Click here to switch to the map view.

The map label for this gene is hisC [H]

Identifier: 118579943

GI number: 118579943

Start: 1624139

End: 1625266

Strand: Reverse

Name: hisC [H]

Synonym: Ppro_1520

Alternate gene names: 118579943

Gene position: 1625266-1624139 (Counterclockwise)

Preceding gene: 118579944

Following gene: 118579942

Centisome position: 40.55

GC content: 64.36

Gene sequence:

>1128_bases
ATGAACCTGGACACCCTGGTCCCCGACTATGTTCGCTGTTTCCAGGCCTACGTCCCCAGCAGGCCCGACCACCTGCTGAT
GCGTGAGTACGGCGCCCCCCTGCTCTATCGCCTGAACAACAACGAAAACCCCCTGGGTCCTCCCCCGGCGGCAAGCCGCG
AGATCGCCTCCTTCCCCCCGGAGCTGGCCGCCGTCTACCCCAGCGGCGACTCATTCGAGCTGCGCGAGGCTCTGGGGAAC
CGCCTGGGCATCTCCCCCGAGCGCATCCTGGTGGGCAACGGTTCCTGCGAGGTTATCTCGTCGGTGATCAAGGCCTTCTG
CCAGCCGGGCGACAACATCGTCACCGCAGACAAGACCTTTGCCGTCTACGAATGGGTGGCGGAGTTCTCCGGCATCCAGG
CGCACCTGGTTCCGCTCCGCGATCACGCCTTCGATCCCCAGGGGATGCTGGACAGGATCGACAACCGCACCAAGATCATC
TTTGTCTGCAACCCCAACAACCCCACCGGCAGCTACTGGACAGGGCAGCTGCTGACCGACTTCCTGGAAAGGGTGGGAAG
CGAGCGGATCGTGGTGGTGGACGAGGCCTACCGCGAATTCGTGGAGGATGAAGAGTACCCGGACGGGGTCAGCCTGATGG
AGCGCTTCCCCAACCTGGTGGTATTCCGCACCTTCTCCAAGATGTACGCCCTGGCCGGTCTGCGCACCGGCTATCTGGTA
GGGAGCGACCGGGTGGTGGAGGTGGTCCGACGCACCAGCGTGGTCTATTCGGTAAACGTGCAGGCCCAGCGGGCCGCCCT
GGCGGCACTTTCCGACGATGGGGGACATATCGCCGCGACCCGCGCCCTGGTTCGGGAGTCCAGGGCCTATCTGCGCACGG
CGTGCGACGACCTGGGCCTGGAAACCGTCATCGGAGAAGGCAACTACCTGATGATCAGGGTGCCAATCAACGACATGCTC
ATGTACCGCCGCCTGATGAAGCGGGGGATGATGGTCCGCTCCATGACCGGGTTCCGCTACCCCGGCTGGATCCGCGTCAC
CCTCAAGGAGATGGAGGTCATGACCCGCTTTGCCCAGGCTCTGGGCGCTGAGATCGCGGCGATCCGCTCGCGGGGTAGAA
CGTCATGA

Upstream 100 bases:

>100_bases
ATGCCCTGGAGCAGACCGGCTTTGTGCCGCGCCTGCTGGTGCCGGACGCGGGCCAGGGCGACCTGGTGGTGTACGACCAT
TCCGGCGGGAACGGGCAGCC

Downstream 100 bases:

>100_bases
CCATGGATGAACGACAACTGGAAATAGGCCGGCCGGAGATCCGCGGCGACGCCCCTGCCAAGGCCAGGGGTCGGGAGCTG
TTCTCCGCCGACATCTACCC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MNLDTLVPDYVRCFQAYVPSRPDHLLMREYGAPLLYRLNNNENPLGPPPAASREIASFPPELAAVYPSGDSFELREALGN
RLGISPERILVGNGSCEVISSVIKAFCQPGDNIVTADKTFAVYEWVAEFSGIQAHLVPLRDHAFDPQGMLDRIDNRTKII
FVCNPNNPTGSYWTGQLLTDFLERVGSERIVVVDEAYREFVEDEEYPDGVSLMERFPNLVVFRTFSKMYALAGLRTGYLV
GSDRVVEVVRRTSVVYSVNVQAQRAALAALSDDGGHIAATRALVRESRAYLRTACDDLGLETVIGEGNYLMIRVPINDML
MYRRLMKRGMMVRSMTGFRYPGWIRVTLKEMEVMTRFAQALGAEIAAIRSRGRTS

Sequences:

>Translated_375_residues
MNLDTLVPDYVRCFQAYVPSRPDHLLMREYGAPLLYRLNNNENPLGPPPAASREIASFPPELAAVYPSGDSFELREALGN
RLGISPERILVGNGSCEVISSVIKAFCQPGDNIVTADKTFAVYEWVAEFSGIQAHLVPLRDHAFDPQGMLDRIDNRTKII
FVCNPNNPTGSYWTGQLLTDFLERVGSERIVVVDEAYREFVEDEEYPDGVSLMERFPNLVVFRTFSKMYALAGLRTGYLV
GSDRVVEVVRRTSVVYSVNVQAQRAALAALSDDGGHIAATRALVRESRAYLRTACDDLGLETVIGEGNYLMIRVPINDML
MYRRLMKRGMMVRSMTGFRYPGWIRVTLKEMEVMTRFAQALGAEIAAIRSRGRTS
>Mature_375_residues
MNLDTLVPDYVRCFQAYVPSRPDHLLMREYGAPLLYRLNNNENPLGPPPAASREIASFPPELAAVYPSGDSFELREALGN
RLGISPERILVGNGSCEVISSVIKAFCQPGDNIVTADKTFAVYEWVAEFSGIQAHLVPLRDHAFDPQGMLDRIDNRTKII
FVCNPNNPTGSYWTGQLLTDFLERVGSERIVVVDEAYREFVEDEEYPDGVSLMERFPNLVVFRTFSKMYALAGLRTGYLV
GSDRVVEVVRRTSVVYSVNVQAQRAALAALSDDGGHIAATRALVRESRAYLRTACDDLGLETVIGEGNYLMIRVPINDML
MYRRLMKRGMMVRSMTGFRYPGWIRVTLKEMEVMTRFAQALGAEIAAIRSRGRTS

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=309, Percent_Identity=32.3624595469256, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1786816, Length=255, Percent_Identity=25.0980392156863, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788627, Length=224, Percent_Identity=27.2321428571429, Blast_Score=69, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6322075, Length=361, Percent_Identity=27.7008310249307, Blast_Score=107, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 42025; Mature: 42025

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLDTLVPDYVRCFQAYVPSRPDHLLMREYGAPLLYRLNNNENPLGPPPAASREIASFPP
CCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHCCC
ELAAVYPSGDSFELREALGNRLGISPERILVGNGSCEVISSVIKAFCQPGDNIVTADKTF
CCEEECCCCCCHHHHHHCCHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEECCCHH
AVYEWVAEFSGIQAHLVPLRDHAFDPQGMLDRIDNRTKIIFVCNPNNPTGSYWTGQLLTD
HHHHHHHHHCCCEEEEEEHHHCCCCCCHHHHHCCCCEEEEEEECCCCCCCCCEEHHHHHH
FLERVGSERIVVVDEAYREFVEDEEYPDGVSLMERFPNLVVFRTFSKMYALAGLRTGYLV
HHHHHCCCEEEEEHHHHHHHHCCCCCCCHHHHHHHCCCEEEHHHHHHHHHHHCCCCCEEE
GSDRVVEVVRRTSVVYSVNVQAQRAALAALSDDGGHIAATRALVRESRAYLRTACDDLGL
CCHHHHHHHHHHHEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
ETVIGEGNYLMIRVPINDMLMYRRLMKRGMMVRSMTGFRYPGWIRVTLKEMEVMTRFAQA
EEEECCCCEEEEEECHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHH
LGAEIAAIRSRGRTS
HHHHHHHHHHCCCCC
>Mature Secondary Structure
MNLDTLVPDYVRCFQAYVPSRPDHLLMREYGAPLLYRLNNNENPLGPPPAASREIASFPP
CCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHCCC
ELAAVYPSGDSFELREALGNRLGISPERILVGNGSCEVISSVIKAFCQPGDNIVTADKTF
CCEEECCCCCCHHHHHHCCHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEECCCHH
AVYEWVAEFSGIQAHLVPLRDHAFDPQGMLDRIDNRTKIIFVCNPNNPTGSYWTGQLLTD
HHHHHHHHHCCCEEEEEEHHHCCCCCCHHHHHCCCCEEEEEEECCCCCCCCCEEHHHHHH
FLERVGSERIVVVDEAYREFVEDEEYPDGVSLMERFPNLVVFRTFSKMYALAGLRTGYLV
HHHHHCCCEEEEEHHHHHHHHCCCCCCCHHHHHHHCCCEEEHHHHHHHHHHHCCCCCEEE
GSDRVVEVVRRTSVVYSVNVQAQRAALAALSDDGGHIAATRALVRESRAYLRTACDDLGL
CCHHHHHHHHHHHEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
ETVIGEGNYLMIRVPINDMLMYRRLMKRGMMVRSMTGFRYPGWIRVTLKEMEVMTRFAQA
EEEECCCCEEEEEECHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHH
LGAEIAAIRSRGRTS
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA