCETGSVKVSELMVIERYSHVMHIVSNVQGELKPESDAFDLVRATLPAGTLS
GAPKIRAMQIIDELEPVRREVYGGAVGYFSFSGNMDLAITIRTLVIKDGMVHLQAGGGVVADSDPAAEWQETVNKAMAAR
RAIEIAEGGLE

Sequences:

>Translated_491_residues
MACPDFTTFLELSSRGNLIPVYREIMADMDTPVSAFRKLDDGRFSFLLESIEGGEKWARYSFLGSTPSMIVRSKGSCVEI
IEDGVTTTLSSDDPLRCVRDVMARFTPVEVEGLPRFFGGAVGYLGYDMVRHFEHLPTTKPAVIDAYDTYLLITDTIVIFD
TMSQKIKVVSNAHVSQGKSPRQAYDEAIANIESIVKRLRMPLPDMTVPPSARRTELRSNISREEYEAGVEKAKEYIRAGD
IIQVVPSQRFSGKLEADPFDVYRVMRTLNPSPYMFFLRLDGTIIAGASPEVMVRKEGTGVELRPIAGTRPRGVSGEEDIR
LAEELLADPKERAEHVMLVDLGRNDLGRVCETGSVKVSELMVIERYSHVMHIVSNVQGELKPESDAFDLVRATLPAGTLS
GAPKIRAMQIIDELEPVRREVYGGAVGYFSFSGNMDLAITIRTLVIKDGMVHLQAGGGVVADSDPAAEWQETVNKAMAAR
RAIEIAEGGLE
>Mature_490_residues
ACPDFTTFLELSSRGNLIPVYREIMADMDTPVSAFRKLDDGRFSFLLESIEGGEKWARYSFLGSTPSMIVRSKGSCVEII
EDGVTTTLSSDDPLRCVRDVMARFTPVEVEGLPRFFGGAVGYLGYDMVRHFEHLPTTKPAVIDAYDTYLLITDTIVIFDT
MSQKIKVVSNAHVSQGKSPRQAYDEAIANIESIVKRLRMPLPDMTVPPSARRTELRSNISREEYEAGVEKAKEYIRAGDI
IQVVPSQRFSGKLEADPFDVYRVMRTLNPSPYMFFLRLDGTIIAGASPEVMVRKEGTGVELRPIAGTRPRGVSGEEDIRL
AEELLADPKERAEHVMLVDLGRNDLGRVCETGSVKVSELMVIERYSHVMHIVSNVQGELKPESDAFDLVRATLPAGTLSG
APKIRAMQIIDELEPVRREVYGGAVGYFSFSGNMDLAITIRTLVIKDGMVHLQAGGGVVADSDPAAEWQETVNKAMAARR
AIEIAEGGLE

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=469, Percent_Identity=36.0341151385927, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI1787518, Length=418, Percent_Identity=39.7129186602871, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI1786809, Length=205, Percent_Identity=33.6585365853659, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI87082077, Length=225, Percent_Identity=29.3333333333333, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320935, Length=503, Percent_Identity=41.5506958250497, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6324361, Length=403, Percent_Identity=25.0620347394541, Blast_Score=112, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54221; Mature: 54090

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACPDFTTFLELSSRGNLIPVYREIMADMDTPVSAFRKLDDGRFSFLLESIEGGEKWARY
CCCCCHHHHHHHHCCCCEEHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHCCCHHHHHE
SFLGSTPSMIVRSKGSCVEIIEDGVTTTLSSDDPLRCVRDVMARFTPVEVEGLPRFFGGA
EECCCCHHHHEECCCCCHHHHHCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHH
VGYLGYDMVRHFEHLPTTKPAVIDAYDTYLLITDTIVIFDTMSQKIKVVSNAHVSQGKSP
HHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEHHHHEEHHHHHHHHHHHCCHHCCCCCH
RQAYDEAIANIESIVKRLRMPLPDMTVPPSARRTELRSNISREEYEAGVEKAKEYIRAGD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
IIQVVPSQRFSGKLEADPFDVYRVMRTLNPSPYMFFLRLDGTIIAGASPEVMVRKEGTGV
EEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCEEEECCCCCEEEEECCCCE
ELRPIAGTRPRGVSGEEDIRLAEELLADPKERAEHVMLVDLGRNDLGRVCETGSVKVSEL
EEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHCCEEEEEECCCCCHHHHHCCCCEEHHHH
MVIERYSHVMHIVSNVQGELKPESDAFDLVRATLPAGTLSGAPKIRAMQIIDELEPVRRE
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
VYGGAVGYFSFSGNMDLAITIRTLVIKDGMVHLQAGGGVVADSDPAAEWQETVNKAMAAR
HHCCEEEEEEECCCCEEEEEEEEEEEECCEEEEECCCCEEECCCCHHHHHHHHHHHHHHH
RAIEIAEGGLE
HHHHHHCCCCC
>Mature Secondary Structure 
ACPDFTTFLELSSRGNLIPVYREIMADMDTPVSAFRKLDDGRFSFLLESIEGGEKWARY
CCCCHHHHHHHHCCCCEEHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHCCCHHHHHE
SFLGSTPSMIVRSKGSCVEIIEDGVTTTLSSDDPLRCVRDVMARFTPVEVEGLPRFFGGA
EECCCCHHHHEECCCCCHHHHHCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHH
VGYLGYDMVRHFEHLPTTKPAVIDAYDTYLLITDTIVIFDTMSQKIKVVSNAHVSQGKSP
HHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEHHHHEEHHHHHHHHHHHCCHHCCCCCH
RQAYDEAIANIESIVKRLRMPLPDMTVPPSARRTELRSNISREEYEAGVEKAKEYIRAGD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
IIQVVPSQRFSGKLEADPFDVYRVMRTLNPSPYMFFLRLDGTIIAGASPEVMVRKEGTGV
EEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCEEEECCCCCEEEEECCCCE
ELRPIAGTRPRGVSGEEDIRLAEELLADPKERAEHVMLVDLGRNDLGRVCETGSVKVSEL
EEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHCCEEEEEECCCCCHHHHHCCCCEEHHHH
MVIERYSHVMHIVSNVQGELKPESDAFDLVRATLPAGTLSGAPKIRAMQIIDELEPVRRE
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
VYGGAVGYFSFSGNMDLAITIRTLVIKDGMVHLQAGGGVVADSDPAAEWQETVNKAMAAR
HHCCEEEEEEECCCCEEEEEEEEEEEECCEEEEECCCCEEECCCCHHHHHHHHHHHHHHH
RAIEIAEGGLE
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]