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The map label for this gene is accD [C]

Identifier: 118578482

GI number: 118578482

Start: 39685

End: 41235

Strand: Direct

Name: accD [C]

Synonym: Ppro_0034

Alternate gene names: 118578482

Gene position: 39685-41235 (Clockwise)

Preceding gene: 118578481

Following gene: 118578483

Centisome position: 0.99

GC content: 63.25

Gene sequence:

>1551_bases
ATGGCAATCACAATAGAGGATAGAATCCAGGAACTCAACGACAAGAAGGCCGAGATCGCCCTTGGTGGCGGTCGCGCCCG
AATTGAGAAACAGCACGCCGCCGGCAGCATGACCGCCCGTGAGCGTCTCGACTACATGCTGGACCAGGACAGCTTCCTGG
AGAGCGGCATGTACGCCAAGCACCGCTGCACCTACTTCGGCATGGAAGGCAAAGTCCTGCCTGCCGAAGGTGTCGTCACC
GGCGCCGGCACCATCGACGGCCGCCTCGTGCACGTAGCCAGCCAGGACTTCACCGTCGCCGGCGGCGCCGTGGGCGAAGT
CCACGCCGACAAGATCGTGCGGGCCATGGAAGACGCCCTCAAGACCGGCTCTCCCTGCGTCGTCATCAACGACTCCGGCG
GGGCGCGCATCCAGGAAGGTAACCACAGCCTGGGTGGCTACGGCCGCATCTTCTACGCCAACGTCAAGGCCTCCGGCGTC
ATCCCCCAGATCTCCATCATCGCCGGTCCCTGCGCCGGTGGCGCCGTGTACAGCCCGGCTCTCACCGACTTCATCATCCA
GACCAAGAGCGCCCGCATGTTCATCACCGGCCCTGCCGTCATCAAGGCCGTCACCGGTGAAGTGGTCAGCGCCGAAGACC
TGGGTGGGCCGCAGGTTCACATGAACACCTCCGGCGTCATCCACTTCGTCGCCGAAGACGACAAGCACGCCCTGGACATC
ACCCGCAGGCTGCTCTCCTTCCTGCCCAGCAACAACCTGGAAGATCCTCCCCAGCTGGAAGCGGAAGAGACCATCCTGCC
CAACAAGGCTCTCAACAACATCGTACCGCTGGATCCCAAACTGCGTTACGACGTCCGTGACGTCATTGTCAACATCTTTG
ACAAGGGCGACTTCATGGAGATCCAGGCCGGCTACGCCACCAACATCGTCATCGGCTTTGCCCGCCTGCAGGGTCGCACC
GTCGGCGTCATCGCCAACCAGCCCAACGCCATGGCCGGCGTCCTGGACATCAACTGCTCCGACAAGGCTGCCCGCTTCAT
CCGTTTCTGCAACGCCTTCAACATCCCGCTGATCACCTTCGTCGACACCCCCGGCTTCATGCCCGGTGTCCAGCAGGAAT
ACGGCGGCATCATCCGTCACGGCGCCAAGATGCTCTTCGCCTACTCCGCCGCCACCGTACCCAAGCTCACCGTCGAGCTG
CGTAAATCCTACGGCGGCGCCAATCTGGCCATGTGCGCCAAAGACCTGGGCGCCGACCGCGTCCTGGCCTGGCCCACCGC
CGAGATCGCCGTCATGGGTGCCGAAGGCGCCGTCGACGTCATCTTCCGTAAAGAGCTCAAAGAAGCTGCCGATCCCAAGG
CCAAGCGCCAGGAACTCATCGACGAATACCGCGAGAACTTTGCCAACCCGTTTGCCGCCGCCGCCTGCAACCAGGTGGAC
GACGTCATCGAACCGGCGTACACCCGTCGCGAACTGGCCATGGCCCTCGACATCCTCTACCGCAAACGCGAGCTGCGTCC
GGCCAAGAAGCACGGCCTGATTCCGCTGTAA

Upstream 100 bases:

>100_bases
GAAGGGCAGAAACACAAGGTAGTCGTCGCCCCGTACAAAAAGTAACCTGACCACGTAATCGCTTACTTCTACATTGTAAT
TTCAATACAAGTGAGGAACC

Downstream 100 bases:

>100_bases
CCACACACCACACCGGAGGACGCAATGTCGGAAGAGAAAATAGCACCGGAAATACTGATGATCATGTCAGCCTCCATCGC
CGCCTTCCTTGGCAAGAACG

Product: carboxyl transferase

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MAITIEDRIQELNDKKAEIALGGGRARIEKQHAAGSMTARERLDYMLDQDSFLESGMYAKHRCTYFGMEGKVLPAEGVVT
GAGTIDGRLVHVASQDFTVAGGAVGEVHADKIVRAMEDALKTGSPCVVINDSGGARIQEGNHSLGGYGRIFYANVKASGV
IPQISIIAGPCAGGAVYSPALTDFIIQTKSARMFITGPAVIKAVTGEVVSAEDLGGPQVHMNTSGVIHFVAEDDKHALDI
TRRLLSFLPSNNLEDPPQLEAEETILPNKALNNIVPLDPKLRYDVRDVIVNIFDKGDFMEIQAGYATNIVIGFARLQGRT
VGVIANQPNAMAGVLDINCSDKAARFIRFCNAFNIPLITFVDTPGFMPGVQQEYGGIIRHGAKMLFAYSAATVPKLTVEL
RKSYGGANLAMCAKDLGADRVLAWPTAEIAVMGAEGAVDVIFRKELKEAADPKAKRQELIDEYRENFANPFAAAACNQVD
DVIEPAYTRRELAMALDILYRKRELRPAKKHGLIPL

Sequences:

>Translated_516_residues
MAITIEDRIQELNDKKAEIALGGGRARIEKQHAAGSMTARERLDYMLDQDSFLESGMYAKHRCTYFGMEGKVLPAEGVVT
GAGTIDGRLVHVASQDFTVAGGAVGEVHADKIVRAMEDALKTGSPCVVINDSGGARIQEGNHSLGGYGRIFYANVKASGV
IPQISIIAGPCAGGAVYSPALTDFIIQTKSARMFITGPAVIKAVTGEVVSAEDLGGPQVHMNTSGVIHFVAEDDKHALDI
TRRLLSFLPSNNLEDPPQLEAEETILPNKALNNIVPLDPKLRYDVRDVIVNIFDKGDFMEIQAGYATNIVIGFARLQGRT
VGVIANQPNAMAGVLDINCSDKAARFIRFCNAFNIPLITFVDTPGFMPGVQQEYGGIIRHGAKMLFAYSAATVPKLTVEL
RKSYGGANLAMCAKDLGADRVLAWPTAEIAVMGAEGAVDVIFRKELKEAADPKAKRQELIDEYRENFANPFAAAACNQVD
DVIEPAYTRRELAMALDILYRKRELRPAKKHGLIPL
>Mature_515_residues
AITIEDRIQELNDKKAEIALGGGRARIEKQHAAGSMTARERLDYMLDQDSFLESGMYAKHRCTYFGMEGKVLPAEGVVTG
AGTIDGRLVHVASQDFTVAGGAVGEVHADKIVRAMEDALKTGSPCVVINDSGGARIQEGNHSLGGYGRIFYANVKASGVI
PQISIIAGPCAGGAVYSPALTDFIIQTKSARMFITGPAVIKAVTGEVVSAEDLGGPQVHMNTSGVIHFVAEDDKHALDIT
RRLLSFLPSNNLEDPPQLEAEETILPNKALNNIVPLDPKLRYDVRDVIVNIFDKGDFMEIQAGYATNIVIGFARLQGRTV
GVIANQPNAMAGVLDINCSDKAARFIRFCNAFNIPLITFVDTPGFMPGVQQEYGGIIRHGAKMLFAYSAATVPKLTVELR
KSYGGANLAMCAKDLGADRVLAWPTAEIAVMGAEGAVDVIFRKELKEAADPKAKRQELIDEYRENFANPFAAAACNQVDD
VIEPAYTRRELAMALDILYRKRELRPAKKHGLIPL

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=522, Percent_Identity=52.1072796934866, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI295821216, Length=542, Percent_Identity=50.1845018450184, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI11545863, Length=503, Percent_Identity=35.1888667992048, Blast_Score=263, Evalue=4e-70,
Organism=Homo sapiens, GI134142062, Length=405, Percent_Identity=25.679012345679, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI38679974, Length=405, Percent_Identity=24.6913580246914, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI38679960, Length=405, Percent_Identity=24.6913580246914, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI38679971, Length=405, Percent_Identity=24.6913580246914, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI38679977, Length=405, Percent_Identity=24.6913580246914, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI38679967, Length=405, Percent_Identity=24.6913580246914, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1788655, Length=185, Percent_Identity=31.3513513513514, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25147362, Length=511, Percent_Identity=51.2720156555773, Blast_Score=525, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI25147359, Length=511, Percent_Identity=51.2720156555773, Blast_Score=524, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17552936, Length=515, Percent_Identity=35.3398058252427, Blast_Score=283, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI71997163, Length=292, Percent_Identity=27.3972602739726, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI133931226, Length=204, Percent_Identity=26.9607843137255, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6324343, Length=403, Percent_Identity=25.3101736972705, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323863, Length=348, Percent_Identity=24.7126436781609, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24586065, Length=519, Percent_Identity=35.8381502890173, Blast_Score=273, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 55761; Mature: 55630

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITIEDRIQELNDKKAEIALGGGRARIEKQHAAGSMTARERLDYMLDQDSFLESGMYAK
CEEEHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHCCCCHH
HRCTYFGMEGKVLPAEGVVTGAGTIDGRLVHVASQDFTVAGGAVGEVHADKIVRAMEDAL
CCEEEECCCCEEECCCCEEECCCCCCCEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHH
KTGSPCVVINDSGGARIQEGNHSLGGYGRIFYANVKASGVIPQISIIAGPCAGGAVYSPA
HCCCCEEEEECCCCCEEECCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCHH
LTDFIIQTKSARMFITGPAVIKAVTGEVVSAEDLGGPQVHMNTSGVIHFVAEDDKHALDI
HHHHHHEECCCEEEEECHHHHHHHHCCEEECCCCCCCEEEECCCCEEEEEECCCCHHHHH
TRRLLSFLPSNNLEDPPQLEAEETILPNKALNNIVPLDPKLRYDVRDVIVNIFDKGDFME
HHHHHHHCCCCCCCCCCCCCCCHHCCCCHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEE
IQAGYATNIVIGFARLQGRTVGVIANQPNAMAGVLDINCSDKAARFIRFCNAFNIPLITF
EECCCEEEEEEEEEECCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHCCCCCCEEEE
VDTPGFMPGVQQEYGGIIRHGAKMLFAYSAATVPKLTVELRKSYGGANLAMCAKDLGADR
ECCCCCCCCCHHHHHHHHHHCHHHEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCC
VLAWPTAEIAVMGAEGAVDVIFRKELKEAADPKAKRQELIDEYRENFANPFAAAACNQVD
EEECCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
DVIEPAYTRRELAMALDILYRKRELRPAKKHGLIPL
HHHCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC
>Mature Secondary Structure 
AITIEDRIQELNDKKAEIALGGGRARIEKQHAAGSMTARERLDYMLDQDSFLESGMYAK
EEEHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHCCCCHH
HRCTYFGMEGKVLPAEGVVTGAGTIDGRLVHVASQDFTVAGGAVGEVHADKIVRAMEDAL
CCEEEECCCCEEECCCCEEECCCCCCCEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHH
KTGSPCVVINDSGGARIQEGNHSLGGYGRIFYANVKASGVIPQISIIAGPCAGGAVYSPA
HCCCCEEEEECCCCCEEECCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCHH
LTDFIIQTKSARMFITGPAVIKAVTGEVVSAEDLGGPQVHMNTSGVIHFVAEDDKHALDI
HHHHHHEECCCEEEEECHHHHHHHHCCEEECCCCCCCEEEECCCCEEEEEECCCCHHHHH
TRRLLSFLPSNNLEDPPQLEAEETILPNKALNNIVPLDPKLRYDVRDVIVNIFDKGDFME
HHHHHHHCCCCCCCCCCCCCCCHHCCCCHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEE
IQAGYATNIVIGFARLQGRTVGVIANQPNAMAGVLDINCSDKAARFIRFCNAFNIPLITF
EECCCEEEEEEEEEECCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHCCCCCCEEEE
VDTPGFMPGVQQEYGGIIRHGAKMLFAYSAATVPKLTVELRKSYGGANLAMCAKDLGADR
ECCCCCCCCCHHHHHHHHHHCHHHEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCC
VLAWPTAEIAVMGAEGAVDVIFRKELKEAADPKAKRQELIDEYRENFANPFAAAACNQVD
EEECCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
DVIEPAYTRRELAMALDILYRKRELRPAKKHGLIPL
HHHCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]