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The map label for this gene is moeA [H]

Identifier: 118578894

GI number: 118578894

Start: 477479

End: 478693

Strand: Reverse

Name: moeA [H]

Synonym: Ppro_0454

Alternate gene names: 118578894

Gene position: 478693-477479 (Counterclockwise)

Preceding gene: 118578903

Following gene: 118578893

Centisome position: 11.94

GC content: 67.41

Gene sequence:

>1215_bases
ATGCTGTCGTTCGAAGAGGCTCGCAGAACCATACTGGCCCATGTCCGGCCCCTGGGCACGGAGCGGGTCCCGCTGCTGGA
CGCTCTCGGCCGCGTGCTGGCCGAGGACGCGGTCGCCCCCTGGGACATGCCCCTGTGGGACAATGCGGCCATGGACGGGT
ATGCGGTGCGCGCAGAGGATTGCGGCACCATTCCCCGCAGCCTGAGGGTGAGCGGGTTTCTTCCCGCCGGGGGCGGCACC
GCGGGGGAGCGCCTGGAACCGGGATGCGCGATCAGGATCATGACCGGCGCTCCGCTTCCGGACGGCTGCGATGCCGTGAT
GCCGCTGGAGGAGACCGACAACGGAAAGCGCTATGTCACGCTGCTGCGGCCGGTCAAGAAGGGGCAGCACATCCGCTTTC
GGGGCGGGGTGGTCAGGGAGGGAGGTGTCTTTGCCGCCGCCGGCACGCCTGTCGGAGCACCCCTCATCGGCATGTTGGCC
AGCTTCGGCATGACCATGGCTCCGGTGTGGCGGCGGCCGGTTGTGGCCCTGCTCTCCTCGGGAGACGAACTGATCGAGCC
GGGCAGGACGCCCGGGCCGGGACAGATCGTCAACAGCAATGCCCTGGCGCTGGCAGCAGCGGTACGGGAGGCGGGCGGAA
TCCCCCGCATGATCGGCATTGCCCGCGACAACCGGGTGAGCCACCATACTCTGTTGGCCGAGGGGTTGGGGGCGGACATG
CTGGTCACCTCGGCCGGTGTCTCGGCCGGGGACCGCGATTTCGTGCGCGATGTGCTGGAGGAACTGGGGGCACGTCAGCT
CTTCTGGAAGGTGGCAATGAGGCCCGGTGGGCCAAGCGCCTTTGCCCTGCATGGCTCCACACCGGCCTTCTGCCTGCCGG
GCAATCCCCTGGCAACCCTGATCACCTTCGAGGAGTTCGTACGACCGGCACTACTCAGGATGCAGGGTTTGCGGTCGGTT
CTGCGTCCGCTGTTCAGGGCCGTACTCCGTGACGAATTTCGCAAAAAGCCGGGCATCCTGCAGATCGTGCCGGTCCACCT
GGAGCGCGACGAGGGAAGATGGTACGCCTCCTTGACCACCAGACAGGGGACGGTCATTGGCGGGGATGCAAGCGGCGCCG
AGGCACTTGCCGTCCTGCCGGCCGAATCCGGCAGTTGCGACGCAGGAGACCAGGTGGAGGTACACCTCTGGGGAAACCGC
TCCGACCTGATCTGA

Upstream 100 bases:

>100_bases
CCTGCCAGGATGCCGCGAAGGGCAGGACCGCTGGCCTCGTCACGGTTGTATTTGACTCATCTTCCCGCTATTCTGTCACG
ACTCTACTCAGGAGGGGTAT

Downstream 100 bases:

>100_bases
GGCGAAGCAACCGGAATGAAAAATCACGTGAATACAGAGGTGAGCAATGCCTGATTATCTTGGCGCCCACATGTCCATAG
CAGGCGGCCTGCACCGGGCC

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MLSFEEARRTILAHVRPLGTERVPLLDALGRVLAEDAVAPWDMPLWDNAAMDGYAVRAEDCGTIPRSLRVSGFLPAGGGT
AGERLEPGCAIRIMTGAPLPDGCDAVMPLEETDNGKRYVTLLRPVKKGQHIRFRGGVVREGGVFAAAGTPVGAPLIGMLA
SFGMTMAPVWRRPVVALLSSGDELIEPGRTPGPGQIVNSNALALAAAVREAGGIPRMIGIARDNRVSHHTLLAEGLGADM
LVTSAGVSAGDRDFVRDVLEELGARQLFWKVAMRPGGPSAFALHGSTPAFCLPGNPLATLITFEEFVRPALLRMQGLRSV
LRPLFRAVLRDEFRKKPGILQIVPVHLERDEGRWYASLTTRQGTVIGGDASGAEALAVLPAESGSCDAGDQVEVHLWGNR
SDLI

Sequences:

>Translated_404_residues
MLSFEEARRTILAHVRPLGTERVPLLDALGRVLAEDAVAPWDMPLWDNAAMDGYAVRAEDCGTIPRSLRVSGFLPAGGGT
AGERLEPGCAIRIMTGAPLPDGCDAVMPLEETDNGKRYVTLLRPVKKGQHIRFRGGVVREGGVFAAAGTPVGAPLIGMLA
SFGMTMAPVWRRPVVALLSSGDELIEPGRTPGPGQIVNSNALALAAAVREAGGIPRMIGIARDNRVSHHTLLAEGLGADM
LVTSAGVSAGDRDFVRDVLEELGARQLFWKVAMRPGGPSAFALHGSTPAFCLPGNPLATLITFEEFVRPALLRMQGLRSV
LRPLFRAVLRDEFRKKPGILQIVPVHLERDEGRWYASLTTRQGTVIGGDASGAEALAVLPAESGSCDAGDQVEVHLWGNR
SDLI
>Mature_404_residues
MLSFEEARRTILAHVRPLGTERVPLLDALGRVLAEDAVAPWDMPLWDNAAMDGYAVRAEDCGTIPRSLRVSGFLPAGGGT
AGERLEPGCAIRIMTGAPLPDGCDAVMPLEETDNGKRYVTLLRPVKKGQHIRFRGGVVREGGVFAAAGTPVGAPLIGMLA
SFGMTMAPVWRRPVVALLSSGDELIEPGRTPGPGQIVNSNALALAAAVREAGGIPRMIGIARDNRVSHHTLLAEGLGADM
LVTSAGVSAGDRDFVRDVLEELGARQLFWKVAMRPGGPSAFALHGSTPAFCLPGNPLATLITFEEFVRPALLRMQGLRSV
LRPLFRAVLRDEFRKKPGILQIVPVHLERDEGRWYASLTTRQGTVIGGDASGAEALAVLPAESGSCDAGDQVEVHLWGNR
SDLI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=355, Percent_Identity=36.9014084507042, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI10880983, Length=355, Percent_Identity=36.9014084507042, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1787049, Length=393, Percent_Identity=38.1679389312977, Blast_Score=213, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI25147659, Length=374, Percent_Identity=29.6791443850267, Blast_Score=137, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17562606, Length=311, Percent_Identity=24.4372990353698, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17136978, Length=368, Percent_Identity=29.3478260869565, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24638841, Length=368, Percent_Identity=29.3478260869565, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42989; Mature: 42989

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSFEEARRTILAHVRPLGTERVPLLDALGRVLAEDAVAPWDMPLWDNAAMDGYAVRAED
CCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCC
CGTIPRSLRVSGFLPAGGGTAGERLEPGCAIRIMTGAPLPDGCDAVMPLEETDNGKRYVT
CCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEECCCCCCCCCEEEE
LLRPVKKGQHIRFRGGVVREGGVFAAAGTPVGAPLIGMLASFGMTMAPVWRRPVVALLSS
EEEHHCCCCEEEEECCEEECCCEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHC
GDELIEPGRTPGPGQIVNSNALALAAAVREAGGIPRMIGIARDNRVSHHTLLAEGLGADM
CHHHHCCCCCCCCCCEECCCHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCCCCCE
LVTSAGVSAGDRDFVRDVLEELGARQLFWKVAMRPGGPSAFALHGSTPAFCLPGNPLATL
EEEECCCCCCCHHHHHHHHHHCCHHHEEHHHEECCCCCCEEEEECCCCEEEECCCCHHHH
ITFEEFVRPALLRMQGLRSVLRPLFRAVLRDEFRKKPGILQIVPVHLERDEGRWYASLTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCEEEEEEE
RQGTVIGGDASGAEALAVLPAESGSCDAGDQVEVHLWGNRSDLI
CCCEEEECCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure
MLSFEEARRTILAHVRPLGTERVPLLDALGRVLAEDAVAPWDMPLWDNAAMDGYAVRAED
CCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCC
CGTIPRSLRVSGFLPAGGGTAGERLEPGCAIRIMTGAPLPDGCDAVMPLEETDNGKRYVT
CCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEECCCCCCCCCEEEE
LLRPVKKGQHIRFRGGVVREGGVFAAAGTPVGAPLIGMLASFGMTMAPVWRRPVVALLSS
EEEHHCCCCEEEEECCEEECCCEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHC
GDELIEPGRTPGPGQIVNSNALALAAAVREAGGIPRMIGIARDNRVSHHTLLAEGLGADM
CHHHHCCCCCCCCCCEECCCHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCCCCCE
LVTSAGVSAGDRDFVRDVLEELGARQLFWKVAMRPGGPSAFALHGSTPAFCLPGNPLATL
EEEECCCCCCCHHHHHHHHHHCCHHHEEHHHEECCCCCCEEEEECCCCEEEECCCCHHHH
ITFEEFVRPALLRMQGLRSVLRPLFRAVLRDEFRKKPGILQIVPVHLERDEGRWYASLTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCEEEEEEE
RQGTVIGGDASGAEALAVLPAESGSCDAGDQVEVHLWGNRSDLI
CCCEEEECCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]