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The map label for this gene is pth

Identifier: 118579183

GI number: 118579183

Start: 785660

End: 786241

Strand: Direct

Name: pth

Synonym: Ppro_0745

Alternate gene names: 118579183

Gene position: 785660-786241 (Clockwise)

Preceding gene: 118579182

Following gene: 118579184

Centisome position: 19.6

GC content: 59.11

Gene sequence:

>582_bases
ATGAGCATGCATATCATAGCGGGGCTGGGTAATCCCGGCTCCCACTATCAATGGACCCGCCACAACGCGGGTTTCCTTTT
TTTGGATCGCCTGGCCCATCTGGAGAATGTCAGCATAACCCGCAAGAGCTTTTCAGGCCTGGCGGGTGAGTGGAGCCGCG
CCAACTGCCGCCATATCCTCCTGAAACCCCAGACCTTCATGAACCTCTCCGGCCGGTCGGTCATGCAGGCGCTTCAGTTC
TACAAGCTCCCCCTCTCCCAGGCGATCGTGGTTCACGACGATCTTGATCTCCCCTTCGGCACCGTCCGCCTCAAGCAGGG
TGGGGGGCACGGCGGCCACAACGGCCTGCGCTCCATCATGGAGCAGTTGGGCAAGGGGGACTTCATCCGTCTGCGCGTTG
GCATTGGCAGGCCACTCCATGGCGACACGGTAAACTACGTGCTGGGCAGCATGCCGCCGGAGCAGATGGAACTCCTTCCC
CGTATTCTGGATGGCGGCCTGGAAATGCTGGAAATGCTGCTGGATCAGGGGCTGCCGAAGGCCATGAGTCTGTTCAATAA
TAGAAATTTCCTGGAAAAGTGA

Upstream 100 bases:

>100_bases
ACCCCAAAACTCCGGTGGTCAGCGTTCTCGGCAGGGTCAAGGAAGAGGCTGAGGCCGCTGCCGAGGCCGCCGAAGCCTAG
TCCGGCCAGCGTCACATTCA

Downstream 100 bases:

>100_bases
TTTCCCAGATGAAAGGCGAGTCTTTATGGGTTTCAACTGCGGTATCGTCGGTCTCCCCAATGTGGGGAAATCCACCATAT
TCAATGCGCTGACTTCCGCC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MSMHIIAGLGNPGSHYQWTRHNAGFLFLDRLAHLENVSITRKSFSGLAGEWSRANCRHILLKPQTFMNLSGRSVMQALQF
YKLPLSQAIVVHDDLDLPFGTVRLKQGGGHGGHNGLRSIMEQLGKGDFIRLRVGIGRPLHGDTVNYVLGSMPPEQMELLP
RILDGGLEMLEMLLDQGLPKAMSLFNNRNFLEK

Sequences:

>Translated_193_residues
MSMHIIAGLGNPGSHYQWTRHNAGFLFLDRLAHLENVSITRKSFSGLAGEWSRANCRHILLKPQTFMNLSGRSVMQALQF
YKLPLSQAIVVHDDLDLPFGTVRLKQGGGHGGHNGLRSIMEQLGKGDFIRLRVGIGRPLHGDTVNYVLGSMPPEQMELLP
RILDGGLEMLEMLLDQGLPKAMSLFNNRNFLEK
>Mature_192_residues
SMHIIAGLGNPGSHYQWTRHNAGFLFLDRLAHLENVSITRKSFSGLAGEWSRANCRHILLKPQTFMNLSGRSVMQALQFY
KLPLSQAIVVHDDLDLPFGTVRLKQGGGHGGHNGLRSIMEQLGKGDFIRLRVGIGRPLHGDTVNYVLGSMPPEQMELLPR
ILDGGLEMLEMLLDQGLPKAMSLFNNRNFLEK

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=170, Percent_Identity=39.4117647058824, Blast_Score=112, Evalue=2e-25,
Organism=Escherichia coli, GI1787455, Length=188, Percent_Identity=40.9574468085106, Blast_Score=110, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6321983, Length=169, Percent_Identity=28.9940828402367, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_PELPD (A1AM05)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_900433.1
- ProteinModelPortal:   A1AM05
- SMR:   A1AM05
- STRING:   A1AM05
- GeneID:   4572017
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_0745
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- PhylomeDB:   A1AM05
- ProtClustDB:   PRK05426
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21541; Mature: 21410

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMHIIAGLGNPGSHYQWTRHNAGFLFLDRLAHLENVSITRKSFSGLAGEWSRANCRHIL
CCEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCEEEE
LKPQTFMNLSGRSVMQALQFYKLPLSQAIVVHDDLDLPFGTVRLKQGGGHGGHNGLRSIM
ECCHHHHCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHH
EQLGKGDFIRLRVGIGRPLHGDTVNYVLGSMPPEQMELLPRILDGGLEMLEMLLDQGLPK
HHHCCCCEEEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AMSLFNNRNFLEK
HHHHHCCCCCCCC
>Mature Secondary Structure 
SMHIIAGLGNPGSHYQWTRHNAGFLFLDRLAHLENVSITRKSFSGLAGEWSRANCRHIL
CEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCEEEE
LKPQTFMNLSGRSVMQALQFYKLPLSQAIVVHDDLDLPFGTVRLKQGGGHGGHNGLRSIM
ECCHHHHCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHH
EQLGKGDFIRLRVGIGRPLHGDTVNYVLGSMPPEQMELLPRILDGGLEMLEMLLDQGLPK
HHHCCCCEEEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AMSLFNNRNFLEK
HHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA