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The map label for this gene is nadC [H]

Identifier: 118579092

GI number: 118579092

Start: 691410

End: 692237

Strand: Direct

Name: nadC [H]

Synonym: Ppro_0653

Alternate gene names: 118579092

Gene position: 691410-692237 (Clockwise)

Preceding gene: 118579091

Following gene: 118579093

Centisome position: 17.25

GC content: 62.92

Gene sequence:

>828_bases
ATGCTTACACTTGACCGATTCATCGATGCTGCCCTGGCCGAAGACATTCACACCGGAGATATCACCACCCGTGCCCTCCT
GCCGAAGAAGCGGCCGGCAACCGCGCGCCTGGTGGCCAAGGAAGACTTCGTGCTGGCCGGCATCTCTGTTGCCGAAAGGG
TTTTTGACCGCCTTGGCGGCTCTCCCGTTGATTTTGCCGCCCGCGCCGTCGACGGAGAGTTGATCGCCAGCGGGAGCGTC
TTCGCTACCCTGGAGGGGGATGCGGCCGACCTGCTCATGGGTGAGCGGGTTGCCCTCAACCTGCTGCAGCGCATGTGCGG
TGTCGCCACCATCACCTCCCACTTCGTCCAGGCGGTGCGGGGGACCAGGACGCGTATCGTGGATACCCGCAAGACCACCC
CCGGCCTGCGGGAGCTGGAAAAGTACGCCGTCCGGGTGGGCGGGGGCTTTAACCACCGCACCGGGCTGTACGACGGCGTG
CTGATCAAGGAAAACCACATTGCCGCGGCTGGCGGCATTGGCGAGGCTATCAGCCGCGCCCGGGCATATATTCCCCATAC
CCTGAAAATCGAGATCGAGACTGAGACCCTGGCACAGGTTGAAGAAGCGCTGACTGCGGGGGCCGATGTGATCATGCTGG
ACAACATGACTCTGGATGATATGCGTGCGGCTGTCTCGCTGGTATCCGGTCGTGTGCCGCTGGAGGCGTCGGGAGGTGTC
TCGCTGGATACGGTGAGAGCCATTGCCGAAACAGGGGTCGACATCATCTCGGTCGGCGCCCTGACCCATTCGGCGCGGGC
CATGGACATATCGATGCTGCTTGAATAG

Upstream 100 bases:

>100_bases
CGCCCCCCTGGAAAGCACTGCCCGGCGCGCCGGTTTTGCGGTTGATACCCCCCCTAACCTGTGGTATACAGGGACACATT
TACCCTATCAGGCGGATGAC

Downstream 100 bases:

>100_bases
CCCGGACAGCCGTTTGATCCGGGCATGTTTTATCTTTCTGGGAGGCTTGTAGCTGGAGATGTTACCATCGGCCGCCATAC
TGCGACTGTTCCGTGAACAG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MLTLDRFIDAALAEDIHTGDITTRALLPKKRPATARLVAKEDFVLAGISVAERVFDRLGGSPVDFAARAVDGELIASGSV
FATLEGDAADLLMGERVALNLLQRMCGVATITSHFVQAVRGTRTRIVDTRKTTPGLRELEKYAVRVGGGFNHRTGLYDGV
LIKENHIAAAGGIGEAISRARAYIPHTLKIEIETETLAQVEEALTAGADVIMLDNMTLDDMRAAVSLVSGRVPLEASGGV
SLDTVRAIAETGVDIISVGALTHSARAMDISMLLE

Sequences:

>Translated_275_residues
MLTLDRFIDAALAEDIHTGDITTRALLPKKRPATARLVAKEDFVLAGISVAERVFDRLGGSPVDFAARAVDGELIASGSV
FATLEGDAADLLMGERVALNLLQRMCGVATITSHFVQAVRGTRTRIVDTRKTTPGLRELEKYAVRVGGGFNHRTGLYDGV
LIKENHIAAAGGIGEAISRARAYIPHTLKIEIETETLAQVEEALTAGADVIMLDNMTLDDMRAAVSLVSGRVPLEASGGV
SLDTVRAIAETGVDIISVGALTHSARAMDISMLLE
>Mature_275_residues
MLTLDRFIDAALAEDIHTGDITTRALLPKKRPATARLVAKEDFVLAGISVAERVFDRLGGSPVDFAARAVDGELIASGSV
FATLEGDAADLLMGERVALNLLQRMCGVATITSHFVQAVRGTRTRIVDTRKTTPGLRELEKYAVRVGGGFNHRTGLYDGV
LIKENHIAAAGGIGEAISRARAYIPHTLKIEIETETLAQVEEALTAGADVIMLDNMTLDDMRAAVSLVSGRVPLEASGGV
SLDTVRAIAETGVDIISVGALTHSARAMDISMLLE

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=278, Percent_Identity=36.3309352517986, Blast_Score=153, Evalue=1e-37,
Organism=Escherichia coli, GI1786299, Length=267, Percent_Identity=45.6928838951311, Blast_Score=203, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6321162, Length=254, Percent_Identity=35.8267716535433, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29189; Mature: 29189

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLDRFIDAALAEDIHTGDITTRALLPKKRPATARLVAKEDFVLAGISVAERVFDRLGG
CCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCEEEEECCCEEEEHHHHHHHHHHHHCC
SPVDFAARAVDGELIASGSVFATLEGDAADLLMGERVALNLLQRMCGVATITSHFVQAVR
CCHHHHHHHCCCCEEECCCEEEEECCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
GTRTRIVDTRKTTPGLRELEKYAVRVGGGFNHRTGLYDGVLIKENHIAAAGGIGEAISRA
CCHHEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEEECCCHHHHHHHH
RAYIPHTLKIEIETETLAQVEEALTAGADVIMLDNMTLDDMRAAVSLVSGRVPLEASGGV
HHHCCEEEEEEECHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCC
SLDTVRAIAETGVDIISVGALTHSARAMDISMLLE
CHHHHHHHHHCCCCEEEECHHHHCCHHEEHHHHCC
>Mature Secondary Structure
MLTLDRFIDAALAEDIHTGDITTRALLPKKRPATARLVAKEDFVLAGISVAERVFDRLGG
CCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCEEEEECCCEEEEHHHHHHHHHHHHCC
SPVDFAARAVDGELIASGSVFATLEGDAADLLMGERVALNLLQRMCGVATITSHFVQAVR
CCHHHHHHHCCCCEEECCCEEEEECCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
GTRTRIVDTRKTTPGLRELEKYAVRVGGGFNHRTGLYDGVLIKENHIAAAGGIGEAISRA
CCHHEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEEECCCHHHHHHHH
RAYIPHTLKIEIETETLAQVEEALTAGADVIMLDNMTLDDMRAAVSLVSGRVPLEASGGV
HHHCCEEEEEEECHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCC
SLDTVRAIAETGVDIISVGALTHSARAMDISMLLE
CHHHHHHHHHCCCCEEEECHHHHCCHHEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659 [H]