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The map label for this gene is hom [H]

Identifier: 118579722

GI number: 118579722

Start: 1363554

End: 1364870

Strand: Reverse

Name: hom [H]

Synonym: Ppro_1294

Alternate gene names: 118579722

Gene position: 1364870-1363554 (Counterclockwise)

Preceding gene: 118579723

Following gene: 118579721

Centisome position: 34.05

GC content: 61.05

Gene sequence:

>1317_bases
ATGAATGACATCAAAGTTGGCTTGATAGGTTTCGGAAACATTGGCGCCGGAGTGGTCAAACTGCTCACAAACAATGCGGA
GGTCATTCGCGGCAAGGTGGGCGCTGGAATTGTCCTCAAGCGCATCGCCGACCGGGATATCACCACCGATCGCGGCGTTG
CCGTGGATCCGTCCTGCATGACCACCGATGTCAACGACATCTTCGACGACCCGGAAATTTCCGTGGTTATCGAACTGGTC
GGCGGCTACGAGCCGGCCAAGAGCTTCGTCCTTAGGGCAATCGAAAAAGGAAAGCACATCGTCACCGCCAACAAGGCTCT
TCTGGCCCTGCATGGCCAGGATATTTTCGCCGCCGCTGCCAGGAAGAACGTGGAGGTGCAGTTCGAGGCGGCCGTTGGGG
GGGGCATCCCGGTGCTTACCGCCATCAAGGGCAACATGGCCGCCAACAACTTCGGCAGCGTGTTCGGCATCATGAACGGC
ACCTGCAACTACATCCTGACCCGCATGACCCAGGAGGGAGCCGACTTCGCCGACATGCTCACGGCTGCCCAGGAGCTGGG
CTACGCCGAGCCCGACCCCACCTTCGACATCGAAGGGGTCGACACCGCCCACAAGCTGGCCATCCTGGTCTCGCTCTGCT
TCGGGACACGCATCGATTTCAACGCCATCCACACCGAAGGGATCTCCAGGATCAGCGGCCTGGATGTGAAATTCGCCCGC
GACTTCGGCTATCGCATCAAGCTGCTTGCCATCGGCAAGCTGTCCGACGGCAAGGTCGAGGCCCGTGTCCACCCCACCAT
GATCCCACTGCACAACCCCATGGCCGATGTGAACGGCGTCTTCAACGCCATCCGCCTGACCGGAGACTTCGTCGGCGCGG
TGATGTTTTACGGACGCGGCGCCGGCCAGGACCCCACCGCCAGCGCCATCGTCGGCGACCTGATCGGGCTCTCCCGCAGC
ATGCTCGCCGGTGCCGGCCGCAGGATGGCACCGCTGGGGCTCATGGACGAGCAGGTCAGGGACCTTCCGGTCAAGCCCAT
GGCCGATATTGTCAGCAAATACATGCTCCGTTTCAGCACCCGCGACATTCCCGGCGTCCTGGGGACCATCACCGGCGCCC
TGGGCAAGCACGGCATCAGCATTTCATCCATGGTGCAGACCGCCCATGAGGCGAACGACAACGCACCGGTTCCGATCGTG
ATCATGACCCATGAGGCGGTTGAAGGCTCCGTACAAGCAGCCCTGGAGGAGATCGACCGACTCGACTTCGTCTGCGAAAA
GACCAGTTTTATCAGGATCGAGGACAATCTGGAATAA

Upstream 100 bases:

>100_bases
ACGGCATCCTGGACGAGATACCTTCCTGCGCAAAGGCGGAGGAACCCGACAGGGAGCAGTAACGCGAAACTAAATTAATG
TCTGAGAATCGAGGCTTTCA

Downstream 100 bases:

>100_bases
TATGAAATAATCCTGGAGCGACTTAAGTGAACACAAAAATTCTACTCAACGAAGATCAGATTCCCCGCCAGTGGTACAAC
ATCATCCCCGATATGCCAGG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MNDIKVGLIGFGNIGAGVVKLLTNNAEVIRGKVGAGIVLKRIADRDITTDRGVAVDPSCMTTDVNDIFDDPEISVVIELV
GGYEPAKSFVLRAIEKGKHIVTANKALLALHGQDIFAAAARKNVEVQFEAAVGGGIPVLTAIKGNMAANNFGSVFGIMNG
TCNYILTRMTQEGADFADMLTAAQELGYAEPDPTFDIEGVDTAHKLAILVSLCFGTRIDFNAIHTEGISRISGLDVKFAR
DFGYRIKLLAIGKLSDGKVEARVHPTMIPLHNPMADVNGVFNAIRLTGDFVGAVMFYGRGAGQDPTASAIVGDLIGLSRS
MLAGAGRRMAPLGLMDEQVRDLPVKPMADIVSKYMLRFSTRDIPGVLGTITGALGKHGISISSMVQTAHEANDNAPVPIV
IMTHEAVEGSVQAALEEIDRLDFVCEKTSFIRIEDNLE

Sequences:

>Translated_438_residues
MNDIKVGLIGFGNIGAGVVKLLTNNAEVIRGKVGAGIVLKRIADRDITTDRGVAVDPSCMTTDVNDIFDDPEISVVIELV
GGYEPAKSFVLRAIEKGKHIVTANKALLALHGQDIFAAAARKNVEVQFEAAVGGGIPVLTAIKGNMAANNFGSVFGIMNG
TCNYILTRMTQEGADFADMLTAAQELGYAEPDPTFDIEGVDTAHKLAILVSLCFGTRIDFNAIHTEGISRISGLDVKFAR
DFGYRIKLLAIGKLSDGKVEARVHPTMIPLHNPMADVNGVFNAIRLTGDFVGAVMFYGRGAGQDPTASAIVGDLIGLSRS
MLAGAGRRMAPLGLMDEQVRDLPVKPMADIVSKYMLRFSTRDIPGVLGTITGALGKHGISISSMVQTAHEANDNAPVPIV
IMTHEAVEGSVQAALEEIDRLDFVCEKTSFIRIEDNLE
>Mature_438_residues
MNDIKVGLIGFGNIGAGVVKLLTNNAEVIRGKVGAGIVLKRIADRDITTDRGVAVDPSCMTTDVNDIFDDPEISVVIELV
GGYEPAKSFVLRAIEKGKHIVTANKALLALHGQDIFAAAARKNVEVQFEAAVGGGIPVLTAIKGNMAANNFGSVFGIMNG
TCNYILTRMTQEGADFADMLTAAQELGYAEPDPTFDIEGVDTAHKLAILVSLCFGTRIDFNAIHTEGISRISGLDVKFAR
DFGYRIKLLAIGKLSDGKVEARVHPTMIPLHNPMADVNGVFNAIRLTGDFVGAVMFYGRGAGQDPTASAIVGDLIGLSRS
MLAGAGRRMAPLGLMDEQVRDLPVKPMADIVSKYMLRFSTRDIPGVLGTITGALGKHGISISSMVQTAHEANDNAPVPIV
IMTHEAVEGSVQAALEEIDRLDFVCEKTSFIRIEDNLE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=250, Percent_Identity=27.2, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322599, Length=127, Percent_Identity=30.7086614173228, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46652; Mature: 46652

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDIKVGLIGFGNIGAGVVKLLTNNAEVIRGKVGAGIVLKRIADRDITTDRGVAVDPSCM
CCCEEEEEEECCCHHHHHHHHHHCCHHHEEECCCCHHHHHHHHCCCCCCCCCCEECCCCE
TTDVNDIFDDPEISVVIELVGGYEPAKSFVLRAIEKGKHIVTANKALLALHGQDIFAAAA
ECCHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCEEEEECCCHHHHHHH
RKNVEVQFEAAVGGGIPVLTAIKGNMAANNFGSVFGIMNGTCNYILTRMTQEGADFADML
CCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCHHHHH
TAAQELGYAEPDPTFDIEGVDTAHKLAILVSLCFGTRIDFNAIHTEGISRISGLDVKFAR
HHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEC
DFGYRIKLLAIGKLSDGKVEARVHPTMIPLHNPMADVNGVFNAIRLTGDFVGAVMFYGRG
CCCCEEEEEEEECCCCCEEEEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
AGQDPTASAIVGDLIGLSRSMLAGAGRRMAPLGLMDEQVRDLPVKPMADIVSKYMLRFST
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCC
RDIPGVLGTITGALGKHGISISSMVQTAHEANDNAPVPIVIMTHEAVEGSVQAALEEIDR
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHH
LDFVCEKTSFIRIEDNLE
HHHHCCCCEEEEEECCCC
>Mature Secondary Structure
MNDIKVGLIGFGNIGAGVVKLLTNNAEVIRGKVGAGIVLKRIADRDITTDRGVAVDPSCM
CCCEEEEEEECCCHHHHHHHHHHCCHHHEEECCCCHHHHHHHHCCCCCCCCCCEECCCCE
TTDVNDIFDDPEISVVIELVGGYEPAKSFVLRAIEKGKHIVTANKALLALHGQDIFAAAA
ECCHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCEEEEECCCHHHHHHH
RKNVEVQFEAAVGGGIPVLTAIKGNMAANNFGSVFGIMNGTCNYILTRMTQEGADFADML
CCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCHHHHH
TAAQELGYAEPDPTFDIEGVDTAHKLAILVSLCFGTRIDFNAIHTEGISRISGLDVKFAR
HHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEC
DFGYRIKLLAIGKLSDGKVEARVHPTMIPLHNPMADVNGVFNAIRLTGDFVGAVMFYGRG
CCCCEEEEEEEECCCCCEEEEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
AGQDPTASAIVGDLIGLSRSMLAGAGRRMAPLGLMDEQVRDLPVKPMADIVSKYMLRFST
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCC
RDIPGVLGTITGALGKHGISISSMVQTAHEANDNAPVPIVIMTHEAVEGSVQAALEEIDR
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHH
LDFVCEKTSFIRIEDNLE
HHHHCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]