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The map label for this gene is lexA1 [H]

Identifier: 118579995

GI number: 118579995

Start: 1677350

End: 1678003

Strand: Direct

Name: lexA1 [H]

Synonym: Ppro_1572

Alternate gene names: 118579995

Gene position: 1677350-1678003 (Clockwise)

Preceding gene: 118579994

Following gene: 118579996

Centisome position: 41.85

GC content: 62.54

Gene sequence:

>654_bases
ATGGAGCCGCTCTCACCCCGTCAGAAAGACGTCCTGGATTTCCTCAGGGAGTTCCTGGACAGTAACGGCTATCCCCCCAC
GCTGCGGGAAATTGCCCGTCACCTGGATATCAGCGGCACGGTGGCGGTCGTGCGCCACCTGGAGGCGCTGGAGAAAAAGG
GGTGGATCAGGCGCCAGCCGGGCGCGTTCCGCTCCATCAGCCTGGTGGCTGAAAAGGCCGTCCTCTATCCCCTGGATGAG
GAGGGGATCTTCGCTGCCGACCAGCTCCCCGTGTCGCTGCCCATCGTGGGGACGGTGCGGGCCGGCACTCCGGAGATCCC
CCGGGAAGACATCGAAGGGTACCTCTCCCTGGACAGGAACATTGTTGCCAGTGGCGGCAGTTTTTTTCTGCGCATCAAGG
GTGATTCCATGAAGAACGCCGGCATGCTCCCCGGTGACCTGGTATTGATCCGCCCCCAGCCCACGGCTGACAACGGTGAC
GTGGTGGTGGCCCTGGTGGATGGCGAAGCCACAGTCAAACGCTTCTTCCGCGAGGAAGAGATGATCAGGCTTCAGCCCGA
GAATGAACTGCTGGAACCGATCCTGATCGCTGACGACAGCGCCGACGTCACCGTCATCGGCAAGGTGGTCTCCCTCTTCC
GGCCAACGGTCTGA

Upstream 100 bases:

>100_bases
TGAAGTAATCGCCCTGAACCGCCGCCATCTTGACACTCCCCCCTTGTTGGTGTTATGGTGACACTTGTAACCTATTACAA
GTGTAAACGGAGTATCACCC

Downstream 100 bases:

>100_bases
ATCCCATGCAGCGACACCAGACCCGTGAACAGATACGCGTGGCGGTCATCTTCGGCGCGAACGGCAGGATCCAGCCGGTC
TGGTTCGAGTGGCGTCGCCG

Product: SOS-response transcriptional repressor LexA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MEPLSPRQKDVLDFLREFLDSNGYPPTLREIARHLDISGTVAVVRHLEALEKKGWIRRQPGAFRSISLVAEKAVLYPLDE
EGIFAADQLPVSLPIVGTVRAGTPEIPREDIEGYLSLDRNIVASGGSFFLRIKGDSMKNAGMLPGDLVLIRPQPTADNGD
VVVALVDGEATVKRFFREEEMIRLQPENELLEPILIADDSADVTVIGKVVSLFRPTV

Sequences:

>Translated_217_residues
MEPLSPRQKDVLDFLREFLDSNGYPPTLREIARHLDISGTVAVVRHLEALEKKGWIRRQPGAFRSISLVAEKAVLYPLDE
EGIFAADQLPVSLPIVGTVRAGTPEIPREDIEGYLSLDRNIVASGGSFFLRIKGDSMKNAGMLPGDLVLIRPQPTADNGD
VVVALVDGEATVKRFFREEEMIRLQPENELLEPILIADDSADVTVIGKVVSLFRPTV
>Mature_217_residues
MEPLSPRQKDVLDFLREFLDSNGYPPTLREIARHLDISGTVAVVRHLEALEKKGWIRRQPGAFRSISLVAEKAVLYPLDE
EGIFAADQLPVSLPIVGTVRAGTPEIPREDIEGYLSLDRNIVASGGSFFLRIKGDSMKNAGMLPGDLVLIRPQPTADNGD
VVVALVDGEATVKRFFREEEMIRLQPENELLEPILIADDSADVTVIGKVVSLFRPTV

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=214, Percent_Identity=35.981308411215, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1787431, Length=107, Percent_Identity=33.6448598130841, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 23941; Mature: 23941

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPLSPRQKDVLDFLREFLDSNGYPPTLREIARHLDISGTVAVVRHLEALEKKGWIRRQP
CCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
GAFRSISLVAEKAVLYPLDEEGIFAADQLPVSLPIVGTVRAGTPEIPREDIEGYLSLDRN
CCCHHHHHHHHHHEEEECCCCCEEEECCCCEECCEEEEECCCCCCCCHHHHHHHHHCCCE
IVASGGSFFLRIKGDSMKNAGMLPGDLVLIRPQPTADNGDVVVALVDGEATVKRFFREEE
EEECCCEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHCC
MIRLQPENELLEPILIADDSADVTVIGKVVSLFRPTV
EEEECCCHHHHCEEEEECCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MEPLSPRQKDVLDFLREFLDSNGYPPTLREIARHLDISGTVAVVRHLEALEKKGWIRRQP
CCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
GAFRSISLVAEKAVLYPLDEEGIFAADQLPVSLPIVGTVRAGTPEIPREDIEGYLSLDRN
CCCHHHHHHHHHHEEEECCCCCEEEECCCCEECCEEEEECCCCCCCCHHHHHHHHHCCCE
IVASGGSFFLRIKGDSMKNAGMLPGDLVLIRPQPTADNGDVVVALVDGEATVKRFFREEE
EEECCCEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHCC
MIRLQPENELLEPILIADDSADVTVIGKVVSLFRPTV
EEEECCCHHHHCEEEEECCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA