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The map label for this gene is comEB [H]

Identifier: 118479492

GI number: 118479492

Start: 4127816

End: 4128382

Strand: Reverse

Name: comEB [H]

Synonym: BALH_3914

Alternate gene names: 118479492

Gene position: 4128382-4127816 (Counterclockwise)

Preceding gene: 118479493

Following gene: 118479491

Centisome position: 78.53

GC content: 34.92

Gene sequence:

>567_bases
GTGAAGAATATGGAACGAATTTCATGGGATCAATATTTTATGACGCAAAGCCATTTGCTATCTTTACGTAGTACATGTAC
AAGGCTTGCAGTAGGAGCAACAATCGTTCGTGATAAACGAATTATTGCTGGTGGATATAATGGTTCAATTAAAGGTGGCG
TACATTGTATAGATGATGGATGCTACGTTATTGATAATCATTGTGTTCGTACAATTCACGCAGAAATGAATGCTTTATTA
CAATGTGCAAAATTTGGCGTGAAAACGGAGGAAGCGGAAATTTATGTTACGCATTTTCCGTGTTTACAATGTTGTAAGGC
GATTATACAAAGTGGTATTACAGCAGTTTATTATGCACAGGATTATAAAAATCATCCATATGCCGTAGAGTTATTTGAAA
AAGCGAATGTAACGGTGAAACACGTTCCGTTAGAATATGATATTGCAGCATTAGAGGATCAAAAGCGTCATATGGAGTTA
AAAGAACTATTTGCATCTTTAGAAAAAGAGAACTTATCAATGGAAGAATTACAGCATGTATTCACGAAAGCAAAAATGAT
GCTATAA

Upstream 100 bases:

>100_bases
TGTGAAGTCTCTGGAAAAAATAAAAGATCAAATTATTATTCCGTAAAAGATTGACGAAGTTTTTCTTCATTCGCTACACT
ACAAGTAGACAAAAAAGTAG

Downstream 100 bases:

>100_bases
GGAGTGAGTATGAGTTGCAAGGACAATGGGGCTACGTTGCAATCTCATTTATAATAGGGATTGCAATCGCCTTCTCCTCT
TCAGTTGTATTGCTGACTTG

Product: comE operon protein 2

Products: dUMP; NH3

Alternate protein names: NA

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MKNMERISWDQYFMTQSHLLSLRSTCTRLAVGATIVRDKRIIAGGYNGSIKGGVHCIDDGCYVIDNHCVRTIHAEMNALL
QCAKFGVKTEEAEIYVTHFPCLQCCKAIIQSGITAVYYAQDYKNHPYAVELFEKANVTVKHVPLEYDIAALEDQKRHMEL
KELFASLEKENLSMEELQHVFTKAKMML

Sequences:

>Translated_188_residues
MKNMERISWDQYFMTQSHLLSLRSTCTRLAVGATIVRDKRIIAGGYNGSIKGGVHCIDDGCYVIDNHCVRTIHAEMNALL
QCAKFGVKTEEAEIYVTHFPCLQCCKAIIQSGITAVYYAQDYKNHPYAVELFEKANVTVKHVPLEYDIAALEDQKRHMEL
KELFASLEKENLSMEELQHVFTKAKMML
>Mature_188_residues
MKNMERISWDQYFMTQSHLLSLRSTCTRLAVGATIVRDKRIIAGGYNGSIKGGVHCIDDGCYVIDNHCVRTIHAEMNALL
QCAKFGVKTEEAEIYVTHFPCLQCCKAIIQSGITAVYYAQDYKNHPYAVELFEKANVTVKHVPLEYDIAALEDQKRHMEL
KELFASLEKENLSMEELQHVFTKAKMML

Specific function: Dispensable for transformability [H]

COG id: COG2131

COG function: function code F; Deoxycytidylate deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI61742819, Length=155, Percent_Identity=34.1935483870968, Blast_Score=64, Evalue=6e-11,
Organism=Homo sapiens, GI61742821, Length=155, Percent_Identity=34.1935483870968, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6321938, Length=147, Percent_Identity=36.0544217687075, Blast_Score=99, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24667298, Length=186, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24667302, Length=186, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR013404
- InterPro:   IPR015517
- InterPro:   IPR016193
- InterPro:   IPR016473 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.12

Molecular weight: Translated: 21454; Mature: 21454

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
8.5 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
8.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNMERISWDQYFMTQSHLLSLRSTCTRLAVGATIVRDKRIIAGGYNGSIKGGVHCIDDG
CCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEECCCCCCCCCCEEEECCC
CYVIDNHCVRTIHAEMNALLQCAKFGVKTEEAEIYVTHFPCLQCCKAIIQSGITAVYYAQ
CEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHCCCEEEEEEC
DYKNHPYAVELFEKANVTVKHVPLEYDIAALEDQKRHMELKELFASLEKENLSMEELQHV
CCCCCCEEEEEECCCCCEEEECCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
FTKAKMML
HHHHHHCC
>Mature Secondary Structure
MKNMERISWDQYFMTQSHLLSLRSTCTRLAVGATIVRDKRIIAGGYNGSIKGGVHCIDDG
CCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEECCCCCCCCCCEEEECCC
CYVIDNHCVRTIHAEMNALLQCAKFGVKTEEAEIYVTHFPCLQCCKAIIQSGITAVYYAQ
CEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHCCCEEEEEEC
DYKNHPYAVELFEKANVTVKHVPLEYDIAALEDQKRHMELKELFASLEKENLSMEELQHV
CCCCCCEEEEEECCCCCEEEECCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
FTKAKMML
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dCMP; H2O

Specific reaction: dCMP + H2O = dUMP + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]