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The map label for this gene is ipdC [H]

Identifier: 118579994

GI number: 118579994

Start: 1675620

End: 1677257

Strand: Direct

Name: ipdC [H]

Synonym: Ppro_1571

Alternate gene names: 118579994

Gene position: 1675620-1677257 (Clockwise)

Preceding gene: 118579993

Following gene: 118579995

Centisome position: 41.81

GC content: 60.26

Gene sequence:

>1638_bases
ATGGAACCTGCTGAAACAACGATCGGAGAATATCTCATTCACAGGCTGTATCAGCTCCGGGTGCAGCATGCATTTGGCAT
TCCGGGCGATTACGTGCTTGGCTTTTACAAGCAACTGGACGAGAGCCGCATCAAAATCATCAACACCTGTGATGAGCAGG
GCGCAGGCTTTGCGGCTACCGCCTATGCCCGCGTGCGCGGTCTGGGGGCTGTCTGCGTTACCTATGGCGTGGGAGGGCTG
AAGGTGGTGAATACCACCGCCCAGGCCTATGCCGAAGAGACCGCGGTGGTTGTGATCAGCGGGGCGCCGGGCGTCAGGGA
ACAGGCGGGGAACCCGTTGCTGCACCACAAGGTCAAGGAGTTCGATACCCAGCTGAAAGTATTCCAACAGCTTACCGTCG
CCCAGACCGTGCTGGACAACCCGGCAACGGCCTGCCGGGAGATCAACCGGGTACTGGGTGCCGCACTCTGCTACAGACGC
CCGGTCTACATCGAACTTCCCCGCGACATGGTGACTGTAAAGATTGTCCCGCAGGAGGAACCGCTGCAACCGCCCGATGT
GGACAGGGAGCCGTTCAGGGAGGCTTCGCGGGAAGCGGTGGACATGATCAACGCGGCCACACAGCCGGTCATCGTGGCCG
GCGTGGAATTGCTGCGCTACGGGATGCACCACCACCTGCAGGAGTTGGTGGAAAAAACGAATATTCCGGTCACCTCGACC
CTCCTGGGCAAGTCGGCCATGGGCGAGCGCCATCCAGGGTACATCGGACTGTACGAAGGAGGATTGAGCCGGGAGGATAT
CAGGCAGTATGTGGAGAGCAGTGACTGCATCGTTCTCTTGGGGGTTCTCCTGACCGACCTGGACTTGGGGATCTTTACCG
CCCATCTCGACCAGGGGAAATCCATCCATGCCACTAGCGAAAAGACCTCCATCCGCCATCACACCTATCCCGGAGTCTAT
CTCAACGGTTTTCTGCTGGGACTTTTACAGGCCGATATCCGGCGCCGGGAGACCTGCGAGACACCCCATGCGCCTGCGCC
GACCCCATTCCACCCTGCCCCCGATACCAGGATCACGGTGGAGCGTCTGTTCCAGCGCCTGGAAACGTTTTTCGACGACA
GCACGTTCGTCATCGCCGATACGGGCGATGCGTTGTTTGCGGCGGCGGATATCTCCATTCCCCGGGCAGCGGAATTCATG
TCTTCGGCTTATTACGCTTCCCTGGGGTTTGCGGTCCCCGCCAGTCTCGGGGTCCAACTGGCGCTCCCCACCCTGCGCCC
GCTGGTTCTGGTCGGCGACGGGGCCTTTCAGATGACCGGGATGGAAGTCGCGACCGCCGCCCGCTACCACCTCAATCCGA
TCATCATCGTGCTGAACAATTCGGGCTATGGGACTGAGAGGCCGATGCTGGACGGCAGCTTCAACGATGTGTATCCATGG
CGCTACGCGCGCCTCCCCGAGCTGCTTGGCGCCGGCAGAGGTTTCGACGTTCAGACGGAAGAGCAGCTTGAAGTTGCTCT
GGAAGCGGCCCGCGGCTACCGTGACGGCTTTTGCATCCTGGATGTTCGGCTTGATCCATACGATTTCTCCCCTGCGTTAC
GGCGAATGACCAGCGTCCTGGGGAAAAAGGTGAAGTAA

Upstream 100 bases:

>100_bases
GGGGTAGCGTGTTTGCCAAACAGGAAAACATGACTGATTGCATGTGCACACATACGTGGGATTGAGTGTGGCTTGTTCAC
CTTCTTTTGGAGGAATTGCC

Downstream 100 bases:

>100_bases
TCGCCCTGAACCGCCGCCATCTTGACACTCCCCCCTTGTTGGTGTTATGGTGACACTTGTAACCTATTACAAGTGTAAAC
GGAGTATCACCCATGGAGCC

Product: thiamine pyrophosphate binding domain-containing protein

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MEPAETTIGEYLIHRLYQLRVQHAFGIPGDYVLGFYKQLDESRIKIINTCDEQGAGFAATAYARVRGLGAVCVTYGVGGL
KVVNTTAQAYAEETAVVVISGAPGVREQAGNPLLHHKVKEFDTQLKVFQQLTVAQTVLDNPATACREINRVLGAALCYRR
PVYIELPRDMVTVKIVPQEEPLQPPDVDREPFREASREAVDMINAATQPVIVAGVELLRYGMHHHLQELVEKTNIPVTST
LLGKSAMGERHPGYIGLYEGGLSREDIRQYVESSDCIVLLGVLLTDLDLGIFTAHLDQGKSIHATSEKTSIRHHTYPGVY
LNGFLLGLLQADIRRRETCETPHAPAPTPFHPAPDTRITVERLFQRLETFFDDSTFVIADTGDALFAAADISIPRAAEFM
SSAYYASLGFAVPASLGVQLALPTLRPLVLVGDGAFQMTGMEVATAARYHLNPIIIVLNNSGYGTERPMLDGSFNDVYPW
RYARLPELLGAGRGFDVQTEEQLEVALEAARGYRDGFCILDVRLDPYDFSPALRRMTSVLGKKVK

Sequences:

>Translated_545_residues
MEPAETTIGEYLIHRLYQLRVQHAFGIPGDYVLGFYKQLDESRIKIINTCDEQGAGFAATAYARVRGLGAVCVTYGVGGL
KVVNTTAQAYAEETAVVVISGAPGVREQAGNPLLHHKVKEFDTQLKVFQQLTVAQTVLDNPATACREINRVLGAALCYRR
PVYIELPRDMVTVKIVPQEEPLQPPDVDREPFREASREAVDMINAATQPVIVAGVELLRYGMHHHLQELVEKTNIPVTST
LLGKSAMGERHPGYIGLYEGGLSREDIRQYVESSDCIVLLGVLLTDLDLGIFTAHLDQGKSIHATSEKTSIRHHTYPGVY
LNGFLLGLLQADIRRRETCETPHAPAPTPFHPAPDTRITVERLFQRLETFFDDSTFVIADTGDALFAAADISIPRAAEFM
SSAYYASLGFAVPASLGVQLALPTLRPLVLVGDGAFQMTGMEVATAARYHLNPIIIVLNNSGYGTERPMLDGSFNDVYPW
RYARLPELLGAGRGFDVQTEEQLEVALEAARGYRDGFCILDVRLDPYDFSPALRRMTSVLGKKVK
>Mature_545_residues
MEPAETTIGEYLIHRLYQLRVQHAFGIPGDYVLGFYKQLDESRIKIINTCDEQGAGFAATAYARVRGLGAVCVTYGVGGL
KVVNTTAQAYAEETAVVVISGAPGVREQAGNPLLHHKVKEFDTQLKVFQQLTVAQTVLDNPATACREINRVLGAALCYRR
PVYIELPRDMVTVKIVPQEEPLQPPDVDREPFREASREAVDMINAATQPVIVAGVELLRYGMHHHLQELVEKTNIPVTST
LLGKSAMGERHPGYIGLYEGGLSREDIRQYVESSDCIVLLGVLLTDLDLGIFTAHLDQGKSIHATSEKTSIRHHTYPGVY
LNGFLLGLLQADIRRRETCETPHAPAPTPFHPAPDTRITVERLFQRLETFFDDSTFVIADTGDALFAAADISIPRAAEFM
SSAYYASLGFAVPASLGVQLALPTLRPLVLVGDGAFQMTGMEVATAARYHLNPIIIVLNNSGYGTERPMLDGSFNDVYPW
RYARLPELLGAGRGFDVQTEEQLEVALEAARGYRDGFCILDVRLDPYDFSPALRRMTSVLGKKVK

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1790104, Length=555, Percent_Identity=25.045045045045, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI87081685, Length=558, Percent_Identity=23.4767025089606, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI1786717, Length=479, Percent_Identity=23.7995824634656, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6323163, Length=508, Percent_Identity=31.8897637795276, Blast_Score=253, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6321524, Length=510, Percent_Identity=31.3725490196078, Blast_Score=252, Evalue=9e-68,
Organism=Saccharomyces cerevisiae, GI6323073, Length=507, Percent_Identity=31.7554240631164, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6320123, Length=514, Percent_Identity=26.2645914396887, Blast_Score=216, Evalue=9e-57,
Organism=Saccharomyces cerevisiae, GI6320588, Length=610, Percent_Identity=26.0655737704918, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6323755, Length=578, Percent_Identity=24.0484429065744, Blast_Score=106, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017765
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 60032; Mature: 60032

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPAETTIGEYLIHRLYQLRVQHAFGIPGDYVLGFYKQLDESRIKIINTCDEQGAGFAAT
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHH
AYARVRGLGAVCVTYGVGGLKVVNTTAQAYAEETAVVVISGAPGVREQAGNPLLHHKVKE
HHHHHHCCHHHHHHHCCCCEEEEEHHHHHHHCCCEEEEEECCCCCHHHCCCCHHHHHHHH
FDTQLKVFQQLTVAQTVLDNPATACREINRVLGAALCYRRPVYIELPRDMVTVKIVPQEE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEECCCC
PLQPPDVDREPFREASREAVDMINAATQPVIVAGVELLRYGMHHHLQELVEKTNIPVTST
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHH
LLGKSAMGERHPGYIGLYEGGLSREDIRQYVESSDCIVLLGVLLTDLDLGIFTAHLDQGK
HHCHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHEEEECCCCC
SIHATSEKTSIRHHTYPGVYLNGFLLGLLQADIRRRETCETPHAPAPTPFHPAPDTRITV
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHH
ERLFQRLETFFDDSTFVIADTGDALFAAADISIPRAAEFMSSAYYASLGFAVPASLGVQL
HHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCHHHCCCEE
ALPTLRPLVLVGDGAFQMTGMEVATAARYHLNPIIIVLNNSGYGTERPMLDGSFNDVYPW
ECCCCCCEEEEECCCEEECCHHHHHHHHEECCEEEEEECCCCCCCCCCCCCCCCCCCCCC
RYARLPELLGAGRGFDVQTEEQLEVALEAARGYRDGFCILDVRLDPYDFSPALRRMTSVL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHH
GKKVK
CCCCC
>Mature Secondary Structure
MEPAETTIGEYLIHRLYQLRVQHAFGIPGDYVLGFYKQLDESRIKIINTCDEQGAGFAAT
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHH
AYARVRGLGAVCVTYGVGGLKVVNTTAQAYAEETAVVVISGAPGVREQAGNPLLHHKVKE
HHHHHHCCHHHHHHHCCCCEEEEEHHHHHHHCCCEEEEEECCCCCHHHCCCCHHHHHHHH
FDTQLKVFQQLTVAQTVLDNPATACREINRVLGAALCYRRPVYIELPRDMVTVKIVPQEE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEECCCC
PLQPPDVDREPFREASREAVDMINAATQPVIVAGVELLRYGMHHHLQELVEKTNIPVTST
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHH
LLGKSAMGERHPGYIGLYEGGLSREDIRQYVESSDCIVLLGVLLTDLDLGIFTAHLDQGK
HHCHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHEEEECCCCC
SIHATSEKTSIRHHTYPGVYLNGFLLGLLQADIRRRETCETPHAPAPTPFHPAPDTRITV
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHH
ERLFQRLETFFDDSTFVIADTGDALFAAADISIPRAAEFMSSAYYASLGFAVPASLGVQL
HHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCHHHCCCEE
ALPTLRPLVLVGDGAFQMTGMEVATAARYHLNPIIIVLNNSGYGTERPMLDGSFNDVYPW
ECCCCCCEEEEECCCEEECCHHHHHHHHEECCEEEEEECCCCCCCCCCCCCCCCCCCCCC
RYARLPELLGAGRGFDVQTEEQLEVALEAARGYRDGFCILDVRLDPYDFSPALRRMTSVL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHH
GKKVK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8202090 [H]