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The map label for this gene is cobC [H]

Identifier: 118579967

GI number: 118579967

Start: 1648314

End: 1649084

Strand: Reverse

Name: cobC [H]

Synonym: Ppro_1544

Alternate gene names: 118579967

Gene position: 1649084-1648314 (Counterclockwise)

Preceding gene: 118579968

Following gene: 118579966

Centisome position: 41.14

GC content: 63.04

Gene sequence:

>771_bases
ATGAGCGACACACACAACCGCAACTACCCCACCACCGTCTTTCTCATGCGCCATGGCGATATCCGCCAGGACAACGTCAG
ACGGTACATCGGACAGGCGGACATCGAACTGAACGCCACCGGCCGCGCCCAGGCCATAAGCTGGCGCACGGAACTGGCAA
ACATCCCCCTGAAGCGGATCTACTGCAGCGACCTCTGCCGCTCCCACGAAACCGCCTGCATCATCGCCGAGGGGAGAAAC
GCCCCGGTCCAGCCGCTCTCCAAGCTGCGGGAGATCAACATGGGTGCCTGGGACGGCCAGGCCATGGACGACGTGCGTAG
CCACTACGCGGGCGAATACGAGAAGCGCGGCGCCGACATGGTCTACTACCGCCCGCCGGCAGGCGAGTGTTTCGCCGATG
TGGCGGCGCGGGTCATCCCGTTGTTCGAGGAGATCGTGCGCAACACCACCGGCAATCTGCTGATCGTGGGGCATGCCGGG
GTCAACCGGATTATCCTTTCCCACATACTGGGAATGCCCCTGGACAACCTGTTCCGGCTGCGCCAGGACTACGCCTGCCT
GAACGTGATCGACTGCGGCAGGGATGGCATGCGGCTCAGGGAGATGAACCTGGACAGTCAGGTCTTCCAGCGGATCATCT
CCCGGGCAACGGAAGAGCACGGGGACTATTCCAGCCAAGGCGAAGAGCAGGCGACGGCGGCAACCACGGAAGGCAGGCCC
GACAATGGACGGAAAGCAACCATCAGGTTACAGGGAGCGGTCCTTTCGTGA

Upstream 100 bases:

>100_bases
TTTTAAAGAACGTTACCAACCGGTTACACGCGGCACTCAGCATACAAACACGCCTGGAAGCCACTCTGGGGTGCCCCATG
GCAGAGGTTATCAGCAGACA

Downstream 100 bases:

>100_bases
ACGCCGGCGCCCCGGCCACACCCGACGAATCCCCCTGACCAGGATCCAACACCCAGGCATACGCCGTTTCCTCTCTCCTC
AACATCCCCCATGACCGTCA

Product: phosphoglycerate mutase

Products: NA

Alternate protein names: Alpha-ribazole-5'-phosphate phosphatase [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MSDTHNRNYPTTVFLMRHGDIRQDNVRRYIGQADIELNATGRAQAISWRTELANIPLKRIYCSDLCRSHETACIIAEGRN
APVQPLSKLREINMGAWDGQAMDDVRSHYAGEYEKRGADMVYYRPPAGECFADVAARVIPLFEEIVRNTTGNLLIVGHAG
VNRIILSHILGMPLDNLFRLRQDYACLNVIDCGRDGMRLREMNLDSQVFQRIISRATEEHGDYSSQGEEQATAATTEGRP
DNGRKATIRLQGAVLS

Sequences:

>Translated_256_residues
MSDTHNRNYPTTVFLMRHGDIRQDNVRRYIGQADIELNATGRAQAISWRTELANIPLKRIYCSDLCRSHETACIIAEGRN
APVQPLSKLREINMGAWDGQAMDDVRSHYAGEYEKRGADMVYYRPPAGECFADVAARVIPLFEEIVRNTTGNLLIVGHAG
VNRIILSHILGMPLDNLFRLRQDYACLNVIDCGRDGMRLREMNLDSQVFQRIISRATEEHGDYSSQGEEQATAATTEGRP
DNGRKATIRLQGAVLS
>Mature_255_residues
SDTHNRNYPTTVFLMRHGDIRQDNVRRYIGQADIELNATGRAQAISWRTELANIPLKRIYCSDLCRSHETACIIAEGRNA
PVQPLSKLREINMGAWDGQAMDDVRSHYAGEYEKRGADMVYYRPPAGECFADVAARVIPLFEEIVRNTTGNLLIVGHAGV
NRIILSHILGMPLDNLFRLRQDYACLNVIDCGRDGMRLREMNLDSQVFQRIISRATEEHGDYSSQGEEQATAATTEGRPD
NGRKATIRLQGAVLS

Specific function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin [H]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family [H]

Homologues:

Organism=Homo sapiens, GI224282149, Length=174, Percent_Identity=30.4597701149425, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI4758900, Length=174, Percent_Identity=30.4597701149425, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI64762445, Length=172, Percent_Identity=27.906976744186, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI64762406, Length=172, Percent_Identity=27.906976744186, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI118582286, Length=174, Percent_Identity=28.735632183908, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1786857, Length=192, Percent_Identity=28.6458333333333, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790856, Length=180, Percent_Identity=30.5555555555556, Blast_Score=71, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI25145314, Length=168, Percent_Identity=27.3809523809524, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17510917, Length=172, Percent_Identity=26.1627906976744, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71993390, Length=172, Percent_Identity=26.1627906976744, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24643264, Length=170, Percent_Identity=28.8235294117647, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24643254, Length=170, Percent_Identity=28.8235294117647, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24643260, Length=170, Percent_Identity=28.8235294117647, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24643258, Length=170, Percent_Identity=28.8235294117647, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24643256, Length=170, Percent_Identity=28.8235294117647, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24643262, Length=170, Percent_Identity=28.8235294117647, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24643252, Length=170, Percent_Identity=28.8235294117647, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137706, Length=170, Percent_Identity=28.8235294117647, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR017578 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =3.1.3.73 [H]

Molecular weight: Translated: 28765; Mature: 28634

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTHNRNYPTTVFLMRHGDIRQDNVRRYIGQADIELNATGRAQAISWRTELANIPLKRI
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCCHHHH
YCSDLCRSHETACIIAEGRNAPVQPLSKLREINMGAWDGQAMDDVRSHYAGEYEKRGADM
HHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHCCCCE
VYYRPPAGECFADVAARVIPLFEEIVRNTTGNLLIVGHAGVNRIILSHILGMPLDNLFRL
EEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCHHHHHHH
RQDYACLNVIDCGRDGMRLREMNLDSQVFQRIISRATEEHGDYSSQGEEQATAATTEGRP
HHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCC
DNGRKATIRLQGAVLS
CCCCEEEEEEECEECC
>Mature Secondary Structure 
SDTHNRNYPTTVFLMRHGDIRQDNVRRYIGQADIELNATGRAQAISWRTELANIPLKRI
CCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCCHHHH
YCSDLCRSHETACIIAEGRNAPVQPLSKLREINMGAWDGQAMDDVRSHYAGEYEKRGADM
HHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHCCCCE
VYYRPPAGECFADVAARVIPLFEEIVRNTTGNLLIVGHAGVNRIILSHILGMPLDNLFRL
EEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCHHHHHHH
RQDYACLNVIDCGRDGMRLREMNLDSQVFQRIISRATEEHGDYSSQGEEQATAATTEGRP
HHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCC
DNGRKATIRLQGAVLS
CCCCEEEEEEECEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]