Click here to switch to the map view.

The map label for this gene is nuoF2 [H]

Identifier: 118579913

GI number: 118579913

Start: 1595698

End: 1597410

Strand: Direct

Name: nuoF2 [H]

Synonym: Ppro_1489

Alternate gene names: 118579913

Gene position: 1595698-1597410 (Clockwise)

Preceding gene: 118579912

Following gene: 118579914

Centisome position: 39.81

GC content: 57.5

Gene sequence:

>1713_bases
GTGAGTCACGTTAAATCCTCCGTTCAAACGGGCTCAAAGCGGCGCATCATCATCTGTGCCGGCACCGGCTGTGTCTCCAG
TGGGGCACTCAAGGTCCATGGGGCGTTACTAAAAAAACTCTCTGAGCGCAACATGGATATCGATGTAAAACTTGCTCCGG
AGAGCCAGAACCTGCACCTCTCCAAAAGCGGTTGCCAGGGGTTCTGTCAGATGGGGCCACTTGTCACCGTACTTCCCGAC
AATATCCTCTACTGCAAGGTGACAACGTCCGATGTGGATGACATTGTCGAACAGACCATCCTGAAAGGCGAGGTTGTCCA
GCGTCTGACGTACCTTGACCCTGCCACGAACAAACATTGCACATCGTATGACGAAATCCCCTTTTATACGCGGCAGACAC
GATTCGTTTTAAAGGAATGTGGCTGGATTGATCCTGAAAGCCTGAATGAGTACATTGCGACCGGCGGCTATGGTGGTGCA
ATAAAGGCTTTCCTGGAAATGACCCCCGAAGAAATCTGCAGGGAGGTGATCGCTTCCGGTCTTCGCGGCCGAGGGGGGGG
CGGTTTCCCCACCGGCCGCAAATGGGAAATAGCCCGCATGCAGCCGGCGGAGAAGAAATACGTCATCTGCAATGGCGACG
AGGGCGATCCCGGCGCATTCATGAACAGAAGCGTCATGGAGGGGAACCCCCACGCGGTTATCGAGGGGCTGATGATCGCT
GCCCGCGCAATCGGCTCCGATGAGGTATATGTCTATGTCCGTGCCGAGTATCCACTGGCGGTGAAACGGATGAATATGGC
GGTTGAGGATGCCGAGGCCGCGGGGATACTGGGCAACAACATCTTCGGCACCGGCAAGCGGATGAAATGCACCATACTGC
CCAGTGCCGGAGCATTTGTGTGCGGAGAAGAAACCGCCATGCTGGCCTCCATCGAAGGCCTGCGCGGTACGCCCGTCCCC
AAACCCCCCTTTCCGGCGCAGTGCGGTCTCAGGGGCAAACCGACTATCATCAACAATGTGGAGACCCTTGCCCAGATTCC
GCGCATTCTGCTGGCTGGTGCCCAGAGCTTCAAAAAAATGGGGACTCCCGCTTCGCCCGGCACCAAGACATTTGCGCTCA
CCGGCCATGTTGTCAATACCGGCCTGATCGAGGTGCCATTCGGAACGACGCTGCGTGAAATTGTCTTCTCCATCGGTGGC
GGCGTCACCACTGATGAGGGAACCCCCACGGACGGCATGTTCAAGGCCGTTCAGGTGGGCGGCCCCTCCGGTGGATGCCT
GCCTCCTGAACTGCTCGATATGCCGCTGGACTTCGATTCACTGCTGTCGGCGGGCGCCATGGTCGGTTCAGGCGGTCTTG
TGGTCATGAATCAGCAGACCTGCATGGTGAGCGTGGCGCGTTTCTTCATGGAGTTCACCCAGCGGGAATCCTGCGGCAAA
TGCGTACTCTGCCGCGAGGGGACACGCCAGCTGCTTGTCCTGCTGGACGATGTTATTGAAGGGCGGGCAACACTGCAAAC
CCTCGACATCATGGAACTATTGGCAAAGAGTATTAAGCTCGGTTCGCTGTGTGGCCTCGGCAAGACCGCGCCGAACGCCG
TGCTGTCGACGCTCAAATATTTCCGCGCGGAGTTCGAATCCCATGTGGTGGATAAGCAGTGTCCTACCGGCCAGTGCAGT
CTTCTCACTAAACCGGACAGGGTGACTGCATGA

Upstream 100 bases:

>100_bases
TTGCGCCGGTTATGCTTATCAACGAGGAAGTCTATGGCCGGGTGACTCCCGCCAGCGCGGTGGCGCTGATTGATGAAATC
ATTGCAAAGGAGGCAAACGC

Downstream 100 bases:

>100_bases
GCAGGAGATGGGCAGCACAGTGCGCCAGGGAGTGTGAGTAATGACCAGATTTGCCGATACTACTGTCTACATAAACAATC
GACCGGTCGTTATGGAGGGG

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 570; Mature: 569

Protein sequence:

>570_residues
MSHVKSSVQTGSKRRIIICAGTGCVSSGALKVHGALLKKLSERNMDIDVKLAPESQNLHLSKSGCQGFCQMGPLVTVLPD
NILYCKVTTSDVDDIVEQTILKGEVVQRLTYLDPATNKHCTSYDEIPFYTRQTRFVLKECGWIDPESLNEYIATGGYGGA
IKAFLEMTPEEICREVIASGLRGRGGGGFPTGRKWEIARMQPAEKKYVICNGDEGDPGAFMNRSVMEGNPHAVIEGLMIA
ARAIGSDEVYVYVRAEYPLAVKRMNMAVEDAEAAGILGNNIFGTGKRMKCTILPSAGAFVCGEETAMLASIEGLRGTPVP
KPPFPAQCGLRGKPTIINNVETLAQIPRILLAGAQSFKKMGTPASPGTKTFALTGHVVNTGLIEVPFGTTLREIVFSIGG
GVTTDEGTPTDGMFKAVQVGGPSGGCLPPELLDMPLDFDSLLSAGAMVGSGGLVVMNQQTCMVSVARFFMEFTQRESCGK
CVLCREGTRQLLVLLDDVIEGRATLQTLDIMELLAKSIKLGSLCGLGKTAPNAVLSTLKYFRAEFESHVVDKQCPTGQCS
LLTKPDRVTA

Sequences:

>Translated_570_residues
MSHVKSSVQTGSKRRIIICAGTGCVSSGALKVHGALLKKLSERNMDIDVKLAPESQNLHLSKSGCQGFCQMGPLVTVLPD
NILYCKVTTSDVDDIVEQTILKGEVVQRLTYLDPATNKHCTSYDEIPFYTRQTRFVLKECGWIDPESLNEYIATGGYGGA
IKAFLEMTPEEICREVIASGLRGRGGGGFPTGRKWEIARMQPAEKKYVICNGDEGDPGAFMNRSVMEGNPHAVIEGLMIA
ARAIGSDEVYVYVRAEYPLAVKRMNMAVEDAEAAGILGNNIFGTGKRMKCTILPSAGAFVCGEETAMLASIEGLRGTPVP
KPPFPAQCGLRGKPTIINNVETLAQIPRILLAGAQSFKKMGTPASPGTKTFALTGHVVNTGLIEVPFGTTLREIVFSIGG
GVTTDEGTPTDGMFKAVQVGGPSGGCLPPELLDMPLDFDSLLSAGAMVGSGGLVVMNQQTCMVSVARFFMEFTQRESCGK
CVLCREGTRQLLVLLDDVIEGRATLQTLDIMELLAKSIKLGSLCGLGKTAPNAVLSTLKYFRAEFESHVVDKQCPTGQCS
LLTKPDRVTA
>Mature_569_residues
SHVKSSVQTGSKRRIIICAGTGCVSSGALKVHGALLKKLSERNMDIDVKLAPESQNLHLSKSGCQGFCQMGPLVTVLPDN
ILYCKVTTSDVDDIVEQTILKGEVVQRLTYLDPATNKHCTSYDEIPFYTRQTRFVLKECGWIDPESLNEYIATGGYGGAI
KAFLEMTPEEICREVIASGLRGRGGGGFPTGRKWEIARMQPAEKKYVICNGDEGDPGAFMNRSVMEGNPHAVIEGLMIAA
RAIGSDEVYVYVRAEYPLAVKRMNMAVEDAEAAGILGNNIFGTGKRMKCTILPSAGAFVCGEETAMLASIEGLRGTPVPK
PPFPAQCGLRGKPTIINNVETLAQIPRILLAGAQSFKKMGTPASPGTKTFALTGHVVNTGLIEVPFGTTLREIVFSIGGG
VTTDEGTPTDGMFKAVQVGGPSGGCLPPELLDMPLDFDSLLSAGAMVGSGGLVVMNQQTCMVSVARFFMEFTQRESCGKC
VLCREGTRQLLVLLDDVIEGRATLQTLDIMELLAKSIKLGSLCGLGKTAPNAVLSTLKYFRAEFESHVVDKQCPTGQCSL
LTKPDRVTA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=390, Percent_Identity=35.8974358974359, Blast_Score=255, Evalue=7e-68,
Organism=Homo sapiens, GI260656005, Length=390, Percent_Identity=35.8974358974359, Blast_Score=255, Evalue=7e-68,
Organism=Escherichia coli, GI1788620, Length=408, Percent_Identity=38.9705882352941, Blast_Score=295, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI17531727, Length=384, Percent_Identity=36.71875, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI19920794, Length=383, Percent_Identity=35.7702349869452, Blast_Score=254, Evalue=8e-68,
Organism=Drosophila melanogaster, GI45550452, Length=380, Percent_Identity=34.7368421052632, Blast_Score=244, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24653819, Length=391, Percent_Identity=30.690537084399, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24653817, Length=362, Percent_Identity=28.1767955801105, Blast_Score=169, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 61025; Mature: 60893

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHVKSSVQTGSKRRIIICAGTGCVSSGALKVHGALLKKLSERNMDIDVKLAPESQNLHL
CCCHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEE
SKSGCQGFCQMGPLVTVLPDNILYCKVTTSDVDDIVEQTILKGEVVQRLTYLDPATNKHC
ECCCCHHHHHHCCEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TSYDEIPFYTRQTRFVLKECGWIDPESLNEYIATGGYGGAIKAFLEMTPEEICREVIASG
CCCCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHC
LRGRGGGGFPTGRKWEIARMQPAEKKYVICNGDEGDPGAFMNRSVMEGNPHAVIEGLMIA
CCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCHHHCCHHCCCCCHHHHHHHHHH
ARAIGSDEVYVYVRAEYPLAVKRMNMAVEDAEAAGILGNNIFGTGKRMKCTILPSAGAFV
HHHCCCCCEEEEEEECCCCHHHHHHHHHHCCHHCCEECCCCCCCCCEEEEEEECCCCCEE
CGEETAMLASIEGLRGTPVPKPPFPAQCGLRGKPTIINNVETLAQIPRILLAGAQSFKKM
ECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GTPASPGTKTFALTGHVVNTGLIEVPFGTTLREIVFSIGGGVTTDEGTPTDGMFKAVQVG
CCCCCCCCEEEEEEEEEEECCEEEECCCHHHHHHHHHHCCCEECCCCCCCCCCEEEEEEC
GPSGGCLPPELLDMPLDFDSLLSAGAMVGSGGLVVMNQQTCMVSVARFFMEFTQRESCGK
CCCCCCCCHHHHCCCCCHHHHHHCCCEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCC
CVLCREGTRQLLVLLDDVIEGRATLQTLDIMELLAKSIKLGSLCGLGKTAPNAVLSTLKY
EEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
FRAEFESHVVDKQCPTGQCSLLTKPDRVTA
HHHHHHHHHHCCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure 
SHVKSSVQTGSKRRIIICAGTGCVSSGALKVHGALLKKLSERNMDIDVKLAPESQNLHL
CCHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEE
SKSGCQGFCQMGPLVTVLPDNILYCKVTTSDVDDIVEQTILKGEVVQRLTYLDPATNKHC
ECCCCHHHHHHCCEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TSYDEIPFYTRQTRFVLKECGWIDPESLNEYIATGGYGGAIKAFLEMTPEEICREVIASG
CCCCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHC
LRGRGGGGFPTGRKWEIARMQPAEKKYVICNGDEGDPGAFMNRSVMEGNPHAVIEGLMIA
CCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCHHHCCHHCCCCCHHHHHHHHHH
ARAIGSDEVYVYVRAEYPLAVKRMNMAVEDAEAAGILGNNIFGTGKRMKCTILPSAGAFV
HHHCCCCCEEEEEEECCCCHHHHHHHHHHCCHHCCEECCCCCCCCCEEEEEEECCCCCEE
CGEETAMLASIEGLRGTPVPKPPFPAQCGLRGKPTIINNVETLAQIPRILLAGAQSFKKM
ECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GTPASPGTKTFALTGHVVNTGLIEVPFGTTLREIVFSIGGGVTTDEGTPTDGMFKAVQVG
CCCCCCCCEEEEEEEEEEECCEEEECCCHHHHHHHHHHCCCEECCCCCCCCCCEEEEEEC
GPSGGCLPPELLDMPLDFDSLLSAGAMVGSGGLVVMNQQTCMVSVARFFMEFTQRESCGK
CCCCCCCCHHHHCCCCCHHHHHHCCCEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCC
CVLCREGTRQLLVLLDDVIEGRATLQTLDIMELLAKSIKLGSLCGLGKTAPNAVLSTLKY
EEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
FRAEFESHVVDKQCPTGQCSLLTKPDRVTA
HHHHHHHHHHCCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]