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The map label for this gene is hup [H]

Identifier: 118579611

GI number: 118579611

Start: 1233454

End: 1233732

Strand: Reverse

Name: hup [H]

Synonym: Ppro_1181

Alternate gene names: 118579611

Gene position: 1233732-1233454 (Counterclockwise)

Preceding gene: 118579612

Following gene: 118579610

Centisome position: 30.78

GC content: 53.76

Gene sequence:

>279_bases
GTGACAAAGGCGGAACTGATTAGCGCAGTGGCAGAGGAGTCCGGGCTCAAGAAAGTCGATGCCGAGAAGGCTCTCAGCGC
ATTCATATCAACGGTGACCGAGGCTCTCAAGCAGGGTGACAAGCTGAGTCTGGTCGGTTTCGGTACGTTCTGCACTTCCA
AACGAGCCGCACGCAAGGGGCAGAATCCACAGACAGGAAAGAAAATCAATATTCCGGCCGCAACCATCCCGAAGTTCAGA
CCGGGCAAGACACTGAAGGATGCGGTTAACGCAAAATAA

Upstream 100 bases:

>100_bases
CATGAAATGTGGATTCGCCAGACATTTTGCTTGACAGTTTCCGATGTAATCTGGTAAAAACCAACTCTCCTTGCATCACA
CAATACACAGGAGGTGTAGC

Downstream 100 bases:

>100_bases
GCAGGGACGGTAATTTTTTACTACAGGTAGTAGTTTGCGGGGTTGTAGCTCAGTTGGTTAGAGTGCCAGCCTGTCACGCT
GGAAGTCGCGGGTTCGAGCC

Product: histone family protein DNA-binding protein

Products: NA

Alternate protein names: DNA-binding protein II; HB [H]

Number of amino acids: Translated: 92; Mature: 91

Protein sequence:

>92_residues
MTKAELISAVAEESGLKKVDAEKALSAFISTVTEALKQGDKLSLVGFGTFCTSKRAARKGQNPQTGKKINIPAATIPKFR
PGKTLKDAVNAK

Sequences:

>Translated_92_residues
MTKAELISAVAEESGLKKVDAEKALSAFISTVTEALKQGDKLSLVGFGTFCTSKRAARKGQNPQTGKKINIPAATIPKFR
PGKTLKDAVNAK
>Mature_91_residues
TKAELISAVAEESGLKKVDAEKALSAFISTVTEALKQGDKLSLVGFGTFCTSKRAARKGQNPQTGKKINIPAATIPKFRP
GKTLKDAVNAK

Specific function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions [H]

COG id: COG0776

COG function: function code L; Bacterial nucleoid DNA-binding protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial histone-like protein family [H]

Homologues:

Organism=Escherichia coli, GI1786644, Length=90, Percent_Identity=56.6666666666667, Blast_Score=107, Evalue=2e-25,
Organism=Escherichia coli, GI1790433, Length=89, Percent_Identity=52.8089887640449, Blast_Score=97, Evalue=2e-22,
Organism=Escherichia coli, GI1787141, Length=91, Percent_Identity=37.3626373626374, Blast_Score=74, Evalue=1e-15,
Organism=Escherichia coli, GI1788005, Length=89, Percent_Identity=38.2022471910112, Blast_Score=69, Evalue=6e-14,

Paralogues:

None

Copy number: 860 Molecules/Cell In: Growth-Phase, Minimal Media (Based on E. coli). 2040 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000119
- InterPro:   IPR020816
- InterPro:   IPR010992 [H]

Pfam domain/function: PF00216 Bac_DNA_binding [H]

EC number: NA

Molecular weight: Translated: 9718; Mature: 9587

Theoretical pI: Translated: 10.79; Mature: 10.79

Prosite motif: PS00045 HISTONE_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKAELISAVAEESGLKKVDAEKALSAFISTVTEALKQGDKLSLVGFGTFCTSKRAARKG
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCC
QNPQTGKKINIPAATIPKFRPGKTLKDAVNAK
CCCCCCCEECCCCCCCCCCCCCCHHHHHCCCC
>Mature Secondary Structure 
TKAELISAVAEESGLKKVDAEKALSAFISTVTEALKQGDKLSLVGFGTFCTSKRAARKG
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCC
QNPQTGKKINIPAATIPKFRPGKTLKDAVNAK
CCCCCCCEECCCCCCCCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1644313 [H]