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The map label for this gene is zraS [C]

Identifier: 118579601

GI number: 118579601

Start: 1222686

End: 1224269

Strand: Direct

Name: zraS [C]

Synonym: Ppro_1171

Alternate gene names: 118579601

Gene position: 1222686-1224269 (Clockwise)

Preceding gene: 118579600

Following gene: 118579603

Centisome position: 30.51

GC content: 63.57

Gene sequence:

>1584_bases
ATGCTGCTGGTTCTGCTGGTCTGCGCCCAGGTGAACAGGCTGGAACGGAGCGCACACGAACTGCGCGAAGCCCAGGATGA
CTGGGAGGCCTCCTTCAATACCATTACCGATGGCATCCTGCTGGAGGATGCCGGGGGGGCGGTGATCAGGATGAACCAGG
CCGCCCGGAGCATGCAGGGGGCACGTCTGCTGGAACAGCTTGCTCGTGCTCCCCTGTCCGGCTGCGGGGAGGAAATGGGC
GATCAGGGCCGTACCCGTGAGTTCGTTGACCCGCTTTCCGGCAACTGCTACGAGATCAGGTCGCGTGCCCGCTCCGACCA
TCCGCGGGGGGGGGGTGGGGTTGTGCATGTCATCCGGGATGTGACGGCCAGGAAAAAGATGGAGAAGGAGAAGGAGTTGC
TCCAGTTCCAGTTTCTCCAGGCCCAGAAGATGGAGTCCGTCGGCCGGCTAGCGGGTGGCGTGGCCCATGACTTCAACAAC
ATACTGACCGCCATACTGGGCTACAGCGAGATTGCCCGCCTGAGGGCCGCCCATGACGAGAAGCTTGCTGAGTGCCTGGA
TATTATCCATGACTCGGGCATGAAGGCGGCATCCCTTGTCCGGCAGCTGTTGATCTTCAGCCGCAAGAGTACGCTGGAGC
CGCAGGTGGTTGATATCAGGTCGCTCATCGACAACATGGCCAAGATCCTGGCGCGGGTGATCGGAGAGGACGTCATCCTC
GGGCTGCAGACCGAATCGCCGGTCGGGAATATACTCGTTGACCCGGCCCAGGTCGAGCAGATCATCATGAACCTGGTGGT
CAACGCCCGGGACGCCATGCCCCAGGGCGGGACGGTGACCATCCGGGCCGAGGATGTGGAACTGGACAGCTCCTACACCT
GCAGCCATCTGGACCTTGTCCCCGGTCCCTATGTGATGCTCTCGGTGAGGGATACCGGCATGGGTATGAGCCCGGAGGTG
CGGGCGCGGATCTTCGAACCCTTCTTCACCACCAAGGAGGTGGGGGAGGGGACCGGCCTGGGATTGTCAACGGTCTACGG
AATTGTCAGGCAGATGGCGGGACACATCTACGTCTACAGCGAGCCGGGCAGGGGAAGCGAGTTCAAGGTGTATTTTCCGG
TTTGCCGGGAGAACGTCGCCGCGGTTGGGCCGGAGGTGGAGAAAACCGTAGCCGGCGGCAGCGAGACGATCCTGGTCGTG
GAGGACGATGCCTCGATCCTGACCCTGATCGCCTCCCTGCTGGAGCCGCTGGGCTATGCCGTTCTGGCGGCCCATTCCGG
CGACGAGGCCCTGGCGCTGGCGGAGCGGAGCGGAAAACGGATCGATCTGCTGCTGACGGACGTTGTCATGCCGGGAATGG
GGGGGAGGAAGCTGGCCGGGCTGTTCCTTGAAAAACATCCCGCGGCGCGGGTTGTCTTCATGTCCGGCTACACCGATGAC
ATCATCATTCGCCAGGGGGTGAGCCAGGGGCAGTGCGCCTTTGTCCAGAAGCCGCTCTCGCCGCGCTCCCTGGCCAGGAA
GCTGCGGGAGGTGCTGGATGGCCAGGGGCGGGAAGGCGCTGCTCCCCCTGTGCCGGCTGGCTGA

Upstream 100 bases:

>100_bases
GCTGTTCTGCTGCGGTCTGGGCCTGGCCGCTGTCTGGCTCGTGTCTCTTGCGCTCTTTGCCTGGCTGGATTTCTGGTTCA
GCCCGATCCTGCCCTCGCTT

Downstream 100 bases:

>100_bases
CCTCAGCGCCGTTTCCTGCCCCCCGTGCGGACGGCCCCCTTTTTCGTCCGCTTTTGCCCCTCACGCCTGCCGGCCGCTGG
GGAGGGTTTCGTTCCCTCGG

Product: histidine kinase

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MLLVLLVCAQVNRLERSAHELREAQDDWEASFNTITDGILLEDAGGAVIRMNQAARSMQGARLLEQLARAPLSGCGEEMG
DQGRTREFVDPLSGNCYEIRSRARSDHPRGGGGVVHVIRDVTARKKMEKEKELLQFQFLQAQKMESVGRLAGGVAHDFNN
ILTAILGYSEIARLRAAHDEKLAECLDIIHDSGMKAASLVRQLLIFSRKSTLEPQVVDIRSLIDNMAKILARVIGEDVIL
GLQTESPVGNILVDPAQVEQIIMNLVVNARDAMPQGGTVTIRAEDVELDSSYTCSHLDLVPGPYVMLSVRDTGMGMSPEV
RARIFEPFFTTKEVGEGTGLGLSTVYGIVRQMAGHIYVYSEPGRGSEFKVYFPVCRENVAAVGPEVEKTVAGGSETILVV
EDDASILTLIASLLEPLGYAVLAAHSGDEALALAERSGKRIDLLLTDVVMPGMGGRKLAGLFLEKHPAARVVFMSGYTDD
IIIRQGVSQGQCAFVQKPLSPRSLARKLREVLDGQGREGAAPPVPAG

Sequences:

>Translated_527_residues
MLLVLLVCAQVNRLERSAHELREAQDDWEASFNTITDGILLEDAGGAVIRMNQAARSMQGARLLEQLARAPLSGCGEEMG
DQGRTREFVDPLSGNCYEIRSRARSDHPRGGGGVVHVIRDVTARKKMEKEKELLQFQFLQAQKMESVGRLAGGVAHDFNN
ILTAILGYSEIARLRAAHDEKLAECLDIIHDSGMKAASLVRQLLIFSRKSTLEPQVVDIRSLIDNMAKILARVIGEDVIL
GLQTESPVGNILVDPAQVEQIIMNLVVNARDAMPQGGTVTIRAEDVELDSSYTCSHLDLVPGPYVMLSVRDTGMGMSPEV
RARIFEPFFTTKEVGEGTGLGLSTVYGIVRQMAGHIYVYSEPGRGSEFKVYFPVCRENVAAVGPEVEKTVAGGSETILVV
EDDASILTLIASLLEPLGYAVLAAHSGDEALALAERSGKRIDLLLTDVVMPGMGGRKLAGLFLEKHPAARVVFMSGYTDD
IIIRQGVSQGQCAFVQKPLSPRSLARKLREVLDGQGREGAAPPVPAG
>Mature_527_residues
MLLVLLVCAQVNRLERSAHELREAQDDWEASFNTITDGILLEDAGGAVIRMNQAARSMQGARLLEQLARAPLSGCGEEMG
DQGRTREFVDPLSGNCYEIRSRARSDHPRGGGGVVHVIRDVTARKKMEKEKELLQFQFLQAQKMESVGRLAGGVAHDFNN
ILTAILGYSEIARLRAAHDEKLAECLDIIHDSGMKAASLVRQLLIFSRKSTLEPQVVDIRSLIDNMAKILARVIGEDVIL
GLQTESPVGNILVDPAQVEQIIMNLVVNARDAMPQGGTVTIRAEDVELDSSYTCSHLDLVPGPYVMLSVRDTGMGMSPEV
RARIFEPFFTTKEVGEGTGLGLSTVYGIVRQMAGHIYVYSEPGRGSEFKVYFPVCRENVAAVGPEVEKTVAGGSETILVV
EDDASILTLIASLLEPLGYAVLAAHSGDEALALAERSGKRIDLLLTDVVMPGMGGRKLAGLFLEKHPAARVVFMSGYTDD
IIIRQGVSQGQCAFVQKPLSPRSLARKLREVLDGQGREGAAPPVPAG

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=251, Percent_Identity=29.4820717131474, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788549, Length=393, Percent_Identity=29.7709923664122, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI48994928, Length=440, Percent_Identity=25, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788713, Length=403, Percent_Identity=24.0694789081886, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI145693157, Length=457, Percent_Identity=26.4770240700219, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790300, Length=261, Percent_Identity=28.3524904214559, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87081816, Length=364, Percent_Identity=23.9010989010989, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1789149, Length=248, Percent_Identity=25.4032258064516, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786600, Length=364, Percent_Identity=23.3516483516484, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI87082128, Length=202, Percent_Identity=26.7326732673267, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790861, Length=212, Percent_Identity=28.7735849056604, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57079; Mature: 57079

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLVLLVCAQVNRLERSAHELREAQDDWEASFNTITDGILLEDAGGAVIRMNQAARSMQG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEHHHHHHHHH
ARLLEQLARAPLSGCGEEMGDQGRTREFVDPLSGNCYEIRSRARSDHPRGGGGVVHVIRD
HHHHHHHHHCCHHHCCHHHCCCCCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHH
VTARKKMEKEKELLQFQFLQAQKMESVGRLAGGVAHDFNNILTAILGYSEIARLRAAHDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLAECLDIIHDSGMKAASLVRQLLIFSRKSTLEPQVVDIRSLIDNMAKILARVIGEDVIL
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEE
GLQTESPVGNILVDPAQVEQIIMNLVVNARDAMPQGGTVTIRAEDVELDSSYTCSHLDLV
EEECCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECEECCCCCCCCEEECC
PGPYVMLSVRDTGMGMSPEVRARIFEPFFTTKEVGEGTGLGLSTVYGIVRQMAGHIYVYS
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEEEC
EPGRGSEFKVYFPVCRENVAAVGPEVEKTVAGGSETILVVEDDASILTLIASLLEPLGYA
CCCCCCEEEEEEHHHHCHHHHCCCCHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCEE
VLAAHSGDEALALAERSGKRIDLLLTDVVMPGMGGRKLAGLFLEKHPAARVVFMSGYTDD
EEEECCCCCHHHHHHCCCCEEEEEEHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCCC
IIIRQGVSQGQCAFVQKPLSPRSLARKLREVLDGQGREGAAPPVPAG
HHEECCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLLVLLVCAQVNRLERSAHELREAQDDWEASFNTITDGILLEDAGGAVIRMNQAARSMQG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEHHHHHHHHH
ARLLEQLARAPLSGCGEEMGDQGRTREFVDPLSGNCYEIRSRARSDHPRGGGGVVHVIRD
HHHHHHHHHCCHHHCCHHHCCCCCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHH
VTARKKMEKEKELLQFQFLQAQKMESVGRLAGGVAHDFNNILTAILGYSEIARLRAAHDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLAECLDIIHDSGMKAASLVRQLLIFSRKSTLEPQVVDIRSLIDNMAKILARVIGEDVIL
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEE
GLQTESPVGNILVDPAQVEQIIMNLVVNARDAMPQGGTVTIRAEDVELDSSYTCSHLDLV
EEECCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECEECCCCCCCCEEECC
PGPYVMLSVRDTGMGMSPEVRARIFEPFFTTKEVGEGTGLGLSTVYGIVRQMAGHIYVYS
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEEEC
EPGRGSEFKVYFPVCRENVAAVGPEVEKTVAGGSETILVVEDDASILTLIASLLEPLGYA
CCCCCCEEEEEEHHHHCHHHHCCCCHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCEE
VLAAHSGDEALALAERSGKRIDLLLTDVVMPGMGGRKLAGLFLEKHPAARVVFMSGYTDD
EEEECCCCCHHHHHHCCCCEEEEEEHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCCC
IIIRQGVSQGQCAFVQKPLSPRSLARKLREVLDGQGREGAAPPVPAG
HHEECCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA