| Definition | Bacillus thuringiensis str. Al Hakam chromosome, complete genome. |
|---|---|
| Accession | NC_008600 |
| Length | 5,257,091 |
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The map label for this gene is manA/manC [H]
Identifier: 118480309
GI number: 118480309
Start: 5025761
End: 5027140
Strand: Reverse
Name: manA/manC [H]
Synonym: BALH_4770
Alternate gene names: 118480309
Gene position: 5027140-5025761 (Counterclockwise)
Preceding gene: 118480310
Following gene: 118480308
Centisome position: 95.63
GC content: 35.29
Gene sequence:
>1380_bases ATGAAGTTAGTGTTACTATCAGGTGGATCTGGAAAGCGCCTTTGGCCATTATCGAATGATTCACGCTCTAAGCAATTTTT AAAAGTACTTAAAAGTGAAAAGAATGAAATGCAATCTATGGTTCAAAGAGTGTGGGAACAATTAAAAAGCTTAGGGATTG AAAATGATGCAGTTATTGCTACAAGTAAATCTCAAGTAGATATGATTAATAGTCAGCTAGGAAATGATGTACCTATTATT ATCGAGCCAGAACGCCGTGATACATTCCCGGCAATCGCTCTTGCTGCTTCATATCTATATTCTAAAGAGCACGTTGATTT GGATGAGGTTGTAGGTGTATTACCTGTAGATCCATACGTAGAAAATAGTTTCTTTGAAAGGCTATTGGATTTAGAAAATG CATTAAACTCTTCAAACGCAGATTTAGGTTTAATGGGGGTTACTCCTACATATCCATCTGAAAAATATGGTTATATTGTT CCCAATGTAGAGAAGAGTACACAGGAACTTATTCAAGTAAGTCATTTTAAAGAAAAGCCAGCCACTGCTGAGGCGGAAGA GTTACTAAAACAAAATGCACTTTGGAACAGTGGTGTATTTGCATTTAAATTAGATAAAATTATCTCCCTATTAGATCAAA AAGGACTTCCTGTTCAATATGATGTGTTAGTTCAACAATATGCAAGTTTACCAAAGATAAGTTTTGATTATGAAGTAGTA GAGAAAACAGAAAATATTATTGCGCTTCCTTATAGTGGTTCGTGGAAAGATCTTGGAACTTGGAATACTCTTACAGAAGA AATGGGAACGAACATCCTTGGTAAAGGAAATATGGGGGTTGAGTGTGAACAAAACCATATTATTAATGAGTTAGATATTC CAGTTTCTGTATTAGGTCTTTCTAACATAATTGTAGCTGCTAGCCCAGATGGTATTTTAGTTTCAGAAAAAGATGCCAGC CCTCGAGTAAAAGAATTAGTAGGGGATTGGGATCAAAGACCAATGTATGAAGAGCGTCGCTGGGGTTGGTACCGTGTACT AGATCACACTAAATATGATGATGGAAATGAAGTATTAACGAAGCGTATTGGTATTACAGCTAGTAAAAATTTAAGCTATC AATATCATAATAATAGAAGTGAAGTTTGGACAGTTGTAAAAGGTGAAGGTATTTTTGTATTAGATGAAGAAATACGAGTT GTTCGCCCTGGGGATGTGCTGGAAATTCAACCTGGACAGAAGCATGCAATTAAAGCTGTTACAGACTTAGAATTTATTGA AGTGCAATCAGGAAGTGAATTAATTGAGGAAGATATTGTCCGGATTTATATGCAATGGAACGAGATAGAGGAAGCTTGTT ATTTAAAAAGTAAAAATTAG
Upstream 100 bases:
>100_bases ATTGTTATCAAAAAGTATTAGAAAAGTATGATTGGAGTGCAATTGCAAAGGAAACGGAACATGTTTTAAAGCAGACTCTA TAATAAAAGGGTGAGTATGA
Downstream 100 bases:
>100_bases TAGTAAGTGCAACTAGAGGTGGAGTCATTTTGTATAAAGAACCATTATTTTTTCAACCAGTATTACAGGAGCGGATTTGG GGAGGAGAATCTTTAAAAGA
Product: mannose-1-phosphate guanylyltransferase (GDP)
Products: NA
Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]
Number of amino acids: Translated: 459; Mature: 459
Protein sequence:
>459_residues MKLVLLSGGSGKRLWPLSNDSRSKQFLKVLKSEKNEMQSMVQRVWEQLKSLGIENDAVIATSKSQVDMINSQLGNDVPII IEPERRDTFPAIALAASYLYSKEHVDLDEVVGVLPVDPYVENSFFERLLDLENALNSSNADLGLMGVTPTYPSEKYGYIV PNVEKSTQELIQVSHFKEKPATAEAEELLKQNALWNSGVFAFKLDKIISLLDQKGLPVQYDVLVQQYASLPKISFDYEVV EKTENIIALPYSGSWKDLGTWNTLTEEMGTNILGKGNMGVECEQNHIINELDIPVSVLGLSNIIVAASPDGILVSEKDAS PRVKELVGDWDQRPMYEERRWGWYRVLDHTKYDDGNEVLTKRIGITASKNLSYQYHNNRSEVWTVVKGEGIFVLDEEIRV VRPGDVLEIQPGQKHAIKAVTDLEFIEVQSGSELIEEDIVRIYMQWNEIEEACYLKSKN
Sequences:
>Translated_459_residues MKLVLLSGGSGKRLWPLSNDSRSKQFLKVLKSEKNEMQSMVQRVWEQLKSLGIENDAVIATSKSQVDMINSQLGNDVPII IEPERRDTFPAIALAASYLYSKEHVDLDEVVGVLPVDPYVENSFFERLLDLENALNSSNADLGLMGVTPTYPSEKYGYIV PNVEKSTQELIQVSHFKEKPATAEAEELLKQNALWNSGVFAFKLDKIISLLDQKGLPVQYDVLVQQYASLPKISFDYEVV EKTENIIALPYSGSWKDLGTWNTLTEEMGTNILGKGNMGVECEQNHIINELDIPVSVLGLSNIIVAASPDGILVSEKDAS PRVKELVGDWDQRPMYEERRWGWYRVLDHTKYDDGNEVLTKRIGITASKNLSYQYHNNRSEVWTVVKGEGIFVLDEEIRV VRPGDVLEIQPGQKHAIKAVTDLEFIEVQSGSELIEEDIVRIYMQWNEIEEACYLKSKN >Mature_459_residues MKLVLLSGGSGKRLWPLSNDSRSKQFLKVLKSEKNEMQSMVQRVWEQLKSLGIENDAVIATSKSQVDMINSQLGNDVPII IEPERRDTFPAIALAASYLYSKEHVDLDEVVGVLPVDPYVENSFFERLLDLENALNSSNADLGLMGVTPTYPSEKYGYIV PNVEKSTQELIQVSHFKEKPATAEAEELLKQNALWNSGVFAFKLDKIISLLDQKGLPVQYDVLVQQYASLPKISFDYEVV EKTENIIALPYSGSWKDLGTWNTLTEEMGTNILGKGNMGVECEQNHIINELDIPVSVLGLSNIIVAASPDGILVSEKDAS PRVKELVGDWDQRPMYEERRWGWYRVLDHTKYDDGNEVLTKRIGITASKNLSYQYHNNRSEVWTVVKGEGIFVLDEEIRV VRPGDVLEIQPGQKHAIKAVTDLEFIEVQSGSELIEEDIVRIYMQWNEIEEACYLKSKN
Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]
COG id: COG0836
COG function: function code M; Mannose-1-phosphate guanylyltransferase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]
Homologues:
Organism=Escherichia coli, GI1788362, Length=489, Percent_Identity=28.0163599182004, Blast_Score=149, Evalue=5e-37,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011051 - InterPro: IPR006375 - InterPro: IPR001538 - InterPro: IPR005835 - InterPro: IPR014710 [H]
Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]
EC number: =5.3.1.8; =2.7.7.13 [H]
Molecular weight: Translated: 51874; Mature: 51874
Theoretical pI: Translated: 4.50; Mature: 4.50
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.0 %Met (Mature Protein) 2.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKLVLLSGGSGKRLWPLSNDSRSKQFLKVLKSEKNEMQSMVQRVWEQLKSLGIENDAVIA CEEEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE TSKSQVDMINSQLGNDVPIIIEPERRDTFPAIALAASYLYSKEHVDLDEVVGVLPVDPYV ECCHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHH ENSFFERLLDLENALNSSNADLGLMGVTPTYPSEKYGYIVPNVEKSTQELIQVSHFKEKP HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCC ATAEAEELLKQNALWNSGVFAFKLDKIISLLDQKGLPVQYDVLVQQYASLPKISFDYEVV CCHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHH EKTENIIALPYSGSWKDLGTWNTLTEEMGTNILGKGNMGVECEQNHIINELDIPVSVLGL HCCCCEEEECCCCCCCCCCCHHHHHHHHCCCEECCCCCCCEECCCCCCCCCCCCEEEECC SNIIVAASPDGILVSEKDASPRVKELVGDWDQRPMYEERRWGWYRVLDHTKYDDGNEVLT CCEEEEECCCCEEEECCCCCCHHHHHHCCCCCCCCCHHHCCCEEEEECCCCCCCCHHHHH KRIGITASKNLSYQYHNNRSEVWTVVKGEGIFVLDEEIRVVRPGDVLEIQPGQKHAIKAV HHHCCEECCCCEEEEECCCCEEEEEEECCEEEEECCCEEEECCCCEEEECCCCHHHHHHH TDLEFIEVQSGSELIEEDIVRIYMQWNEIEEACYLKSKN CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC >Mature Secondary Structure MKLVLLSGGSGKRLWPLSNDSRSKQFLKVLKSEKNEMQSMVQRVWEQLKSLGIENDAVIA CEEEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE TSKSQVDMINSQLGNDVPIIIEPERRDTFPAIALAASYLYSKEHVDLDEVVGVLPVDPYV ECCHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHH ENSFFERLLDLENALNSSNADLGLMGVTPTYPSEKYGYIVPNVEKSTQELIQVSHFKEKP HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCC ATAEAEELLKQNALWNSGVFAFKLDKIISLLDQKGLPVQYDVLVQQYASLPKISFDYEVV CCHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHH EKTENIIALPYSGSWKDLGTWNTLTEEMGTNILGKGNMGVECEQNHIINELDIPVSVLGL HCCCCEEEECCCCCCCCCCCHHHHHHHHCCCEECCCCCCCEECCCCCCCCCCCCEEEECC SNIIVAASPDGILVSEKDASPRVKELVGDWDQRPMYEERRWGWYRVLDHTKYDDGNEVLT CCEEEEECCCCEEEECCCCCCHHHHHHCCCCCCCCCHHHCCCEEEEECCCCCCCCHHHHH KRIGITASKNLSYQYHNNRSEVWTVVKGEGIFVLDEEIRVVRPGDVLEIQPGQKHAIKAV HHHCCEECCCCEEEEECCCCEEEEEEECCEEEEECCCEEEECCCCEEEECCCCHHHHHHH TDLEFIEVQSGSELIEEDIVRIYMQWNEIEEACYLKSKN CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12928499 [H]