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The map label for this gene is trpA

Identifier: 118579593

GI number: 118579593

Start: 1212717

End: 1213520

Strand: Reverse

Name: trpA

Synonym: Ppro_1162

Alternate gene names: 118579593

Gene position: 1213520-1212717 (Counterclockwise)

Preceding gene: 118579594

Following gene: 118579592

Centisome position: 30.28

GC content: 65.55

Gene sequence:

>804_bases
ATGAACAGACTCACCCACTGCTTCAACGAACTCAAGCAGCGCAACACAAAGGCGCTGGTCACCTTCATCACCGCCGGCGA
CCCTGATCTGGCCACTACGCAAGCCATGATCCCGCTCCTGCAGCAGGCCGGGGCGGACATCATCGAACTGGGCATGCCCT
TTTCCGATCCCATGGCCGACGGCCCCACCATCCAGCTCTCATCGGAACGCGCCCTGGCGGCCAGCACGACTCTGGAAAGA
ATTCTGGCCATGGTCCGCGCGGTGCGCCGCAGCTGCCAGGTACCCATCGTGCTGATGGGCTACCTGAATCCGATCCACGC
CTACGGCTACGAGCGCTTTGCCAACGATGCCGCCGAGGCCGGCGTTGACGGCGTCCTGGTGGTGGACATGCCCCCCGAGG
AGGCGGAGTCGTTCCTGAACCATGCCAATGCCCGCGACCTGCAGGTGGCCTTCCTGCTGACACCCACGTCCACCGACAGC
CGAATCGCCACCGTGGGCCGACTGGGGCGCGGCTTCGTCTACTACGTGACGGTCACCGGTGTCACCGGAGCACGCCAGCA
GGTATCCACCACCCTGGGCGGCGAGCTTGCCAAGGTGCGCGCCAAAATCAGCGTCCCCATTGTGGCCGGCTTCGGCATTT
CCACCCCCCAGCAGGCGGCAGACGTTGCCGCCATGGCCGACGGGGTCGTGGTGGGAAGCGCCCTGGTCAAACTCTTCCAA
CTCCACAGCGGAGAAGAGCTCCGCCAGGAAGTCACGCGCTTTGTCGCCTCGCTCAGACAGGCCATCCCTGGCGGGGCCGC
CTGA

Upstream 100 bases:

>100_bases
GATGGCTCCCTGACCGCCCTGGGGGAACAGATCAGGCTGCTGAGAAGCGAACTGTCGGACTTCAGTGCATAACCCCACTC
CACACGCAACGGACACCACA

Downstream 100 bases:

>100_bases
TCCCGCCTCCCCCCGGGAAGCGTTGCAATAGGGTTGACGCAGACGTTTACGGCGGTACGCCGGGGAGCCGGTGGCACAGG
CAACGAGAGAAAAGACTCTA

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MNRLTHCFNELKQRNTKALVTFITAGDPDLATTQAMIPLLQQAGADIIELGMPFSDPMADGPTIQLSSERALAASTTLER
ILAMVRAVRRSCQVPIVLMGYLNPIHAYGYERFANDAAEAGVDGVLVVDMPPEEAESFLNHANARDLQVAFLLTPTSTDS
RIATVGRLGRGFVYYVTVTGVTGARQQVSTTLGGELAKVRAKISVPIVAGFGISTPQQAADVAAMADGVVVGSALVKLFQ
LHSGEELRQEVTRFVASLRQAIPGGAA

Sequences:

>Translated_267_residues
MNRLTHCFNELKQRNTKALVTFITAGDPDLATTQAMIPLLQQAGADIIELGMPFSDPMADGPTIQLSSERALAASTTLER
ILAMVRAVRRSCQVPIVLMGYLNPIHAYGYERFANDAAEAGVDGVLVVDMPPEEAESFLNHANARDLQVAFLLTPTSTDS
RIATVGRLGRGFVYYVTVTGVTGARQQVSTTLGGELAKVRAKISVPIVAGFGISTPQQAADVAAMADGVVVGSALVKLFQ
LHSGEELRQEVTRFVASLRQAIPGGAA
>Mature_267_residues
MNRLTHCFNELKQRNTKALVTFITAGDPDLATTQAMIPLLQQAGADIIELGMPFSDPMADGPTIQLSSERALAASTTLER
ILAMVRAVRRSCQVPIVLMGYLNPIHAYGYERFANDAAEAGVDGVLVVDMPPEEAESFLNHANARDLQVAFLLTPTSTDS
RIATVGRLGRGFVYYVTVTGVTGARQQVSTTLGGELAKVRAKISVPIVAGFGISTPQQAADVAAMADGVVVGSALVKLFQ
LHSGEELRQEVTRFVASLRQAIPGGAA

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family

Homologues:

Organism=Escherichia coli, GI1787514, Length=247, Percent_Identity=36.4372469635627, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6321412, Length=238, Percent_Identity=45.3781512605042, Blast_Score=203, Evalue=2e-53,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPA_PELPD (A1AN65)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_900843.1
- ProteinModelPortal:   A1AN65
- SMR:   A1AN65
- STRING:   A1AN65
- GeneID:   4573852
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_1162
- eggNOG:   COG0159
- HOGENOM:   HBG391690
- OMA:   ERFANDA
- PhylomeDB:   A1AN65
- ProtClustDB:   PRK13111
- HAMAP:   MF_00131
- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00262

Pfam domain/function: PF00290 Trp_syntA; SSF51366 RibP_bind_barrel

EC number: =4.2.1.20

Molecular weight: Translated: 28367; Mature: 28367

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: ACT_SITE 49-49 ACT_SITE 60-60

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLTHCFNELKQRNTKALVTFITAGDPDLATTQAMIPLLQQAGADIIELGMPFSDPMAD
CCHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCC
GPTIQLSSERALAASTTLERILAMVRAVRRSCQVPIVLMGYLNPIHAYGYERFANDAAEA
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCHHHHHHHHHHHHHHHHC
GVDGVLVVDMPPEEAESFLNHANARDLQVAFLLTPTSTDSRIATVGRLGRGFVYYVTVTG
CCCCEEEEECCHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHCCCCEEEEEEEEC
VTGARQQVSTTLGGELAKVRAKISVPIVAGFGISTPQQAADVAAMADGVVVGSALVKLFQ
CCCCHHHHHHHHCHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LHSGEELRQEVTRFVASLRQAIPGGAA
HCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNRLTHCFNELKQRNTKALVTFITAGDPDLATTQAMIPLLQQAGADIIELGMPFSDPMAD
CCHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCC
GPTIQLSSERALAASTTLERILAMVRAVRRSCQVPIVLMGYLNPIHAYGYERFANDAAEA
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCHHHHHHHHHHHHHHHHC
GVDGVLVVDMPPEEAESFLNHANARDLQVAFLLTPTSTDSRIATVGRLGRGFVYYVTVTG
CCCCEEEEECCHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHCCCCEEEEEEEEC
VTGARQQVSTTLGGELAKVRAKISVPIVAGFGISTPQQAADVAAMADGVVVGSALVKLFQ
CCCCHHHHHHHHCHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LHSGEELRQEVTRFVASLRQAIPGGAA
HCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA