Click here to switch to the map view.

The map label for this gene is nuoI1

Identifier: 118579075

GI number: 118579075

Start: 672654

End: 673214

Strand: Direct

Name: nuoI1

Synonym: Ppro_0636

Alternate gene names: 118579075

Gene position: 672654-673214 (Clockwise)

Preceding gene: 118579074

Following gene: 118579076

Centisome position: 16.78

GC content: 61.14

Gene sequence:

>561_bases
ATGAAGAAAGAGTACTGGAATAAGCCAACCATGGATCTGTGGGATCGCCTCTACATCTTCGAGGTGATCCGCGGGCTCTG
CATCACCGGATCGGTCTTCTTCGGCAACATGTGGAAATGGCTCACCTTCCGCAAGGGTGCCTTAACCGCCTACTATCCGG
AAGAACTGCGGGCCGACTACTCCAGCGCCAACCGGGGCCGGCACCTCCTGACCACGCGTGCCGACGGCAAGGTACAGTGC
GTATCGTGCAACATGTGCGCCACGGTCTGCCCTGCCTACTGCATCGAGATCCAGTCCGCCGCCGACTTTAACGACCCGTT
CCACCCCAAGTCCCCGGACCGGTTCGAGATCGACTACTCGCGCTGCATCTTCTGCGGTTTCTGTGTCGAAGCCTGCCCCG
AAGACGCCATCCGCATGTCCAAGGACACGCCCAACTTCCCCGGCTTCGACCGGGAGAACATGTGGGCCACCCAGGACCTG
CTCATGAACTGGCAGCCTGCGAGTGACGCGGCCAAGAGCTACCCCGGCTCCGGTCAGGCCCATCAGGAGGTTCATCCGTG
A

Upstream 100 bases:

>100_bases
GACCAGCTCATGCGATTCGGCTGGAAGTTCCTGCTTCCCCTGGCCGCCCTGAACCTCGTTGCCACGGCATGTGTCCGCTG
GTTCACGCTGAAAGGATGAT

Downstream 100 bases:

>100_bases
TCGACGTCTTCATCGCCTTCTTCAGTCTGCTGGCGGTCATCTTCGCCGCTCTGGTCCTGACACTGCGTCAGCCCATGCGC
TGCGCCCTGGCCCTGGTCAG

Product: 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MKKEYWNKPTMDLWDRLYIFEVIRGLCITGSVFFGNMWKWLTFRKGALTAYYPEELRADYSSANRGRHLLTTRADGKVQC
VSCNMCATVCPAYCIEIQSAADFNDPFHPKSPDRFEIDYSRCIFCGFCVEACPEDAIRMSKDTPNFPGFDRENMWATQDL
LMNWQPASDAAKSYPGSGQAHQEVHP

Sequences:

>Translated_186_residues
MKKEYWNKPTMDLWDRLYIFEVIRGLCITGSVFFGNMWKWLTFRKGALTAYYPEELRADYSSANRGRHLLTTRADGKVQC
VSCNMCATVCPAYCIEIQSAADFNDPFHPKSPDRFEIDYSRCIFCGFCVEACPEDAIRMSKDTPNFPGFDRENMWATQDL
LMNWQPASDAAKSYPGSGQAHQEVHP
>Mature_186_residues
MKKEYWNKPTMDLWDRLYIFEVIRGLCITGSVFFGNMWKWLTFRKGALTAYYPEELRADYSSANRGRHLLTTRADGKVQC
VSCNMCATVCPAYCIEIQSAADFNDPFHPKSPDRFEIDYSRCIFCGFCVEACPEDAIRMSKDTPNFPGFDRENMWATQDL
LMNWQPASDAAKSYPGSGQAHQEVHP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

Organism=Homo sapiens, GI4505371, Length=126, Percent_Identity=34.9206349206349, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI1788617, Length=150, Percent_Identity=36, Blast_Score=84, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17555194, Length=157, Percent_Identity=32.484076433121, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17864306, Length=139, Percent_Identity=33.0935251798561, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NUOI_PELPD (A1ALP7)

Other databases:

- EMBL:   CP000482
- EMBL:   CP000482
- EMBL:   CP000482
- RefSeq:   YP_900325.1
- RefSeq:   YP_901304.1
- RefSeq:   YP_902836.1
- ProteinModelPortal:   A1ALP7
- SMR:   A1ALP7
- STRING:   A1ALP7
- GeneID:   4571848
- GeneID:   4571992
- GeneID:   4573287
- GenomeReviews:   CP000482_GR
- GenomeReviews:   CP000482_GR
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_0636
- KEGG:   ppd:Ppro_1631
- KEGG:   ppd:Ppro_3185
- eggNOG:   COG1143
- HOGENOM:   HBG724359
- OMA:   DAIRMDS
- PhylomeDB:   A1ALP7
- ProtClustDB:   CLSK781333
- HAMAP:   MF_01351
- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR010226

Pfam domain/function: PF00037 Fer4

EC number: =1.6.99.5

Molecular weight: Translated: 21370; Mature: 21370

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
9.1 %Cys+Met (Translated Protein)
5.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
9.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKEYWNKPTMDLWDRLYIFEVIRGLCITGSVFFGNMWKWLTFRKGALTAYYPEELRADY
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHCCCCEEEECHHHHHHHH
SSANRGRHLLTTRADGKVQCVSCNMCATVCPAYCIEIQSAADFNDPFHPKSPDRFEIDYS
HCCCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECHH
RCIFCGFCVEACPEDAIRMSKDTPNFPGFDRENMWATQDLLMNWQPASDAAKSYPGSGQA
HHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHCCCCCCCC
HQEVHP
CCCCCC
>Mature Secondary Structure
MKKEYWNKPTMDLWDRLYIFEVIRGLCITGSVFFGNMWKWLTFRKGALTAYYPEELRADY
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHCCCCEEEECHHHHHHHH
SSANRGRHLLTTRADGKVQCVSCNMCATVCPAYCIEIQSAADFNDPFHPKSPDRFEIDYS
HCCCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECHH
RCIFCGFCVEACPEDAIRMSKDTPNFPGFDRENMWATQDLLMNWQPASDAAKSYPGSGQA
HHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHCCCCCCCC
HQEVHP
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA