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The map label for this gene is gltA [H]

Identifier: 118579566

GI number: 118579566

Start: 1176644

End: 1177969

Strand: Reverse

Name: gltA [H]

Synonym: Ppro_1134

Alternate gene names: 118579566

Gene position: 1177969-1176644 (Counterclockwise)

Preceding gene: 118579567

Following gene: 118579565

Centisome position: 29.39

GC content: 62.37

Gene sequence:

>1326_bases
ATGTCACTGAAAGAAACCCTCAGACGGAAGATCGAGGAATTCCGGCCACGCACCCAGAGATTGCTCAGGGAGTTCGGCAA
GGTAAAAATCGACGAAGTAACCATCGAGCAGTGCATCGGCGGCGGCCGTGACATCCCCTCCCTGGTGACCGACATCTCCT
ACCTGGACCCCTATGACGGAATCCGCTTCCGAGGCAAGAGCATCAACGAGACCTTCGAGGCCCTGCCCAAGCCACCGGGT
GCCCTGTATCCCACGGTGGAGGCGTTCTGGTACTTCCTGCTCACCGGCGACGTGCCCAGCGATGACCATGTGGAAGAGGT
CCTGCACGAGTTCAGGGCCCGCGCCAATGTCCCCTACTACGTCTACGACATCATCCGCGCCCTGCCGGTAGGAACGCACC
CCATGGTCATGCTCTCCAGCGCCGTGCTCTCCATGCAGCGGGACTCGAAATTCGCCCGCTTCTACAATTCGGGCACGTTC
AACAAGAGAGATGCCTGGGCGTACATGTACGAGGACGCCAGCGACCTGGTGGCCCGCCTGCCCGAGATCGCCGCATTCAT
CTACCGCTACCGCTACCGGAACTGCGACATCATCACCTCCAACCCGGAACTGGACCTGGGGGCCAACTTTGCCCACATGA
TGGGCATTGCCCCCCCCTACGACGACCTCTCCCGGATGTACTTCATCATCCACTCCGACCACGAGTCGGGCAACGTATCC
GCCCATACAACCCACCTGGTGGCCTCGGCCCTTTCGGACGCCTTCTACGCCTACTCCGCCGGCCTGAACGGGTTGGCAGG
CCCCCTGCACGGCCTGGCAAACCAGGAGGTTCTGCGCTGGATCATGGCCTTCGAGAAGAAGCTGGGCGGCGCCGCGCCCA
CCAAGGAGAACGTCACCAGGGCTCTCTGGGACACCCTCGACGCCGGACAGATCATTCCCGGCTACGGCCACGCCGTCCTG
CGCAAGACCGACCCGCGTTTCCTGGCCCAGCGGGATTTCTGTCTGAGAATCCCCGAACTTAAGGAGGATCCGCTGGTCAA
GCTGGTGGCCATGCTGTTCGAGACCGCACCCGCCGTTCTGGCCGAGCACGGCAAGATACGCAACCCCTGGCCGAACGTGG
ATGCCCACTCCGGGGCGATCCAGTCCCACTACGGCGTCAAGGAATGGGACTTCTACACCGTGCTCTTCGGCGTGGGCCGT
TCCATCGGCTGCATGGCCAACATCACCTGGGACCGAGCCCTGGGCTATGCCATTGAACGCCCCAAATCGGTTACCACCAG
CATGCTGGAGAAATGGGCCGCGAACGGCGGCAGACAGAAGCACTGA

Upstream 100 bases:

>100_bases
CGTCTTCAGGAAGCAGGGGCGTGCCAGCAACAACCAGTCGCGCATCCCCCCATGACCATGACGCCACTGCCCTCCCTCAG
GCACGAAGGAGATTCACCGG

Downstream 100 bases:

>100_bases
TTTACGGCAGGATAGGCTATCAATCCGTTTTATAAAATTATCGCTTGCATAACACCAATCATACGATATAAATAGGATAT
TATTTATCCTATTTGTGCCA

Product: type I citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MSLKETLRRKIEEFRPRTQRLLREFGKVKIDEVTIEQCIGGGRDIPSLVTDISYLDPYDGIRFRGKSINETFEALPKPPG
ALYPTVEAFWYFLLTGDVPSDDHVEEVLHEFRARANVPYYVYDIIRALPVGTHPMVMLSSAVLSMQRDSKFARFYNSGTF
NKRDAWAYMYEDASDLVARLPEIAAFIYRYRYRNCDIITSNPELDLGANFAHMMGIAPPYDDLSRMYFIIHSDHESGNVS
AHTTHLVASALSDAFYAYSAGLNGLAGPLHGLANQEVLRWIMAFEKKLGGAAPTKENVTRALWDTLDAGQIIPGYGHAVL
RKTDPRFLAQRDFCLRIPELKEDPLVKLVAMLFETAPAVLAEHGKIRNPWPNVDAHSGAIQSHYGVKEWDFYTVLFGVGR
SIGCMANITWDRALGYAIERPKSVTTSMLEKWAANGGRQKH

Sequences:

>Translated_441_residues
MSLKETLRRKIEEFRPRTQRLLREFGKVKIDEVTIEQCIGGGRDIPSLVTDISYLDPYDGIRFRGKSINETFEALPKPPG
ALYPTVEAFWYFLLTGDVPSDDHVEEVLHEFRARANVPYYVYDIIRALPVGTHPMVMLSSAVLSMQRDSKFARFYNSGTF
NKRDAWAYMYEDASDLVARLPEIAAFIYRYRYRNCDIITSNPELDLGANFAHMMGIAPPYDDLSRMYFIIHSDHESGNVS
AHTTHLVASALSDAFYAYSAGLNGLAGPLHGLANQEVLRWIMAFEKKLGGAAPTKENVTRALWDTLDAGQIIPGYGHAVL
RKTDPRFLAQRDFCLRIPELKEDPLVKLVAMLFETAPAVLAEHGKIRNPWPNVDAHSGAIQSHYGVKEWDFYTVLFGVGR
SIGCMANITWDRALGYAIERPKSVTTSMLEKWAANGGRQKH
>Mature_440_residues
SLKETLRRKIEEFRPRTQRLLREFGKVKIDEVTIEQCIGGGRDIPSLVTDISYLDPYDGIRFRGKSINETFEALPKPPGA
LYPTVEAFWYFLLTGDVPSDDHVEEVLHEFRARANVPYYVYDIIRALPVGTHPMVMLSSAVLSMQRDSKFARFYNSGTFN
KRDAWAYMYEDASDLVARLPEIAAFIYRYRYRNCDIITSNPELDLGANFAHMMGIAPPYDDLSRMYFIIHSDHESGNVSA
HTTHLVASALSDAFYAYSAGLNGLAGPLHGLANQEVLRWIMAFEKKLGGAAPTKENVTRALWDTLDAGQIIPGYGHAVLR
KTDPRFLAQRDFCLRIPELKEDPLVKLVAMLFETAPAVLAEHGKIRNPWPNVDAHSGAIQSHYGVKEWDFYTVLFGVGRS
IGCMANITWDRALGYAIERPKSVTTSMLEKWAANGGRQKH

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=433, Percent_Identity=45.4965357967667, Blast_Score=398, Evalue=1e-111,
Organism=Escherichia coli, GI1786939, Length=352, Percent_Identity=26.9886363636364, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786527, Length=333, Percent_Identity=22.2222222222222, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17555174, Length=434, Percent_Identity=45.852534562212, Blast_Score=395, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6324328, Length=429, Percent_Identity=47.5524475524476, Blast_Score=414, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6319850, Length=440, Percent_Identity=46.3636363636364, Blast_Score=409, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6325257, Length=452, Percent_Identity=38.716814159292, Blast_Score=303, Evalue=5e-83,
Organism=Drosophila melanogaster, GI24640124, Length=432, Percent_Identity=47.6851851851852, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24640126, Length=432, Percent_Identity=47.6851851851852, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI21356863, Length=434, Percent_Identity=43.3179723502304, Blast_Score=348, Evalue=4e-96,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 49775; Mature: 49644

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKETLRRKIEEFRPRTQRLLREFGKVKIDEVTIEQCIGGGRDIPSLVTDISYLDPYDG
CCHHHHHHHHHHHHCHHHHHHHHHHCCCEEHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
IRFRGKSINETFEALPKPPGALYPTVEAFWYFLLTGDVPSDDHVEEVLHEFRARANVPYY
CEECCCCHHHHHHHCCCCCCCCCCCHHHHEEHHEECCCCCHHHHHHHHHHHHHHCCCCHH
VYDIIRALPVGTHPMVMLSSAVLSMQRDSKFARFYNSGTFNKRDAWAYMYEDASDLVARL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHH
PEIAAFIYRYRYRNCDIITSNPELDLGANFAHMMGIAPPYDDLSRMYFIIHSDHESGNVS
HHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHCCCCCHHHHCCEEEEEECCCCCCCCC
AHTTHLVASALSDAFYAYSAGLNGLAGPLHGLANQEVLRWIMAFEKKLGGAAPTKENVTR
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
ALWDTLDAGQIIPGYGHAVLRKTDPRFLAQRDFCLRIPELKEDPLVKLVAMLFETAPAVL
HHHHHCCCCCCCCCCCCHHEECCCCHHHHCCCHHEECCCCCCCHHHHHHHHHHHHHHHHH
AEHGKIRNPWPNVDAHSGAIQSHYGVKEWDFYTVLFGVGRSIGCMANITWDRALGYAIER
HHCCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHCC
PKSVTTSMLEKWAANGGRQKH
CHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SLKETLRRKIEEFRPRTQRLLREFGKVKIDEVTIEQCIGGGRDIPSLVTDISYLDPYDG
CHHHHHHHHHHHHCHHHHHHHHHHCCCEEHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
IRFRGKSINETFEALPKPPGALYPTVEAFWYFLLTGDVPSDDHVEEVLHEFRARANVPYY
CEECCCCHHHHHHHCCCCCCCCCCCHHHHEEHHEECCCCCHHHHHHHHHHHHHHCCCCHH
VYDIIRALPVGTHPMVMLSSAVLSMQRDSKFARFYNSGTFNKRDAWAYMYEDASDLVARL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHH
PEIAAFIYRYRYRNCDIITSNPELDLGANFAHMMGIAPPYDDLSRMYFIIHSDHESGNVS
HHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHCCCCCHHHHCCEEEEEECCCCCCCCC
AHTTHLVASALSDAFYAYSAGLNGLAGPLHGLANQEVLRWIMAFEKKLGGAAPTKENVTR
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
ALWDTLDAGQIIPGYGHAVLRKTDPRFLAQRDFCLRIPELKEDPLVKLVAMLFETAPAVL
HHHHHCCCCCCCCCCCCHHEECCCCHHHHCCCHHEECCCCCCCHHHHHHHHHHHHHHHHH
AEHGKIRNPWPNVDAHSGAIQSHYGVKEWDFYTVLFGVGRSIGCMANITWDRALGYAIER
HHCCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHCC
PKSVTTSMLEKWAANGGRQKH
CHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7522844; 12948626 [H]